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The map label for this gene is clpP [H]

Identifier: 157962502

GI number: 157962502

Start: 3267599

End: 3268210

Strand: Reverse

Name: clpP [H]

Synonym: Spea_2681

Alternate gene names: 157962502

Gene position: 3268210-3267599 (Counterclockwise)

Preceding gene: 157962503

Following gene: 157962501

Centisome position: 63.16

GC content: 45.1

Gene sequence:

>612_bases
ATGCACAAAGCGCCAGAATCAGTACTTAACGCACTCGTTCCTATGGTTGTTGAACAAACAGCTAAAGGTGAACGTTCATA
TGATATTTATTCTCGCCTTTTGAAAGAGCGAGTGATCTTTCTTGTTGGCCAAGTTGAAGAACATATGGCTAACCTTATCG
TTGCTCAGTTACTGTTTTTGGAATCAGAGAGCCCAGATAAGGATATCTACCTATACATCAACTCGCCAGGCGGCAGCGTA
ACTGCAGGTATGGCGATTTATGACACAATGCAGTTTATTAAGCCAAACGTGAGCACTGTGTGTATTGGTCAAGCGGCGAG
CATGGGCGCATTTTTGTTAGCAGGCGGTGCAGAAGGCAAACGTCATTGCTTACCGAACTCTAGAGTGATGATCCATCAGC
CACTAGGCGGCTTCCAAGGACAGGCGTCGGATATTGCTATTCATGCTCAAGAGATCTTGGGTATTAAGAATAAGCTAAAC
ACCATGTTAGCTGAGCATACTGGTCAGCCTCTTGAAGTGATTGAACGTGATACAGACCGTGATAACTTCATGAGCGCGAC
AGAAGCCGCTGAATATGGTTTAGTCGATTCAGTGATAGCAAAACGAGGCTGA

Upstream 100 bases:

>100_bases
GTCGCGCGTAACCATCGCTTGACTTAAATGGCTATTAGCCATTTATAATGGCTCGTATGAGGTTCCTCATGCGGGCCATT
TTTATTTAGGGAAGTTAATC

Downstream 100 bases:

>100_bases
TTTTTACTTCGCTCTGAGCTATGCTCAAATATGAAGTAACGATAAGATTTAGGCAGTAGAATTGCTGCAAACAGAGGTAA
AGTAATGGGTGAAGACAAAG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MHKAPESVLNALVPMVVEQTAKGERSYDIYSRLLKERVIFLVGQVEEHMANLIVAQLLFLESESPDKDIYLYINSPGGSV
TAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGAEGKRHCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKNKLN
TMLAEHTGQPLEVIERDTDRDNFMSATEAAEYGLVDSVIAKRG

Sequences:

>Translated_203_residues
MHKAPESVLNALVPMVVEQTAKGERSYDIYSRLLKERVIFLVGQVEEHMANLIVAQLLFLESESPDKDIYLYINSPGGSV
TAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGAEGKRHCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKNKLN
TMLAEHTGQPLEVIERDTDRDNFMSATEAAEYGLVDSVIAKRG
>Mature_203_residues
MHKAPESVLNALVPMVVEQTAKGERSYDIYSRLLKERVIFLVGQVEEHMANLIVAQLLFLESESPDKDIYLYINSPGGSV
TAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGAEGKRHCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKNKLN
TMLAEHTGQPLEVIERDTDRDNFMSATEAAEYGLVDSVIAKRG

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=59.0425531914894, Blast_Score=244, Evalue=4e-65,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=77.0833333333333, Blast_Score=325, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17538017, Length=191, Percent_Identity=54.9738219895288, Blast_Score=222, Evalue=8e-59,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=56.9148936170213, Blast_Score=234, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22104; Mature: 22104

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKAPESVLNALVPMVVEQTAKGERSYDIYSRLLKERVIFLVGQVEEHMANLIVAQLLFL
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESESPDKDIYLYINSPGGSVTAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGAEGK
CCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCEEEECCHHCCCEEEEECCCCCC
RHCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKNKLNTMLAEHTGQPLEVIERDTDR
CCCCCCCCEEEECCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCH
DNFMSATEAAEYGLVDSVIAKRG
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHKAPESVLNALVPMVVEQTAKGERSYDIYSRLLKERVIFLVGQVEEHMANLIVAQLLFL
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESESPDKDIYLYINSPGGSVTAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGAEGK
CCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCEEEECCHHCCCEEEEECCCCCC
RHCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKNKLNTMLAEHTGQPLEVIERDTDR
CCCCCCCCEEEECCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCH
DNFMSATEAAEYGLVDSVIAKRG
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA