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The map label for this gene is pdxH

Identifier: 157962298

GI number: 157962298

Start: 3022089

End: 3022727

Strand: Reverse

Name: pdxH

Synonym: Spea_2477

Alternate gene names: 157962298

Gene position: 3022727-3022089 (Counterclockwise)

Preceding gene: 157962299

Following gene: 157962297

Centisome position: 58.41

GC content: 43.97

Gene sequence:

>639_bases
ATGTCAGAGATCAGTGGTATCAGACGCGAATACACATTAGGTGAATTACATAATGAAGAGGTGCCTAGTGATCCTATGGA
CCTATTTAACGCGTGGTTGGAAGTCATTCGTGACTCTGACATCAAAGATCCAACGGCTATGTCGGTAGCGACAGTCGATG
AGAATGGCCAACCTTTCCAAAGAATTGTATTGCTCAAGCGATTTGATAACCATGGTTTTGTATTTTTTACTAATCTTGAG
AGCCGTAAGGCTCAGCACATCGCTAATAATGCGCAGGTTAGCATTCTATTCCCTTGGCACAGTTTAGATAAGCAAGTAGC
CGTTACCGGTATTGCTGAACCCTTATCTAAAACAGAGGTGCTTAAGTACTTTATGAGCCGGCCTAAGGAGAGCCAAATAG
CCTCTTGGGTGTCTAAACAGTCGAGCCCTATTAGCGCAAGAAAAGCACTCGAGAGTAAGTTTGCCGAAATGAAAGCCAAG
TTCTCTCAAGGTGATGTACCGCTGCCAAAATTTTGGGGCGGTTATCTTGTTAGGCCAAAAAGTATTGAGTTTTGGCAAGG
TGGGGAACATCGTTTACACGACCGATTCATCTATACCAAGAAAGAAGAGAGCTGGGAGCACACTCGTTTAGCTCCATAA

Upstream 100 bases:

>100_bases
GAGTGTATTAAAAGGCTCCCGTCTAACGGCTAAGATTGTTATGATTAAAGAAGCGCTCAATGAGCGCTTCTTTTTTTATG
TGCTTTGAAAGGATTTTAAC

Downstream 100 bases:

>100_bases
CTACCGTTATTTAAAAAGCCGCATTGTTTGCGGCTTTTGTGTTTTTGGCGATCCCTTCTAATATAAATGAATGTATTGTG
AGTTATTGGTCTAACAATTA

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSEISGIRREYTLGELHNEEVPSDPMDLFNAWLEVIRDSDIKDPTAMSVATVDENGQPFQRIVLLKRFDNHGFVFFTNLE
SRKAQHIANNAQVSILFPWHSLDKQVAVTGIAEPLSKTEVLKYFMSRPKESQIASWVSKQSSPISARKALESKFAEMKAK
FSQGDVPLPKFWGGYLVRPKSIEFWQGGEHRLHDRFIYTKKEESWEHTRLAP

Sequences:

>Translated_212_residues
MSEISGIRREYTLGELHNEEVPSDPMDLFNAWLEVIRDSDIKDPTAMSVATVDENGQPFQRIVLLKRFDNHGFVFFTNLE
SRKAQHIANNAQVSILFPWHSLDKQVAVTGIAEPLSKTEVLKYFMSRPKESQIASWVSKQSSPISARKALESKFAEMKAK
FSQGDVPLPKFWGGYLVRPKSIEFWQGGEHRLHDRFIYTKKEESWEHTRLAP
>Mature_211_residues
SEISGIRREYTLGELHNEEVPSDPMDLFNAWLEVIRDSDIKDPTAMSVATVDENGQPFQRIVLLKRFDNHGFVFFTNLES
RKAQHIANNAQVSILFPWHSLDKQVAVTGIAEPLSKTEVLKYFMSRPKESQIASWVSKQSSPISARKALESKFAEMKAKF
SQGDVPLPKFWGGYLVRPKSIEFWQGGEHRLHDRFIYTKKEESWEHTRLAP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=205, Percent_Identity=41.4634146341463, Blast_Score=159, Evalue=2e-39,
Organism=Escherichia coli, GI1787926, Length=212, Percent_Identity=60.8490566037736, Blast_Score=278, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17553712, Length=220, Percent_Identity=34.5454545454545, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319509, Length=209, Percent_Identity=37.799043062201, Blast_Score=145, Evalue=5e-36,
Organism=Drosophila melanogaster, GI45551845, Length=206, Percent_Identity=42.2330097087379, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24644901, Length=206, Percent_Identity=42.2330097087379, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24644903, Length=176, Percent_Identity=29.5454545454545, Blast_Score=84, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_SHEPA (A8H5G0)

Other databases:

- EMBL:   CP000851
- RefSeq:   YP_001502332.1
- ProteinModelPortal:   A8H5G0
- SMR:   A8H5G0
- STRING:   A8H5G0
- GeneID:   5662870
- GenomeReviews:   CP000851_GR
- KEGG:   spl:Spea_2477
- NMPDR:   fig|398579.3.peg.2135
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- ProtClustDB:   CLSK982155
- BioCyc:   SPEA398579:SPEA_2477-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24408; Mature: 24277

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 61-61 BINDING 64-64 BINDING 66-66 BINDING 83-83 BINDING 123-123 BINDING 127-127 BINDING 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEISGIRREYTLGELHNEEVPSDPMDLFNAWLEVIRDSDIKDPTAMSVATVDENGQPFQ
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHH
RIVLLKRFDNHGFVFFTNLESRKAQHIANNAQVSILFPWHSLDKQVAVTGIAEPLSKTEV
HHHHHHHCCCCCEEEEECCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
LKYFMSRPKESQIASWVSKQSSPISARKALESKFAEMKAKFSQGDVPLPKFWGGYLVRPK
HHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEECCC
SIEFWQGGEHRLHDRFIYTKKEESWEHTRLAP
CCCCCCCCCCCHHHHEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SEISGIRREYTLGELHNEEVPSDPMDLFNAWLEVIRDSDIKDPTAMSVATVDENGQPFQ
CCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHH
RIVLLKRFDNHGFVFFTNLESRKAQHIANNAQVSILFPWHSLDKQVAVTGIAEPLSKTEV
HHHHHHHCCCCCEEEEECCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
LKYFMSRPKESQIASWVSKQSSPISARKALESKFAEMKAKFSQGDVPLPKFWGGYLVRPK
HHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEECCC
SIEFWQGGEHRLHDRFIYTKKEESWEHTRLAP
CCCCCCCCCCCHHHHEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA