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The map label for this gene is gabT [H]

Identifier: 157960780

GI number: 157960780

Start: 1161738

End: 1163015

Strand: Direct

Name: gabT [H]

Synonym: Spea_0952

Alternate gene names: 157960780

Gene position: 1161738-1163015 (Clockwise)

Preceding gene: 157960779

Following gene: 157960782

Centisome position: 22.45

GC content: 51.25

Gene sequence:

>1278_bases
ATGACAACCAATGAGTCACTTATGGTGCGACGCCAAGCCGCTGTAGCCAATGGCGTAGGGCAAATTCACCCTATCTATAC
TCAGCGTGCCGATAACGCCACCGTGTGGGATGTAGAAGGGCGCGAGTTTATTGACTTTGCTGGTGGTATTGCGGTGCTCA
ATACTGGCCACTTGCACGATAATGTTAAGGCGGCGGTAGCAGAGCAACTGGAGCTGTTTTCCCATACCTGCTTTATGGTG
CTGGGCTATGAGAATTATATCCAGGTGTGCGAGAAGCTTAATCATCTTGTGCCCGGCGATTTTGCTAAGAAAACAGCGTT
GTTCACCAGTGGTTCAGAGGCGGTTGAAAACGCGGTGAAGGTGGCGCGGGCTTATACTAAACGCAGCGGTGTTATTGCTT
TTACCTCGGGTTACCATGGGCGCACCATGGCGGCGTTAGCGCTAACGGGCAAGGTCGCACCTTACAGTAAAGGTATGGGG
CTGATGTCGGCCAATGTGTTTAGAGCCGAGTTTCCTTGTGAGCTGCATGGGGTGAGCGATGAGGATGCCATCTCATCCAT
AGAGCGAATCTTTAAAAATGATGCCGAGCCCGATGATATTGCAGCAATTATTATCGAGCCAGTGCAAGGTGAGGGCGGTT
TTTACCATACCTCAGTCGAGTTTATGCAGCGTTTACGTCAGTTATGCGATAAGCACGGCATCATGCTGATCGCCGATGAA
GTACAAACAGGCGCGGGGCGAACGGGTACCTTTTTTGCTATGGAGCAGATGAAGGTGAGCGCGGATATTACTACTTTTGC
TAAGTCTATCGCCGGAGGTTTCCCGCTGTCAGGGATCACCGGCCGAGCCGAAGTGATGGACTCTATTGGTGCGGGTGGCT
TAGGCGGTACCTATGGTGGCAGTCCGTTAGCCTGCGCTGCAGCGCTTGCCGTAATTGAGGTATTTGAAGAGGAACAACTA
CTGCAAAGAGCCAATGCGCTTGGTGCTAAGCTCAAAGAGTCGCTTAACGCGATGGCGAGTAAGCATGAGCCAATTGTCGA
TGTACGCGGTCTTGGTGCCATGATAGCGGTTGAGTTGATGCAAGAAGGTAAGCCTGCGCCAGAACTGTGCGCGCAAATAC
TCAAAGAGGCACGTGATAGAGGACTTATCCTGCTATCTTGCGGCACTTACGGTAATGTACTGCGCATTCTTGTACCGCTA
ACAGCTCCCGATGAGCAAATCGATAAAGGACTGGAGATCATTCAGTCTTGCTTTGAAGTGGTCTTGAAGCCCGCTTAA

Upstream 100 bases:

>100_bases
GCTCAAAGTTTGGCATCGAAGAGTACTTAGAGATGAAGTACATCTGCATGTCAGTTTAATAGGATTAAGTTCATAAGTAG
TTAGTTAAAAGGAATTCATT

Downstream 100 bases:

