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The map label for this gene is fadB [H]

Identifier: 15887850

GI number: 15887850

Start: 493225

End: 495441

Strand: Direct

Name: fadB [H]

Synonym: Atu0503

Alternate gene names: 15887850

Gene position: 493225-495441 (Clockwise)

Preceding gene: 15887849

Following gene: 159184346

Centisome position: 17.36

GC content: 61.52

Gene sequence:

>2217_bases
ATGAGCACTTATACCAATTTCACCATCGAGACGGACGCAGACGGCATTGCCCTCGTCACCTGGGACATGCCGGAAAAATC
CATGAACGTCTTCACGGCAGAGGTTCTTGAGGAACTGAACGCCATTGTCGATGCCACCGTTGCCGATGGCGCGGTTAAGG
GTGTCGTCTTCACTTCGGGCAAAAGCAGCTTTTCCGGCGGTGCCGATCTGTCGATGCTGAAGTCCATGTTCGCCCTTTAT
AATGACGAAAAGGCGAAAAGCCCCGACGCTGCCGCGGCGAAGCTGTTCGAACTCGTCGGTCGCATGACGGGCCTGTTCCG
CAAGATCGAGACCAATGGCAAGCCGTGGGTCTCGGCCATCAACGGCACCTGCATGGGTGGCGCATTTGAGCTTTCGCTTG
CCTGCCATGGCCGCGTGGCCTCCAGTGCCAAGAGCCTCAAGATCGCACTGCCGGAAGTCAAGGTCGGCATCTTCCCCGGT
GCCGGCGGTACCCAACGCGTATCGCGCCTGACCGACGCGCAATCGGCGTTGCAGATGATGACGACAGGGCAATCCCTGAC
CGGCGCGCGCGCCAAGGCCATGGGGCTGGTGCACCAGGTGGTCGAGCCGGATCAACTGGTCGCAACCGCAAAGCAGATGA
TCAAGGACGGCCTGAAGCCGGTGGCACCCTGGGATGAGAAGGGCTTCAAGGCCCCCGGCGGCGGCATCTGGACGCCGGCC
GCAGCCCAGCTCTGGCCTGCCGCTCCCGCCATCCTGCGCCGCGAAAGCGCCGGCAACTACCCGGCTGCACTTGCCATCCT
GAAATGTGTTTATGAAGGCCTGCAATTGCCCTTCGACACGGCGTTGAAGGTGGAGCAGCGTTATTTCACCGAAATCCTTC
GCTCGAAGGAAGCCTTCGGCATGATCCGCTCGCTGTTCATTTCCATGCAGGAACTGAACAAGGGTGCGCGCCGCCCGGCA
GGCCAGCCGAAGACGGAGTTCAAGAAGGTCGGCGTCGTCGGCGCGGGCTTCATGGGCGCTGCCGTGGCTTACGTCACCGC
CGCAGCCGGCATTCCCGTGACGCTGGTGGATCGTGACCAGGACGCGGCCGACAAGGGCAAGGGCCATTGCGAGGAGAGTG
TGAAGGCCGCCATCGGCAAGGGCAGGCTGACGCAGGAAGAGGGTAAGGCCCTGCTCGACCTCGTTACCCCGACATCCGAT
TACGCCACACTCGCCGATGCCGATCTCGTCATCGAAGCCGTCTTCGAGGATCGTGACGTGAAGAAGGCCGTCATCGAGGC
CGTGGAAGCCGTGTTGCCCGAAGGTGCGATCTTTGCCTCCAACACCTCCACTTTGCCAATCACGGGCCTCGCGAAGAACT
CGAAGCGCCCGGCGGATTTCATCGGCATCCATTTCTTCTCGCCGGTCGAGAAGATGATGCTGACGGAAGTGATCCTCGGC
AAGGAAACCGGTGACAAGGCGCTGGCCGTCGCGCTGGATTACGTGGCGAAGATCAGGAAAACGCCGATCGTGGTCAACGA
TACGCGCGGTTTCTTCGTCAATCGCTGCGTGCTGCGCTATATGGCGGAAAGCTACGACATGCTGATCGAAGGCGTGCCCG
CCGCCATGATCGAAAATGCCGCGAAATTTGCCGGCATGCCGGTCGGTCCACTGGCGCTGAATGACGAGGTGGCGATCGAT
CTTTCCTACAAGATCCTGAAAGCCACTGTCGCCGATCTCGGCGAAAAGGCCGTCGATCCGCGTCATATGGAACTGGTGAA
GAAGCTGGTGGAAGGCGACGGCCGCTTTGGCCGCAAGAACGCCAAGGGCTTTTACGACTACCCGCCAAAGCCCGCCAAGA
AATCCCTCTGGCCCGGCCTGAAGGACCTCTATCCGCAGCAGAAGCCTGAAGACGTGGATATGGATGTGCTGAAACAGCGC
TTCCTCGTCACCGTGGCGCTCGAAGCCGCCCGCACGGTGGAAGAAGGCATCGTCACCGATCCGCGTGAGGCGGATGTCGG
CTCCATCCTCGGTTTCGGCTTCGCGCCCTATACCGGCGGTGCGCTGTCCTACATCGACGGCATGGGCGTGAAGAATTTCG
TCGCTCTGGCCGAGAAGCTCAGCGAAGCCTATGGCCCGCGCTTCCAGCCGACGCCGCTCCTGAAGGACATGGCGGCCAAG
GGCGAGACCTTCTACGGTCGCTTCGACCCCTATGCCAGCGCCGCGAAGGCGGCATAA

