Click here to switch to the map view.

The map label for this gene is ptxR [H]

Identifier: 157963236

GI number: 157963236

Start: 4181389

End: 4182255

Strand: Direct

Name: ptxR [H]

Synonym: Spea_3422

Alternate gene names: 157963236

Gene position: 4181389-4182255 (Clockwise)

Preceding gene: 157963233

Following gene: 157963241

Centisome position: 80.81

GC content: 45.56

Gene sequence:

>867_bases
ATGAATATTAGCTTAGATGATCTACATCTGTTTGTATTAACCGTGCAACATGGTGGAATTAGCGCTGCGGCAAAGCAACA
TTCGCTCCAACGCTCGAAAGTGAGTCGGCGCCTGCAGGAGTTAGAAAAAACCTTAGGTTGCCAGCTACTTATTCGCACGA
CTCGTCAAATTGAGTTAACCGAGAATGGCCGGTTGCTTTATCAGCAGGTCAGTCAGCCGCTAACCGAGGTCACCCAAGCC
GCCAAACTCCTTAGCAATCAGCAGAAATCATTGCAAGGTGTGTTACGCGTCGCGGTCCCAGCAGCGCTTATCACCTCCAA
TATGTTTAGCCTATTAATCGATAAATACCTAGGCCAGTTTCCCGATGTCTTGTTAGAGGTACTACACTGTCAGGAGAGCG
TCGATCTCAAACGAGAGAATATCGATATCCAAATCTTACCCGACGGAGTGAAAGTGCAAAATGAAGATTATGTACAACAA
ACCCTGCTGCGTTTTCCCAGTAGTTTAGTCGCATCAAAGGAATACCTTCAAAGCCACCAGCCCATTACAGAGTTAAGTGA
GTTAGTCGCTCACCCATTAATGGTCAGTCGCTATAACCAAGCCTCTTTACCCGATACCCTAACCCTTAGGCTCTGCTCTG
ATGATCTGCGCTTAATTCAGCATATGGCGACAACGGGCAAAGGCATTGCGCTGCTGCCAAGTATTTTACTTAAAGACGCC
CTTAAATCCGGTGAGTTAACCGCAATATTGGTCAACGAAAAACTACCTGAAATCAAACTGACGCTTATCTACCCTTCAAA
GCAGTTTTTACCGGAAAAGACCCGAGCGCTAATCACACTGCTTAGAGATACTTTTAAACTCACTTAA

Upstream 100 bases:

>100_bases
GAATGAGTCCAAGGTCTATCTGAGGGGCGACTATTATAGATATTGCTAATTAGATTAAATAGAATGACAAATAGCACACT
TGAGACCTATAGGTAGGACA

Downstream 100 bases:

>100_bases
AAAGCAAGAAACTTAAACCACAAGCGCTTTGCGGCTAAACGCTGTTAGACCAAGTACTGTTCAACTGAGCGCTATTTAAT
TAAGAACTTTAGACATAGGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MNISLDDLHLFVLTVQHGGISAAAKQHSLQRSKVSRRLQELEKTLGCQLLIRTTRQIELTENGRLLYQQVSQPLTEVTQA
AKLLSNQQKSLQGVLRVAVPAALITSNMFSLLIDKYLGQFPDVLLEVLHCQESVDLKRENIDIQILPDGVKVQNEDYVQQ
TLLRFPSSLVASKEYLQSHQPITELSELVAHPLMVSRYNQASLPDTLTLRLCSDDLRLIQHMATTGKGIALLPSILLKDA
LKSGELTAILVNEKLPEIKLTLIYPSKQFLPEKTRALITLLRDTFKLT

Sequences:

>Translated_288_residues
MNISLDDLHLFVLTVQHGGISAAAKQHSLQRSKVSRRLQELEKTLGCQLLIRTTRQIELTENGRLLYQQVSQPLTEVTQA
AKLLSNQQKSLQGVLRVAVPAALITSNMFSLLIDKYLGQFPDVLLEVLHCQESVDLKRENIDIQILPDGVKVQNEDYVQQ
TLLRFPSSLVASKEYLQSHQPITELSELVAHPLMVSRYNQASLPDTLTLRLCSDDLRLIQHMATTGKGIALLPSILLKDA
LKSGELTAILVNEKLPEIKLTLIYPSKQFLPEKTRALITLLRDTFKLT
>Mature_288_residues
MNISLDDLHLFVLTVQHGGISAAAKQHSLQRSKVSRRLQELEKTLGCQLLIRTTRQIELTENGRLLYQQVSQPLTEVTQA
AKLLSNQQKSLQGVLRVAVPAALITSNMFSLLIDKYLGQFPDVLLEVLHCQESVDLKRENIDIQILPDGVKVQNEDYVQQ
TLLRFPSSLVASKEYLQSHQPITELSELVAHPLMVSRYNQASLPDTLTLRLCSDDLRLIQHMATTGKGIALLPSILLKDA
LKSGELTAILVNEKLPEIKLTLIYPSKQFLPEKTRALITLLRDTFKLT

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=300, Percent_Identity=25.6666666666667, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789639, Length=293, Percent_Identity=26.6211604095563, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI145693193, Length=298, Percent_Identity=27.5167785234899, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI87081978, Length=294, Percent_Identity=25.8503401360544, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788706, Length=303, Percent_Identity=26.4026402640264, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1789440, Length=261, Percent_Identity=25.6704980842912, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787128, Length=297, Percent_Identity=22.5589225589226, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788748, Length=299, Percent_Identity=27.0903010033445, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32333; Mature: 32333

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISLDDLHLFVLTVQHGGISAAAKQHSLQRSKVSRRLQELEKTLGCQLLIRTTRQIELT
CCCCHHHEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEECCCEEEEC
ENGRLLYQQVSQPLTEVTQAAKLLSNQQKSLQGVLRVAVPAALITSNMFSLLIDKYLGQF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PDVLLEVLHCQESVDLKRENIDIQILPDGVKVQNEDYVQQTLLRFPSSLVASKEYLQSHQ
HHHHHHHHHHHHHHCHHHHCCEEEEECCCCEECCHHHHHHHHHHCCHHHHHHHHHHHCCC
PITELSELVAHPLMVSRYNQASLPDTLTLRLCSDDLRLIQHMATTGKGIALLPSILLKDA
CHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LKSGELTAILVNEKLPEIKLTLIYPSKQFLPEKTRALITLLRDTFKLT
HCCCCEEEEEECCCCCCEEEEEECCCHHHCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNISLDDLHLFVLTVQHGGISAAAKQHSLQRSKVSRRLQELEKTLGCQLLIRTTRQIELT
CCCCHHHEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEECCCEEEEC
ENGRLLYQQVSQPLTEVTQAAKLLSNQQKSLQGVLRVAVPAALITSNMFSLLIDKYLGQF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PDVLLEVLHCQESVDLKRENIDIQILPDGVKVQNEDYVQQTLLRFPSSLVASKEYLQSHQ
HHHHHHHHHHHHHHCHHHHCCEEEEECCCCEECCHHHHHHHHHHCCHHHHHHHHHHHCCC
PITELSELVAHPLMVSRYNQASLPDTLTLRLCSDDLRLIQHMATTGKGIALLPSILLKDA
CHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LKSGELTAILVNEKLPEIKLTLIYPSKQFLPEKTRALITLLRDTFKLT
HCCCCEEEEEECCCCCCEEEEEECCCHHHCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]