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The map label for this gene is thrC [H]

Identifier: 157960896

GI number: 157960896

Start: 1292605

End: 1293891

Strand: Direct

Name: thrC [H]

Synonym: Spea_1068

Alternate gene names: 157960896

Gene position: 1292605-1293891 (Clockwise)

Preceding gene: 157960895

Following gene: 157960897

Centisome position: 24.98

GC content: 45.92

Gene sequence:

>1287_bases
ATGGAGCTGTATAACCTAAAACACCCATCACAGGTGGTGAGTTTTACCCAAGCGGTCAAGCTAGGCCTTGGAAAAGACAG
AGGCTTATTTTTCCCGAAAGTCATCCCAGAGTTGCAAGATGTGGAAAGCTTATTGGCATTGCCATTTGTTGAAAGAAGTA
AAAAAGTCATCGGTGCTTGGTTAGCATCGGAGCTTGGCCAAGATACCGTCGATAGATTAGTGGAACGTGCCTTTAACTTC
GAGCTTCCTTTAGTGAAAGCCGATAGCAATCTCTATAGTCTTGAGCTATTTCACGGGCCAACCCTTGCCTTTAAGGATTT
TGGCGCACGCTTTATGGCGCAGTGTTTAAATGAGTTGGCAAAGACGGAGAAGATTAACATCTTGACCGCTACCTCTGGTG
ATACCGGGGCGGCGGTGGCTGATGCCTTCTATGGCTTAGACAATATCAATGTGGTTGTCTTATACCCTAGGGGGAAGATC
AGTGTGCTCCAGGAAAAGATGTTCACCACGTTAGGGGAGAATATTCACACGGTAGCGGTAGAGTCTGATTTTGATGCGTG
CCAAAGCTTAGTGAAGCAATCTTTTGAAGATCTGGATATTCGAGATGGCTTGCACCTTAACTCTGCAAACTCAATCAACA
TTAGCCGCCTATTGGCTCAGATCTGTTACTACTTCGAGGCAGTTGCTCAATTTAAACAACACAATGAAAGTGAGCCTGTC
ATTGCAGTTCCTAGTGGCAATTTCGGCAACCTAACGGCGGGTCTATTTGCTAAGGCGATGGGACTACCAGTAAAACGTTT
TGTGGCTGCAACAAACAGTAATGATACTGTGCCTCGCTATCTAGGCAGCGGTGACTGGCAACCTGAAGCAACAGTCGCCA
CCATATCTAATGCTATGGATGTAGCTGAGCCGAGCAATTGGCCACGTGTAGAGGCAATTGTAGAGGCGATGGGCTGGTCA
TTGGCAGATATCATAGGTTTAGGCGTCTCTGAGACTGATACTGCTGAGTCGGTAAAAGCCTTGAACAGTGCCGGATATTT
GTCTGAGCCCCATGCTGCGATTGCGGCATTGGCACTAAAACAAACCATGTCTGCAGATGAGAAAGGTATCTTCTTGGCAA
CGGCGCACCCTGCAAAGTTTAATGAGGTGGTGGAAGATATTCTTAAAATAGAGCTTACTCTGCCAGAACCTTTAGCCCGA
GTTGTGCCAAAGCAAATTTTATCGGCTGAGTTACCAGCAGATTTTGGTTTACTAAAACAACATCTTTTTAAGTTGTTAGC
CGACTAA

Upstream 100 bases:

>100_bases
TAAAGGCTTCTCTCATATATGCAGAATTGATAATCAAGGGACTCGTCGAGTCGATTAAACGTCTTAACTAGACCTAATAA
CAGAATTTAAGGAAGTCGTC

Downstream 100 bases:

>100_bases
AATTACGACAATAGTTACGACAAAAGATAGCCATTACCTAAACAAGGAAGCTGTTAATGCTTCCTTTTTTTTGTTGGTTA
AATGTGTGTATTCATTTAAA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MELYNLKHPSQVVSFTQAVKLGLGKDRGLFFPKVIPELQDVESLLALPFVERSKKVIGAWLASELGQDTVDRLVERAFNF
ELPLVKADSNLYSLELFHGPTLAFKDFGARFMAQCLNELAKTEKINILTATSGDTGAAVADAFYGLDNINVVVLYPRGKI
SVLQEKMFTTLGENIHTVAVESDFDACQSLVKQSFEDLDIRDGLHLNSANSINISRLLAQICYYFEAVAQFKQHNESEPV
IAVPSGNFGNLTAGLFAKAMGLPVKRFVAATNSNDTVPRYLGSGDWQPEATVATISNAMDVAEPSNWPRVEAIVEAMGWS
LADIIGLGVSETDTAESVKALNSAGYLSEPHAAIAALALKQTMSADEKGIFLATAHPAKFNEVVEDILKIELTLPEPLAR
VVPKQILSAELPADFGLLKQHLFKLLAD

Sequences:

>Translated_428_residues
MELYNLKHPSQVVSFTQAVKLGLGKDRGLFFPKVIPELQDVESLLALPFVERSKKVIGAWLASELGQDTVDRLVERAFNF
ELPLVKADSNLYSLELFHGPTLAFKDFGARFMAQCLNELAKTEKINILTATSGDTGAAVADAFYGLDNINVVVLYPRGKI
SVLQEKMFTTLGENIHTVAVESDFDACQSLVKQSFEDLDIRDGLHLNSANSINISRLLAQICYYFEAVAQFKQHNESEPV
IAVPSGNFGNLTAGLFAKAMGLPVKRFVAATNSNDTVPRYLGSGDWQPEATVATISNAMDVAEPSNWPRVEAIVEAMGWS
LADIIGLGVSETDTAESVKALNSAGYLSEPHAAIAALALKQTMSADEKGIFLATAHPAKFNEVVEDILKIELTLPEPLAR
VVPKQILSAELPADFGLLKQHLFKLLAD
>Mature_428_residues
MELYNLKHPSQVVSFTQAVKLGLGKDRGLFFPKVIPELQDVESLLALPFVERSKKVIGAWLASELGQDTVDRLVERAFNF
ELPLVKADSNLYSLELFHGPTLAFKDFGARFMAQCLNELAKTEKINILTATSGDTGAAVADAFYGLDNINVVVLYPRGKI
SVLQEKMFTTLGENIHTVAVESDFDACQSLVKQSFEDLDIRDGLHLNSANSINISRLLAQICYYFEAVAQFKQHNESEPV
IAVPSGNFGNLTAGLFAKAMGLPVKRFVAATNSNDTVPRYLGSGDWQPEATVATISNAMDVAEPSNWPRVEAIVEAMGWS
LADIIGLGVSETDTAESVKALNSAGYLSEPHAAIAALALKQTMSADEKGIFLATAHPAKFNEVVEDILKIELTLPEPLAR
VVPKQILSAELPADFGLLKQHLFKLLAD

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=443, Percent_Identity=31.1512415349887, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI149193323, Length=418, Percent_Identity=32.2966507177034, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1786185, Length=422, Percent_Identity=57.345971563981, Blast_Score=479, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6319901, Length=451, Percent_Identity=32.8159645232816, Blast_Score=213, Evalue=6e-56,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46581; Mature: 46581

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELYNLKHPSQVVSFTQAVKLGLGKDRGLFFPKVIPELQDVESLLALPFVERSKKVIGAW
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LASELGQDTVDRLVERAFNFELPLVKADSNLYSLELFHGPTLAFKDFGARFMAQCLNELA
HHHHHCHHHHHHHHHHHHCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
KTEKINILTATSGDTGAAVADAFYGLDNINVVVLYPRGKISVLQEKMFTTLGENIHTVAV
CCCEEEEEEECCCCCCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
ESDFDACQSLVKQSFEDLDIRDGLHLNSANSINISRLLAQICYYFEAVAQFKQHNESEPV
ECCHHHHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCE
IAVPSGNFGNLTAGLFAKAMGLPVKRFVAATNSNDTVPRYLGSGDWQPEATVATISNAMD
EEECCCCCCCHHHHHHHHHHCCCHHHHHEECCCCCCCHHHCCCCCCCCCHHHHHHHHHHH
VAEPSNWPRVEAIVEAMGWSLADIIGLGVSETDTAESVKALNSAGYLSEPHAAIAALALK
HCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHH
QTMSADEKGIFLATAHPAKFNEVVEDILKIELTLPEPLARVVPKQILSAELPADFGLLKQ
HHHCCCCCCEEEEECCCHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCCHHHHHHH
HLFKLLAD
HHHHHHCC
>Mature Secondary Structure
MELYNLKHPSQVVSFTQAVKLGLGKDRGLFFPKVIPELQDVESLLALPFVERSKKVIGAW
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LASELGQDTVDRLVERAFNFELPLVKADSNLYSLELFHGPTLAFKDFGARFMAQCLNELA
HHHHHCHHHHHHHHHHHHCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
KTEKINILTATSGDTGAAVADAFYGLDNINVVVLYPRGKISVLQEKMFTTLGENIHTVAV
CCCEEEEEEECCCCCCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
ESDFDACQSLVKQSFEDLDIRDGLHLNSANSINISRLLAQICYYFEAVAQFKQHNESEPV
ECCHHHHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCE
IAVPSGNFGNLTAGLFAKAMGLPVKRFVAATNSNDTVPRYLGSGDWQPEATVATISNAMD
EEECCCCCCCHHHHHHHHHHCCCHHHHHEECCCCCCCHHHCCCCCCCCCHHHHHHHHHHH
VAEPSNWPRVEAIVEAMGWSLADIIGLGVSETDTAESVKALNSAGYLSEPHAAIAALALK
HCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHH
QTMSADEKGIFLATAHPAKFNEVVEDILKIELTLPEPLARVVPKQILSAELPADFGLLKQ
HHHCCCCCCEEEEECCCHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCCHHHHHHH
HLFKLLAD
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]