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The map label for this gene is hyuA [H]

Identifier: 158423979

GI number: 158423979

Start: 2681912

End: 2684005

Strand: Reverse

Name: hyuA [H]

Synonym: AZC_2355

Alternate gene names: 158423979

Gene position: 2684005-2681912 (Counterclockwise)

Preceding gene: 158423981

Following gene: 158423978

Centisome position: 49.98

GC content: 67.53

Gene sequence:

>2094_bases
ATGACCTCCTCACGGCAGATCCGCCTCGGTGCCGACATCGGCGGCACGTTCACCGACATCGTGCTCGATGTGCGTGGGCG
GCTTCATTCCACCAAGGTGCTCACCAGTTACACCGCCCCCGAACAGGCGATCCTCGACGGCATCGCGATCCTGACCAAGG
AAGCGGGAATCGGCGTGGCGGAAATCGATCTCGTCATTCATGGCACGACGCTCGCCACCAATGCGCTCATCGAGCGGCGG
GGTGCGCGGACGGCCTTCGTCACCACCGAGGGTTTCCGTGACGTGATCGAAATGCGGACCGAGAACCGCTTCGAGCAATA
TGACCTTAACCTGCGGCTGCCCACCCCGCTGGTGCCGCGCGAGCACCGCTTTACGGTGAAGGGCCGCATCGGTGCCGACG
GGCGCGAACTCCTGCCGCTCGACGAAGCGGCGCTGGAGGCGCTGGCGGAGCAACTGGCGGGCGCGGGTTTCGGCGCCGTG
GCCATCGGCTTCATCCATGCCTATGCCAATCCGGCCCATGAGAAGCGGGCCAAGGAGATTCTCGCGCGCAGGATTTCCGC
GCCCATCTCCCTTTCCTCGGAAGTCTCGCCGCAGATGCGCGAGTTCGAGCGCTTCAACACGGTATGCGCCAATGCCTATG
TGCGCCCGCAGATGGCCGATTATCTCGGCCGCTTCCAGGTGCGACTGAAGGAGGCCGGCGCCACCTGTCCCATCTTCATG
ATCCATTCCGGCGGTGGTCTCGTCTCCGTGGAGACGGCGGCGGAATTTCCTGTGCGGCTGGTGGAATCCGGGCCGGCGGG
CGGCGCCATCTTCGCGGCGGACATCGCCCGGCGCTTCAGCATCGGGAAGGCCGCCTCCTACGACATGGGCGGCACCACGG
CGAAGATCTGCCTCATCGAGGACTATCAGCCCCGCACGGCCCGAACCTTCGAGGTGGCACGCACCTATCGCTTCAGTAAG
GGCTCGGGCATGCCCATCTCCATCCCGGTCATCGAGATGATCGAGATCGGCGCCGGTGGCGGCTCCATCGCCTGGGTGGA
TTCGATGGGCCGCATCCAGACCGGTCCCGAGAGCGCGGCCTCCGAGCCGGGTCCGGCCTGCTACCAGCGCGGTGGCACGC
GGCCCGCCATTACGGACGCGGATCTCGTCCTCGCCAAGATCGACCCTGACAATTTCGCCGGCGGCGCCATCCGCCTCTCG
CGCGAGAAGGCGGAGGCTGCGATCCGCGCCGAAGTGGGAGACCGCCTCGGCCTCGCCCCCCTGTCCGCCGCCTTCGGCAT
CTGCGAGGTGGTGGACGAGAACATGGCCAATGCCGCCCGCGTGCATGCGGTGGAGAATGGCAAGAACATCTCCGACAACG
TGATGATCGCCTTCGGCGGCGCCGCGCCGCTCCATGCGGCGCGGCTGTGCGAGAAACTCGGTCTCGATCTGTGCCTCGTG
CCGTCCGGCGCCGGCGTGGGATCGGCCATCGGCTTCCTCAAGGCGCCCTTCGGCTATGAGGCGGTGGGTTCGCGTCTCGT
GCGCCTGTCACAGTTCGATCCGGCGCTGGTGAACGGGCTGGTGGCCGACCTGAAGGCGAGCGCCGAGCAGTTCGTGCGTG
CCGGAACCGACGCGCCGCTGATCTGCGAAATCACCGCTTTCATGCGCTATGCCGGACAGGGCTGGGAAATCCCGGTCGCG
CTCCCCGATCGCGCCTTCACGGCGGCTGATGCCGATCTCATCCGTGAGGCCTTCCGCGCCAATTATGCGCGCTTCTTCGG
CCGCGCCATCGACGGGCTGGATGGTCTCGAAATCGAGATCGTGACCATCTCCGTGAAGATGCAGGACGAACGGCCCGCAC
CGGACCCCGTCGCCCTGGATACCCGAGGCCGCCCGGCAGCGATCGCCGGCGCCACCCGCGCCGTGTTCGATCCGGCGAGC
GGCGCGCTGCGCGACAGCGCCATCGTCGAGCGCGGGGCGCTCTCGGCCGGGGACCGCGTGAGTGGCCCCGCAGTGATCGT
GGAGCGGGAGACCGCCACGGTCATCACCTCTCTCTTCGATGCCGTGCTGCAGAGCGACGGCTCCATCCTCCTCGTCCGCA
AGGGCCGCCACTGA

Upstream 100 bases:

>100_bases
TACCGAAGGTCTGTAATCTCGCCATCTCTGCAATCGGGCTCACGCCCCGCCATCTCCTCTCCCCGATCCGAGCCGCAGTT
CCCGCGGCAAAGGAAAACGC

Downstream 100 bases:

>100_bases
TGAGCGAAATCGACGACATCCGTATGCAGGTGATGTGGAATCGCCTGATCTCGGTGGTGGAAGAGCAGGCGATGACCCTG
CTGCGCACGGCCTTCTCGAC

Product: hydantoinase A

Products: NA

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 697; Mature: 696

Protein sequence:

>697_residues
MTSSRQIRLGADIGGTFTDIVLDVRGRLHSTKVLTSYTAPEQAILDGIAILTKEAGIGVAEIDLVIHGTTLATNALIERR
GARTAFVTTEGFRDVIEMRTENRFEQYDLNLRLPTPLVPREHRFTVKGRIGADGRELLPLDEAALEALAEQLAGAGFGAV
AIGFIHAYANPAHEKRAKEILARRISAPISLSSEVSPQMREFERFNTVCANAYVRPQMADYLGRFQVRLKEAGATCPIFM
IHSGGGLVSVETAAEFPVRLVESGPAGGAIFAADIARRFSIGKAASYDMGGTTAKICLIEDYQPRTARTFEVARTYRFSK
GSGMPISIPVIEMIEIGAGGGSIAWVDSMGRIQTGPESAASEPGPACYQRGGTRPAITDADLVLAKIDPDNFAGGAIRLS
REKAEAAIRAEVGDRLGLAPLSAAFGICEVVDENMANAARVHAVENGKNISDNVMIAFGGAAPLHAARLCEKLGLDLCLV
PSGAGVGSAIGFLKAPFGYEAVGSRLVRLSQFDPALVNGLVADLKASAEQFVRAGTDAPLICEITAFMRYAGQGWEIPVA
LPDRAFTAADADLIREAFRANYARFFGRAIDGLDGLEIEIVTISVKMQDERPAPDPVALDTRGRPAAIAGATRAVFDPAS
GALRDSAIVERGALSAGDRVSGPAVIVERETATVITSLFDAVLQSDGSILLVRKGRH

Sequences:

>Translated_697_residues
MTSSRQIRLGADIGGTFTDIVLDVRGRLHSTKVLTSYTAPEQAILDGIAILTKEAGIGVAEIDLVIHGTTLATNALIERR
GARTAFVTTEGFRDVIEMRTENRFEQYDLNLRLPTPLVPREHRFTVKGRIGADGRELLPLDEAALEALAEQLAGAGFGAV
AIGFIHAYANPAHEKRAKEILARRISAPISLSSEVSPQMREFERFNTVCANAYVRPQMADYLGRFQVRLKEAGATCPIFM
IHSGGGLVSVETAAEFPVRLVESGPAGGAIFAADIARRFSIGKAASYDMGGTTAKICLIEDYQPRTARTFEVARTYRFSK
GSGMPISIPVIEMIEIGAGGGSIAWVDSMGRIQTGPESAASEPGPACYQRGGTRPAITDADLVLAKIDPDNFAGGAIRLS
REKAEAAIRAEVGDRLGLAPLSAAFGICEVVDENMANAARVHAVENGKNISDNVMIAFGGAAPLHAARLCEKLGLDLCLV
PSGAGVGSAIGFLKAPFGYEAVGSRLVRLSQFDPALVNGLVADLKASAEQFVRAGTDAPLICEITAFMRYAGQGWEIPVA
LPDRAFTAADADLIREAFRANYARFFGRAIDGLDGLEIEIVTISVKMQDERPAPDPVALDTRGRPAAIAGATRAVFDPAS
GALRDSAIVERGALSAGDRVSGPAVIVERETATVITSLFDAVLQSDGSILLVRKGRH
>Mature_696_residues
TSSRQIRLGADIGGTFTDIVLDVRGRLHSTKVLTSYTAPEQAILDGIAILTKEAGIGVAEIDLVIHGTTLATNALIERRG
ARTAFVTTEGFRDVIEMRTENRFEQYDLNLRLPTPLVPREHRFTVKGRIGADGRELLPLDEAALEALAEQLAGAGFGAVA
IGFIHAYANPAHEKRAKEILARRISAPISLSSEVSPQMREFERFNTVCANAYVRPQMADYLGRFQVRLKEAGATCPIFMI
HSGGGLVSVETAAEFPVRLVESGPAGGAIFAADIARRFSIGKAASYDMGGTTAKICLIEDYQPRTARTFEVARTYRFSKG
SGMPISIPVIEMIEIGAGGGSIAWVDSMGRIQTGPESAASEPGPACYQRGGTRPAITDADLVLAKIDPDNFAGGAIRLSR
EKAEAAIRAEVGDRLGLAPLSAAFGICEVVDENMANAARVHAVENGKNISDNVMIAFGGAAPLHAARLCEKLGLDLCLVP
SGAGVGSAIGFLKAPFGYEAVGSRLVRLSQFDPALVNGLVADLKASAEQFVRAGTDAPLICEITAFMRYAGQGWEIPVAL
PDRAFTAADADLIREAFRANYARFFGRAIDGLDGLEIEIVTISVKMQDERPAPDPVALDTRGRPAAIAGATRAVFDPASG
ALRDSAIVERGALSAGDRVSGPAVIVERETATVITSLFDAVLQSDGSILLVRKGRH

Specific function: HyuA and hyuB convert D- and L-substituted hydantoins to corresponding N-carbamyl-amino acids [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=512, Percent_Identity=31.640625, Blast_Score=181, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI133901900, Length=730, Percent_Identity=25.4794520547945, Blast_Score=159, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6322634, Length=545, Percent_Identity=30.0917431192661, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI45550492, Length=726, Percent_Identity=28.6501377410468, Blast_Score=204, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: NA

Molecular weight: Translated: 73972; Mature: 73841

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSRQIRLGADIGGTFTDIVLDVRGRLHSTKVLTSYTAPEQAILDGIAILTKEAGIGVA
CCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHEECCCCCCEE
EIDLVIHGTTLATNALIERRGARTAFVTTEGFRDVIEMRTENRFEQYDLNLRLPTPLVPR
EEEEEEECCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCHHHEEEEEECCCCCCCC
EHRFTVKGRIGADGRELLPLDEAALEALAEQLAGAGFGAVAIGFIHAYANPAHEKRAKEI
CCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHH
LARRISAPISLSSEVSPQMREFERFNTVCANAYVRPQMADYLGRFQVRLKEAGATCPIFM
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEECCCCCCEEEE
IHSGGGLVSVETAAEFPVRLVESGPAGGAIFAADIARRFSIGKAASYDMGGTTAKICLIE
EECCCCEEEEECCCCCCEEEEECCCCCCEEEHHHHHHHHCCCCCCCCCCCCCEEEEEEEE
DYQPRTARTFEVARTYRFSKGSGMPISIPVIEMIEIGAGGGSIAWVDSMGRIQTGPESAA
CCCCCCHHHHHHHHHEEECCCCCCEEEECCEEEEEECCCCCCEEEEECCCCCCCCCCCCC
SEPGPACYQRGGTRPAITDADLVLAKIDPDNFAGGAIRLSREKAEAAIRAEVGDRLGLAP
CCCCCHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCH
LSAAFGICEVVDENMANAARVHAVENGKNISDNVMIAFGGAAPLHAARLCEKLGLDLCLV
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEE
PSGAGVGSAIGFLKAPFGYEAVGSRLVRLSQFDPALVNGLVADLKASAEQFVRAGTDAPL
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCE
ICEITAFMRYAGQGWEIPVALPDRAFTAADADLIREAFRANYARFFGRAIDGLDGLEIEI
EHHHHHHHHHCCCCCEEEEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
VTISVKMQDERPAPDPVALDTRGRPAAIAGATRAVFDPASGALRDSAIVERGALSAGDRV
EEEEEEEECCCCCCCCEEECCCCCCCEECCCCHHEECCCCCCHHHHHHHHHCCCCCCCCC
SGPAVIVERETATVITSLFDAVLQSDGSILLVRKGRH
CCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCC
>Mature Secondary Structure 
TSSRQIRLGADIGGTFTDIVLDVRGRLHSTKVLTSYTAPEQAILDGIAILTKEAGIGVA
CCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHEECCCCCCEE
EIDLVIHGTTLATNALIERRGARTAFVTTEGFRDVIEMRTENRFEQYDLNLRLPTPLVPR
EEEEEEECCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCHHHEEEEEECCCCCCCC
EHRFTVKGRIGADGRELLPLDEAALEALAEQLAGAGFGAVAIGFIHAYANPAHEKRAKEI
CCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHH
LARRISAPISLSSEVSPQMREFERFNTVCANAYVRPQMADYLGRFQVRLKEAGATCPIFM
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEECCCCCCEEEE
IHSGGGLVSVETAAEFPVRLVESGPAGGAIFAADIARRFSIGKAASYDMGGTTAKICLIE
EECCCCEEEEECCCCCCEEEEECCCCCCEEEHHHHHHHHCCCCCCCCCCCCCEEEEEEEE
DYQPRTARTFEVARTYRFSKGSGMPISIPVIEMIEIGAGGGSIAWVDSMGRIQTGPESAA
CCCCCCHHHHHHHHHEEECCCCCCEEEECCEEEEEECCCCCCEEEEECCCCCCCCCCCCC
SEPGPACYQRGGTRPAITDADLVLAKIDPDNFAGGAIRLSREKAEAAIRAEVGDRLGLAP
CCCCCHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCH
LSAAFGICEVVDENMANAARVHAVENGKNISDNVMIAFGGAAPLHAARLCEKLGLDLCLV
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEE
PSGAGVGSAIGFLKAPFGYEAVGSRLVRLSQFDPALVNGLVADLKASAEQFVRAGTDAPL
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCE
ICEITAFMRYAGQGWEIPVALPDRAFTAADADLIREAFRANYARFFGRAIDGLDGLEIEI
EHHHHHHHHHCCCCCEEEEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
VTISVKMQDERPAPDPVALDTRGRPAAIAGATRAVFDPASGALRDSAIVERGALSAGDRV
EEEEEEEECCCCCCCCEEECCCCCCCEECCCCHHEECCCCCCHHHHHHHHHCCCCCCCCC
SGPAVIVERETATVITSLFDAVLQSDGSILLVRKGRH
CCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1732229 [H]