Upstream 100 bases:

>100_bases
TCTAGCCCAAAGACTTGGGCTGACTGGATTCCTGTGACGAGCACAGGAATGAGGGATCGGGAAGCCCGACGAAACGAAAT
TCAGGGAAGAGGAATCCCAA

Downstream 100 bases:

>100_bases
GGCACCAAGCCAGATCATCGAACAGGCCCTTCGGGGCCTGTTTTATTATGTGGATGCCATCGCTTTTCGTGCATCCTTTG
CCGGGCTGAGGCGTTGAAAA

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase; 3-hydroxyacyl-CoA dehydrogenase [H]

Number of amino acids: Translated: 738; Mature: 737

Protein sequence:

>738_residues
MSTYTNFTIETDADGIALVTWDMPEKSMNVFTAEVLEELNAIVDATVADGAVKGVVFTSGKSSFSGGADLSMLKSMFALY
NDEKAKSPDAAAAKLFELVGRMTGLFRKIETNGKPWVSAINGTCMGGAFELSLACHGRVASSAKSLKIALPEVKVGIFPG
AGGTQRVSRLTDAQSALQMMTTGQSLTGARAKAMGLVHQVVEPDQLVATAKQMIKDGLKPVAPWDEKGFKAPGGGIWTPA
AAQLWPAAPAILRRESAGNYPAALAILKCVYEGLQLPFDTALKVEQRYFTEILRSKEAFGMIRSLFISMQELNKGARRPA
GQPKTEFKKVGVVGAGFMGAAVAYVTAAAGIPVTLVDRDQDAADKGKGHCEESVKAAIGKGRLTQEEGKALLDLVTPTSD
YATLADADLVIEAVFEDRDVKKAVIEAVEAVLPEGAIFASNTSTLPITGLAKNSKRPADFIGIHFFSPVEKMMLTEVILG
KETGDKALAVALDYVAKIRKTPIVVNDTRGFFVNRCVLRYMAESYDMLIEGVPAAMIENAAKFAGMPVGPLALNDEVAID
LSYKILKATVADLGEKAVDPRHMELVKKLVEGDGRFGRKNAKGFYDYPPKPAKKSLWPGLKDLYPQQKPEDVDMDVLKQR
FLVTVALEAARTVEEGIVTDPREADVGSILGFGFAPYTGGALSYIDGMGVKNFVALAEKLSEAYGPRFQPTPLLKDMAAK
GETFYGRFDPYASAAKAA

Sequences:

>Translated_738_residues
MSTYTNFTIETDADGIALVTWDMPEKSMNVFTAEVLEELNAIVDATVADGAVKGVVFTSGKSSFSGGADLSMLKSMFALY
NDEKAKSPDAAAAKLFELVGRMTGLFRKIETNGKPWVSAINGTCMGGAFELSLACHGRVASSAKSLKIALPEVKVGIFPG
AGGTQRVSRLTDAQSALQMMTTGQSLTGARAKAMGLVHQVVEPDQLVATAKQMIKDGLKPVAPWDEKGFKAPGGGIWTPA
AAQLWPAAPAILRRESAGNYPAALAILKCVYEGLQLPFDTALKVEQRYFTEILRSKEAFGMIRSLFISMQELNKGARRPA
GQPKTEFKKVGVVGAGFMGAAVAYVTAAAGIPVTLVDRDQDAADKGKGHCEESVKAAIGKGRLTQEEGKALLDLVTPTSD
YATLADADLVIEAVFEDRDVKKAVIEAVEAVLPEGAIFASNTSTLPITGLAKNSKRPADFIGIHFFSPVEKMMLTEVILG
KETGDKALAVALDYVAKIRKTPIVVNDTRGFFVNRCVLRYMAESYDMLIEGVPAAMIENAAKFAGMPVGPLALNDEVAID
LSYKILKATVADLGEKAVDPRHMELVKKLVEGDGRFGRKNAKGFYDYPPKPAKKSLWPGLKDLYPQQKPEDVDMDVLKQR
FLVTVALEAARTVEEGIVTDPREADVGSILGFGFAPYTGGALSYIDGMGVKNFVALAEKLSEAYGPRFQPTPLLKDMAAK
GETFYGRFDPYASAAKAA
>Mature_737_residues
STYTNFTIETDADGIALVTWDMPEKSMNVFTAEVLEELNAIVDATVADGAVKGVVFTSGKSSFSGGADLSMLKSMFALYN
DEKAKSPDAAAAKLFELVGRMTGLFRKIETNGKPWVSAINGTCMGGAFELSLACHGRVASSAKSLKIALPEVKVGIFPGA
GGTQRVSRLTDAQSALQMMTTGQSLTGARAKAMGLVHQVVEPDQLVATAKQMIKDGLKPVAPWDEKGFKAPGGGIWTPAA
AQLWPAAPAILRRESAGNYPAALAILKCVYEGLQLPFDTALKVEQRYFTEILRSKEAFGMIRSLFISMQELNKGARRPAG
QPKTEFKKVGVVGAGFMGAAVAYVTAAAGIPVTLVDRDQDAADKGKGHCEESVKAAIGKGRLTQEEGKALLDLVTPTSDY
ATLADADLVIEAVFEDRDVKKAVIEAVEAVLPEGAIFASNTSTLPITGLAKNSKRPADFIGIHFFSPVEKMMLTEVILGK
ETGDKALAVALDYVAKIRKTPIVVNDTRGFFVNRCVLRYMAESYDMLIEGVPAAMIENAAKFAGMPVGPLALNDEVAIDL
SYKILKATVADLGEKAVDPRHMELVKKLVEGDGRFGRKNAKGFYDYPPKPAKKSLWPGLKDLYPQQKPEDVDMDVLKQRF
LVTVALEAARTVEEGIVTDPREADVGSILGFGFAPYTGGALSYIDGMGVKNFVALAEKLSEAYGPRFQPTPLLKDMAAKG
ETFYGRFDPYASAAKAA

Specific function: Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI20127408, Length=757, Percent_Identity=32.4966974900925, Blast_Score=361, Evalue=1e-99,
Organism=Homo sapiens, GI68989263, Length=755, Percent_Identity=27.9470198675497, Blast_Score=249, Evalue=7e-66,
Organism=Homo sapiens, GI261878539, Length=630, Percent_Identity=29.0476190476191, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI296179429, Length=292, Percent_Identity=35.6164383561644, Blast_Score=147, Evalue=5e-35,
Organism=Homo sapiens, GI296179427, Length=309, Percent_Identity=33.6569579288026, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI194097323, Length=199, Percent_Identity=28.1407035175879, Blast_Score=90, Evalue=9e-18,
Organism=Escherichia coli, GI1788682, Length=732, Percent_Identity=34.8360655737705, Blast_Score=388, Evalue=1e-109,
Organism=Escherichia coli, GI1790281, Length=725, Percent_Identity=29.7931034482759, Blast_Score=305, Evalue=9e-84,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=33.5689045936396, Blast_Score=144, Evalue=3e-35,
Organism=Escherichia coli, GI1787659, Length=200, Percent_Identity=29, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI221142681, Length=159, Percent_Identity=30.188679245283, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17558304, Length=760, Percent_Identity=32.6315789473684, Blast_Score=347, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI17508951, Length=770, Percent_Identity=33.7662337662338, Blast_Score=346, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI17508953, Length=758, Percent_Identity=33.7730870712401, Blast_Score=345, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI25144276, Length=641, Percent_Identity=34.4773790951638, Blast_Score=297, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71985923, Length=378, Percent_Identity=28.8359788359788, Blast_Score=160, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71985930, Length=367, Percent_Identity=28.0653950953678, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17549919, Length=293, Percent_Identity=34.1296928327645, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17563036, Length=292, Percent_Identity=31.5068493150685, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17553560, Length=290, Percent_Identity=33.1034482758621, Blast_Score=140, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17554946, Length=202, Percent_Identity=26.7326732673267, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17540714, Length=213, Percent_Identity=29.1079812206573, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25145438, Length=200, Percent_Identity=28.5, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320241, Length=214, Percent_Identity=28.5046728971963, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19921000, Length=746, Percent_Identity=32.171581769437, Blast_Score=325, Evalue=8e-89,
Organism=Drosophila melanogaster, GI24583077, Length=738, Percent_Identity=32.2493224932249, Blast_Score=324, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24583079, Length=738, Percent_Identity=32.2493224932249, Blast_Score=324, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24653139, Length=199, Percent_Identity=32.1608040201005, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI20129971, Length=211, Percent_Identity=24.6445497630332, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24653477, Length=211, Percent_Identity=24.6445497630332, Blast_Score=86, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR018376
- InterPro:   IPR012802
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =4.2.1.17; =5.1.2.3; =1.1.1.35 [H]

