Click here to switch to the map view.

The map label for this gene is purM [H]

Identifier: 157962398

GI number: 157962398

Start: 3136435

End: 3137475

Strand: Direct

Name: purM [H]

Synonym: Spea_2577

Alternate gene names: 157962398

Gene position: 3136435-3137475 (Clockwise)

Preceding gene: 157962396

Following gene: 157962399

Centisome position: 60.61

GC content: 45.82

Gene sequence:

>1041_bases
GTGAGCACTCCTACTACCCCACTAAGCTATAAAGATGCAGGCGTTGATATCGATGCCGGAAATGCACTAGTTAACAACAT
CAAGTCAGCAGTAAAACGTACCCGCCGTCCAGAAGTAATGGGCAATCTAGGTGGTTTTGGTGCACTTTGTGAGCTACCAA
CTAAGTATAAGCATCCAGTACTGGTTTCTGGTACTGATGGTGTCGGCACAAAACTACGCCTTGCTATCGACTATAAAAAA
CACGATAACGTTGGTGTTGATTTAGTTGCCATGTGTTCAAACGATCTAATCGTTTCAGGTGCAGAGCCACTGTTCTTCCT
AGACTACTACGCGACAGGCAAACTTGATGTTGAAGTTGCGACCGCCGTTGTTAAAGGAATTGCTGAAGGCTGTGTGCAAT
CAGGCTGTGCATTAATCGGCGGTGAGACTGCTGAAATGCCTGGCATGTATGAAGGCGACGACTACGACCTAGCAGGTTTC
TGCGTTGGTGTTGTAGAGAAAGAAGAGATCATCGATGGCACTAAGGTGCAAGACGGTGATGCCCTTATCGCACTCGCCTC
AAGCGGTCCTCACTCAAATGGTTTCTCACTTATCCGTAAGGTATTAGAAGTGAGCAAGGCAGATCCAGCCCAAGAACTTG
CTGGAAAGCCACTAATTGATCATTTGTTAGAACCTACAAAAATTTATGTAAAGTCATTGCTTAAATTGCTTGAACAGCAT
GATGTTCATGCTATGTCGCACATTACAGGTGGTGGCTTCTGGGAAAATATCCCACGCGTATTACCTGAAGATTGCAAAGC
AGTGGTAAAAAGCGACTCTTGGCAGTGGCCTGTCGTGTTTAATTGGTTGATGGAAAACGGCAACATTTCAGAATTTGAAA
TGTACCGCACCTTCAACTGTGGTGTTGGTATGGTTGTCGCCCTACCAGCTGATAAAGTCGATTCGGCCTTAGAACTGCTA
ACAGCAGAAGGCGAGAACGCTTGGTTAATCGGTAACATTGCCAAGCGTAACGGCGAAGAAGAGCAAGTGGAGATCCTGTA
A

Upstream 100 bases:

>100_bases
GTTTATTGAAAAACTTAGCTTTCGAGCCTACTCACAAGCTGTTAGAATGGCGCCGCGTAAAATCCAATAATAATCTATAC
CCGTACCCGAGAGGATCTCC

Downstream 100 bases:

>100_bases
TGCCCCAGAGTTGTCGCGTTTTAGTATTAATTTCAGGTAACGGCAGTAACCTACAAGCCATTATCGATGGTTGTGACGAT
AACCTCCAAGCCGAAGTTGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSTPTTPLSYKDAGVDIDAGNALVNNIKSAVKRTRRPEVMGNLGGFGALCELPTKYKHPVLVSGTDGVGTKLRLAIDYKK
HDNVGVDLVAMCSNDLIVSGAEPLFFLDYYATGKLDVEVATAVVKGIAEGCVQSGCALIGGETAEMPGMYEGDDYDLAGF
CVGVVEKEEIIDGTKVQDGDALIALASSGPHSNGFSLIRKVLEVSKADPAQELAGKPLIDHLLEPTKIYVKSLLKLLEQH
DVHAMSHITGGGFWENIPRVLPEDCKAVVKSDSWQWPVVFNWLMENGNISEFEMYRTFNCGVGMVVALPADKVDSALELL
TAEGENAWLIGNIAKRNGEEEQVEIL

Sequences:

>Translated_346_residues
MSTPTTPLSYKDAGVDIDAGNALVNNIKSAVKRTRRPEVMGNLGGFGALCELPTKYKHPVLVSGTDGVGTKLRLAIDYKK
HDNVGVDLVAMCSNDLIVSGAEPLFFLDYYATGKLDVEVATAVVKGIAEGCVQSGCALIGGETAEMPGMYEGDDYDLAGF
CVGVVEKEEIIDGTKVQDGDALIALASSGPHSNGFSLIRKVLEVSKADPAQELAGKPLIDHLLEPTKIYVKSLLKLLEQH
DVHAMSHITGGGFWENIPRVLPEDCKAVVKSDSWQWPVVFNWLMENGNISEFEMYRTFNCGVGMVVALPADKVDSALELL
TAEGENAWLIGNIAKRNGEEEQVEIL
>Mature_345_residues
STPTTPLSYKDAGVDIDAGNALVNNIKSAVKRTRRPEVMGNLGGFGALCELPTKYKHPVLVSGTDGVGTKLRLAIDYKKH
DNVGVDLVAMCSNDLIVSGAEPLFFLDYYATGKLDVEVATAVVKGIAEGCVQSGCALIGGETAEMPGMYEGDDYDLAGFC
VGVVEKEEIIDGTKVQDGDALIALASSGPHSNGFSLIRKVLEVSKADPAQELAGKPLIDHLLEPTKIYVKSLLKLLEQHD
VHAMSHITGGGFWENIPRVLPEDCKAVVKSDSWQWPVVFNWLMENGNISEFEMYRTFNCGVGMVVALPADKVDSALELLT
AEGENAWLIGNIAKRNGEEEQVEIL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=344, Percent_Identity=49.1279069767442, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI209869995, Length=344, Percent_Identity=49.1279069767442, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI209869993, Length=344, Percent_Identity=49.1279069767442, Blast_Score=329, Evalue=3e-90,
Organism=Escherichia coli, GI1788845, Length=342, Percent_Identity=73.0994152046784, Blast_Score=529, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17567511, Length=345, Percent_Identity=42.6086956521739, Blast_Score=250, Evalue=9e-67,
Organism=Saccharomyces cerevisiae, GI6321203, Length=337, Percent_Identity=47.7744807121662, Blast_Score=311, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24582400, Length=316, Percent_Identity=43.0379746835443, Blast_Score=242, Evalue=3e-64,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37255; Mature: 37124

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPTTPLSYKDAGVDIDAGNALVNNIKSAVKRTRRPEVMGNLGGFGALCELPTKYKHPV
CCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHCCCCCCCCCE
LVSGTDGVGTKLRLAIDYKKHDNVGVDLVAMCSNDLIVSGAEPLFFLDYYATGKLDVEVA
EEECCCCCCCEEEEEEEECCCCCCCEEEEEECCCCEEEECCCCEEEEEEEECCCCHHHHH
TAVVKGIAEGCVQSGCALIGGETAEMPGMYEGDDYDLAGFCVGVVEKEEIIDGTKVQDGD
HHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHEEECCCHHHHCCCCEECCCC
ALIALASSGPHSNGFSLIRKVLEVSKADPAQELAGKPLIDHLLEPTKIYVKSLLKLLEQH
EEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHC
DVHAMSHITGGGFWENIPRVLPEDCKAVVKSDSWQWPVVFNWLMENGNISEFEMYRTFNC
CHHHHHHCCCCCHHHHHHHCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEEEECC
GVGMVVALPADKVDSALELLTAEGENAWLIGNIAKRNGEEEQVEIL
CCCEEEEECCHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCEEEEC
>Mature Secondary Structure 
STPTTPLSYKDAGVDIDAGNALVNNIKSAVKRTRRPEVMGNLGGFGALCELPTKYKHPV
CCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHCCCCCCCCCE
LVSGTDGVGTKLRLAIDYKKHDNVGVDLVAMCSNDLIVSGAEPLFFLDYYATGKLDVEVA
EEECCCCCCCEEEEEEEECCCCCCCEEEEEECCCCEEEECCCCEEEEEEEECCCCHHHHH
TAVVKGIAEGCVQSGCALIGGETAEMPGMYEGDDYDLAGFCVGVVEKEEIIDGTKVQDGD
HHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHEEECCCHHHHCCCCEECCCC
ALIALASSGPHSNGFSLIRKVLEVSKADPAQELAGKPLIDHLLEPTKIYVKSLLKLLEQH
EEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHC
DVHAMSHITGGGFWENIPRVLPEDCKAVVKSDSWQWPVVFNWLMENGNISEFEMYRTFNC
CHHHHHHCCCCCHHHHHHHCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEEEECC
GVGMVVALPADKVDSALELLTAEGENAWLIGNIAKRNGEEEQVEIL
CCCEEEEECCHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA