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The map label for this gene is acsA1 [H]

Identifier: 158423867

GI number: 158423867

Start: 2563572

End: 2565536

Strand: Direct

Name: acsA1 [H]

Synonym: AZC_2243

Alternate gene names: 158423867

Gene position: 2563572-2565536 (Clockwise)

Preceding gene: 158423865

Following gene: 158423873

Centisome position: 47.74

GC content: 64.68

Gene sequence:

>1965_bases
ATGACCGAACAAGCCGCTCACCCGCTGTGGCAACCCGGCGCCGAGCGTATCGCCAAGAGCCACGTGACGTGGCTGATCGG
CGAAGTGAACAGCCGATTCGGCACCTCCCTTTCCAATTATGCCGACCTGCACGCTTGGTCCGTGAAGAATCTCTCCGCCT
TCTGGGATCTCGTCTGGGACAGCTGCGGTGTGATCGGCGAGAAGGGCGCTCAGCGTCTCATCGACGCGGACAAGATGCCG
GGCGCGCAGTTCTTTCCCGATGCGAAGCTCAATTTCGCCGAGAACCTGCTCCGCAAGACCGGCTCCGGCGAGGCGCTGGT
CTTCCGCGGCGAGGACAAGCTGGAGAAGCGCCTCACCCATGACGACCTGCATGCGCTGGTCTCCCGCCTCCAGCAGGCGC
TGAAGGCCGAGGGCGTGGGCGTCGGCGACCGGGTGGCGGCAATGATGCCGAACATGCCGGAGACCATAGCCATCATGCTG
GCGGCGACCTCTCTCGGTGCCATCTTCTCGTCCTGCTCGCCGGATTTCGGCGAGCGCGGCGTGCTGGACCGCTTCGGCCA
GATCGAACCCAAGGTGTTCTTCGCCTGCGACGGCTACTGGTACAACGGCAAGCGCGTCTCCATCGCCGACAAGCTGGTGG
AGATATCGAAGCACCTCACCACGCCGTCGAAGCTTGTGGTGGTGCCCTATCTCGGCGAGGCTGCGGAAACCGCCGGGCGG
CTCGACCGGGGCGTCGATCTCGACGCCTTCCTCACGCCTTTCGCGGCCAAGGCCGTGACCTTCGAGCGCCTGCCCTTCAA
CCATCCCATCTACATCCTGTTCTCCTCCGGCACGACGGGCGTGCCCAAGTGCATCGTCCACGGCGCCGGCGGCACGCTGC
TCCAGCACCTGAAGGAGCATCGCTACCAGTGCGACCTGTCGCCGGGTGACAAGCTCTTCTATTTCACCACCTGCGGCTGG
ATGATGTGGAACTGGCTCGTCTCGGGCCTCGCCAGCGAGCTGACGCTGTTTCTCTTCGACGGCTCGCCCTTCGCGCCGAG
CCCGAAGGTGCTGTTCGATTATGCGCAGGACGAAGGTTTCAACGTCTTCGGAACCTCGGCCAAGTACATCGATTCCCTGC
ACAAAGAGGGGCTGAAGCCGATCGAGACCCACGATCTCTCGGCCCTGCGCCTGATCACCTCGACGGGCTCGCCTCTGGCG
CCGGAATCGTTCGAATATGTCTATTCCGGCATCAAGAAGGACGTGCACCTCGCCTCCATCTCGGGCGGCACCGACATCGT
CTCCTGCTTCGTGCTGGGGGATCCGACCGCGCCGGTGTGGAAGGGCGAGATCCAGGCGGCCGGCCTCGGCATGGCCGTGG
ACGTCTGGTCGGAGGACGGCCGTCCGGTGAAGCTGGAGCGGGGCGAGCTTGTCTGCACCCGTCCCTTCCCGTCGATGCCG
GTGATGTTCTGGAACGACAAGGACGGCGCCAAGTATCATGCCGCCTATTTCGACCGCTTCCCGAACATCTGGTGCCATGG
CGACTTCGCCATGTGGACGGAGCATGGCGGCCTCGTGATCCTCGGGCGCTCCGATGCCACCCTGAACCCGCAGGGCGTCC
GCATCGGCACGGCGGAAATCTATGCGCAGGTGGAGCAGATTCCCGACGTGATGGAATCAGTCGCCATCGGCCAGGATTGG
GACAATGACGTGCGTGTCGTGCTGTTCGTGCGCCTGCGCGAAGGCACGACGCTGGATGAGGATCTCGTGCGGCGCATCAA
GACCCAGATCCGCGTCGGCGCGAGCCCCCGCCATGTGCCGGCCAAGATCGTGCAGGTAACGGACATTCCGCGCACCCGTT
CGGGCAAGATCACGGAACTGGCGGTGCGCGAGGTGGTGCACGGGCGGCCGGTGAAGAACACGGAGGCGCTCTCCAATCCC
GAGGCGCTGGACCAGTATCGGGAAGTGCCGGACCTGCTGTCCTGA

Upstream 100 bases:

>100_bases
CCGCTTTGTGCGAAAACCCTGCCAAGGCATTGAAAAGAAACAGGTAGCGCCAGGGCGCCTCAGGCGTCCGTCGAATGTCA
GAGTGCTAGGAGAGGAAGCG

Downstream 100 bases:

>100_bases
CGTCGAGGACCGGAGCCCGCACCCGCGGGTTCCGGTTTCGCCGAAACTTCAAAAAGGCAGTTTAAGTGCCTGATTTTGAA
GAGCTTGAGGGGCGAGCTGC

Product: acetoacetyl-CoA synthetase

Products: NA

Alternate protein names: Acetoacetate--CoA ligase 1; Acyl-activating enzyme 1 [H]

Number of amino acids: Translated: 654; Mature: 653

Protein sequence:

>654_residues
MTEQAAHPLWQPGAERIAKSHVTWLIGEVNSRFGTSLSNYADLHAWSVKNLSAFWDLVWDSCGVIGEKGAQRLIDADKMP
GAQFFPDAKLNFAENLLRKTGSGEALVFRGEDKLEKRLTHDDLHALVSRLQQALKAEGVGVGDRVAAMMPNMPETIAIML
AATSLGAIFSSCSPDFGERGVLDRFGQIEPKVFFACDGYWYNGKRVSIADKLVEISKHLTTPSKLVVVPYLGEAAETAGR
LDRGVDLDAFLTPFAAKAVTFERLPFNHPIYILFSSGTTGVPKCIVHGAGGTLLQHLKEHRYQCDLSPGDKLFYFTTCGW
MMWNWLVSGLASELTLFLFDGSPFAPSPKVLFDYAQDEGFNVFGTSAKYIDSLHKEGLKPIETHDLSALRLITSTGSPLA
PESFEYVYSGIKKDVHLASISGGTDIVSCFVLGDPTAPVWKGEIQAAGLGMAVDVWSEDGRPVKLERGELVCTRPFPSMP
VMFWNDKDGAKYHAAYFDRFPNIWCHGDFAMWTEHGGLVILGRSDATLNPQGVRIGTAEIYAQVEQIPDVMESVAIGQDW
DNDVRVVLFVRLREGTTLDEDLVRRIKTQIRVGASPRHVPAKIVQVTDIPRTRSGKITELAVREVVHGRPVKNTEALSNP
EALDQYREVPDLLS

Sequences:

>Translated_654_residues
MTEQAAHPLWQPGAERIAKSHVTWLIGEVNSRFGTSLSNYADLHAWSVKNLSAFWDLVWDSCGVIGEKGAQRLIDADKMP
GAQFFPDAKLNFAENLLRKTGSGEALVFRGEDKLEKRLTHDDLHALVSRLQQALKAEGVGVGDRVAAMMPNMPETIAIML
AATSLGAIFSSCSPDFGERGVLDRFGQIEPKVFFACDGYWYNGKRVSIADKLVEISKHLTTPSKLVVVPYLGEAAETAGR
LDRGVDLDAFLTPFAAKAVTFERLPFNHPIYILFSSGTTGVPKCIVHGAGGTLLQHLKEHRYQCDLSPGDKLFYFTTCGW
MMWNWLVSGLASELTLFLFDGSPFAPSPKVLFDYAQDEGFNVFGTSAKYIDSLHKEGLKPIETHDLSALRLITSTGSPLA
PESFEYVYSGIKKDVHLASISGGTDIVSCFVLGDPTAPVWKGEIQAAGLGMAVDVWSEDGRPVKLERGELVCTRPFPSMP
VMFWNDKDGAKYHAAYFDRFPNIWCHGDFAMWTEHGGLVILGRSDATLNPQGVRIGTAEIYAQVEQIPDVMESVAIGQDW
DNDVRVVLFVRLREGTTLDEDLVRRIKTQIRVGASPRHVPAKIVQVTDIPRTRSGKITELAVREVVHGRPVKNTEALSNP
EALDQYREVPDLLS
>Mature_653_residues
TEQAAHPLWQPGAERIAKSHVTWLIGEVNSRFGTSLSNYADLHAWSVKNLSAFWDLVWDSCGVIGEKGAQRLIDADKMPG
AQFFPDAKLNFAENLLRKTGSGEALVFRGEDKLEKRLTHDDLHALVSRLQQALKAEGVGVGDRVAAMMPNMPETIAIMLA
ATSLGAIFSSCSPDFGERGVLDRFGQIEPKVFFACDGYWYNGKRVSIADKLVEISKHLTTPSKLVVVPYLGEAAETAGRL
DRGVDLDAFLTPFAAKAVTFERLPFNHPIYILFSSGTTGVPKCIVHGAGGTLLQHLKEHRYQCDLSPGDKLFYFTTCGWM
MWNWLVSGLASELTLFLFDGSPFAPSPKVLFDYAQDEGFNVFGTSAKYIDSLHKEGLKPIETHDLSALRLITSTGSPLAP
ESFEYVYSGIKKDVHLASISGGTDIVSCFVLGDPTAPVWKGEIQAAGLGMAVDVWSEDGRPVKLERGELVCTRPFPSMPV
MFWNDKDGAKYHAAYFDRFPNIWCHGDFAMWTEHGGLVILGRSDATLNPQGVRIGTAEIYAQVEQIPDVMESVAIGQDWD
NDVRVVLFVRLREGTTLDEDLVRRIKTQIRVGASPRHVPAKIVQVTDIPRTRSGKITELAVREVVHGRPVKNTEALSNPE
ALDQYREVPDLLS

Specific function: Involved in poly-3-hydroxybutyrate degradation. Activates acetoacetate to acetoacetyl-CoA [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI31982927, Length=664, Percent_Identity=44.8795180722892, Blast_Score=573, Evalue=1e-163,
Organism=Homo sapiens, GI28416953, Length=647, Percent_Identity=27.047913446677, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI8923896, Length=664, Percent_Identity=25.1506024096386, Blast_Score=160, Evalue=5e-39,
Organism=Homo sapiens, GI253970489, Length=677, Percent_Identity=24.8153618906942, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI13375727, Length=639, Percent_Identity=24.1001564945227, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1790505, Length=621, Percent_Identity=26.8921095008052, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1786529, Length=609, Percent_Identity=25.2873563218391, Blast_Score=129, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17569507, Length=627, Percent_Identity=38.9154704944179, Blast_Score=434, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI71983001, Length=648, Percent_Identity=25.6172839506173, Blast_Score=165, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI71982997, Length=648, Percent_Identity=25.6172839506173, Blast_Score=165, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6323182, Length=658, Percent_Identity=26.1398176291793, Blast_Score=180, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6319264, Length=587, Percent_Identity=27.5979557069847, Blast_Score=167, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24667955, Length=650, Percent_Identity=26.4615384615385, Blast_Score=189, Evalue=6e-48,
Organism=Drosophila melanogaster, GI62472339, Length=560, Percent_Identity=27.3214285714286, Blast_Score=180, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24667959, Length=523, Percent_Identity=26.7686424474187, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI21355225, Length=615, Percent_Identity=24.7154471544715, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005914
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.16 [H]

Molecular weight: Translated: 72142; Mature: 72011

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQAAHPLWQPGAERIAKSHVTWLIGEVNSRFGTSLSNYADLHAWSVKNLSAFWDLVWD
CCCCCCCCCCCCHHHHHHHHHHEEEEECHHHHHCCCHHHCHHHEEECHHHHHHHHHHHHH
SCGVIGEKGAQRLIDADKMPGAQFFPDAKLNFAENLLRKTGSGEALVFRGEDKLEKRLTH
HCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHCCH
DDLHALVSRLQQALKAEGVGVGDRVAAMMPNMPETIAIMLAATSLGAIFSSCSPDFGERG
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
VLDRFGQIEPKVFFACDGYWYNGKRVSIADKLVEISKHLTTPSKLVVVPYLGEAAETAGR
HHHHHCCCCCEEEEEECCEEECCEEEEHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHH
LDRGVDLDAFLTPFAAKAVTFERLPFNHPIYILFSSGTTGVPKCIVHGAGGTLLQHLKEH
HHCCCCHHHHHCCHHHHHEEEECCCCCCCEEEEECCCCCCCCCEEEECCCHHHHHHHHHH
RYQCDLSPGDKLFYFTTCGWMMWNWLVSGLASELTLFLFDGSPFAPSPKVLFDYAQDEGF
CEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCEEEEECCCCCC
NVFGTSAKYIDSLHKEGLKPIETHDLSALRLITSTGSPLAPESFEYVYSGIKKDVHLASI
EEECCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEE
SGGTDIVSCFVLGDPTAPVWKGEIQAAGLGMAVDVWSEDGRPVKLERGELVCTRPFPSMP
CCCCCEEEEEEECCCCCCCCCCCEEECCCCEEEEEECCCCCEEEEECCCEEEECCCCCCC
VMFWNDKDGAKYHAAYFDRFPNIWCHGDFAMWTEHGGLVILGRSDATLNPQGVRIGTAEI
EEEEECCCCCEEHHHHHHHCCCEEECCCEEEEECCCCEEEEECCCCCCCCCCEEEEHHHH
YAQVEQIPDVMESVAIGQDWDNDVRVVLFVRLREGTTLDEDLVRRIKTQIRVGASPRHVP
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCC
AKIVQVTDIPRTRSGKITELAVREVVHGRPVKNTEALSNPEALDQYREVPDLLS
EEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHCHHHCC
>Mature Secondary Structure 
TEQAAHPLWQPGAERIAKSHVTWLIGEVNSRFGTSLSNYADLHAWSVKNLSAFWDLVWD
CCCCCCCCCCCHHHHHHHHHHEEEEECHHHHHCCCHHHCHHHEEECHHHHHHHHHHHHH
SCGVIGEKGAQRLIDADKMPGAQFFPDAKLNFAENLLRKTGSGEALVFRGEDKLEKRLTH
HCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHCCH
DDLHALVSRLQQALKAEGVGVGDRVAAMMPNMPETIAIMLAATSLGAIFSSCSPDFGERG
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
VLDRFGQIEPKVFFACDGYWYNGKRVSIADKLVEISKHLTTPSKLVVVPYLGEAAETAGR
HHHHHCCCCCEEEEEECCEEECCEEEEHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHH
LDRGVDLDAFLTPFAAKAVTFERLPFNHPIYILFSSGTTGVPKCIVHGAGGTLLQHLKEH
HHCCCCHHHHHCCHHHHHEEEECCCCCCCEEEEECCCCCCCCCEEEECCCHHHHHHHHHH
RYQCDLSPGDKLFYFTTCGWMMWNWLVSGLASELTLFLFDGSPFAPSPKVLFDYAQDEGF
CEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCEEEEECCCCCC
NVFGTSAKYIDSLHKEGLKPIETHDLSALRLITSTGSPLAPESFEYVYSGIKKDVHLASI
EEECCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEE
SGGTDIVSCFVLGDPTAPVWKGEIQAAGLGMAVDVWSEDGRPVKLERGELVCTRPFPSMP
CCCCCEEEEEEECCCCCCCCCCCEEECCCCEEEEEECCCCCEEEEECCCEEEECCCCCCC
VMFWNDKDGAKYHAAYFDRFPNIWCHGDFAMWTEHGGLVILGRSDATLNPQGVRIGTAEI
EEEEECCCCCEEHHHHHHHCCCEEECCCEEEEECCCCEEEEECCCCCCCCCCEEEEHHHH
YAQVEQIPDVMESVAIGQDWDNDVRVVLFVRLREGTTLDEDLVRRIKTQIRVGASPRHVP
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCC
AKIVQVTDIPRTRSGKITELAVREVVHGRPVKNTEALSNPEALDQYREVPDLLS
EEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10735852; 11481430 [H]