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The map label for this gene is metC [H]

Identifier: 157962341

GI number: 157962341

Start: 3071448

End: 3072668

Strand: Direct

Name: metC [H]

Synonym: Spea_2520

Alternate gene names: 157962341

Gene position: 3071448-3072668 (Clockwise)

Preceding gene: 157962340

Following gene: 157962342

Centisome position: 59.36

GC content: 47.34

Gene sequence:

>1221_bases
ATGTTAAGATGGCTAAAAATTAAAACTGATGGAATTCGCCCTATGAAGAAAGAAACCCAAATAGTCAGTCTTGGCCGCGA
TAAGAAATGGACCCAAGGGGTGATTAACCCGCCCGTTTACCGAGCTTCCACCATGGTATTCGATACCATTGAAGATATGC
GCTTTGCCGCAAAAAACAAGGCAAATGGCGAGATGTTCTATGGCCGCCGTGGCGGACCAACACACTTTGCCTTTCAAGCA
GCCATCGCCGAATTAGAAGGCGGTGTGGGTACGGCACTATATCCATCGGGTAGCGCCGCTATCAGCAACAGTTTGCTCTC
TTTCTTAAAATCAGGTGACCACCTATTAATGGTCGACAGTGCCTACGAACCAACTCGTGACTTATGCGATAAGTTACTGG
CTGGCTACGGTATTGAGACGACCTATTACGACCCAATGATAGGTGATGACATCGAGGCGTTAATCCAACCTAACACTAAG
GTGTTATTTTTGGAGTCTCCAGGCTCTATCACCATGGAAGTACAAGATGTACCTACCCTGAGTCGTATCGCCCACCAGCA
CGATATCGTGGTCATGCTCGACAATACTTGGGCGTCACCGATTAACTCTCGCCCATTTGAAATGGGCGTAGATATCTCTA
TCCAAGCGGCGACAAAGTATATTGTCGGCCACTCAGATGTGATGATGGGCACCGCCACCGCCAATGAAAAGCATTGGGAA
CAACTTAGAGAACATAGCTACCTGCTTGGCCAGTGCACCTCTCCCGATGATGTTTATCTTGCCAGTCGCGGCCTGAGAAC
CTTAGGTATTCGCTTAGCTCAGCATGAACAGAACGCACTTAAAATAGCCAATTGGCTAAATAGCCGCCCAGAAGTCGATC
ATCTGCGTCACCCCGCTTTTGAGTCTTGCCCCGGCCATGAATTCTTTAAACGCGACTTTAGTGCTTCAAACGGTTTGTTC
TCATTTGTGTTAAAGCAAGGCGATGTTAGATCGGTTACCGCGTTCGTTGAAAATATGAAGCACTTTAAAATGGGCTTCTC
ATGGGGTGGATATGAGAGCCTTATCTTAGGCGTTTTTGGCATCGACAAGCTGCGCACTGCAACTCAGTGGGACAGCAGTA
AGCCTCTCATACGATTGCATATTGGTCTTGAAAATGTGGATGACTTAATCGCCGATCTCGATGCAGCGTTTGAGCGTTAT
AATCAAGTCTTGAACCGTTAA

Upstream 100 bases:

>100_bases
CGATTACAAACAATTGAGATAGCAAATTCAGACAGTCAACTGAATTGATCTTGAAAAGATAAACACTTGTTGTGATAGAC
ACTTCATTTTAGCCGTTTAG

Downstream 100 bases:

>100_bases
GAACTATGCATTGTTAATGCTATAACAACCTGTAATGTTAAGCATGTTAATCCCAAAAGCCGGCTTCGTTGTCGGCTTGT
TTTATTGATGCCGATAAGAA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MLRWLKIKTDGIRPMKKETQIVSLGRDKKWTQGVINPPVYRASTMVFDTIEDMRFAAKNKANGEMFYGRRGGPTHFAFQA
AIAELEGGVGTALYPSGSAAISNSLLSFLKSGDHLLMVDSAYEPTRDLCDKLLAGYGIETTYYDPMIGDDIEALIQPNTK
VLFLESPGSITMEVQDVPTLSRIAHQHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMMGTATANEKHWE
QLREHSYLLGQCTSPDDVYLASRGLRTLGIRLAQHEQNALKIANWLNSRPEVDHLRHPAFESCPGHEFFKRDFSASNGLF
SFVLKQGDVRSVTAFVENMKHFKMGFSWGGYESLILGVFGIDKLRTATQWDSSKPLIRLHIGLENVDDLIADLDAAFERY
NQVLNR

Sequences:

>Translated_406_residues
MLRWLKIKTDGIRPMKKETQIVSLGRDKKWTQGVINPPVYRASTMVFDTIEDMRFAAKNKANGEMFYGRRGGPTHFAFQA
AIAELEGGVGTALYPSGSAAISNSLLSFLKSGDHLLMVDSAYEPTRDLCDKLLAGYGIETTYYDPMIGDDIEALIQPNTK
VLFLESPGSITMEVQDVPTLSRIAHQHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMMGTATANEKHWE
QLREHSYLLGQCTSPDDVYLASRGLRTLGIRLAQHEQNALKIANWLNSRPEVDHLRHPAFESCPGHEFFKRDFSASNGLF
SFVLKQGDVRSVTAFVENMKHFKMGFSWGGYESLILGVFGIDKLRTATQWDSSKPLIRLHIGLENVDDLIADLDAAFERY
NQVLNR
>Mature_406_residues
MLRWLKIKTDGIRPMKKETQIVSLGRDKKWTQGVINPPVYRASTMVFDTIEDMRFAAKNKANGEMFYGRRGGPTHFAFQA
AIAELEGGVGTALYPSGSAAISNSLLSFLKSGDHLLMVDSAYEPTRDLCDKLLAGYGIETTYYDPMIGDDIEALIQPNTK
VLFLESPGSITMEVQDVPTLSRIAHQHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMMGTATANEKHWE
QLREHSYLLGQCTSPDDVYLASRGLRTLGIRLAQHEQNALKIANWLNSRPEVDHLRHPAFESCPGHEFFKRDFSASNGLF
SFVLKQGDVRSVTAFVENMKHFKMGFSWGGYESLILGVFGIDKLRTATQWDSSKPLIRLHIGLENVDDLIADLDAAFERY
NQVLNR

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=339, Percent_Identity=34.2182890855457, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI299473759, Length=339, Percent_Identity=31.5634218289086, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI25453487, Length=338, Percent_Identity=29.8816568047337, Blast_Score=152, Evalue=4e-37,
Organism=Escherichia coli, GI1789383, Length=389, Percent_Identity=53.2133676092545, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1790375, Length=392, Percent_Identity=30.8673469387755, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71980708, Length=371, Percent_Identity=34.5013477088949, Blast_Score=220, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI17538055, Length=341, Percent_Identity=33.1378299120235, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17560056, Length=376, Percent_Identity=31.6489361702128, Blast_Score=181, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6321170, Length=333, Percent_Identity=48.948948948949, Blast_Score=330, Evalue=4e-91,
Organism=Saccharomyces cerevisiae, GI6319307, Length=362, Percent_Identity=31.2154696132597, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6321904, Length=386, Percent_Identity=26.1658031088083, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323333, Length=420, Percent_Identity=25.952380952381, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321254, Length=423, Percent_Identity=26.9503546099291, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19922554, Length=402, Percent_Identity=33.3333333333333, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45467; Mature: 45467

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRWLKIKTDGIRPMKKETQIVSLGRDKKWTQGVINPPVYRASTMVFDTIEDMRFAAKNK
CCEEEEEECCCCCCCHHCCCEEECCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
ANGEMFYGRRGGPTHFAFQAAIAELEGGVGTALYPSGSAAISNSLLSFLKSGDHLLMVDS
CCCCEEECCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCEEEEEEC
AYEPTRDLCDKLLAGYGIETTYYDPMIGDDIEALIQPNTKVLFLESPGSITMEVQDVPTL
CCCCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHCCCCCEEEEEECCCCEEEEEECCCHH
SRIAHQHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMMGTATANEKHWE
HHHHCCCCEEEEECCCCCCCCCCCCCEECCCEEEEEHHEEEECCCCEEEEECCCCHHHHH
QLREHSYLLGQCTSPDDVYLASRGLRTLGIRLAQHEQNALKIANWLNSRPEVDHLRHPAF
HHHHCCEEEECCCCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCC
ESCPGHEFFKRDFSASNGLFSFVLKQGDVRSVTAFVENMKHFKMGFSWGGYESLILGVFG
CCCCCHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHC
IDKLRTATQWDSSKPLIRLHIGLENVDDLIADLDAAFERYNQVLNR
HHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLRWLKIKTDGIRPMKKETQIVSLGRDKKWTQGVINPPVYRASTMVFDTIEDMRFAAKNK
CCEEEEEECCCCCCCHHCCCEEECCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
ANGEMFYGRRGGPTHFAFQAAIAELEGGVGTALYPSGSAAISNSLLSFLKSGDHLLMVDS
CCCCEEECCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCEEEEEEC
AYEPTRDLCDKLLAGYGIETTYYDPMIGDDIEALIQPNTKVLFLESPGSITMEVQDVPTL
CCCCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHCCCCCEEEEEECCCCEEEEEECCCHH
SRIAHQHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMMGTATANEKHWE
HHHHCCCCEEEEECCCCCCCCCCCCCEECCCEEEEEHHEEEECCCCEEEEECCCCHHHHH
QLREHSYLLGQCTSPDDVYLASRGLRTLGIRLAQHEQNALKIANWLNSRPEVDHLRHPAF
HHHHCCEEEECCCCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCC
ESCPGHEFFKRDFSASNGLFSFVLKQGDVRSVTAFVENMKHFKMGFSWGGYESLILGVFG
CCCCCHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHC
IDKLRTATQWDSSKPLIRLHIGLENVDDLIADLDAAFERYNQVLNR
HHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3513164; 9278503; 3307782; 8831789 [H]