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The map label for this gene is rrmA [H]

Identifier: 157962307

GI number: 157962307

Start: 3031906

End: 3032712

Strand: Reverse

Name: rrmA [H]

Synonym: Spea_2486

Alternate gene names: 157962307

Gene position: 3032712-3031906 (Counterclockwise)

Preceding gene: 157962310

Following gene: 157962306

Centisome position: 58.61

GC content: 41.26

Gene sequence:

>807_bases
ATGATTTACCGCTGCCCATTATGTGAACAGGCTTTATCAAAACAAGATAAGACCTGGTGCTGCCCAGCAAACCATAGATT
TGATTGTGCAAAAGAAGGGTATGTGAATCTACTACCTGTACAGAAGAAGAAATCGAGCGATCCCGGTGACAATAAAGAGA
TGATGTTCGCTAGGCGCGAGTTTCTCAATAAAGGTTATTACCAGGTCCTTAGTGACAAGGTCAATCTTTTAGCTAACGAG
TATTTAGATGGTGCGCGCTCTGGCTTAGATATTGGCTGCGGGGAAGGCTATTATTCAAATCGCTTGGTTGAGAGCTTATC
ACCAGATTTTGTTCTTTATGGTGTCGATATCAGTAAATCAGCTCTTAAGTATGCAGCAAAGCGTTATCCAAAGATCGCTT
TTAGTGTCGCCAGTGCCTTTGATATGCCATTCCCTGATAATAGTTTCGACTTTATGTTGCGTATTTATGCGCCGTCTCTA
GATGTAGAGCTTAAACGGGTGATTAAACCGGGCGGGATGTTAATTACGGTTTGCGCTGGGCCTAGGCATCATTTTGCTCT
TAAAGAGTTAATTTATGACAACCCAAAAGAGCACACTCAAGAAGCTTCACACATAGAGGGCTTTGAGCTAGTTCATCAGG
AGCGGATTGAGCAGTTGTTAACACTTAGCGATTCTGACGACATCGGCCATTTCTTAAAAATGACACCTTATAACTGGAAA
TTAACAGAAGAACAAAAATTAGCATTGGCTAATTCTGGCTTGAGTTGTGAGTTAGATTTTAAAGTGGAAGTCTTTAGAGC
CTTATAA

Upstream 100 bases:

>100_bases
AGTTTAAGGCTGAATTTAAAGTGTTACATTTTTCATGCGAGGTAGAAGTATGAGCCTAAGCTTTACTTCTAAAAGCATGG
TCTTTTTTGGAGATTGAAAA

Downstream 100 bases:

>100_bases
ATCAAAGGTTGCAGCTTGGTGGTTGTTTTTTAAGCGGTTGTTGTGGTTTAAGTTTGAACGGATAGAAATTATTTTTTGAT
CTTTTTAGCAAGCTGCAGAA

Product: 23S rRNA methyltransferase A

Products: NA

Alternate protein names: 23S rRNA m1G745 methyltransferase; rRNA (guanine-N(1)-)-methyltransferase [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MIYRCPLCEQALSKQDKTWCCPANHRFDCAKEGYVNLLPVQKKKSSDPGDNKEMMFARREFLNKGYYQVLSDKVNLLANE
YLDGARSGLDIGCGEGYYSNRLVESLSPDFVLYGVDISKSALKYAAKRYPKIAFSVASAFDMPFPDNSFDFMLRIYAPSL
DVELKRVIKPGGMLITVCAGPRHHFALKELIYDNPKEHTQEASHIEGFELVHQERIEQLLTLSDSDDIGHFLKMTPYNWK
LTEEQKLALANSGLSCELDFKVEVFRAL

Sequences:

>Translated_268_residues
MIYRCPLCEQALSKQDKTWCCPANHRFDCAKEGYVNLLPVQKKKSSDPGDNKEMMFARREFLNKGYYQVLSDKVNLLANE
YLDGARSGLDIGCGEGYYSNRLVESLSPDFVLYGVDISKSALKYAAKRYPKIAFSVASAFDMPFPDNSFDFMLRIYAPSL
DVELKRVIKPGGMLITVCAGPRHHFALKELIYDNPKEHTQEASHIEGFELVHQERIEQLLTLSDSDDIGHFLKMTPYNWK
LTEEQKLALANSGLSCELDFKVEVFRAL
>Mature_268_residues
MIYRCPLCEQALSKQDKTWCCPANHRFDCAKEGYVNLLPVQKKKSSDPGDNKEMMFARREFLNKGYYQVLSDKVNLLANE
YLDGARSGLDIGCGEGYYSNRLVESLSPDFVLYGVDISKSALKYAAKRYPKIAFSVASAFDMPFPDNSFDFMLRIYAPSL
DVELKRVIKPGGMLITVCAGPRHHFALKELIYDNPKEHTQEASHIEGFELVHQERIEQLLTLSDSDDIGHFLKMTPYNWK
LTEEQKLALANSGLSCELDFKVEVFRAL

Specific function: Specifically methylates the guanosine in position 745 of 23S rRNA [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RlmA family [H]

Homologues:

Organism=Escherichia coli, GI1788125, Length=269, Percent_Identity=46.4684014869888, Blast_Score=245, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216
- InterPro:   IPR016718 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: =2.1.1.187 [H]

Molecular weight: Translated: 30517; Mature: 30517

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYRCPLCEQALSKQDKTWCCPANHRFDCAKEGYVNLLPVQKKKSSDPGDNKEMMFARRE
CCEECCCHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
FLNKGYYQVLSDKVNLLANEYLDGARSGLDIGCGEGYYSNRLVESLSPDFVLYGVDISKS
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCHH
ALKYAAKRYPKIAFSVASAFDMPFPDNSFDFMLRIYAPSLDVELKRVIKPGGMLITVCAG
HHHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHCCCCCEEEEEECC
PRHHFALKELIYDNPKEHTQEASHIEGFELVHQERIEQLLTLSDSDDIGHFLKMTPYNWK
CCHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCHHEEECCCCEE
LTEEQKLALANSGLSCELDFKVEVFRAL
ECHHHHHHHHCCCCEEEEECCHHHHHCC
>Mature Secondary Structure
MIYRCPLCEQALSKQDKTWCCPANHRFDCAKEGYVNLLPVQKKKSSDPGDNKEMMFARRE
CCEECCCHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
FLNKGYYQVLSDKVNLLANEYLDGARSGLDIGCGEGYYSNRLVESLSPDFVLYGVDISKS
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCHH
ALKYAAKRYPKIAFSVASAFDMPFPDNSFDFMLRIYAPSLDVELKRVIKPGGMLITVCAG
HHHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHCCCCCEEEEEECC
PRHHFALKELIYDNPKEHTQEASHIEGFELVHQERIEQLLTLSDSDDIGHFLKMTPYNWK
CCHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCHHEEECCCCEE
LTEEQKLALANSGLSCELDFKVEVFRAL
ECHHHHHHHHCCCCEEEEECCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7984109; 9097040; 9278503; 9440525 [H]