>100_bases
TACTGGTTAGTTTAAGCAGTAAAGGCCTGTTGAGTATAGGTAATACAGAAATCCGAGAGCTGTTTTTGTCTCGGATTTTT
TACTTTCCAATTGTACTGCT

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTTNESLMVRRQAAVANGVGQIHPIYTQRADNATVWDVEGREFIDFAGGIAVLNTGHLHDNVKAAVAEQLELFSHTCFMV
LGYENYIQVCEKLNHLVPGDFAKKTALFTSGSEAVENAVKVARAYTKRSGVIAFTSGYHGRTMAALALTGKVAPYSKGMG
LMSANVFRAEFPCELHGVSDEDAISSIERIFKNDAEPDDIAAIIIEPVQGEGGFYHTSVEFMQRLRQLCDKHGIMLIADE
VQTGAGRTGTFFAMEQMKVSADITTFAKSIAGGFPLSGITGRAEVMDSIGAGGLGGTYGGSPLACAAALAVIEVFEEEQL
LQRANALGAKLKESLNAMASKHEPIVDVRGLGAMIAVELMQEGKPAPELCAQILKEARDRGLILLSCGTYGNVLRILVPL
TAPDEQIDKGLEIIQSCFEVVLKPA

Sequences:

>Translated_425_residues
MTTNESLMVRRQAAVANGVGQIHPIYTQRADNATVWDVEGREFIDFAGGIAVLNTGHLHDNVKAAVAEQLELFSHTCFMV
LGYENYIQVCEKLNHLVPGDFAKKTALFTSGSEAVENAVKVARAYTKRSGVIAFTSGYHGRTMAALALTGKVAPYSKGMG
LMSANVFRAEFPCELHGVSDEDAISSIERIFKNDAEPDDIAAIIIEPVQGEGGFYHTSVEFMQRLRQLCDKHGIMLIADE
VQTGAGRTGTFFAMEQMKVSADITTFAKSIAGGFPLSGITGRAEVMDSIGAGGLGGTYGGSPLACAAALAVIEVFEEEQL
LQRANALGAKLKESLNAMASKHEPIVDVRGLGAMIAVELMQEGKPAPELCAQILKEARDRGLILLSCGTYGNVLRILVPL
TAPDEQIDKGLEIIQSCFEVVLKPA
>Mature_424_residues
TTNESLMVRRQAAVANGVGQIHPIYTQRADNATVWDVEGREFIDFAGGIAVLNTGHLHDNVKAAVAEQLELFSHTCFMVL
GYENYIQVCEKLNHLVPGDFAKKTALFTSGSEAVENAVKVARAYTKRSGVIAFTSGYHGRTMAALALTGKVAPYSKGMGL
MSANVFRAEFPCELHGVSDEDAISSIERIFKNDAEPDDIAAIIIEPVQGEGGFYHTSVEFMQRLRQLCDKHGIMLIADEV
QTGAGRTGTFFAMEQMKVSADITTFAKSIAGGFPLSGITGRAEVMDSIGAGGLGGTYGGSPLACAAALAVIEVFEEEQLL
QRANALGAKLKESLNAMASKHEPIVDVRGLGAMIAVELMQEGKPAPELCAQILKEARDRGLILLSCGTYGNVLRILVPLT
APDEQIDKGLEIIQSCFEVVLKPA

