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The map label for this gene is msrA [H]

Identifier: 157962327

GI number: 157962327

Start: 3054666

End: 3055568

Strand: Reverse

Name: msrA [H]

Synonym: Spea_2506

Alternate gene names: 157962327

Gene position: 3055568-3054666 (Counterclockwise)

Preceding gene: 157962330

Following gene: 157962324

Centisome position: 59.05

GC content: 43.96

Gene sequence:

>903_bases
ATGCGAGAACTAACCGAATATGAGAAGCATGTGATTGAAGATAAAGGCACTGAAAGGCCTTTTAGTGGCGAATATAATCA
ACACGATGCTCAAGGTGTATATTGTTGCAAGAAGTGTGATGCCCCCTTATATCGCTCGGAGAGTAAGTTTAATGCCCACT
GTGGTTGGCCGGCATTTGATGATGAGATTGCAGGCGCTGTGAAACGAAATATTGATGCTGATGGCATGCGAGTTGAAATT
GTCTGCGCTAAGTGCGACGGTCATTTAGGCCATGTTTTTGAGGGCGAGCTCTTAACGCCCAAAAACCTTAGACACTGTGT
TAATTCAGTATCTATGACCTTTAGGCCTATAGAGCAAGAGACAAATGAGACTAAGCTCGAGTTGGCAACCTTTGGTGGCG
GCTGTTTTTGGTGTATCGAAGCCATTTTTTCAGCGATTAAAGGCGTAACAAAAGTGACTTCCGGTTATGCTGGTGGAGAT
AGCCATGATGCGAATTACAAAGCTGTATGCAGTGGCAATACCAACCATGCTGAAGTGGTGCAGATTGAATTTAATCCAAG
AGAAGTCAGCTTTGAAAGCTTGCTGGAGGTCTTTTGGCAAAGCCACAATCCAACCACACTAAACCGCCAAGGCAATGATG
TGGGCCCGCAGTATCGCTCGGTGATCTTTATTCATAATGAGCAACAAGCCTTGATCGCGAATAATATGATAGATGACTTA
ACAAGAATAGCGGCATGGCCGGACCCGATAGTGACTCAAGTGATTGCTTATGATGGCTTCTTTGCTGCTGAAGATTATCA
TAATGATTACTATGAGCTAAACGGTGAGCAACCCTATTGTCAGATGGTAGTGAAACCTAAGGTCGACAAAGTTAAGGCGC
TGTTTGCGGATAAATTGAAATGA

Upstream 100 bases:

>100_bases
GTGCAGTGCTAGTCGTGAACGGCTTGCTAAGCAGCGGGTGATCAGCTTCAGAATTGATTAATTTTAAGAAGACAGTTGTA
ACGAGTTCAGAGAGGGTGAT

Downstream 100 bases:

>100_bases
GCGACTGACTCGAGTTTACACATAATAAAAAAGACAGGCATAGCCTGTCTTTTTTATTGTTAAGCTTAATGCTATTTACG
AGTCTAGCTTATCGTCAGCA

Product: bifunctional methionine sulfoxide reductase B/A protein

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MRELTEYEKHVIEDKGTERPFSGEYNQHDAQGVYCCKKCDAPLYRSESKFNAHCGWPAFDDEIAGAVKRNIDADGMRVEI
VCAKCDGHLGHVFEGELLTPKNLRHCVNSVSMTFRPIEQETNETKLELATFGGGCFWCIEAIFSAIKGVTKVTSGYAGGD
SHDANYKAVCSGNTNHAEVVQIEFNPREVSFESLLEVFWQSHNPTTLNRQGNDVGPQYRSVIFIHNEQQALIANNMIDDL
TRIAAWPDPIVTQVIAYDGFFAAEDYHNDYYELNGEQPYCQMVVKPKVDKVKALFADKLK

Sequences:

