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The map label for this gene is cysM [C]

Identifier: 157962168

GI number: 157962168

Start: 2859892

End: 2860968

Strand: Direct

Name: cysM [C]

Synonym: Spea_2347

Alternate gene names: 157962168

Gene position: 2859892-2860968 (Clockwise)

Preceding gene: 157962164

Following gene: 157962170

Centisome position: 55.27

GC content: 44.66

Gene sequence:

>1077_bases
GTGACTAATACTTGGGTAAATCAAGCAATCGAAAAAATTGAAGCTGACTTTCAACGAAGTGCAGACACGCATCTGATCAA
GCTAGATACGCCTGGCTTAAATGGTATTGATATTTACCTAAAAGATGAAAGTACTCACCCAACAGGAAGTTTAAAACACC
GTCTCGCTCGCTCACTCTTTCTTTATGCTCTGTGTAACGGCTGGATAAAGGAAGGCACTACAGTTATAGAATCATCTTCT
GGCAGTACTGCCGTATCAGAAGCCTATTTCGCACGACTACTGGGTTTGCCATTTATTGCCGTCATGCCAAGTACCACAGC
TAAGAAGAAAATCCAGCAAATTGAGTTTTATGGCGGTCAATGCCACTTTGTCGATCACTCGAGTAAGATCTATGCCGAGT
CTGAACGTCTCGCTCAGCAACTCGACGGCCATTACATGGATCAGTTCACCTATGCCGAGCGCGCAACGGATTGGCGAGGA
AACAACAATATTGCTAACTCTATCTTTAACCAGATGGAAAAAGAGCAATATTCGATTCCCACATGGATTGTAATGAGTCC
AGGAACGGGCGGAACCTCGGCAACAATCGGTCGCTATATCCGCTATCAAAGATTAACGACCAAACTGTGTGTGGTCGACC
CTGAAAACTCCGTTTTCTTTGATTACTTCAACACCGGTGATAAAAACGTTAGTTGTGCGAATGGTAGTAAGATCGAAGGC
ATTGGCAGACCCCGCGCCGAACCGTCATTTATTCCAGGAGTAGTTGATGAGATGCGTAAGATCCCAGATCCGGCATCGGT
CGCTACTATCAATTGGCTAGAGAACATTATTGGCCGTAAGACAGGCGCATCTACTGGCACCAACCTTTACGGTGCCCTAC
AGCTCGCAAGTGAAATGGCTGCTAAAGGTGAGACAGGCTCTATCGTCACTCTTATTTGTGACTCGGGTGAACGCTATTTA
GACACTTATTACAACAATGAGTGGATCAAAGAGAATATCGGCGATCTTAGCGACTATGAAGATGCTTTAGCACATTTTAG
CGCGACTTGTGTATTAAATTGCCCAAGTTTGAAATAA

Upstream 100 bases:

>100_bases
TACATTTCTTTGACAAGTAGTATCAAATCCTTTTATTAGTACCATTCATCTCATATTTTCACTATGATTTAAAATCAATG
TTTTAATCAGAGGCGATAAA

Downstream 100 bases:

>100_bases
GCCTGTCAGATAAAAAAGCCCTTGAGTTCGTAAGAATCAAGGGCTTGTTATTTAAACTATTGCAGCCAATTCGGGCGAAT
TAATTGCTGTCTAAGTCATA

Product: pyridoxal-5'-phosphate-dependent protein subunit beta

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MTNTWVNQAIEKIEADFQRSADTHLIKLDTPGLNGIDIYLKDESTHPTGSLKHRLARSLFLYALCNGWIKEGTTVIESSS
GSTAVSEAYFARLLGLPFIAVMPSTTAKKKIQQIEFYGGQCHFVDHSSKIYAESERLAQQLDGHYMDQFTYAERATDWRG
NNNIANSIFNQMEKEQYSIPTWIVMSPGTGGTSATIGRYIRYQRLTTKLCVVDPENSVFFDYFNTGDKNVSCANGSKIEG
IGRPRAEPSFIPGVVDEMRKIPDPASVATINWLENIIGRKTGASTGTNLYGALQLASEMAAKGETGSIVTLICDSGERYL
DTYYNNEWIKENIGDLSDYEDALAHFSATCVLNCPSLK

Sequences:

>Translated_358_residues
MTNTWVNQAIEKIEADFQRSADTHLIKLDTPGLNGIDIYLKDESTHPTGSLKHRLARSLFLYALCNGWIKEGTTVIESSS
GSTAVSEAYFARLLGLPFIAVMPSTTAKKKIQQIEFYGGQCHFVDHSSKIYAESERLAQQLDGHYMDQFTYAERATDWRG
NNNIANSIFNQMEKEQYSIPTWIVMSPGTGGTSATIGRYIRYQRLTTKLCVVDPENSVFFDYFNTGDKNVSCANGSKIEG
IGRPRAEPSFIPGVVDEMRKIPDPASVATINWLENIIGRKTGASTGTNLYGALQLASEMAAKGETGSIVTLICDSGERYL
DTYYNNEWIKENIGDLSDYEDALAHFSATCVLNCPSLK
>Mature_357_residues
TNTWVNQAIEKIEADFQRSADTHLIKLDTPGLNGIDIYLKDESTHPTGSLKHRLARSLFLYALCNGWIKEGTTVIESSSG
STAVSEAYFARLLGLPFIAVMPSTTAKKKIQQIEFYGGQCHFVDHSSKIYAESERLAQQLDGHYMDQFTYAERATDWRGN
NNIANSIFNQMEKEQYSIPTWIVMSPGTGGTSATIGRYIRYQRLTTKLCVVDPENSVFFDYFNTGDKNVSCANGSKIEGI
GRPRAEPSFIPGVVDEMRKIPDPASVATINWLENIIGRKTGASTGTNLYGALQLASEMAAKGETGSIVTLICDSGERYLD
TYYNNEWIKENIGDLSDYEDALAHFSATCVLNCPSLK

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=328, Percent_Identity=23.780487804878, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI295821200, Length=328, Percent_Identity=23.780487804878, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4557415, Length=328, Percent_Identity=23.780487804878, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI2367138, Length=314, Percent_Identity=28.0254777070064, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71996324, Length=352, Percent_Identity=34.375, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17539800, Length=356, Percent_Identity=33.4269662921348, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17539640, Length=358, Percent_Identity=30.4469273743017, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17562970, Length=313, Percent_Identity=28.1150159744409, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32566674, Length=302, Percent_Identity=28.8079470198675, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI115535073, Length=337, Percent_Identity=27.5964391691395, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=24.5454545454545, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24643623, Length=319, Percent_Identity=27.5862068965517, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20129101, Length=319, Percent_Identity=27.5862068965517, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 39690; Mature: 39559

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTWVNQAIEKIEADFQRSADTHLIKLDTPGLNGIDIYLKDESTHPTGSLKHRLARSLF
CCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
LYALCNGWIKEGTTVIESSSGSTAVSEAYFARLLGLPFIAVMPSTTAKKKIQQIEFYGGQ
HHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHEECCE
CHFVDHSSKIYAESERLAQQLDGHYMDQFTYAERATDWRGNNNIANSIFNQMEKEQYSIP
EEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCC
TWIVMSPGTGGTSATIGRYIRYQRLTTKLCVVDPENSVFFDYFNTGDKNVSCANGSKIEG
EEEEECCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCEEEECCCCEECC
IGRPRAEPSFIPGVVDEMRKIPDPASVATINWLENIIGRKTGASTGTNLYGALQLASEMA
CCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AKGETGSIVTLICDSGERYLDTYYNNEWIKENIGDLSDYEDALAHFSATCVLNCPSLK
CCCCCCCEEEEEECCCCHHHHHHCCCCHHHHHCCCHHHHHHHHHHCCCEEEEECCCCC
>Mature Secondary Structure 
TNTWVNQAIEKIEADFQRSADTHLIKLDTPGLNGIDIYLKDESTHPTGSLKHRLARSLF
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
LYALCNGWIKEGTTVIESSSGSTAVSEAYFARLLGLPFIAVMPSTTAKKKIQQIEFYGGQ
HHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHEECCE
CHFVDHSSKIYAESERLAQQLDGHYMDQFTYAERATDWRGNNNIANSIFNQMEKEQYSIP
EEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCC
TWIVMSPGTGGTSATIGRYIRYQRLTTKLCVVDPENSVFFDYFNTGDKNVSCANGSKIEG
EEEEECCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCEEEECCCCEECC
IGRPRAEPSFIPGVVDEMRKIPDPASVATINWLENIIGRKTGASTGTNLYGALQLASEMA
CCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AKGETGSIVTLICDSGERYLDTYYNNEWIKENIGDLSDYEDALAHFSATCVLNCPSLK
CCCCCCCEEEEEECCCCHHHHHHCCCCHHHHHCCCHHHHHHHHHHCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]