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The map label for this gene is thrC [H]

Identifier: 158423863

GI number: 158423863

Start: 2557846

End: 2559258

Strand: Direct

Name: thrC [H]

Synonym: AZC_2239

Alternate gene names: 158423863

Gene position: 2557846-2559258 (Clockwise)

Preceding gene: 158423858

Following gene: 158423864

Centisome position: 47.63

GC content: 68.86

Gene sequence:

>1413_bases
TTGCGTTACGTCTCCACCCGGGGCGAGGCCCCGACGCTGTCTTTTGCCGATGCGCTCCTCGCCGGTCTGGCCCGCGATGG
CGGGCTCTATGTGCCGGAGACCTGGCCGACACTGTCGGCCGCGGAGATCGCGGGACTTGCGGGCAAATCCTATGCGGACG
TGGCGCGTGCGGTGATCACGCCTTTCGTGGGGGACGCGCTGCCGAAGGCCGCCCTCGACACCATGATCAGCGATGCCTAC
CGCGCCTTCCGCCATCCGGCGACGACGCCGGTGGTGCAGCTCGGCCCGAACCGGTTCCTGCTGGAGCTGTTCCATGGTCC
GACCCTGGCGTTCAAGGACGTCGCCATGCAGTTGCTGGCGCGCCTGATGGACCACGTGCTCGCCACCCGCAACGGCCGCG
CCACCATCGTCGGCGCCACCTCGGGCGACACGGGCAGTGCCGCCATCGAGGCGTTCCGGCACACGGATGCGGTGGATGTG
TTCATCCTCTATCCGCACAACCGCGTCTCGGAAGTGCAGCGCCGGCAGATGACCACGGTGGGCGGGGCGAATGTCCACGC
CATCGCTGTGGAAGGCACGTTCGACGACTGCCAGGCCCATGTGAAGGCCATGTTCAACCACGCCGCCTTCCGCGACCGGC
TGGCCCTGGCGGGCGTGAACTCCATCAACTGGGCGCGCATCGTCGCCCAGGTGGTCTATTATTTCTATGCCGCCGTGGCG
CTCGGCGCGCCGCATCGCGAAGTGTCGTTCGTGGTGCCCACGGGCAATTTCGGCGACATCTTCGCCGGCTGGGTGGCCAA
GCGCATGGGCCTGCCGGTGCGCGATCTGACCATCGCCACCAACGTCAATGACATCCTGGCCCGCACGCTCGCCACCGGGC
GCTATGAGGTGAAGGGCGTGCAGCCCTCCTCCTCGCCCTCCATGGACATTCAGGTCTCGTCGAATTTCGAGCGCCTGCTG
TTCGAGGCGGTGGATCGCGACGCCGGCACCGTGCGCCAGCTTATGGCCTCGCTCGGCCAGTCCGGTGCCTTCACCCTGCC
GCACGCGGCGCAGGCGGCCATCGCCGGCGAATTCTCCGCTGACCGGGCCGACGAGCCGGAGACCGCCGCCACCATCTCCC
GCCTCTATCGCGAGAGCGGCTATGTGGCCGATCCCCATACCGCCGTGGCGCTGGCCGTGGCGGAGAAGGTGGAGCACGCC
CGCGCCGTGCCGCAGATCGTGCTCTCCACCGCCCACCCGGCCAAGTTCCCGGATGCCGTGGAAGCGGCCACGGGCAAGCG
GCCGGTGCTGCCGCCTCACATGGCGGACCTGTTCAACCGCAAGGAGCGCCTGAGCGTGCTGCCGAACGATCTCGACGCCA
TCGAGGCCTTCATCTCGGCGCGGGCGCGGATCGTCTCGGGAGCCGCCGCATGA

Upstream 100 bases:

>100_bases
TCTTCGCGCCGTTCAATCCGCCGCGCCTTTAATCGCGGGACCGTCGGCGTTACCTTCAGAGGGCACGCCATCGATCTCCC
GCGTGCGAGTGAGGTCCCCT

Downstream 100 bases:

>100_bases
GCGCGACAGAGACCGGCGTTAAGACGACGACCCTGCCGAACGGCATCACGGTCGTCTCAGATGCCATGCCTCACCTCGGC
ACGGCCTCGCTCGGCATCTG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MRYVSTRGEAPTLSFADALLAGLARDGGLYVPETWPTLSAAEIAGLAGKSYADVARAVITPFVGDALPKAALDTMISDAY
RAFRHPATTPVVQLGPNRFLLELFHGPTLAFKDVAMQLLARLMDHVLATRNGRATIVGATSGDTGSAAIEAFRHTDAVDV
FILYPHNRVSEVQRRQMTTVGGANVHAIAVEGTFDDCQAHVKAMFNHAAFRDRLALAGVNSINWARIVAQVVYYFYAAVA
LGAPHREVSFVVPTGNFGDIFAGWVAKRMGLPVRDLTIATNVNDILARTLATGRYEVKGVQPSSSPSMDIQVSSNFERLL
FEAVDRDAGTVRQLMASLGQSGAFTLPHAAQAAIAGEFSADRADEPETAATISRLYRESGYVADPHTAVALAVAEKVEHA
RAVPQIVLSTAHPAKFPDAVEAATGKRPVLPPHMADLFNRKERLSVLPNDLDAIEAFISARARIVSGAAA

Sequences:

>Translated_470_residues
MRYVSTRGEAPTLSFADALLAGLARDGGLYVPETWPTLSAAEIAGLAGKSYADVARAVITPFVGDALPKAALDTMISDAY
RAFRHPATTPVVQLGPNRFLLELFHGPTLAFKDVAMQLLARLMDHVLATRNGRATIVGATSGDTGSAAIEAFRHTDAVDV
FILYPHNRVSEVQRRQMTTVGGANVHAIAVEGTFDDCQAHVKAMFNHAAFRDRLALAGVNSINWARIVAQVVYYFYAAVA
LGAPHREVSFVVPTGNFGDIFAGWVAKRMGLPVRDLTIATNVNDILARTLATGRYEVKGVQPSSSPSMDIQVSSNFERLL
FEAVDRDAGTVRQLMASLGQSGAFTLPHAAQAAIAGEFSADRADEPETAATISRLYRESGYVADPHTAVALAVAEKVEHA
RAVPQIVLSTAHPAKFPDAVEAATGKRPVLPPHMADLFNRKERLSVLPNDLDAIEAFISARARIVSGAAA
>Mature_470_residues
MRYVSTRGEAPTLSFADALLAGLARDGGLYVPETWPTLSAAEIAGLAGKSYADVARAVITPFVGDALPKAALDTMISDAY
RAFRHPATTPVVQLGPNRFLLELFHGPTLAFKDVAMQLLARLMDHVLATRNGRATIVGATSGDTGSAAIEAFRHTDAVDV
FILYPHNRVSEVQRRQMTTVGGANVHAIAVEGTFDDCQAHVKAMFNHAAFRDRLALAGVNSINWARIVAQVVYYFYAAVA
LGAPHREVSFVVPTGNFGDIFAGWVAKRMGLPVRDLTIATNVNDILARTLATGRYEVKGVQPSSSPSMDIQVSSNFERLL
FEAVDRDAGTVRQLMASLGQSGAFTLPHAAQAAIAGEFSADRADEPETAATISRLYRESGYVADPHTAVALAVAEKVEHA
RAVPQIVLSTAHPAKFPDAVEAATGKRPVLPPHMADLFNRKERLSVLPNDLDAIEAFISARARIVSGAAA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=456, Percent_Identity=33.9912280701754, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI153792148, Length=448, Percent_Identity=36.3839285714286, Blast_Score=265, Evalue=6e-71,
Organism=Escherichia coli, GI1786185, Length=438, Percent_Identity=34.0182648401827, Blast_Score=233, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6319901, Length=455, Percent_Identity=43.7362637362637, Blast_Score=353, Evalue=4e-98,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50236; Mature: 50236

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYVSTRGEAPTLSFADALLAGLARDGGLYVPETWPTLSAAEIAGLAGKSYADVARAVIT
CCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHH
PFVGDALPKAALDTMISDAYRAFRHPATTPVVQLGPNRFLLELFHGPTLAFKDVAMQLLA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCHHHHHHHHHHHH
RLMDHVLATRNGRATIVGATSGDTGSAAIEAFRHTDAVDVFILYPHNRVSEVQRRQMTTV
HHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHC
GGANVHAIAVEGTFDDCQAHVKAMFNHAAFRDRLALAGVNSINWARIVAQVVYYFYAAVA
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGAPHREVSFVVPTGNFGDIFAGWVAKRMGLPVRDLTIATNVNDILARTLATGRYEVKGV
HCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHEEEECCHHHHHHHHHHCCCEEEEEC
QPSSSPSMDIQVSSNFERLLFEAVDRDAGTVRQLMASLGQSGAFTLPHAAQAAIAGEFSA
CCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCEECCHHHHHHHHCCCCC
DRADEPETAATISRLYRESGYVADPHTAVALAVAEKVEHARAVPQIVLSTAHPAKFPDAV
CCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
EAATGKRPVLPPHMADLFNRKERLSVLPNDLDAIEAFISARARIVSGAAA
HHCCCCCCCCCHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRYVSTRGEAPTLSFADALLAGLARDGGLYVPETWPTLSAAEIAGLAGKSYADVARAVIT
CCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHH
PFVGDALPKAALDTMISDAYRAFRHPATTPVVQLGPNRFLLELFHGPTLAFKDVAMQLLA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCHHHHHHHHHHHH
RLMDHVLATRNGRATIVGATSGDTGSAAIEAFRHTDAVDVFILYPHNRVSEVQRRQMTTV
HHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHC
GGANVHAIAVEGTFDDCQAHVKAMFNHAAFRDRLALAGVNSINWARIVAQVVYYFYAAVA
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGAPHREVSFVVPTGNFGDIFAGWVAKRMGLPVRDLTIATNVNDILARTLATGRYEVKGV
HCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHEEEECCHHHHHHHHHHCCCEEEEEC
QPSSSPSMDIQVSSNFERLLFEAVDRDAGTVRQLMASLGQSGAFTLPHAAQAAIAGEFSA
CCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCEECCHHHHHHHHCCCCC
DRADEPETAATISRLYRESGYVADPHTAVALAVAEKVEHARAVPQIVLSTAHPAKFPDAV
CCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
EAATGKRPVLPPHMADLFNRKERLSVLPNDLDAIEAFISARARIVSGAAA
HHCCCCCCCCCHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]