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The map label for this gene is hrcA

Identifier: 15887679

GI number: 15887679

Start: 321899

End: 322990

Strand: Direct

Name: hrcA

Synonym: Atu0328

Alternate gene names: 15887679

Gene position: 321899-322990 (Clockwise)

Preceding gene: 159184258

Following gene: 15887680

Centisome position: 11.33

GC content: 59.43

Gene sequence:

>1092_bases
ATGGGTTTTTCAGCACCGCTTTCAAAAGATCAGGCATCGCTGCTCGATGAGCGGTCGCGGGAAATTTTCCGGCGCATCGT
CGAAGGTTATCTCGATACGGGCGAGCCGCTCGGATCGCGCAGCCTGTCGCGGCTTCTGCCGATGTCGCTTTCCCCGGCCT
CCGTCCGCAACGTCATGAGCGACCTGGAGGAGCTTGGTCTCATCTATTCGCCGCATATCAGCGCCGGACGCCTGCCCACG
CAGACGGGGCTGCGCTTCTTCGTGGATGCCTTCATGCAGGTGGGCGATCTTCCTGCCGATGAGCGGGCGAATATCGACCG
TCAGATCGGGCCGGTTGCCGGCCACGAACAATCGCTGGAAGGTTTGCTGACGGAAGCGAGCCGCATGCTGTCAGGCATGT
CGCGCGGGGCTGGCCTCGTGCTGACGGCCAAGAATGATGTCATCCTCAAACATGTCGAATTCATCAGGCTCGAGCCCACC
AAGGCGCTCGCGGTGCTGGTCGGCGATCACAATCAGGTCGAAAACCGTATCATCGAATTGCCGGCCGGCATCTCCTCTTC
GCAATTGACCGAGGCGGCGAATTTCATCAATGCCCACCTGTCCGGACAGACGCTGCAGGAGTTACGCGGGCAGTTCCAGA
CCCAGCGTACGGAGTTGCAGTCGGAACTCGGCATGCTGGCGCAGGATCTCGTGGAGCGTGGTCTCGCTATATGGGCGGGC
GACAATGAGGAAGGCAAGCTCGGCCGGCTCATCGTTCGCGGCCGCTCCAACCTGCTCGAGGGCCTCGCTGGTGAGGAAGA
TATCGATCGGGTACGCATGTTGTTCGACGATCTCGAGCGTAAGGAAAATCTGATCGAGATTCTCAATCTGGCGGAAAGCG
GTTCAGGGGTCAGGATTTTCATCGGCTCTGAAAACAAGCTGTTTTCGCTCTCCGGTTCCTCTCTCATCGTCGCGCCCTAT
CGCGATGAGGAAAATCGTGTCGTGGGTGCTGTCGGCGTCATCGGGCCTACCAGGCTGAACTATGCCCGTATCGTACCGAT
GGTCGATTATACCGCGCAGATCATGGCGCGCCTTTCCCGCAAACAGAGATAG

Upstream 100 bases:

>100_bases
GTGCGCTCCGGGCTTTTGCAAAGCCAATTTCCGTTTTGCCCCGGCGTTGCAACGCATTATATTGGCGTAAAGTAGATTTG
GACGATAAAGAACGGACAAG

Downstream 100 bases:

>100_bases
GACACATCAGCAAGATCAGAGAATGCGGCAAGCTTTTTGCCGCAAGCCTTGATTTTTGCCCGTCAAAGCTCGATATCGGG
CCCAACCCAATAACAGTCTA

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MGFSAPLSKDQASLLDERSREIFRRIVEGYLDTGEPLGSRSLSRLLPMSLSPASVRNVMSDLEELGLIYSPHISAGRLPT
QTGLRFFVDAFMQVGDLPADERANIDRQIGPVAGHEQSLEGLLTEASRMLSGMSRGAGLVLTAKNDVILKHVEFIRLEPT
KALAVLVGDHNQVENRIIELPAGISSSQLTEAANFINAHLSGQTLQELRGQFQTQRTELQSELGMLAQDLVERGLAIWAG
DNEEGKLGRLIVRGRSNLLEGLAGEEDIDRVRMLFDDLERKENLIEILNLAESGSGVRIFIGSENKLFSLSGSSLIVAPY
RDEENRVVGAVGVIGPTRLNYARIVPMVDYTAQIMARLSRKQR

Sequences:

>Translated_363_residues
MGFSAPLSKDQASLLDERSREIFRRIVEGYLDTGEPLGSRSLSRLLPMSLSPASVRNVMSDLEELGLIYSPHISAGRLPT
QTGLRFFVDAFMQVGDLPADERANIDRQIGPVAGHEQSLEGLLTEASRMLSGMSRGAGLVLTAKNDVILKHVEFIRLEPT
KALAVLVGDHNQVENRIIELPAGISSSQLTEAANFINAHLSGQTLQELRGQFQTQRTELQSELGMLAQDLVERGLAIWAG
DNEEGKLGRLIVRGRSNLLEGLAGEEDIDRVRMLFDDLERKENLIEILNLAESGSGVRIFIGSENKLFSLSGSSLIVAPY
RDEENRVVGAVGVIGPTRLNYARIVPMVDYTAQIMARLSRKQR
>Mature_362_residues
GFSAPLSKDQASLLDERSREIFRRIVEGYLDTGEPLGSRSLSRLLPMSLSPASVRNVMSDLEELGLIYSPHISAGRLPTQ
TGLRFFVDAFMQVGDLPADERANIDRQIGPVAGHEQSLEGLLTEASRMLSGMSRGAGLVLTAKNDVILKHVEFIRLEPTK
ALAVLVGDHNQVENRIIELPAGISSSQLTEAANFINAHLSGQTLQELRGQFQTQRTELQSELGMLAQDLVERGLAIWAGD
NEEGKLGRLIVRGRSNLLEGLAGEEDIDRVRMLFDDLERKENLIEILNLAESGSGVRIFIGSENKLFSLSGSSLIVAPYR
DEENRVVGAVGVIGPTRLNYARIVPMVDYTAQIMARLSRKQR

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_AGRT5 (P0A3I8)

Other databases:

- EMBL:   AE007869
- PIR:   AH2616
- PIR:   H97398
- RefSeq:   NP_353360.1
- ProteinModelPortal:   P0A3I8
- SMR:   P0A3I8
- STRING:   P0A3I8
- GeneID:   1132366
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0328
- eggNOG:   COG1420
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   ATUM176299-1:ATU0328-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 39900; Mature: 39769

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFSAPLSKDQASLLDERSREIFRRIVEGYLDTGEPLGSRSLSRLLPMSLSPASVRNVMS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHH
DLEELGLIYSPHISAGRLPTQTGLRFFVDAFMQVGDLPADERANIDRQIGPVAGHEQSLE
HHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCHHHHH
GLLTEASRMLSGMSRGAGLVLTAKNDVILKHVEFIRLEPTKALAVLVGDHNQVENRIIEL
HHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHEECCCCEEEEEECCCHHHHHHHEEC
PAGISSSQLTEAANFINAHLSGQTLQELRGQFQTQRTELQSELGMLAQDLVERGLAIWAG
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
DNEEGKLGRLIVRGRSNLLEGLAGEEDIDRVRMLFDDLERKENLIEILNLAESGSGVRIF
CCCCCCCHHEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
IGSENKLFSLSGSSLIVAPYRDEENRVVGAVGVIGPTRLNYARIVPMVDYTAQIMARLSR
ECCCCCEEEECCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHHH
KQR
CCC
>Mature Secondary Structure 
GFSAPLSKDQASLLDERSREIFRRIVEGYLDTGEPLGSRSLSRLLPMSLSPASVRNVMS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHH
DLEELGLIYSPHISAGRLPTQTGLRFFVDAFMQVGDLPADERANIDRQIGPVAGHEQSLE
HHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCHHHHH
GLLTEASRMLSGMSRGAGLVLTAKNDVILKHVEFIRLEPTKALAVLVGDHNQVENRIIEL
HHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHEECCCCEEEEEECCCHHHHHHHEEC
PAGISSSQLTEAANFINAHLSGQTLQELRGQFQTQRTELQSELGMLAQDLVERGLAIWAG
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
DNEEGKLGRLIVRGRSNLLEGLAGEEDIDRVRMLFDDLERKENLIEILNLAESGSGVRIF
CCCCCCCHHEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
IGSENKLFSLSGSSLIVAPYRDEENRVVGAVGVIGPTRLNYARIVPMVDYTAQIMARLSR
ECCCCCEEEECCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHHH
KQR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194