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The map label for this gene is murB

Identifier: 15834838

GI number: 15834838

Start: 259297

End: 260187

Strand: Reverse

Name: murB

Synonym: TC0218

Alternate gene names: 15834838

Gene position: 260187-259297 (Counterclockwise)

Preceding gene: 15834839

Following gene: 15834833

Centisome position: 24.25

GC content: 40.18

Gene sequence:

>891_bases
ATGACTAACGCATTTCCCTTCTCCGTCCAAGAATCTGTTCCGTTAAACCGCTTCTCTACTTTTCGCATTGGAGGGCCTGC
GCGATACTTTAAAGAGTTAGTTTCTGTTGATGAAGCTCTGAAAGTTTTTTCATTCTTACACACCTCTCCTATTCCTTATA
TTATTATAGGGAAGGGATCCAATTGCTTGTTTCATGACCAAGGATTCAATGGTCTTGTTCTATACAATAATATCCAAGGC
CAAACATTCCTTTCTGATACACAAATTAAAGTGCTTTCTGGAGTTTCTTTTTCTCTTTTAGGGAGGCAGCTTTCTTCTAA
AGGATTTTCAGGGCTAGAATTTGCTGTAGGAATTCCAGGAACTGTTGGAGGTGCCGTATTTATGAATGCTGGAACCGCAT
TAGCTAATACGGCCTCATCTCTTGTCAGCGTAGAGATTATCGATCATGCGGGGAATTTACTTTCACTATCTAGAGAAGAG
CTGCTTTTTTCTTATCGAACATCGCCTTTTCAAAAAAAAACTGCATTCATTGTTTCTGCAACATTCCAGTTAACTCGAGA
TTCTCAAGCAGCTCAACGAGCAAAAGCTTTAATTGAAGAACGCATCCTTAAACAACCGTACGAATACCCTTCTGTGGGAT
GTATCTTCCGCAATCCAGAAGGCGTGTCTGCAGGAGCACTTATTGATCAAGCAGGATTAAAAGGACTAACCATAGGGGGA
GGACAGATATCCCAAAAACATGGCAATTTCATCATTAACACTGGAAATGCCAGTGCTGCTGATGTTCTAGAACTTATTGA
AACCATTCAAAAAACTCTTAAACAACAGGGAATTGCTTTGGAAAAAGAGGTGCGCATTATTCCCTTTCAACCTAATCTTG
GCGTTTCCTAA

Upstream 100 bases:

>100_bases
TTTAGCATTACCCCTTATCAAATTAAGATGACAGAGCATAAGGAAATACCGTTATGTATGGTGTTTCCTCTTCGCAACGA
TCAACTTTGCAATATATTTT

Downstream 100 bases:

>100_bases
AAAGAAATAAGCGTGGGGCTTTCTTTCTATTCACGGAATAGTGCGTACACACTTCCCATTTGCTCGGATCCAAATTCACA
GCTAACTGATCTACACAGAG

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTNAFPFSVQESVPLNRFSTFRIGGPARYFKELVSVDEALKVFSFLHTSPIPYIIIGKGSNCLFHDQGFNGLVLYNNIQG
QTFLSDTQIKVLSGVSFSLLGRQLSSKGFSGLEFAVGIPGTVGGAVFMNAGTALANTASSLVSVEIIDHAGNLLSLSREE
LLFSYRTSPFQKKTAFIVSATFQLTRDSQAAQRAKALIEERILKQPYEYPSVGCIFRNPEGVSAGALIDQAGLKGLTIGG
GQISQKHGNFIINTGNASAADVLELIETIQKTLKQQGIALEKEVRIIPFQPNLGVS

Sequences:

>Translated_296_residues
MTNAFPFSVQESVPLNRFSTFRIGGPARYFKELVSVDEALKVFSFLHTSPIPYIIIGKGSNCLFHDQGFNGLVLYNNIQG
QTFLSDTQIKVLSGVSFSLLGRQLSSKGFSGLEFAVGIPGTVGGAVFMNAGTALANTASSLVSVEIIDHAGNLLSLSREE
LLFSYRTSPFQKKTAFIVSATFQLTRDSQAAQRAKALIEERILKQPYEYPSVGCIFRNPEGVSAGALIDQAGLKGLTIGG
GQISQKHGNFIINTGNASAADVLELIETIQKTLKQQGIALEKEVRIIPFQPNLGVS
>Mature_295_residues
TNAFPFSVQESVPLNRFSTFRIGGPARYFKELVSVDEALKVFSFLHTSPIPYIIIGKGSNCLFHDQGFNGLVLYNNIQGQ
TFLSDTQIKVLSGVSFSLLGRQLSSKGFSGLEFAVGIPGTVGGAVFMNAGTALANTASSLVSVEIIDHAGNLLSLSREEL
LFSYRTSPFQKKTAFIVSATFQLTRDSQAAQRAKALIEERILKQPYEYPSVGCIFRNPEGVSAGALIDQAGLKGLTIGGG
QISQKHGNFIINTGNASAADVLELIETIQKTLKQQGIALEKEVRIIPFQPNLGVS

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_CHLMU (Q9PL89)

Other databases:

- EMBL:   AE002160
- PIR:   H81726
- RefSeq:   NP_296597.1
- ProteinModelPortal:   Q9PL89
- GeneID:   1246345
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0218
- TIGR:   TC_0218
- HOGENOM:   HBG686573
- OMA:   LESSKIP
- PhylomeDB:   Q9PL89
- ProtClustDB:   PRK13905
- BioCyc:   CMUR243161:TC_0218-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 31882; Mature: 31751

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 166-166 ACT_SITE 214-214 ACT_SITE 283-283

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNAFPFSVQESVPLNRFSTFRIGGPARYFKELVSVDEALKVFSFLHTSPIPYIIIGKGS
CCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
NCLFHDQGFNGLVLYNNIQGQTFLSDTQIKVLSGVSFSLLGRQLSSKGFSGLEFAVGIPG
CEEEECCCCCEEEEEECCCCCEEECCCEEEEECCCCHHHHHHHHHCCCCCCEEEEEECCC
TVGGAVFMNAGTALANTASSLVSVEIIDHAGNLLSLSREELLFSYRTSPFQKKTAFIVSA
CCCCEEEEECCCHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEE
TFQLTRDSQAAQRAKALIEERILKQPYEYPSVGCIFRNPEGVSAGALIDQAGLKGLTIGG
EEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHCCCCEEEECC
GQISQKHGNFIINTGNASAADVLELIETIQKTLKQQGIALEKEVRIIPFQPNLGVS
CEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEECCEEEEEECCCCCCC
>Mature Secondary Structure 
TNAFPFSVQESVPLNRFSTFRIGGPARYFKELVSVDEALKVFSFLHTSPIPYIIIGKGS
CCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
NCLFHDQGFNGLVLYNNIQGQTFLSDTQIKVLSGVSFSLLGRQLSSKGFSGLEFAVGIPG
CEEEECCCCCEEEEEECCCCCEEECCCEEEEECCCCHHHHHHHHHCCCCCCEEEEEECCC
TVGGAVFMNAGTALANTASSLVSVEIIDHAGNLLSLSREELLFSYRTSPFQKKTAFIVSA
CCCCEEEEECCCHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEE
TFQLTRDSQAAQRAKALIEERILKQPYEYPSVGCIFRNPEGVSAGALIDQAGLKGLTIGG
EEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHCCCCEEEECC
GQISQKHGNFIINTGNASAADVLELIETIQKTLKQQGIALEKEVRIIPFQPNLGVS
CEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEECCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935