Molecular weight: Translated: 79005; Mature: 78874

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTYTNFTIETDADGIALVTWDMPEKSMNVFTAEVLEELNAIVDATVADGAVKGVVFTSG
CCCEECEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
KSSFSGGADLSMLKSMFALYNDEKAKSPDAAAAKLFELVGRMTGLFRKIETNGKPWVSAI
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCC
NGTCMGGAFELSLACHGRVASSAKSLKIALPEVKVGIFPGAGGTQRVSRLTDAQSALQMM
CCCCCCCEEEEEEEECCCHHCCCCCEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
TTGQSLTGARAKAMGLVHQVVEPDQLVATAKQMIKDGLKPVAPWDEKGFKAPGGGIWTPA
HCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
AAQLWPAAPAILRRESAGNYPAALAILKCVYEGLQLPFDTALKVEQRYFTEILRSKEAFG
HHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
MIRSLFISMQELNKGARRPAGQPKTEFKKVGVVGAGFMGAAVAYVTAAAGIPVTLVDRDQ
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCC
DAADKGKGHCEESVKAAIGKGRLTQEEGKALLDLVTPTSDYATLADADLVIEAVFEDRDV
CCHHCCCCHHHHHHHHHHCCCCCCHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCHH
KKAVIEAVEAVLPEGAIFASNTSTLPITGLAKNSKRPADFIGIHFFSPVEKMMLTEVILG
HHHHHHHHHHHCCCCCEEECCCCCCEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHC
KETGDKALAVALDYVAKIRKTPIVVNDTRGFFVNRCVLRYMAESYDMLIEGVPAAMIENA
CCCCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AKFAGMPVGPLALNDEVAIDLSYKILKATVADLGEKAVDPRHMELVKKLVEGDGRFGRKN
HHHCCCCCCCEEECCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCC
AKGFYDYPPKPAKKSLWPGLKDLYPQQKPEDVDMDVLKQRFLVTVALEAARTVEEGIVTD
CCCCCCCCCCCCCHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
PREADVGSILGFGFAPYTGGALSYIDGMGVKNFVALAEKLSEAYGPRFQPTPLLKDMAAK
CCCCCHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHC
GETFYGRFDPYASAAKAA
CCCEECCCCCHHHHHCCC
>Mature Secondary Structure 
STYTNFTIETDADGIALVTWDMPEKSMNVFTAEVLEELNAIVDATVADGAVKGVVFTSG
CCEECEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
KSSFSGGADLSMLKSMFALYNDEKAKSPDAAAAKLFELVGRMTGLFRKIETNGKPWVSAI
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCC
NGTCMGGAFELSLACHGRVASSAKSLKIALPEVKVGIFPGAGGTQRVSRLTDAQSALQMM
CCCCCCCEEEEEEEECCCHHCCCCCEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
TTGQSLTGARAKAMGLVHQVVEPDQLVATAKQMIKDGLKPVAPWDEKGFKAPGGGIWTPA
HCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
AAQLWPAAPAILRRESAGNYPAALAILKCVYEGLQLPFDTALKVEQRYFTEILRSKEAFG
HHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
MIRSLFISMQELNKGARRPAGQPKTEFKKVGVVGAGFMGAAVAYVTAAAGIPVTLVDRDQ
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCC
DAADKGKGHCEESVKAAIGKGRLTQEEGKALLDLVTPTSDYATLADADLVIEAVFEDRDV
CCHHCCCCHHHHHHHHHHCCCCCCHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCHH
KKAVIEAVEAVLPEGAIFASNTSTLPITGLAKNSKRPADFIGIHFFSPVEKMMLTEVILG
HHHHHHHHHHHCCCCCEEECCCCCCEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHC
KETGDKALAVALDYVAKIRKTPIVVNDTRGFFVNRCVLRYMAESYDMLIEGVPAAMIENA
CCCCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AKFAGMPVGPLALNDEVAIDLSYKILKATVADLGEKAVDPRHMELVKKLVEGDGRFGRKN
HHHCCCCCCCEEECCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCC
AKGFYDYPPKPAKKSLWPGLKDLYPQQKPEDVDMDVLKQRFLVTVALEAARTVEEGIVTD
CCCCCCCCCCCCCHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
PREADVGSILGFGFAPYTGGALSYIDGMGVKNFVALAEKLSEAYGPRFQPTPLLKDMAAK
CCCCCHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHC
GETFYGRFDPYASAAKAA
CCCEECCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA