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The map label for this gene is hemN [H]

Identifier: 157963155

GI number: 157963155

Start: 4081047

End: 4082486

Strand: Direct

Name: hemN [H]

Synonym: Spea_3339

Alternate gene names: 157963155

Gene position: 4081047-4082486 (Clockwise)

Preceding gene: 157963154

Following gene: 157963156

Centisome position: 78.87

GC content: 49.1

Gene sequence:

>1440_bases
ATGATTTTAACGCCAAGCATGACAGGCATTGCTAGCCCAGATCCGTTGCAACATGCCTTTAAGGTTAAAAGTGCGCCCCA
CGCTGGTCGCAGTGGAAGCCGTCCCGTGTTTCTTGAGCCACAGCAGTGGCACCAATGGTGGCAGCAGCCAAGCCAAGCCA
CTGAACGCGCGCTATATATCCATATTCCTTTTTGCCGCAAACGTTGTACTTTCTGTAACTTTTTTGAGAACGGTACCAAT
CCAGAGCGGATCAGTCGTTACATTAAAAATCTTACCCAGCAGCTTCATATTGCCGCCGACACGCCACTGGCACAAAGCCG
TGGGTTTAATACCGTCTATGTGGGCGGTGGCACACCAACCGATATCAGTAGCGATGAAGTCAAACAGCTAGGTGAGGCCA
TCAGCCGATTTCCGTTAGTAGACAATGCCGAAGTGACATTAGAAGGTCGACTCAACGGCTTCGATGACGATAAATGGCAT
AACGCCACCGCTAACGGCTTTAACCGTTTTTCCTTTGGTGTGCAGAGCTTTGATACTCAAGTACGCCAAGCCGCTGGCCG
CTTTGACGATAAAGATTTTTTACTTAACCGATTGCAGCAGCTTAGCCAGCACCCAAGTGCCAGTATCGTCATTGATTTGA
TTTTTGGCTTACCCGGCCAGACCTTAGATGTTTGGCAGCAAGACTTACAAGCGGTTATCGACAGCGGCGTACATGGAGTG
GATCTCTATCAGCTAATTGGTTTGAGCGGGACTCGCATCGAACATGCTCGTGAAAAAGGCAAAATACTCGGTACAGCGCT
AAGTGAGTTTCAAGCCGACAGCCAAACTCGCGCCAAAATGTATGCTAGTGGCGCAAACCACTTTGAGGCGCAAAACTGGC
AGCGGTTATCGAGCTGCCATTGGCGTCGAGATAGTCGCGAGCGTAGCGTTTATAATAGTTTGGCAAAAAGTGGGATTGAG
ATCTTACCCTTTGGCGCTGGAGCTGGCGGCAGTATTCATGGCCATGGCTGTATGAACGGCCGAGACTTAAAAAAATGGCA
CCAAGCTCATGATGAAGTCACCTCCCCAAATGAGCTAATAGCAAATGACTCAATAGCAACTGAGCCAATGGCAAATGCGC
CAGTACAGGTGCCGGGCATGCTAATGAGCCCTAATCCGTCGGCTAGCTTAGATGCTATTTTCAAGCGAGGCTTAGATGGC
GGTAAGTTAAATCTCAGCTTATTGCCCAGCGCTATGGCGCTACATTTATCGCCTCTATTTAGCGCTTGGCAAAACAATGG
CTTAGCCGAGTTAGTGCAAGACCAGCTCACGCTGACCTTAGCGGGACGTTTTTGGAACGTAAATATGCAAACTGGTTTAT
TTGAGTTTCTTGCTGAAAATCCACTGACGTCTGAAACTAGCAGCCAGCAGACTCACTCGGTTCACGCCATAGCAAGCTAG

Upstream 100 bases:

>100_bases
CTTTACAATGCAAAGAGCGATTAGTTGATCTACCGCACCAAAATCGCATTTGATAATAATTATCATTATCAAAACACTTT
TTTGTATTTTGAGAGTCGCG

Downstream 100 bases:

>100_bases
TCGTGAATCCTTTAAGCGCACTGCACAACTCAAAGTAGAGCTGATATAGTGCGCTTATTCTTCGCTAGGCATTCATATAC
TTATGGCAGCAACAAACGCT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MILTPSMTGIASPDPLQHAFKVKSAPHAGRSGSRPVFLEPQQWHQWWQQPSQATERALYIHIPFCRKRCTFCNFFENGTN
PERISRYIKNLTQQLHIAADTPLAQSRGFNTVYVGGGTPTDISSDEVKQLGEAISRFPLVDNAEVTLEGRLNGFDDDKWH
NATANGFNRFSFGVQSFDTQVRQAAGRFDDKDFLLNRLQQLSQHPSASIVIDLIFGLPGQTLDVWQQDLQAVIDSGVHGV
DLYQLIGLSGTRIEHAREKGKILGTALSEFQADSQTRAKMYASGANHFEAQNWQRLSSCHWRRDSRERSVYNSLAKSGIE
ILPFGAGAGGSIHGHGCMNGRDLKKWHQAHDEVTSPNELIANDSIATEPMANAPVQVPGMLMSPNPSASLDAIFKRGLDG
GKLNLSLLPSAMALHLSPLFSAWQNNGLAELVQDQLTLTLAGRFWNVNMQTGLFEFLAENPLTSETSSQQTHSVHAIAS

Sequences:

>Translated_479_residues
MILTPSMTGIASPDPLQHAFKVKSAPHAGRSGSRPVFLEPQQWHQWWQQPSQATERALYIHIPFCRKRCTFCNFFENGTN
PERISRYIKNLTQQLHIAADTPLAQSRGFNTVYVGGGTPTDISSDEVKQLGEAISRFPLVDNAEVTLEGRLNGFDDDKWH
NATANGFNRFSFGVQSFDTQVRQAAGRFDDKDFLLNRLQQLSQHPSASIVIDLIFGLPGQTLDVWQQDLQAVIDSGVHGV
DLYQLIGLSGTRIEHAREKGKILGTALSEFQADSQTRAKMYASGANHFEAQNWQRLSSCHWRRDSRERSVYNSLAKSGIE
ILPFGAGAGGSIHGHGCMNGRDLKKWHQAHDEVTSPNELIANDSIATEPMANAPVQVPGMLMSPNPSASLDAIFKRGLDG
GKLNLSLLPSAMALHLSPLFSAWQNNGLAELVQDQLTLTLAGRFWNVNMQTGLFEFLAENPLTSETSSQQTHSVHAIAS
>Mature_479_residues
MILTPSMTGIASPDPLQHAFKVKSAPHAGRSGSRPVFLEPQQWHQWWQQPSQATERALYIHIPFCRKRCTFCNFFENGTN
PERISRYIKNLTQQLHIAADTPLAQSRGFNTVYVGGGTPTDISSDEVKQLGEAISRFPLVDNAEVTLEGRLNGFDDDKWH
NATANGFNRFSFGVQSFDTQVRQAAGRFDDKDFLLNRLQQLSQHPSASIVIDLIFGLPGQTLDVWQQDLQAVIDSGVHGV
DLYQLIGLSGTRIEHAREKGKILGTALSEFQADSQTRAKMYASGANHFEAQNWQRLSSCHWRRDSRERSVYNSLAKSGIE
ILPFGAGAGGSIHGHGCMNGRDLKKWHQAHDEVTSPNELIANDSIATEPMANAPVQVPGMLMSPNPSASLDAIFKRGLDG
GKLNLSLLPSAMALHLSPLFSAWQNNGLAELVQDQLTLTLAGRFWNVNMQTGLFEFLAENPLTSETSSQQTHSVHAIAS

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=261, Percent_Identity=30.6513409961686, Blast_Score=96, Evalue=1e-19,
Organism=Escherichia coli, GI87082341, Length=301, Percent_Identity=25.9136212624585, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1789325, Length=191, Percent_Identity=31.413612565445, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52854; Mature: 52854

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILTPSMTGIASPDPLQHAFKVKSAPHAGRSGSRPVFLEPQQWHQWWQQPSQATERALYI
CEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHCHHHHHCCEEEE
HIPFCRKRCTFCNFFENGTNPERISRYIKNLTQQLHIAADTPLAQSRGFNTVYVGGGTPT
EEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEECCCCCHHHHCCCCEEEECCCCCC
DISSDEVKQLGEAISRFPLVDNAEVTLEGRLNGFDDDKWHNATANGFNRFSFGVQSFDTQ
CCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
VRQAAGRFDDKDFLLNRLQQLSQHPSASIVIDLIFGLPGQTLDVWQQDLQAVIDSGVHGV
HHHHHCCCCCHHHHHHHHHHHHCCCCHHEEHHHHHCCCCCHHHHHHHHHHHHHHCCCCCH
DLYQLIGLSGTRIEHAREKGKILGTALSEFQADSQTRAKMYASGANHFEAQNWQRLSSCH
HHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
WRRDSRERSVYNSLAKSGIEILPFGAGAGGSIHGHGCMNGRDLKKWHQAHDEVTSPNELI
HCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHH
ANDSIATEPMANAPVQVPGMLMSPNPSASLDAIFKRGLDGGKLNLSLLPSAMALHLSPLF
CCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCCCEEEHEECCHHHHHHHHHHH
SAWQNNGLAELVQDQLTLTLAGRFWNVNMQTGLFEFLAENPLTSETSSQQTHSVHAIAS
HHHHCCCHHHHHHHHHEEEEECEEEECCHHHHHHHHHHCCCCCCCCCCCHHHCEEEECC
>Mature Secondary Structure
MILTPSMTGIASPDPLQHAFKVKSAPHAGRSGSRPVFLEPQQWHQWWQQPSQATERALYI
CEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHCHHHHHCCEEEE
HIPFCRKRCTFCNFFENGTNPERISRYIKNLTQQLHIAADTPLAQSRGFNTVYVGGGTPT
EEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEECCCCCHHHHCCCCEEEECCCCCC
DISSDEVKQLGEAISRFPLVDNAEVTLEGRLNGFDDDKWHNATANGFNRFSFGVQSFDTQ
CCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
VRQAAGRFDDKDFLLNRLQQLSQHPSASIVIDLIFGLPGQTLDVWQQDLQAVIDSGVHGV
HHHHHCCCCCHHHHHHHHHHHHCCCCHHEEHHHHHCCCCCHHHHHHHHHHHHHHCCCCCH
DLYQLIGLSGTRIEHAREKGKILGTALSEFQADSQTRAKMYASGANHFEAQNWQRLSSCH
HHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
WRRDSRERSVYNSLAKSGIEILPFGAGAGGSIHGHGCMNGRDLKKWHQAHDEVTSPNELI
HCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHH
ANDSIATEPMANAPVQVPGMLMSPNPSASLDAIFKRGLDGGKLNLSLLPSAMALHLSPLF
CCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCCCEEEHEECCHHHHHHHHHHH
SAWQNNGLAELVQDQLTLTLAGRFWNVNMQTGLFEFLAENPLTSETSSQQTHSVHAIAS
HHHHCCCHHHHHHHHHEEEEECEEEECCHHHHHHHHHHCCCCCCCCCCCHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]