>Translated_300_residues
MRELTEYEKHVIEDKGTERPFSGEYNQHDAQGVYCCKKCDAPLYRSESKFNAHCGWPAFDDEIAGAVKRNIDADGMRVEI
VCAKCDGHLGHVFEGELLTPKNLRHCVNSVSMTFRPIEQETNETKLELATFGGGCFWCIEAIFSAIKGVTKVTSGYAGGD
SHDANYKAVCSGNTNHAEVVQIEFNPREVSFESLLEVFWQSHNPTTLNRQGNDVGPQYRSVIFIHNEQQALIANNMIDDL
TRIAAWPDPIVTQVIAYDGFFAAEDYHNDYYELNGEQPYCQMVVKPKVDKVKALFADKLK
>Mature_300_residues
MRELTEYEKHVIEDKGTERPFSGEYNQHDAQGVYCCKKCDAPLYRSESKFNAHCGWPAFDDEIAGAVKRNIDADGMRVEI
VCAKCDGHLGHVFEGELLTPKNLRHCVNSVSMTFRPIEQETNETKLELATFGGGCFWCIEAIFSAIKGVTKVTSGYAGGD
SHDANYKAVCSGNTNHAEVVQIEFNPREVSFESLLEVFWQSHNPTTLNRQGNDVGPQYRSVIFIHNEQQALIANNMIDDL
TRIAAWPDPIVTQVIAYDGFFAAEDYHNDYYELNGEQPYCQMVVKPKVDKVKALFADKLK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=178, Percent_Identity=39.8876404494382, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI208609995, Length=173, Percent_Identity=39.8843930635838, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI301336164, Length=120, Percent_Identity=40.8333333333333, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI301336162, Length=120, Percent_Identity=40.8333333333333, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI73089054, Length=120, Percent_Identity=40.8333333333333, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI37620216, Length=120, Percent_Identity=40.8333333333333, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI117606353, Length=125, Percent_Identity=39.2, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI208609993, Length=103, Percent_Identity=40.7766990291262, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1790665, Length=178, Percent_Identity=38.7640449438202, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788077, Length=116, Percent_Identity=42.2413793103448, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17553450, Length=108, Percent_Identity=41.6666666666667, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115532676, Length=108, Percent_Identity=41.6666666666667, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17533973, Length=150, Percent_Identity=32, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319816, Length=120, Percent_Identity=51.6666666666667, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320881, Length=169, Percent_Identity=31.9526627218935, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24645799, Length=117, Percent_Identity=43.5897435897436, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45553335, Length=117, Percent_Identity=43.5897435897436, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21356369, Length=117, Percent_Identity=43.5897435897436, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221378664, Length=117, Percent_Identity=44.4444444444444, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24664627, Length=146, Percent_Identity=36.3013698630137, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24645801, Length=128, Percent_Identity=39.84375, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24645804, Length=128, Percent_Identity=39.84375, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI221378662, Length=124, Percent_Identity=41.9354838709677, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24664631, Length=146, Percent_Identity=36.3013698630137, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=34.7517730496454, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 33777; Mature: 33777

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRELTEYEKHVIEDKGTERPFSGEYNQHDAQGVYCCKKCDAPLYRSESKFNAHCGWPAFD
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCCCCCCCC
DEIAGAVKRNIDADGMRVEIVCAKCDGHLGHVFEGELLTPKNLRHCVNSVSMTFRPIEQE
HHHHHHHHHCCCCCCEEEEEEEEECCCCCCCEECCCCCCHHHHHHHHHHHHHEEECCCCC
TNETKLELATFGGGCFWCIEAIFSAIKGVTKVTSGYAGGDSHDANYKAVCSGNTNHAEVV
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEEE
QIEFNPREVSFESLLEVFWQSHNPTTLNRQGNDVGPQYRSVIFIHNEQQALIANNMIDDL
EEEECCCCCCHHHHHHHHHCCCCCEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHH
TRIAAWPDPIVTQVIAYDGFFAAEDYHNDYYELNGEQPYCQMVVKPKVDKVKALFADKLK
HHHHCCCCHHHHHHHHHCCEEEECCCCCCEEEECCCCCEEEEEECCCHHHHHHHHHHCCC
>Mature Secondary Structure
MRELTEYEKHVIEDKGTERPFSGEYNQHDAQGVYCCKKCDAPLYRSESKFNAHCGWPAFD
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCCCCCCCC
DEIAGAVKRNIDADGMRVEIVCAKCDGHLGHVFEGELLTPKNLRHCVNSVSMTFRPIEQE
HHHHHHHHHCCCCCCEEEEEEEEECCCCCCCEECCCCCCHHHHHHHHHHHHHEEECCCCC
TNETKLELATFGGGCFWCIEAIFSAIKGVTKVTSGYAGGDSHDANYKAVCSGNTNHAEVV
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEEE
QIEFNPREVSFESLLEVFWQSHNPTTLNRQGNDVGPQYRSVIFIHNEQQALIANNMIDDL
EEEECCCCCCHHHHHHHHHCCCCCEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHH
TRIAAWPDPIVTQVIAYDGFFAAEDYHNDYYELNGEQPYCQMVVKPKVDKVKALFADKLK
HHHHCCCCHHHHHHHHHCCEEEECCCCCCEEEECCCCCEEEEEECCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA