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The map label for this gene is dsdC [H]

Identifier: 157963265

GI number: 157963265

Start: 4219098

End: 4220069

Strand: Direct

Name: dsdC [H]

Synonym: Spea_3451

Alternate gene names: 157963265

Gene position: 4219098-4220069 (Clockwise)

Preceding gene: 157963262

Following gene: 157963266

Centisome position: 81.54

GC content: 48.97

Gene sequence:

>972_bases
ATGCTCACATCACAATTTGAGAAGTCAGTCATGTATTCCCAGCAAGATGTGTTCAGCAGAAGCCGCTTACTTAGCAGTTA
TCAACTGGCAAAACTGCATACCTTCGAAGTGGTGGCTCGTCACCAATCCTTTTCTCTCGCCGCCGAAGAGCTATGTGTCA
GCCCCTCGGCCGTTAGCCATAGAATTAGCGCACTGGAGAGTGAGCTAGGCTTTAAACTATTTAGCCGCTTTCATCGAAGA
ATCGAGCTAACTGAAGACGGTAAACGGCTGTATTCAAAACTGAAAGACAGTTTAAAAAGCCTGAATCAGGAGGTGTTTGA
GATTAAAAACCAAGAGGTGTCGGGTAAGCTGACTGTCTACTCTCGCCCCTCCATTGCCCAGTGTTGGCTAGTGCCTAAGA
TTGCCGATTTCAGCCGCCAGTATCCGGCGATCTCGATTAATATTTTGACGGGCAACGAGAATGTTAACTTCAACAGTTTT
CATATCGACTTGGCGATCTACTACGACAATCGCCCCCGCAGCAAACTGTTTTGCCAGCACTTGATGGATGAGACCATCAT
GCCAGTCTGTAGCCCTGAGTACGCCGCCGAGCATGATCTTATCGGCAAGCCTGAGCACTTGAGCCGTTGCACCTTGCTAC
ACGACAACCAAGCCTGGGAGTACGATTCAGATTGTGATGAATGGAAGTATTGGGCCGAGACCCAGAGCCTCAGTATTGAA
GATAACCGCTCAATCGGTTTTGACCGCTCAGACTTAGCCGTCATCGCCGCCATGAACCATGCCGGTATCGCCATGGGACG
TGGTCAACTGGTGAGTAAGCGCATAGTCAGAGGTGAACTCATCGCCCCCTTTGCTGGCCAACAGGTAAACTGTGAGCAGA
CCTATTATGTGGCTTCCCATGACAAAGAGCTCAACCCTAAGGCTAAGCTGTTTGTTGAGTGGCTAAAGCAACAAGCAAAC
CAAACTTTATAG

Upstream 100 bases:

>100_bases
TTGCGGCAAGCTGTATTCAATGGTCACAAAAATGGCTTTAACATGATCTAAGCTTCAACTGTGTTGATCTAATCAGCGTT
AAAACGCGCCTTAGAGTAAA

Downstream 100 bases:

>100_bases
TACGCCTCTGTCATGAGGCCACTCATTATTTAGTTAGTAGCAATCAAACTTCGTTTGATAAAAATCATTAAGTTAGACCT
CATCTTACAATTAACGTCGT

Product: DNA-binding transcriptional regulator DsdC

Products: NA

Alternate protein names: D-serine deaminase activator [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MLTSQFEKSVMYSQQDVFSRSRLLSSYQLAKLHTFEVVARHQSFSLAAEELCVSPSAVSHRISALESELGFKLFSRFHRR
IELTEDGKRLYSKLKDSLKSLNQEVFEIKNQEVSGKLTVYSRPSIAQCWLVPKIADFSRQYPAISINILTGNENVNFNSF
HIDLAIYYDNRPRSKLFCQHLMDETIMPVCSPEYAAEHDLIGKPEHLSRCTLLHDNQAWEYDSDCDEWKYWAETQSLSIE
DNRSIGFDRSDLAVIAAMNHAGIAMGRGQLVSKRIVRGELIAPFAGQQVNCEQTYYVASHDKELNPKAKLFVEWLKQQAN
QTL

Sequences:

>Translated_323_residues
MLTSQFEKSVMYSQQDVFSRSRLLSSYQLAKLHTFEVVARHQSFSLAAEELCVSPSAVSHRISALESELGFKLFSRFHRR
IELTEDGKRLYSKLKDSLKSLNQEVFEIKNQEVSGKLTVYSRPSIAQCWLVPKIADFSRQYPAISINILTGNENVNFNSF
HIDLAIYYDNRPRSKLFCQHLMDETIMPVCSPEYAAEHDLIGKPEHLSRCTLLHDNQAWEYDSDCDEWKYWAETQSLSIE
DNRSIGFDRSDLAVIAAMNHAGIAMGRGQLVSKRIVRGELIAPFAGQQVNCEQTYYVASHDKELNPKAKLFVEWLKQQAN
QTL
>Mature_323_residues
MLTSQFEKSVMYSQQDVFSRSRLLSSYQLAKLHTFEVVARHQSFSLAAEELCVSPSAVSHRISALESELGFKLFSRFHRR
IELTEDGKRLYSKLKDSLKSLNQEVFEIKNQEVSGKLTVYSRPSIAQCWLVPKIADFSRQYPAISINILTGNENVNFNSF
HIDLAIYYDNRPRSKLFCQHLMDETIMPVCSPEYAAEHDLIGKPEHLSRCTLLHDNQAWEYDSDCDEWKYWAETQSLSIE
DNRSIGFDRSDLAVIAAMNHAGIAMGRGQLVSKRIVRGELIAPFAGQQVNCEQTYYVASHDKELNPKAKLFVEWLKQQAN
QTL

Specific function: Regulates the expression of the dsd operon for D-serine deaminase (dsdA) [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788706, Length=303, Percent_Identity=58.7458745874587, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1789173, Length=293, Percent_Identity=31.3993174061433, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1786448, Length=302, Percent_Identity=30.794701986755, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI145693193, Length=295, Percent_Identity=25.0847457627119, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1786401, Length=291, Percent_Identity=24.0549828178694, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1787128, Length=247, Percent_Identity=28.7449392712551, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87081978, Length=293, Percent_Identity=26.2798634812287, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789639, Length=184, Percent_Identity=27.7173913043478, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788748, Length=171, Percent_Identity=31.5789473684211, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693105, Length=169, Percent_Identity=27.2189349112426, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1789440, Length=192, Percent_Identity=27.0833333333333, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790262, Length=211, Percent_Identity=25.1184834123223, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011781
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 37055; Mature: 37055

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTSQFEKSVMYSQQDVFSRSRLLSSYQLAKLHTFEVVARHQSFSLAAEELCVSPSAVSH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHH
RISALESELGFKLFSRFHRRIELTEDGKRLYSKLKDSLKSLNQEVFEIKNQEVSGKLTVY
HHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
SRPSIAQCWLVPKIADFSRQYPAISINILTGNENVNFNSFHIDLAIYYDNRPRSKLFCQH
ECCCHHHEEECCCHHHHHCCCCEEEEEEEECCCCCCEEEEEEEEEEEECCCCHHHHHHHH
LMDETIMPVCSPEYAAEHDLIGKPEHLSRCTLLHDNQAWEYDSDCDEWKYWAETQSLSIE
HHHHHCCCCCCCCHHCCCCCCCCCHHHHHEEEEECCCCCCCCCCCHHHHHHHHCCCCCCC
DNRSIGFDRSDLAVIAAMNHAGIAMGRGQLVSKRIVRGELIAPFAGQQVNCEQTYYVASH
CCCCCCCCCCCEEEEEEECCCCEECCCCHHHHHHHHHCCEECCCCCCCCCCCEEEEEECC
DKELNPKAKLFVEWLKQQANQTL
CCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTSQFEKSVMYSQQDVFSRSRLLSSYQLAKLHTFEVVARHQSFSLAAEELCVSPSAVSH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHH
RISALESELGFKLFSRFHRRIELTEDGKRLYSKLKDSLKSLNQEVFEIKNQEVSGKLTVY
HHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
SRPSIAQCWLVPKIADFSRQYPAISINILTGNENVNFNSFHIDLAIYYDNRPRSKLFCQH
ECCCHHHEEECCCHHHHHCCCCEEEEEEEECCCCCCEEEEEEEEEEEECCCCHHHHHHHH
LMDETIMPVCSPEYAAEHDLIGKPEHLSRCTLLHDNQAWEYDSDCDEWKYWAETQSLSIE
HHHHHCCCCCCCCHHCCCCCCCCCHHHHHEEEEECCCCCCCCCCCHHHHHHHHCCCCCCC
DNRSIGFDRSDLAVIAAMNHAGIAMGRGQLVSKRIVRGELIAPFAGQQVNCEQTYYVASH
CCCCCCCCCCCEEEEEEECCCCEECCCCHHHHHHHHHCCEECCCCCCCCCCCEEEEEECC
DKELNPKAKLFVEWLKQQANQTL
CCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592420; 9205837; 9278503 [H]