Click here to switch to the map view.

The map label for this gene is lspA [H]

Identifier: 15887692

GI number: 15887692

Start: 332938

End: 333426

Strand: Direct

Name: lspA [H]

Synonym: Atu0342

Alternate gene names: 15887692

Gene position: 332938-333426 (Clockwise)

Preceding gene: 159184265

Following gene: 159184266

Centisome position: 11.72

GC content: 56.03

Gene sequence:

>489_bases
ATGGCCAAAGCGGCATTGTTCTCGAAATTCGCACCGGCTTTTACGCTGATCGCCGCCGCACTGGTGCTGGATCAGATCGT
CAAGCAGCTGGTCGAGGCCTATCTGCCGCTGCAGGAGATGGTTCCGGTAGCGCCGTTTCTGGCGCTTTATCGCACCTACA
ATCTCGGTGTCGCCTTTTCGATGCTGGAAGACATGCACGGCTGGTTCATCGTCAGCATGCGCCTCGTCATCGTGGTCTTC
GTTCTATGGCTCTGGCGCAAGACGGCGGCCGACCGGACCTTCGCCCATCTCGGTTTTGCCTTCATCATCGCGGGAGCGGC
CGGCAATCTTCTCGACCGCTTTTTTTACGGTCACGTCATCGACTATATCCTGTTCCACACGCAGACATGGTCGTTCGCGG
TATTCAATCTGGCTGATAGTTTCATAACCATCGGTGCAGCCTGCGTCATTCTCGATGAATTTCTGCATGCCCGGGCGGCC
AAAAAGTAA

Upstream 100 bases:

>100_bases
CCCAGCAGGGCCGCGCCGATAGTCTCAACCTTGCCATCGCAACCGCCGTCATGCTGTTTGAAGCACGGCGACATCTCCTC
GAACTGGCACCGGTGACGTA

Downstream 100 bases:

>100_bases
AATTTTAGCGTTTCAGCCAAACATATCAAAACCGCTGCCGTGGTAGCGGTTATGTATGAGCGAACTTGCACGACTTCGGC
AAAAAGTTTCAGATGGTCTC

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MAKAALFSKFAPAFTLIAAALVLDQIVKQLVEAYLPLQEMVPVAPFLALYRTYNLGVAFSMLEDMHGWFIVSMRLVIVVF
VLWLWRKTAADRTFAHLGFAFIIAGAAGNLLDRFFYGHVIDYILFHTQTWSFAVFNLADSFITIGAACVILDEFLHARAA
KK

Sequences:

>Translated_162_residues
MAKAALFSKFAPAFTLIAAALVLDQIVKQLVEAYLPLQEMVPVAPFLALYRTYNLGVAFSMLEDMHGWFIVSMRLVIVVF
VLWLWRKTAADRTFAHLGFAFIIAGAAGNLLDRFFYGHVIDYILFHTQTWSFAVFNLADSFITIGAACVILDEFLHARAA
KK
>Mature_161_residues
AKAALFSKFAPAFTLIAAALVLDQIVKQLVEAYLPLQEMVPVAPFLALYRTYNLGVAFSMLEDMHGWFIVSMRLVIVVFV
LWLWRKTAADRTFAHLGFAFIIAGAAGNLLDRFFYGHVIDYILFHTQTWSFAVFNLADSFITIGAACVILDEFLHARAAK
K

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=150, Percent_Identity=38, Blast_Score=101, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 18197; Mature: 18066

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKAALFSKFAPAFTLIAAALVLDQIVKQLVEAYLPLQEMVPVAPFLALYRTYNLGVAFS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
MLEDMHGWFIVSMRLVIVVFVLWLWRKTAADRTFAHLGFAFIIAGAAGNLLDRFFYGHVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYILFHTQTWSFAVFNLADSFITIGAACVILDEFLHARAAKK
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKAALFSKFAPAFTLIAAALVLDQIVKQLVEAYLPLQEMVPVAPFLALYRTYNLGVAFS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
MLEDMHGWFIVSMRLVIVVFVLWLWRKTAADRTFAHLGFAFIIAGAAGNLLDRFFYGHVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYILFHTQTWSFAVFNLADSFITIGAACVILDEFLHARAAKK
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]