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The map label for this gene is dctR [H]

Identifier: 157962859

GI number: 157962859

Start: 3731040

End: 3731651

Strand: Direct

Name: dctR [H]

Synonym: Spea_3041

Alternate gene names: 157962859

Gene position: 3731040-3731651 (Clockwise)

Preceding gene: 157962853

Following gene: 157962862

Centisome position: 72.1

GC content: 47.39

Gene sequence:

>612_bases
GTGCAACAACAGCTCAATGGTCCAGTCTATCTCGTCGATGATGACGAAGCGATTATCGACTCAATCAGTTTTCTAATGGA
AGGTTTTGGCTATCAACTCCGCAGCTTTAACAGTGGCGATCGTTTCTTGAAAGAGGTCGACTTAACCCTAGCTGGATGCG
TAATTTTAGATGCACGAATGCCGGGGCTGACTGGTCCTCAGGTGCAGCAGCTGCTAAGCGATGCTAACAGCCCATTGGCG
GTGATTTTCTTAACTGGCCATGGCGATGTACCTATGGCTGTGGATGCTTTTAAGAATGGCGCTTTTGACTTCTTCCAAAA
GCCCGTTCAGGGGAGCATACTGGCACAAGCTATTGCTAAAGGGCTAACCAACAGTCTTGAACAGCACCTGAAACTCACAG
ACCAAGCCTTAATCGATACCTTGTCGGAGCGGGAAGCCCAGATTTTCCAATTAGTCATTGCTGGCAATACCAATAAGCAG
ATGGCAAATGAGCTTTGTGTTGCGATTCGTACTATCGAAGTTCATCGCTCAAAACTGATGACTAAGCTCGGAGTGAGCAA
CCTGGCTGAGTTAGTCAAACTCGCGCCATTGTTAGCAGAGAAGAACGGATAA

Upstream 100 bases:

>100_bases
TTAGAGCGTGATGCAATTCATGCTTTATAGATTATTGTTGGATTAAAGCGACAAACTGGGATATCTATCATTTAAATACC
TGCAAAGATAAGGGTTCGGT

Downstream 100 bases:

>100_bases
ATATTCAGTAGGCTATTCGCTTTAAGATTACGAGTCTTAAAATTACTAGACTTAACACCACGAGTAGCCATTAACCGTTA
AAACTATGATACCAGTCTCT

Product: two component LuxR family transcriptional regulator

Products: NADP; 2 glutathione [C]

Alternate protein names: NA

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MQQQLNGPVYLVDDDEAIIDSISFLMEGFGYQLRSFNSGDRFLKEVDLTLAGCVILDARMPGLTGPQVQQLLSDANSPLA
VIFLTGHGDVPMAVDAFKNGAFDFFQKPVQGSILAQAIAKGLTNSLEQHLKLTDQALIDTLSEREAQIFQLVIAGNTNKQ
MANELCVAIRTIEVHRSKLMTKLGVSNLAELVKLAPLLAEKNG

Sequences:

>Translated_203_residues
MQQQLNGPVYLVDDDEAIIDSISFLMEGFGYQLRSFNSGDRFLKEVDLTLAGCVILDARMPGLTGPQVQQLLSDANSPLA
VIFLTGHGDVPMAVDAFKNGAFDFFQKPVQGSILAQAIAKGLTNSLEQHLKLTDQALIDTLSEREAQIFQLVIAGNTNKQ
MANELCVAIRTIEVHRSKLMTKLGVSNLAELVKLAPLLAEKNG
>Mature_203_residues
MQQQLNGPVYLVDDDEAIIDSISFLMEGFGYQLRSFNSGDRFLKEVDLTLAGCVILDARMPGLTGPQVQQLLSDANSPLA
VIFLTGHGDVPMAVDAFKNGAFDFFQKPVQGSILAQAIAKGLTNSLEQHLKLTDQALIDTLSEREAQIFQLVIAGNTNKQ
MANELCVAIRTIEVHRSKLMTKLGVSNLAELVKLAPLLAEKNG

Specific function: Member of the two-component regulatory system dctS/dctR involved in the transport of C4-dicarboxylates. DctR functions as a transcriptional repressor of genes for C4-dicarboxylate transport [H]

COG id: COG4566

COG function: function code T; Response regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790299, Length=103, Percent_Identity=32.0388349514563, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1786747, Length=154, Percent_Identity=27.9220779220779, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788905, Length=142, Percent_Identity=30.9859154929577, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 22072; Mature: 22072

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQQLNGPVYLVDDDEAIIDSISFLMEGFGYQLRSFNSGDRFLKEVDLTLAGCVILDARM
CCCCCCCCEEEEECCHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHEEECCC
PGLTGPQVQQLLSDANSPLAVIFLTGHGDVPMAVDAFKNGAFDFFQKPVQGSILAQAIAK
CCCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHCCCHHHHHCCCCHHHHHHHHHH
GLTNSLEQHLKLTDQALIDTLSEREAQIFQLVIAGNTNKQMANELCVAIRTIEVHRSKLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
TKLGVSNLAELVKLAPLLAEKNG
HHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQQQLNGPVYLVDDDEAIIDSISFLMEGFGYQLRSFNSGDRFLKEVDLTLAGCVILDARM
CCCCCCCCEEEEECCHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHEEECCC
PGLTGPQVQQLLSDANSPLAVIFLTGHGDVPMAVDAFKNGAFDFFQKPVQGSILAQAIAK
CCCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHCCCHHHHHCCCCHHHHHHHHHH
GLTNSLEQHLKLTDQALIDTLSEREAQIFQLVIAGNTNKQMANELCVAIRTIEVHRSKLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
TKLGVSNLAELVKLAPLLAEKNG
HHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH2; oxidized glutathione [C]

Specific reaction: NADPH2 + oxidized glutathione = NADP + 2 glutathione [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8455557 [H]