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=408, Percent_Identity=30.8823529411765, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI13994255, Length=428, Percent_Identity=30.1401869158879, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI37574042, Length=418, Percent_Identity=28.2296650717703, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI226442705, Length=418, Percent_Identity=27.9904306220096, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI284507298, Length=320, Percent_Identity=31.5625, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI226442709, Length=386, Percent_Identity=28.4974093264249, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI24119277, Length=394, Percent_Identity=28.1725888324873, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI188536080, Length=393, Percent_Identity=24.9363867684478, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI38679950, Length=393, Percent_Identity=24.9363867684478, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI38679946, Length=393, Percent_Identity=24.9363867684478, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1789016, Length=422, Percent_Identity=69.4312796208531, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI1787560, Length=418, Percent_Identity=51.1961722488038, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1789759, Length=403, Percent_Identity=32.7543424317618, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI1788044, Length=395, Percent_Identity=34.4303797468354, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI145693181, Length=392, Percent_Identity=34.9489795918367, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1786991, Length=333, Percent_Identity=34.5345345345345, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1786349, Length=349, Percent_Identity=29.7994269340974, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32564660, Length=419, Percent_Identity=33.1742243436754, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25144271, Length=411, Percent_Identity=29.4403892944039, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71992977, Length=437, Percent_Identity=28.1464530892449, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI25144274, Length=320, Percent_Identity=28.125, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=441, Percent_Identity=25.3968253968254, Blast_Score=109, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323470, Length=414, Percent_Identity=30.4347826086957, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324432, Length=405, Percent_Identity=30.3703703703704, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324386, Length=372, Percent_Identity=23.6559139784946, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321456, Length=246, Percent_Identity=27.6422764227642, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI161085790, Length=460, Percent_Identity=29.1304347826087, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI28574759, Length=441, Percent_Identity=29.7052154195011, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI21357415, Length=406, Percent_Identity=29.5566502463054, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21356575, Length=421, Percent_Identity=29.2161520190024, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI281366494, Length=397, Percent_Identity=25.1889168765743, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24667139, Length=397, Percent_Identity=25.1889168765743, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24667143, Length=397, Percent_Identity=25.1889168765743, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 45501; Mature: 45370

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNESLMVRRQAAVANGVGQIHPIYTQRADNATVWDVEGREFIDFAGGIAVLNTGHLHD
CCCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCCEEEECCCCHHHHHCCCEEEEECCCCCH
NVKAAVAEQLELFSHTCFMVLGYENYIQVCEKLNHLVPGDFAKKTALFTSGSEAVENAVK
HHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHCCCCCCCHHHHHHEECCCHHHHHHHHH
VARAYTKRSGVIAFTSGYHGRTMAALALTGKVAPYSKGMGLMSANVFRAEFPCELHGVSD
HHHHHHHCCCEEEEECCCCCCCEEEHHHHCCCCCCCCCCCHHCCCEEEEECCEEECCCCC
EDAISSIERIFKNDAEPDDIAAIIIEPVQGEGGFYHTSVEFMQRLRQLCDKHGIMLIADE
HHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEECHHHHHHHHHHHHHHCCEEEEEEC
VQTGAGRTGTFFAMEQMKVSADITTFAKSIAGGFPLSGITGRAEVMDSIGAGGLGGTYGG
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCC
SPLACAAALAVIEVFEEEQLLQRANALGAKLKESLNAMASKHEPIVDVRGLGAMIAVELM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHH
QEGKPAPELCAQILKEARDRGLILLSCGTYGNVLRILVPLTAPDEQIDKGLEIIQSCFEV
HCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHH
VLKPA
HHCCC
>Mature Secondary Structure 
TTNESLMVRRQAAVANGVGQIHPIYTQRADNATVWDVEGREFIDFAGGIAVLNTGHLHD
CCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCCEEEECCCCHHHHHCCCEEEEECCCCCH
NVKAAVAEQLELFSHTCFMVLGYENYIQVCEKLNHLVPGDFAKKTALFTSGSEAVENAVK
HHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHCCCCCCCHHHHHHEECCCHHHHHHHHH
VARAYTKRSGVIAFTSGYHGRTMAALALTGKVAPYSKGMGLMSANVFRAEFPCELHGVSD
HHHHHHHCCCEEEEECCCCCCCEEEHHHHCCCCCCCCCCCHHCCCEEEEECCEEECCCCC
EDAISSIERIFKNDAEPDDIAAIIIEPVQGEGGFYHTSVEFMQRLRQLCDKHGIMLIADE
HHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEECHHHHHHHHHHHHHHCCEEEEEEC
VQTGAGRTGTFFAMEQMKVSADITTFAKSIAGGFPLSGITGRAEVMDSIGAGGLGGTYGG
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCC
SPLACAAALAVIEVFEEEQLLQRANALGAKLKESLNAMASKHEPIVDVRGLGAMIAVELM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHH
QEGKPAPELCAQILKEARDRGLILLSCGTYGNVLRILVPLTAPDEQIDKGLEIIQSCFEV
HCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHH
VLKPA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]