Click here to switch to the map view.

The map label for this gene is menA [H]

Identifier: 157962614

GI number: 157962614

Start: 3409881

End: 3410765

Strand: Direct

Name: menA [H]

Synonym: Spea_2793

Alternate gene names: 157962614

Gene position: 3409881-3410765 (Clockwise)

Preceding gene: 157962607

Following gene: 157962617

Centisome position: 65.9

GC content: 49.15

Gene sequence:

>885_bases
ATGAATCCTTGGATACTTGCCATCCGCCCTCGCACCTTGCCTGCGGCGATTGGACCACTGCTGGTTGGTAACGTGCTCGC
ACTACAACTTGAGCAATTCAGCTTATTCATTGCTGTAATCTCAATGCTTTGTGCCTTGTTACTGCAAATTGCCGTGAATT
TAGCCAACGACTATTTCGACTTTAAGAGCGGTGTCGATACAGAAGAGCGTCTAGGCCCTGTTCGCGTTACCCAGAGCGGT
ATGTTGAGCCCTACAGCCGTGCGTAATGCCATGATCTTATGCCTAGTGTTAGCATTACTCGTTGGCTCTTTTCTTATCTA
CCATGGTGGTTTACCGATTGCCTTCTTAGCGGCGGCGGCCGTGCTTGGCGCTTTAGGTTATAGCGGCGGTCCTTACCCGC
TAGCCTCCCATGGCTTAGGCGAAGTCGCAGCATTCGTGTTCTTTGGTCTTGTGGCTGTAGTAGGAAGTTACTTTCTACAA
GCGGGTGAAACGGCAAGCAGTGCTTGGTTGCTCGGTAGTGCCATCGGCTTCTTAAACGCGGCAATTATGTTAGTAAATAA
CACCCGCGATATGGAAACCGACATTAAGGCGGGTAAAAAGACCTTAGCGGTTCGTATGGGACTCGAGCAATCACGGATCT
TCTACCAGAGCTTTGTCTTCCTTCCATTTGCCATCATTATTGCTGGTTTCTTTATGGGTGCGCTGCCTGGCCTGCCTGTG
CTTTTAGCAGGACTTGCATTTGTCATGGCAAGAAAGTTAAGCCGTGATTTTAATGAAGTTAAAGGTGCAGCGCTCAATCC
GTTACTCGGTCGTACCGCTAAGCTAACCATGATTTTCAGTGCGCTGTTCAGTGCAGGTCTACTAGTCGATGTAGTGATGG
CCTAA

Upstream 100 bases:

>100_bases
CACTTTTTAGAAGTTGTTAAATTTGCTATGCTTGCGCTAATTCATTTTAATCTTTATGTCATCCTTCTTTGATGTAAACC
TCTGTAAGTAAATATAAACC

Downstream 100 bases:

>100_bases
TACCAATCAGTATAAAGATTTGATCGCTCAGCGAGAGTTTAGCGGTTCTGAGGCAAGGCAACGAGTGAAGAGCATAGTTG
TTCTACGGTTAAGCTCGTTA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MNPWILAIRPRTLPAAIGPLLVGNVLALQLEQFSLFIAVISMLCALLLQIAVNLANDYFDFKSGVDTEERLGPVRVTQSG
MLSPTAVRNAMILCLVLALLVGSFLIYHGGLPIAFLAAAAVLGALGYSGGPYPLASHGLGEVAAFVFFGLVAVVGSYFLQ
AGETASSAWLLGSAIGFLNAAIMLVNNTRDMETDIKAGKKTLAVRMGLEQSRIFYQSFVFLPFAIIIAGFFMGALPGLPV
LLAGLAFVMARKLSRDFNEVKGAALNPLLGRTAKLTMIFSALFSAGLLVDVVMA

Sequences:

>Translated_294_residues
MNPWILAIRPRTLPAAIGPLLVGNVLALQLEQFSLFIAVISMLCALLLQIAVNLANDYFDFKSGVDTEERLGPVRVTQSG
MLSPTAVRNAMILCLVLALLVGSFLIYHGGLPIAFLAAAAVLGALGYSGGPYPLASHGLGEVAAFVFFGLVAVVGSYFLQ
AGETASSAWLLGSAIGFLNAAIMLVNNTRDMETDIKAGKKTLAVRMGLEQSRIFYQSFVFLPFAIIIAGFFMGALPGLPV
LLAGLAFVMARKLSRDFNEVKGAALNPLLGRTAKLTMIFSALFSAGLLVDVVMA
>Mature_294_residues
MNPWILAIRPRTLPAAIGPLLVGNVLALQLEQFSLFIAVISMLCALLLQIAVNLANDYFDFKSGVDTEERLGPVRVTQSG
MLSPTAVRNAMILCLVLALLVGSFLIYHGGLPIAFLAAAAVLGALGYSGGPYPLASHGLGEVAAFVFFGLVAVVGSYFLQ
AGETASSAWLLGSAIGFLNAAIMLVNNTRDMETDIKAGKKTLAVRMGLEQSRIFYQSFVFLPFAIIIAGFFMGALPGLPV
LLAGLAFVMARKLSRDFNEVKGAALNPLLGRTAKLTMIFSALFSAGLLVDVVMA

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=294, Percent_Identity=28.9115646258503, Blast_Score=95, Evalue=8e-20,
Organism=Escherichia coli, GI1790365, Length=294, Percent_Identity=33.3333333333333, Blast_Score=148, Evalue=4e-37,
Organism=Drosophila melanogaster, GI17737429, Length=297, Percent_Identity=27.9461279461279, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 31089; Mature: 31089

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPWILAIRPRTLPAAIGPLLVGNVLALQLEQFSLFIAVISMLCALLLQIAVNLANDYFD
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKSGVDTEERLGPVRVTQSGMLSPTAVRNAMILCLVLALLVGSFLIYHGGLPIAFLAAAA
HHCCCCHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VLGALGYSGGPYPLASHGLGEVAAFVFFGLVAVVGSYFLQAGETASSAWLLGSAIGFLNA
HHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AIMLVNNTRDMETDIKAGKKTLAVRMGLEQSRIFYQSFVFLPFAIIIAGFFMGALPGLPV
HHHEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LLAGLAFVMARKLSRDFNEVKGAALNPLLGRTAKLTMIFSALFSAGLLVDVVMA
HHHHHHHHHHHHHHHHHHHHCCCHHCHHHCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPWILAIRPRTLPAAIGPLLVGNVLALQLEQFSLFIAVISMLCALLLQIAVNLANDYFD
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKSGVDTEERLGPVRVTQSGMLSPTAVRNAMILCLVLALLVGSFLIYHGGLPIAFLAAAA
HHCCCCHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VLGALGYSGGPYPLASHGLGEVAAFVFFGLVAVVGSYFLQAGETASSAWLLGSAIGFLNA
HHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AIMLVNNTRDMETDIKAGKKTLAVRMGLEQSRIFYQSFVFLPFAIIIAGFFMGALPGLPV
HHHEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LLAGLAFVMARKLSRDFNEVKGAALNPLLGRTAKLTMIFSALFSAGLLVDVVMA
HHHHHHHHHHHHHHHHHHHHCCCHHCHHHCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]