Click here to switch to the map view.

The map label for this gene is ycdW [C]

Identifier: 157963368

GI number: 157963368

Start: 4340562

End: 4341488

Strand: Direct

Name: ycdW [C]

Synonym: Spea_3554

Alternate gene names: 157963368

Gene position: 4340562-4341488 (Clockwise)

Preceding gene: 157963366

Following gene: 157963369

Centisome position: 83.88

GC content: 48.22

Gene sequence:

>927_bases
ATGGGACACAAGCTACTATTACTCACCAGAGAAAATGAGCGATATCGTCAACTTTTAAATTCGTGCCACCTGCCAAATAC
TGAGATCTTAGACGATGATCCCCAAGGTATTTTTAATGCCGATATCTGGTTAGCCGAGCCCAAGCTTGCTGCGCCTTTGC
TGCCCCACGCTGCCAACTTAAAGTGGATGCAGTCTACTTTTGCAGGGGTTGATGCCCTAGTAAAACCAAGACAACGTAAA
GACTATGAGCTCACTAATGTTAGAGGTATTTTTGGGCCACTGATGAGTGAATACCTATTTGGTTATCTGCTGGCTTACCA
AAGAGAACATAGAAAGTACCGCACTCAGCAAGATCAAAAGATTTGGTTACCGGGCAGCTTTAAGACCTTGCAGGGGCAAA
CCCTACTACTCTTGGGCACAGGCTCAATTGCCAAGCATATAGCTCAAACGGCTAAACACTTTGGCATGCATGTCATTGGC
ATCAACCGCGGGGCTAAGCCCACTAGAGGCTTCGACGAAGTCGACACCTTGGCCAATCTTACTCGCTACCTGCCTCAAGC
CGATGCTGTCGCCAGCATTCTGCCTAGCACCCCAGATACCCGAGGCGCTCTCAATAAGCAGACTCTGTCACTACTGAAAG
AAGAGGTGGTGCTGTTCAACCTAGGCCGCGGCGACGTTCTCGATTTAGACGCTCTGTATCAGCAATTAATCAAGCATCCT
GAGCAGCAAGCCATTTTAGACGTGTTTAACCAAGAGCCGTTACCTGAAGAGCACCCCATCTGGTCGCTAGACAATGTCGT
TATTACGCCGCATATCGCTGCGCCGAGTTTTCCTGAGCAGGTGGTCGAAATTTTCACAGAGAATTTTCACAAGTGGATTA
AGGGTGAAAAACTCTCTCACAGAGTGCACTTCGAGCGTGGCTACTAA

Upstream 100 bases:

>100_bases
TGACCCTAAATAGTTAAAAAATTCAATAACCTTAGACATTGTATTAGACATCAGCCCTGCAGGTTTAAATCTAGGTGGAT
GTAGAATATAGGGAGTTAGT

Downstream 100 bases:

>100_bases
CGCTATTAGGTGATACGCAAAATATGAGTGTTATATCAGTCTGCTAAAATATGTGATTTGGGCACGTTTTTTAATAACTG
CCTTAGGCGATCCGACTAAC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NADPH; glyoxylate; glycerate [C]

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MGHKLLLLTRENERYRQLLNSCHLPNTEILDDDPQGIFNADIWLAEPKLAAPLLPHAANLKWMQSTFAGVDALVKPRQRK
DYELTNVRGIFGPLMSEYLFGYLLAYQREHRKYRTQQDQKIWLPGSFKTLQGQTLLLLGTGSIAKHIAQTAKHFGMHVIG
INRGAKPTRGFDEVDTLANLTRYLPQADAVASILPSTPDTRGALNKQTLSLLKEEVVLFNLGRGDVLDLDALYQQLIKHP
EQQAILDVFNQEPLPEEHPIWSLDNVVITPHIAAPSFPEQVVEIFTENFHKWIKGEKLSHRVHFERGY

Sequences:

>Translated_308_residues
MGHKLLLLTRENERYRQLLNSCHLPNTEILDDDPQGIFNADIWLAEPKLAAPLLPHAANLKWMQSTFAGVDALVKPRQRK
DYELTNVRGIFGPLMSEYLFGYLLAYQREHRKYRTQQDQKIWLPGSFKTLQGQTLLLLGTGSIAKHIAQTAKHFGMHVIG
INRGAKPTRGFDEVDTLANLTRYLPQADAVASILPSTPDTRGALNKQTLSLLKEEVVLFNLGRGDVLDLDALYQQLIKHP
EQQAILDVFNQEPLPEEHPIWSLDNVVITPHIAAPSFPEQVVEIFTENFHKWIKGEKLSHRVHFERGY
>Mature_307_residues
GHKLLLLTRENERYRQLLNSCHLPNTEILDDDPQGIFNADIWLAEPKLAAPLLPHAANLKWMQSTFAGVDALVKPRQRKD
YELTNVRGIFGPLMSEYLFGYLLAYQREHRKYRTQQDQKIWLPGSFKTLQGQTLLLLGTGSIAKHIAQTAKHFGMHVIGI
NRGAKPTRGFDEVDTLANLTRYLPQADAVASILPSTPDTRGALNKQTLSLLKEEVVLFNLGRGDVLDLDALYQQLIKHPE
QQAILDVFNQEPLPEEHPIWSLDNVVITPHIAAPSFPEQVVEIFTENFHKWIKGEKLSHRVHFERGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=229, Percent_Identity=28.3842794759825, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI23308577, Length=263, Percent_Identity=26.2357414448669, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87081824, Length=257, Percent_Identity=31.5175097276265, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI87082289, Length=146, Percent_Identity=33.5616438356164, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789279, Length=190, Percent_Identity=29.4736842105263, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=282, Percent_Identity=27.6595744680851, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=184, Percent_Identity=34.2391304347826, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322116, Length=251, Percent_Identity=22.7091633466135, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320925, Length=258, Percent_Identity=22.4806201550388, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28574286, Length=270, Percent_Identity=25.1851851851852, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45552429, Length=243, Percent_Identity=27.9835390946502, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585514, Length=243, Percent_Identity=27.9835390946502, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574282, Length=243, Percent_Identity=27.9835390946502, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574284, Length=243, Percent_Identity=27.9835390946502, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551003, Length=243, Percent_Identity=27.9835390946502, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571528, Length=187, Percent_Identity=28.8770053475936, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24585516, Length=253, Percent_Identity=24.1106719367589, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921140, Length=257, Percent_Identity=28.0155642023346, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: NA

Molecular weight: Translated: 35079; Mature: 34948

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHKLLLLTRENERYRQLLNSCHLPNTEILDDDPQGIFNADIWLAEPKLAAPLLPHAANL
CCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCEECCEEEECCCHHCCCCCCCCCH
KWMQSTFAGVDALVKPRQRKDYELTNVRGIFGPLMSEYLFGYLLAYQREHRKYRTQQDQK
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
IWLPGSFKTLQGQTLLLLGTGSIAKHIAQTAKHFGMHVIGINRGAKPTRGFDEVDTLANL
EECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHHH
TRYLPQADAVASILPSTPDTRGALNKQTLSLLKEEVVLFNLGRGDVLDLDALYQQLIKHP
HHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCEECHHHHHHHHHHCC
EQQAILDVFNQEPLPEEHPIWSLDNVVITPHIAAPSFPEQVVEIFTENFHKWIKGEKLSH
HHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
RVHFERGY
EEECCCCC
>Mature Secondary Structure 
GHKLLLLTRENERYRQLLNSCHLPNTEILDDDPQGIFNADIWLAEPKLAAPLLPHAANL
CCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCEECCEEEECCCHHCCCCCCCCCH
KWMQSTFAGVDALVKPRQRKDYELTNVRGIFGPLMSEYLFGYLLAYQREHRKYRTQQDQK
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
IWLPGSFKTLQGQTLLLLGTGSIAKHIAQTAKHFGMHVIGINRGAKPTRGFDEVDTLANL
EECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHHH
TRYLPQADAVASILPSTPDTRGALNKQTLSLLKEEVVLFNLGRGDVLDLDALYQQLIKHP
HHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCEECHHHHHHHHHHCC
EQQAILDVFNQEPLPEEHPIWSLDNVVITPHIAAPSFPEQVVEIFTENFHKWIKGEKLSH
HHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
RVHFERGY
EEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycolate; NADP; hydroxypyruvate; NADPH [C]

Specific reaction: glycolate + NADP = NADPH + glyoxylate hydroxypyruvate + NADPH = glycerate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]