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The map label for this gene is phoR [H]

Identifier: 15887767

GI number: 15887767

Start: 414781

End: 416082

Strand: Direct

Name: phoR [H]

Synonym: Atu0419

Alternate gene names: 15887767

Gene position: 414781-416082 (Clockwise)

Preceding gene: 159185425

Following gene: 15887768

Centisome position: 14.6

GC content: 61.14

Gene sequence:

>1302_bases
GTGCTGTCAGATGAAAGTGGAGAGCAGGCTGAAATGGCAGTGAGGGAAGGCGAGAGTGGATTGAGGCTTTTGGGGAAGAA
GCTCGGCCGGAACTGGTTGCCCGTTCTCATCGTCAGCATGCTTGCCGTGGTGGCCGTTACCGAGCTGCACACGCCCTATA
TGCCCGCGGCTCTTTGGCTCTGTGCGATCATCGCCATTCTTGCCGTTCGGGAAAAACCGGCGGCGCCCGAAAAGGATAAA
GAGACAGCCGCGGATGTGGATGAGCCGGATGTGCCGGGTGAAAACGTCATTTCCGGCGTAAGGGCGGGCCTTGCAGTACT
GGATACGCCCGTTTTCATTCTCGACAAGAATGCCAGCGTGCTGTTTCAGAACGGTGCAGCCGAGCGCGCCTTCGGCCAGC
TTCCCGCCGGTGCGCATATTTCCGCAAGGCTGCGCTCGCCCGGCTTGCTTGATGTCATTCGCGAAACCATCACCACCGGC
CAGCCCAATCAGGTCGAACATTCCGAACGCTTCCCTTCCGAACGGGTCTTCATCGTCCGCATCGCCCGTGCGGATGTGGG
CGAGGGCGCCAGCCCGCCATTCTACATCCTGTCCTTCCGCGACGTCTCGGAGCTCCGCCGCATCGACCGTATGCGCAGCG
ATTTCGTCGCCAATGCGAGCCATGAGTTGCGCACGCCGCTCGCCTCACTGCGCGGTTTCATCGAAACCATGCAGGGGCCG
GCGCGCAACGACCCCAAGGCGCAAGAGCGCTTCCTTGCCATCATGCTGGATCAGGCAACCCGCATGAGCAGGCTGGTGGA
CGATCTAATGTCCCTTTCACGGCTGGAGCTGCGGGCAAACATCGCGCCGGACCAGAAGGTCGATCTCGTGCCCGTCATCG
GCCATGTGCGTGATGCCTTGTTGCCGCTTGCCGATGAGCTTGATGTAACCATCACGCTGCATCTGCCCGACCGGCCGGCG
GAAGTGCAGGGAGACCGCGACGAGCTGGTGCAGGTATTCCAGAACCTCGTTGAAAACGCTTGCAAATATGGGCAGGAAGG
CAAGGTCGTGGATGTCTGGCTGCGCGCCGAACCCGGCAAGCCGGTGGAGGTCAGCATCATCGACAAGGGGCCGGGCATTC
CCGCCGAACACGTGCCGCGGCTGACCGAGCGTTTTTATCGCGTCAGCGTGGCCGACAGCCGTTCGAAAAAGGGCACGGGT
CTCGGGCTTGCCATCGTTAAGCACATCCTCACCCGCCACCGCGCCAGGCTCATTATTAAATCGGAAATGGGCAGCGGCAC
GGACTTCACCGTCAGATTTTGA

Upstream 100 bases:

>100_bases
CGACGGCGCTGACGATTGCGGCGCGGATTTCGCGCATATACGTTGTGGAAAATGCGCGATGATGAATCTCTGTCATGAAG
CTGGCCTATGAGATTTCGAT

Downstream 100 bases:

>100_bases
CATGAACGACTGGCCGTTTTTAAACATTGCAGAAATATATAAATTAAATCAATAATTTAGTTTGTCACAAATCTTTCGTC
AAAGTGACATAAAAGGATGT

Product: two component sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLSDESGEQAEMAVREGESGLRLLGKKLGRNWLPVLIVSMLAVVAVTELHTPYMPAALWLCAIIAILAVREKPAAPEKDK
ETAADVDEPDVPGENVISGVRAGLAVLDTPVFILDKNASVLFQNGAAERAFGQLPAGAHISARLRSPGLLDVIRETITTG
QPNQVEHSERFPSERVFIVRIARADVGEGASPPFYILSFRDVSELRRIDRMRSDFVANASHELRTPLASLRGFIETMQGP
ARNDPKAQERFLAIMLDQATRMSRLVDDLMSLSRLELRANIAPDQKVDLVPVIGHVRDALLPLADELDVTITLHLPDRPA
EVQGDRDELVQVFQNLVENACKYGQEGKVVDVWLRAEPGKPVEVSIIDKGPGIPAEHVPRLTERFYRVSVADSRSKKGTG
LGLAIVKHILTRHRARLIIKSEMGSGTDFTVRF

Sequences:

>Translated_433_residues
MLSDESGEQAEMAVREGESGLRLLGKKLGRNWLPVLIVSMLAVVAVTELHTPYMPAALWLCAIIAILAVREKPAAPEKDK
ETAADVDEPDVPGENVISGVRAGLAVLDTPVFILDKNASVLFQNGAAERAFGQLPAGAHISARLRSPGLLDVIRETITTG
QPNQVEHSERFPSERVFIVRIARADVGEGASPPFYILSFRDVSELRRIDRMRSDFVANASHELRTPLASLRGFIETMQGP
ARNDPKAQERFLAIMLDQATRMSRLVDDLMSLSRLELRANIAPDQKVDLVPVIGHVRDALLPLADELDVTITLHLPDRPA
EVQGDRDELVQVFQNLVENACKYGQEGKVVDVWLRAEPGKPVEVSIIDKGPGIPAEHVPRLTERFYRVSVADSRSKKGTG
LGLAIVKHILTRHRARLIIKSEMGSGTDFTVRF
>Mature_433_residues
MLSDESGEQAEMAVREGESGLRLLGKKLGRNWLPVLIVSMLAVVAVTELHTPYMPAALWLCAIIAILAVREKPAAPEKDK
ETAADVDEPDVPGENVISGVRAGLAVLDTPVFILDKNASVLFQNGAAERAFGQLPAGAHISARLRSPGLLDVIRETITTG
QPNQVEHSERFPSERVFIVRIARADVGEGASPPFYILSFRDVSELRRIDRMRSDFVANASHELRTPLASLRGFIETMQGP
ARNDPKAQERFLAIMLDQATRMSRLVDDLMSLSRLELRANIAPDQKVDLVPVIGHVRDALLPLADELDVTITLHLPDRPA
EVQGDRDELVQVFQNLVENACKYGQEGKVVDVWLRAEPGKPVEVSIIDKGPGIPAEHVPRLTERFYRVSVADSRSKKGTG
LGLAIVKHILTRHRARLIIKSEMGSGTDFTVRF

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=341, Percent_Identity=34.6041055718475, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1788393, Length=229, Percent_Identity=34.9344978165939, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI145693157, Length=222, Percent_Identity=31.981981981982, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786783, Length=239, Percent_Identity=31.7991631799163, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI48994928, Length=244, Percent_Identity=28.2786885245902, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=29.4871794871795, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788713, Length=374, Percent_Identity=23.5294117647059, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1789403, Length=202, Percent_Identity=32.6732673267327, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789149, Length=228, Percent_Identity=31.140350877193, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790551, Length=227, Percent_Identity=33.920704845815, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790861, Length=199, Percent_Identity=33.1658291457286, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790346, Length=214, Percent_Identity=27.1028037383178, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87082128, Length=276, Percent_Identity=25.7246376811594, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788549, Length=301, Percent_Identity=23.2558139534884, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787374, Length=232, Percent_Identity=25.4310344827586, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786912, Length=223, Percent_Identity=26.457399103139, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788279, Length=201, Percent_Identity=24.8756218905473, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47630; Mature: 47630

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSDESGEQAEMAVREGESGLRLLGKKLGRNWLPVLIVSMLAVVAVTELHTPYMPAALWL
CCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
CAIIAILAVREKPAAPEKDKETAADVDEPDVPGENVISGVRAGLAVLDTPVFILDKNASV
HHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEE
LFQNGAAERAFGQLPAGAHISARLRSPGLLDVIRETITTGQPNQVEHSERFPSERVFIVR
EEECCCHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCHHHCCCCCCEEEEE
IARADVGEGASPPFYILSFRDVSELRRIDRMRSDFVANASHELRTPLASLRGFIETMQGP
EECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
ARNDPKAQERFLAIMLDQATRMSRLVDDLMSLSRLELRANIAPDQKVDLVPVIGHVRDAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
LPLADELDVTITLHLPDRPAEVQGDRDELVQVFQNLVENACKYGQEGKVVDVWLRAEPGK
HCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCC
PVEVSIIDKGPGIPAEHVPRLTERFYRVSVADSRSKKGTGLGLAIVKHILTRHRARLIIK
CEEEEEEECCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHEEEE
SEMGSGTDFTVRF
ECCCCCCCEEEEC
>Mature Secondary Structure
MLSDESGEQAEMAVREGESGLRLLGKKLGRNWLPVLIVSMLAVVAVTELHTPYMPAALWL
CCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
CAIIAILAVREKPAAPEKDKETAADVDEPDVPGENVISGVRAGLAVLDTPVFILDKNASV
HHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEE
LFQNGAAERAFGQLPAGAHISARLRSPGLLDVIRETITTGQPNQVEHSERFPSERVFIVR
EEECCCHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCHHHCCCCCCEEEEE
IARADVGEGASPPFYILSFRDVSELRRIDRMRSDFVANASHELRTPLASLRGFIETMQGP
EECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
ARNDPKAQERFLAIMLDQATRMSRLVDDLMSLSRLELRANIAPDQKVDLVPVIGHVRDAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
LPLADELDVTITLHLPDRPAEVQGDRDELVQVFQNLVENACKYGQEGKVVDVWLRAEPGK
HCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCC
PVEVSIIDKGPGIPAEHVPRLTERFYRVSVADSRSKKGTGLGLAIVKHILTRHRARLIIK
CEEEEEEECCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHEEEE
SEMGSGTDFTVRF
ECCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]