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The map label for this gene is rnc [H]

Identifier: 157960865

GI number: 157960865

Start: 1260111

End: 1260788

Strand: Direct

Name: rnc [H]

Synonym: Spea_1037

Alternate gene names: 157960865

Gene position: 1260111-1260788 (Clockwise)

Preceding gene: 157960864

Following gene: 157960866

Centisome position: 24.35

GC content: 43.81

Gene sequence:

>678_bases
ATGGAACCGATTAAGAACATTCCACGTTTGTGCCGTACTTTAGGGTACGAGTTCAATGAAAAAGCATTTTTAGACCAAGC
ATTGACTCATAGAAGTGCCTCTAATAAGCATAATGAGAGATTAGAGTTTCTTGGAGATTCTATTCTGTCTATCGTGATCT
CTGATGCCCTTTATCATCAGTTCCCAGCGGCCACCGAAGGTGACCTAAGCCGTATGCGCGCAACACTCGTTTGCGGCAAG
ATGCTGGCAGAAATCGCTATCGAATTTAAGCTTGGCGATTACCTAAAGCTAGGTCCTGGAGAGTTAAAAAGTGGCGGCTT
TAGACGAGAGTCAATTCTAGCCGATGCGGTAGAAGCGATTATCGGTGCAATTTATCTCGATTCTGATATTGAGAATTGTC
GTCAGTTAGTGCTTAACTGGTACGAGTCGCGCCTAAAGGTTATTGAGCCTATAAATCAAAAAGATCCAAAAACATTACTG
CAAGAGTATTTGCAGAAATATAGAAAACCACTGCCAGTTTATAGAGTGGCCCATACTGAAGGCGATGCTCACGAGCAGAC
TTTCACCGTTGAATGTATTGTTGAAGACTTGAGCCAAGCCGTTGTCGGAGTAGCCAGTTCGCGCAGAAAAGCGGAACAGA
GTGCTGCGGCTCAAGTGTTGGAGTTAATTAAGAAATGA

Upstream 100 bases:

>100_bases
ATTTGGATTAGCTTCGAGTTTGACAGAAAGCCTGCGGACTTTTTACCGACTTGGATCCCAACTGGGGTTCGCTTTAACCG
TGTAGGCGGAATTGAGTAAT

Downstream 100 bases:

>100_bases
GTGACAACAAAGATTTACCTGAAAGCCAAGAGCCAAGTTTAGACGAACTACTGGCTAATATGAACAATCCGTCGTCAGCG
GTTAAGTACGCGGTGACCTA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MEPIKNIPRLCRTLGYEFNEKAFLDQALTHRSASNKHNERLEFLGDSILSIVISDALYHQFPAATEGDLSRMRATLVCGK
MLAEIAIEFKLGDYLKLGPGELKSGGFRRESILADAVEAIIGAIYLDSDIENCRQLVLNWYESRLKVIEPINQKDPKTLL
QEYLQKYRKPLPVYRVAHTEGDAHEQTFTVECIVEDLSQAVVGVASSRRKAEQSAAAQVLELIKK

Sequences:

>Translated_225_residues
MEPIKNIPRLCRTLGYEFNEKAFLDQALTHRSASNKHNERLEFLGDSILSIVISDALYHQFPAATEGDLSRMRATLVCGK
MLAEIAIEFKLGDYLKLGPGELKSGGFRRESILADAVEAIIGAIYLDSDIENCRQLVLNWYESRLKVIEPINQKDPKTLL
QEYLQKYRKPLPVYRVAHTEGDAHEQTFTVECIVEDLSQAVVGVASSRRKAEQSAAAQVLELIKK
>Mature_225_residues
MEPIKNIPRLCRTLGYEFNEKAFLDQALTHRSASNKHNERLEFLGDSILSIVISDALYHQFPAATEGDLSRMRATLVCGK
MLAEIAIEFKLGDYLKLGPGELKSGGFRRESILADAVEAIIGAIYLDSDIENCRQLVLNWYESRLKVIEPINQKDPKTLL
QEYLQKYRKPLPVYRVAHTEGDAHEQTFTVECIVEDLSQAVVGVASSRRKAEQSAAAQVLELIKK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=219, Percent_Identity=31.5068493150685, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI155030234, Length=219, Percent_Identity=31.5068493150685, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI1788920, Length=211, Percent_Identity=65.8767772511848, Blast_Score=280, Evalue=7e-77,
Organism=Caenorhabditis elegans, GI193202651, Length=189, Percent_Identity=34.3915343915344, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17506883, Length=189, Percent_Identity=34.3915343915344, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323895, Length=112, Percent_Identity=33.9285714285714, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137682, Length=233, Percent_Identity=29.6137339055794, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25335; Mature: 25335

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPIKNIPRLCRTLGYEFNEKAFLDQALTHRSASNKHNERLEFLGDSILSIVISDALYHQ
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FPAATEGDLSRMRATLVCGKMLAEIAIEFKLGDYLKLGPGELKSGGFRRESILADAVEAI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHH
IGAIYLDSDIENCRQLVLNWYESRLKVIEPINQKDPKTLLQEYLQKYRKPLPVYRVAHTE
HHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCC
GDAHEQTFTVECIVEDLSQAVVGVASSRRKAEQSAAAQVLELIKK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MEPIKNIPRLCRTLGYEFNEKAFLDQALTHRSASNKHNERLEFLGDSILSIVISDALYHQ
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FPAATEGDLSRMRATLVCGKMLAEIAIEFKLGDYLKLGPGELKSGGFRRESILADAVEAI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHH
IGAIYLDSDIENCRQLVLNWYESRLKVIEPINQKDPKTLLQEYLQKYRKPLPVYRVAHTE
HHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCC
GDAHEQTFTVECIVEDLSQAVVGVASSRRKAEQSAAAQVLELIKK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA