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The map label for this gene is phoP [H]

Identifier: 157963325

GI number: 157963325

Start: 4290267

End: 4290941

Strand: Direct

Name: phoP [H]

Synonym: Spea_3511

Alternate gene names: 157963325

Gene position: 4290267-4290941 (Clockwise)

Preceding gene: 157963324

Following gene: 157963326

Centisome position: 82.91

GC content: 46.81

Gene sequence:

>675_bases
ATGAAATTACTTCTTGTTGAAGACAACACCTTATTAGTCGAAGAGCTAGTGAAACAGCTTAAACAGGCTGGTTATGTTAC
TGACAGCACAGATAAAGTCAGTGAAGCAGATTATCTAATCAAAGAAACCAACTACGACTGCGTCATTCTCGATATTGGCC
TACCAGACGGTAATGGCCTAGAACTGCTTGAAAGCTGGCGTGAGCAAGGTATCCATACCCCTGTGATTATGCTGACCGCA
CGCAGCCAGTGGCATGAAAAAGTCGAAGGGTTTAACTCGGGCGCAGACGATTATCTAGGTAAGCCATTCCATACCCAAGA
GTTGCTGGTTCGCATTCAGGCTCTTATTCAGCGTGCGCACGGCAAGGCTAACACCCCTAACAAGCAGCTCACCTATGCAG
GCGTAGCTCTCGATGAGGGGCAGCAATCGGTAACAGTTGGCGAGCAAACGTTTGAGCTTACGGCCATGGAGTTTAGGTTA
CTCAAGATCTTCCTGATGTCTCCTAAAAAGCTCCTGTCTAAGGCACAACTGACTGACAAGCTTTATCAGTTTGACGATGA
AAAAGAGAGTAATGTGGTTGAAGTTTACGTGACCCACTTACGTAAGAAGCTTGGCAAAACCGCCATCGAAACTCGTCGTG
GCCAAGGGTATATCTTTCACGGCCTAACCCAATGA

Upstream 100 bases:

>100_bases
AAGAATCAAATCTAATTGCACTGGTGTGGCACTTTTGGGTTAACATGAACTAACTCTGTAAAACGCCTTCCACTCTACTA
GGCATCATTGAGAGCACCCT

Downstream 100 bases:

>100_bases
TATCAATCCGCACCAAACTAAGCCTGTGGTTAACAGGCTTAGTGGTGATCTCCACTGCGGTGGGGATCATCTTTTTCGAG
TCTATGCTACGCCAAGCTTT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKLLLVEDNTLLVEELVKQLKQAGYVTDSTDKVSEADYLIKETNYDCVILDIGLPDGNGLELLESWREQGIHTPVIMLTA
RSQWHEKVEGFNSGADDYLGKPFHTQELLVRIQALIQRAHGKANTPNKQLTYAGVALDEGQQSVTVGEQTFELTAMEFRL
LKIFLMSPKKLLSKAQLTDKLYQFDDEKESNVVEVYVTHLRKKLGKTAIETRRGQGYIFHGLTQ

Sequences:

>Translated_224_residues
MKLLLVEDNTLLVEELVKQLKQAGYVTDSTDKVSEADYLIKETNYDCVILDIGLPDGNGLELLESWREQGIHTPVIMLTA
RSQWHEKVEGFNSGADDYLGKPFHTQELLVRIQALIQRAHGKANTPNKQLTYAGVALDEGQQSVTVGEQTFELTAMEFRL
LKIFLMSPKKLLSKAQLTDKLYQFDDEKESNVVEVYVTHLRKKLGKTAIETRRGQGYIFHGLTQ
>Mature_224_residues
MKLLLVEDNTLLVEELVKQLKQAGYVTDSTDKVSEADYLIKETNYDCVILDIGLPDGNGLELLESWREQGIHTPVIMLTA
RSQWHEKVEGFNSGADDYLGKPFHTQELLVRIQALIQRAHGKANTPNKQLTYAGVALDEGQQSVTVGEQTFELTAMEFRL
LKIFLMSPKKLLSKAQLTDKLYQFDDEKESNVVEVYVTHLRKKLGKTAIETRRGQGYIFHGLTQ

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=36.7713004484305, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1789402, Length=217, Percent_Identity=38.7096774193548, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=36.5296803652968, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=34.0807174887892, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=34.9775784753363, Blast_Score=126, Evalue=9e-31,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=31.25, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1786911, Length=179, Percent_Identity=35.7541899441341, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=32.2869955156951, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=29.004329004329, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1787229, Length=222, Percent_Identity=28.8288288288288, Blast_Score=101, Evalue=3e-23,
Organism=Escherichia coli, GI2367329, Length=234, Percent_Identity=32.9059829059829, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1788394, Length=205, Percent_Identity=28.780487804878, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=31.4655172413793, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=30.1724137931034, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25383; Mature: 25383

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLLVEDNTLLVEELVKQLKQAGYVTDSTDKVSEADYLIKETNYDCVILDIGLPDGNGL
CEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHEEECCCCEEEEEECCCCCCCH
ELLESWREQGIHTPVIMLTARSQWHEKVEGFNSGADDYLGKPFHTQELLVRIQALIQRAH
HHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHC
GKANTPNKQLTYAGVALDEGQQSVTVGEQTFELTAMEFRLLKIFLMSPKKLLSKAQLTDK
CCCCCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LYQFDDEKESNVVEVYVTHLRKKLGKTAIETRRGQGYIFHGLTQ
HHHCCCCCCCCHHHHHHHHHHHHHCHHHHHHCCCCEEEEECCCC
>Mature Secondary Structure
MKLLLVEDNTLLVEELVKQLKQAGYVTDSTDKVSEADYLIKETNYDCVILDIGLPDGNGL
CEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHEEECCCCEEEEEECCCCCCCH
ELLESWREQGIHTPVIMLTARSQWHEKVEGFNSGADDYLGKPFHTQELLVRIQALIQRAH
HHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHC
GKANTPNKQLTYAGVALDEGQQSVTVGEQTFELTAMEFRLLKIFLMSPKKLLSKAQLTDK
CCCCCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LYQFDDEKESNVVEVYVTHLRKKLGKTAIETRRGQGYIFHGLTQ
HHHCCCCCCCCHHHHHHHHHHHHHCHHHHHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA