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The map label for this gene is mltA [H]

Identifier: 15887368

GI number: 15887368

Start: 5865

End: 6977

Strand: Direct

Name: mltA [H]

Synonym: Atu0009

Alternate gene names: 15887368

Gene position: 5865-6977 (Clockwise)

Preceding gene: 159184122

Following gene: 15887369

Centisome position: 0.21

GC content: 60.56

Gene sequence:

>1113_bases
ATGAATACGCCCTTTTCGATCGACGAGGTTTCTTTCCGCGATCTGCCCGGATGGGGGCAGGATGACCCCCGCAAGCTTTT
TCCGGCGATGGCAACGATCCTGTCGCATCTTCGTAATGCGAAACCCTACAGGACCGGTGCGCTCGGGATAACGGCAGCGG
AGCTGGTTTCGCTTCTGGAGCTCGCCGAAAGAGGCCAAGTGAACAGCCCCGAACAGGCGCGCCAGTTTTTCGAAACCAAT
TCTGTGCCTTTCAGGATTTCTCCGGCTCAGGGCAAAAGCGGTTTCGTGACCGCTTTTTATGAGCCCGAACTGGAGGTCTC
CGCCACGCCGGATGATGTGTGGCGTTATCCGATCTACCGCCGGCCGCCGGAGCTGGTGGATATTGACAACGATAACCGGC
CGGATGGTTTCGATCCGTCCTATGCTTTCGGCAAGGCGGATGAAGAGGGCATTTCCTATTTTCCCGATCGCCGCGCCATC
GATGAAGGGTGTCTGCGGGGCAGGGGTCTTGAGATTGCCTGGGCAAGATCGAAGGTCGATCTATTCTTCGTCCATGTGCA
GGGTGCAGCGCGTCTGGTGTTTCCGGATGGCGCGATAAAGCGCATCACCTACGCGGCCAAGGCCGGGCATGTCTTTTCGC
CGATCGGCCGGCTGCTTCTCGACCGCGGTGAGCTCGATCCGAAAACAATCTCGATGCAGACGATCCGCCAATGGCTCGCC
GACCATCCGGATGAGGTGGACGGGGTGCTGTGGCACAACCGCTCCTACATTTTTTTCCGGGAGGCGGATGTCGCCGGTCT
GGACATGGGGCCGATCGCCGCCGCCAAGGTGCCGCTGGTTGCGGGCCGTGCGCTTGCGGTCGACAGGCTGATCCACACCT
TCGGCCTGCCGTTCTTCATCCATGCGCCGACGCTGACCCATCTCGACGATGGAAAGCCGTTCGCCCGGCTGATGCTGGCG
CTGGATACCGGCTCGGCCATTGTCGGCCCGGCGCGCGGCGATATTTTCACCGGCTCGGGTTTCGAAGCGGGAGAGCTTGC
CGGCACGGTGCGCAACGAAGCCGATTTTTATATACTGCTGCCGCGGATTGCTGCGGAAAGGTATCGGCGATGA

Upstream 100 bases:

>100_bases
ACCCGGAAGCGGTTGCGGAGGTGGATGACATCTGGACCTTCTCGCGCGACATCCGCTCGCGCGATCCGAACTGGAAGCTG
ATCGCCACCGAATCCGAGCA

Downstream 100 bases:

>100_bases
AAGGCAGTCGCAAGCTCGGCAAGGAAGAACGCATTCTGTGGGGAAGGGTCGCAAAAACCACGCGGCCAATTTCCGGCAGG
CTGGAAGATTTGCTGGCTTT

Product: membrane-bound lytic murein transglycosylase

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MNTPFSIDEVSFRDLPGWGQDDPRKLFPAMATILSHLRNAKPYRTGALGITAAELVSLLELAERGQVNSPEQARQFFETN
SVPFRISPAQGKSGFVTAFYEPELEVSATPDDVWRYPIYRRPPELVDIDNDNRPDGFDPSYAFGKADEEGISYFPDRRAI
DEGCLRGRGLEIAWARSKVDLFFVHVQGAARLVFPDGAIKRITYAAKAGHVFSPIGRLLLDRGELDPKTISMQTIRQWLA
DHPDEVDGVLWHNRSYIFFREADVAGLDMGPIAAAKVPLVAGRALAVDRLIHTFGLPFFIHAPTLTHLDDGKPFARLMLA
LDTGSAIVGPARGDIFTGSGFEAGELAGTVRNEADFYILLPRIAAERYRR

Sequences:

>Translated_370_residues
MNTPFSIDEVSFRDLPGWGQDDPRKLFPAMATILSHLRNAKPYRTGALGITAAELVSLLELAERGQVNSPEQARQFFETN
SVPFRISPAQGKSGFVTAFYEPELEVSATPDDVWRYPIYRRPPELVDIDNDNRPDGFDPSYAFGKADEEGISYFPDRRAI
DEGCLRGRGLEIAWARSKVDLFFVHVQGAARLVFPDGAIKRITYAAKAGHVFSPIGRLLLDRGELDPKTISMQTIRQWLA
DHPDEVDGVLWHNRSYIFFREADVAGLDMGPIAAAKVPLVAGRALAVDRLIHTFGLPFFIHAPTLTHLDDGKPFARLMLA
LDTGSAIVGPARGDIFTGSGFEAGELAGTVRNEADFYILLPRIAAERYRR
>Mature_370_residues
MNTPFSIDEVSFRDLPGWGQDDPRKLFPAMATILSHLRNAKPYRTGALGITAAELVSLLELAERGQVNSPEQARQFFETN
SVPFRISPAQGKSGFVTAFYEPELEVSATPDDVWRYPIYRRPPELVDIDNDNRPDGFDPSYAFGKADEEGISYFPDRRAI
DEGCLRGRGLEIAWARSKVDLFFVHVQGAARLVFPDGAIKRITYAAKAGHVFSPIGRLLLDRGELDPKTISMQTIRQWLA
DHPDEVDGVLWHNRSYIFFREADVAGLDMGPIAAAKVPLVAGRALAVDRLIHTFGLPFFIHAPTLTHLDDGKPFARLMLA
LDTGSAIVGPARGDIFTGSGFEAGELAGTVRNEADFYILLPRIAAERYRR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=267, Percent_Identity=32.2097378277154, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 41058; Mature: 41058

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPFSIDEVSFRDLPGWGQDDPRKLFPAMATILSHLRNAKPYRTGALGITAAELVSLLE
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
LAERGQVNSPEQARQFFETNSVPFRISPAQGKSGFVTAFYEPELEVSATPDDVWRYPIYR
HHHCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCEEEECCCHHHHCCCCCC
RPPELVDIDNDNRPDGFDPSYAFGKADEEGISYFPDRRAIDEGCLRGRGLEIAWARSKVD
CCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCEE
LFFVHVQGAARLVFPDGAIKRITYAAKAGHVFSPIGRLLLDRGELDPKTISMQTIRQWLA
EEEEEECCCEEEEECCCHHHHEEHHHHCCCHHHHHHHHHHHCCCCCCCEECHHHHHHHHH
DHPDEVDGVLWHNRSYIFFREADVAGLDMGPIAAAKVPLVAGRALAVDRLIHTFGLPFFI
CCCCCCCCEEEECCCEEEEEECCCCCCCCCCCHHHCCCHHCCHHHHHHHHHHHHCCCEEE
HAPTLTHLDDGKPFARLMLALDTGSAIVGPARGDIFTGSGFEAGELAGTVRNEADFYILL
ECCEEEECCCCCCHHHEEEEECCCCEEECCCCCCEEECCCCCHHHHHHHHCCCCCEEEEC
PRIAAERYRR
CHHHHHHHCC
>Mature Secondary Structure
MNTPFSIDEVSFRDLPGWGQDDPRKLFPAMATILSHLRNAKPYRTGALGITAAELVSLLE
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
LAERGQVNSPEQARQFFETNSVPFRISPAQGKSGFVTAFYEPELEVSATPDDVWRYPIYR
HHHCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCEEEECCCHHHHCCCCCC
RPPELVDIDNDNRPDGFDPSYAFGKADEEGISYFPDRRAIDEGCLRGRGLEIAWARSKVD
CCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCEE
LFFVHVQGAARLVFPDGAIKRITYAAKAGHVFSPIGRLLLDRGELDPKTISMQTIRQWLA
EEEEEECCCEEEEECCCHHHHEEHHHHCCCHHHHHHHHHHHCCCCCCCEECHHHHHHHHH
DHPDEVDGVLWHNRSYIFFREADVAGLDMGPIAAAKVPLVAGRALAVDRLIHTFGLPFFI
CCCCCCCCEEEECCCEEEEEECCCCCCCCCCCHHHCCCHHCCHHHHHHHHHHHHCCCEEE
HAPTLTHLDDGKPFARLMLALDTGSAIVGPARGDIFTGSGFEAGELAGTVRNEADFYILL
ECCEEEECCCCCCHHHEEEEECCCCEEECCCCCCEEECCCCCHHHHHHHHCCCCCEEEEC
PRIAAERYRR
CHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]