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Identifier: 15834756

GI number: 15834756

Start: 165930

End: 167471

Strand: Reverse

Name: Not Available

Synonym: TC0136

Alternate gene names: 15834756

Gene position: 167471-165930 (Counterclockwise)

Preceding gene: 15834764

Following gene: 15834755

Centisome position: 15.61

GC content: 41.12

Gene sequence:

>1542_bases
ATGCCTAGCGAAAACAATGAGATGCATCGCAGTACCATCCATCAACTGTTCTCCGGCCTGGATAAAGCTTACCAAATAGT
CAAAGGGTTTTACGGTCCTGCTTACTCCTTTACTACGAAAGATTTTTCCCTGAAAGGAAAGGGCTACCACATTCTCTCTC
GTATAGAATTGTTAGACCCCTTGGAGCGTCTCGGCGTATATTTTGCGCAATCCTTAGCAGAACAAATCTACAATCGCCAT
ACAGATGGAGTCATCTCTTCCGTTATCCTCTTGCGAGCGTTTTTAAAAGCCTCGCTCCCCTTTATTGATCAAGGGATATC
CCCCAGACTTCTTACATCGGCCTTAGCCTCAAAAAAAGAAGCTATTTGCGCTCATTTACAAGCCCACTCATTCCTCTTAA
AAGATACTTCAAAAGTACTTGGACTAATAAGCTCACACACTAATGATCCTTTTATTGGAGAAGTATTTGCACAAGCCGTT
GCATATACAGGACAAGAAGGCACCATTGCTCTATCCCAAAAAAGCGGATCTACTCTACGTTTCGTTCAAGGAATACAAAT
ACAACGTGGGTATCAAGTCCCTTCTTTTTTCCCACAAGATGCTTTTCATGAAAACCTCGTGATAGCCCCCAAAATTTTTG
TCACAGACCAAACAATCCATTCGGTTTTCTCTTTTCTTCCTCTACTTAAACAGTTTTCTGAAGAACAAACTCCCCTTATC
ATTTTTTGCAAAGAGATTGATCATCATCCTCTCGCCACTTGTATTGCAAACCGTATAGCAGGGCTTGTGGATGTTCTAGT
GGTAACCATAGAAGATCCCACCCTTCTAGAAGACATTGCATTACTTACAGGAACTACAGTGTTTTCAACGCCTCCTTTCT
CCAATAAACCTCCCATAGAACTTCCCTTACTAGGTTCTTGTACATGGGCTGAATTGTCTCAAGATCACACCCTATTAGTT
TGTGAAAATTTTGTTCCAGAAGTTGTGAAATTAAAAATTCGCCAACTCGATCATATGATACAAAACGCGGAAAAAGAACT
TTCTCGACAAACACTCAAAGAGCGCAAACATCGCTTAGAACACCCAATCGCAATTATTCCTATTGAACAAGACAAGTCCT
CCCTATACAAACTCGCTTTAAATACTCTAAATACTACAAAAAAATCTGGTTTTGTTGTGGGAGGTGGGGCAGCTCTTCTT
TACGCTTCACAAAATCTTCTATCATCTCAAGATCAGTCTCAAGAAGAACTCGCTGCTTCACATATCTTACAGACCGCCTG
TCGAGCTCTCCTAGAGCAACTAGTTGGCTCCGTACATATGGATGGGAAACTTGTTGCTAACAAACTCTGTTCATTAGGAA
CTCCTAGTCTTGGATTCAATGTCCTCTCGCAACAAATAGAAGATATGATCTCTGCAGGAGTTATTGCACCTTTAGATACT
GTTATGGATATTTTCTCATCTTCCCTCCATGCAGCCTTAGATCTCCTCCTTTCCTCCTATACAACCCCGCCTAGTCCTAT
AACGAACGATAAAAAAACTTAA

Upstream 100 bases:

>100_bases
CGGTTCGATTCCGGGTGCCACCTTCTTAAACTCATTGTGATCTAACTAGCGAGTTGGTAGTGTTCGGGGTAAGAAGCAAC
CTTTTCAGGGTTCCCTCACT

Downstream 100 bases:

>100_bases
TTTTTACTAACTATCCGCCTATTATGCCGAGAACGAGACCTATTAATAATCCAGTCGCTGTTCCTAAAACCTTCACCTCT
CTATGCAAGAAAAACCCTCG

Product: 60 kDa chaperonin, putative

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MPSENNEMHRSTIHQLFSGLDKAYQIVKGFYGPAYSFTTKDFSLKGKGYHILSRIELLDPLERLGVYFAQSLAEQIYNRH
TDGVISSVILLRAFLKASLPFIDQGISPRLLTSALASKKEAICAHLQAHSFLLKDTSKVLGLISSHTNDPFIGEVFAQAV
AYTGQEGTIALSQKSGSTLRFVQGIQIQRGYQVPSFFPQDAFHENLVIAPKIFVTDQTIHSVFSFLPLLKQFSEEQTPLI
IFCKEIDHHPLATCIANRIAGLVDVLVVTIEDPTLLEDIALLTGTTVFSTPPFSNKPPIELPLLGSCTWAELSQDHTLLV
CENFVPEVVKLKIRQLDHMIQNAEKELSRQTLKERKHRLEHPIAIIPIEQDKSSLYKLALNTLNTTKKSGFVVGGGAALL
YASQNLLSSQDQSQEELAASHILQTACRALLEQLVGSVHMDGKLVANKLCSLGTPSLGFNVLSQQIEDMISAGVIAPLDT
VMDIFSSSLHAALDLLLSSYTTPPSPITNDKKT

Sequences:

>Translated_513_residues
MPSENNEMHRSTIHQLFSGLDKAYQIVKGFYGPAYSFTTKDFSLKGKGYHILSRIELLDPLERLGVYFAQSLAEQIYNRH
TDGVISSVILLRAFLKASLPFIDQGISPRLLTSALASKKEAICAHLQAHSFLLKDTSKVLGLISSHTNDPFIGEVFAQAV
AYTGQEGTIALSQKSGSTLRFVQGIQIQRGYQVPSFFPQDAFHENLVIAPKIFVTDQTIHSVFSFLPLLKQFSEEQTPLI
IFCKEIDHHPLATCIANRIAGLVDVLVVTIEDPTLLEDIALLTGTTVFSTPPFSNKPPIELPLLGSCTWAELSQDHTLLV
CENFVPEVVKLKIRQLDHMIQNAEKELSRQTLKERKHRLEHPIAIIPIEQDKSSLYKLALNTLNTTKKSGFVVGGGAALL
YASQNLLSSQDQSQEELAASHILQTACRALLEQLVGSVHMDGKLVANKLCSLGTPSLGFNVLSQQIEDMISAGVIAPLDT
VMDIFSSSLHAALDLLLSSYTTPPSPITNDKKT
>Mature_512_residues
PSENNEMHRSTIHQLFSGLDKAYQIVKGFYGPAYSFTTKDFSLKGKGYHILSRIELLDPLERLGVYFAQSLAEQIYNRHT
DGVISSVILLRAFLKASLPFIDQGISPRLLTSALASKKEAICAHLQAHSFLLKDTSKVLGLISSHTNDPFIGEVFAQAVA
YTGQEGTIALSQKSGSTLRFVQGIQIQRGYQVPSFFPQDAFHENLVIAPKIFVTDQTIHSVFSFLPLLKQFSEEQTPLII
FCKEIDHHPLATCIANRIAGLVDVLVVTIEDPTLLEDIALLTGTTVFSTPPFSNKPPIELPLLGSCTWAELSQDHTLLVC
ENFVPEVVKLKIRQLDHMIQNAEKELSRQTLKERKHRLEHPIAIIPIEQDKSSLYKLALNTLNTTKKSGFVVGGGAALLY
ASQNLLSSQDQSQEELAASHILQTACRALLEQLVGSVHMDGKLVANKLCSLGTPSLGFNVLSQQIEDMISAGVIAPLDTV
MDIFSSSLHAALDLLLSSYTTPPSPITNDKKT

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=463, Percent_Identity=21.5982721382289, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI31542947, Length=463, Percent_Identity=21.5982721382289, Blast_Score=119, Evalue=1e-26,
Organism=Escherichia coli, GI1790586, Length=484, Percent_Identity=24.5867768595041, Blast_Score=159, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17555558, Length=456, Percent_Identity=22.8070175438596, Blast_Score=115, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6323288, Length=455, Percent_Identity=24.6153846153846, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24641193, Length=460, Percent_Identity=23.2608695652174, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24641191, Length=460, Percent_Identity=23.2608695652174, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45550936, Length=470, Percent_Identity=22.7659574468085, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45550132, Length=470, Percent_Identity=22.7659574468085, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45550935, Length=470, Percent_Identity=22.7659574468085, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17864606, Length=452, Percent_Identity=22.5663716814159, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24584129, Length=480, Percent_Identity=22.0833333333333, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921262, Length=480, Percent_Identity=22.0833333333333, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56429; Mature: 56297

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSENNEMHRSTIHQLFSGLDKAYQIVKGFYGPAYSFTTKDFSLKGKGYHILSRIELLDP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEECCCCHHHHHHHHHHHH
LERLGVYFAQSLAEQIYNRHTDGVISSVILLRAFLKASLPFIDQGISPRLLTSALASKKE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHH
AICAHLQAHSFLLKDTSKVLGLISSHTNDPFIGEVFAQAVAYTGQEGTIALSQKSGSTLR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEH
FVQGIQIQRGYQVPSFFPQDAFHENLVIAPKIFVTDQTIHSVFSFLPLLKQFSEEQTPLI
HHHCCCCCCCCCCCCCCCCHHHCCCEEECCEEEEEHHHHHHHHHHHHHHHHHCCCCCCEE
IFCKEIDHHPLATCIANRIAGLVDVLVVTIEDPTLLEDIALLTGTTVFSTPPFSNKPPIE
EEECCCCCCHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCEECCCCCCCCCCCC
LPLLGSCTWAELSQDHTLLVCENFVPEVVKLKIRQLDHMIQNAEKELSRQTLKERKHRLE
CEECCCCCHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HPIAIIPIEQDKSSLYKLALNTLNTTKKSGFVVGGGAALLYASQNLLSSQDQSQEELAAS
CCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEECCCEEEHHHHHHHCCCCCHHHHHHHH
HILQTACRALLEQLVGSVHMDGKLVANKLCSLGTPSLGFNVLSQQIEDMISAGVIAPLDT
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHH
VMDIFSSSLHAALDLLLSSYTTPPSPITNDKKT
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PSENNEMHRSTIHQLFSGLDKAYQIVKGFYGPAYSFTTKDFSLKGKGYHILSRIELLDP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEECCCCHHHHHHHHHHHH
LERLGVYFAQSLAEQIYNRHTDGVISSVILLRAFLKASLPFIDQGISPRLLTSALASKKE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHH
AICAHLQAHSFLLKDTSKVLGLISSHTNDPFIGEVFAQAVAYTGQEGTIALSQKSGSTLR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEH
FVQGIQIQRGYQVPSFFPQDAFHENLVIAPKIFVTDQTIHSVFSFLPLLKQFSEEQTPLI
HHHCCCCCCCCCCCCCCCCHHHCCCEEECCEEEEEHHHHHHHHHHHHHHHHHCCCCCCEE
IFCKEIDHHPLATCIANRIAGLVDVLVVTIEDPTLLEDIALLTGTTVFSTPPFSNKPPIE
EEECCCCCCHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCEECCCCCCCCCCCC
LPLLGSCTWAELSQDHTLLVCENFVPEVVKLKIRQLDHMIQNAEKELSRQTLKERKHRLE
CEECCCCCHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HPIAIIPIEQDKSSLYKLALNTLNTTKKSGFVVGGGAALLYASQNLLSSQDQSQEELAAS
CCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEECCCEEEHHHHHHHCCCCCHHHHHHHH
HILQTACRALLEQLVGSVHMDGKLVANKLCSLGTPSLGFNVLSQQIEDMISAGVIAPLDT
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHH
VMDIFSSSLHAALDLLLSSYTTPPSPITNDKKT
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA