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The map label for this gene is 157960745

Identifier: 157960745

GI number: 157960745

Start: 1122306

End: 1124132

Strand: Direct

Name: 157960745

Synonym: Spea_0917

Alternate gene names: NA

Gene position: 1122306-1124132 (Clockwise)

Preceding gene: 157960740

Following gene: 157960749

Centisome position: 21.69

GC content: 48.28

Gene sequence:

>1827_bases
ATGAGATTAACAAAAGTAGCTACGGCCCTTGTCGCCTTGTCTTTGGGGGTTTCTGCAGGTGCAACTGCAAGCGAAAGATA
TGTTATTCAAGTAGATAATGATAAAAAAGGGATTATAAAAGCCCTAGCTAAAAAAGTGGGCGGTGAGCTCAACCTAGACG
GTAATGGATTTATTGCGGCTACTTTTTCTGGCAAAGACCTATCTCAAGTTAAAGGTTTACTCAACAATCCGCATGTTAAG
TTAGTTGAGGTGGATCAGCCACGTTTTCTTATGTCGTTTAGTGATGATGCGGGTAACCCAATGACCCAGCAAGTCACGCC
TTATGCTGTTTATCAATCAAAGGTCAATGATATTGGTTTCAATGCTAGTGCAGGCATGAAGGTCTGCGTTATCGATTCAG
GTTTAGATAGAAGTAATCAAGATTTCGTTTGGAATAATATCAGTGGTGATAACGATAGCGGTACCGGCGACTGGGATCAA
AATGGTGGCCCACACGGTACACACGTTGCGGGTACGATTGGCGCGGCAGATAATAATGTCGGCGTTGTAGGTATGGCGCC
TGGCGTCGATATGCATATCATCAAAGTATTTAATGCCGATGGCTGGGGTTACTCATCGGATCTAGCCCATGCGGCAGACC
TATGTAGCAACGCAGGGGCTAACATCATTAGCATGAGTTTGGGGGGCGGAGGTTCAAACTCTACCGAGTCTAATGCCTTT
CAGTCTTTCAGTGATGCTGGCGGACTAGTGCTTGCAGCTGCGGGTAACGATGGCAATAGTGTACGTTCATACCCTGCTGG
TTACCCTTCGGTTATGATGATCGGAGCGAATGATGCGACCGATGCGATTGCTGACTTTTCTCAATTCCCAAGCTGTACAA
CTGGCCGAGGCAAGAAGCAGCGCACGGATCTCAGTATCTGTGTTGAGATTGCAGCCGGCGGTGTGGATACGTTATCGACA
TATCCAGCAGGTATGGCAACAGCATCTAATATGAGTGTTGATGGAAATCCTCTAGCGAGCTCGTCGATGGAAAATGCGGG
CTCTGTATCGGGTAGCACATACTTTATGGGCACGGCTGAAGCGACGGATTTTGGTGCAAATGGTAAGGTTTGTGTTATCG
ACCGCGGCGCAATCTCATTCCATGACAAGGTACTTAACTGTGAAAACTCTGGTGGCGTCGGTGCCGTTATCATTAACAAT
GAGTCGGGTATGTTGTATGGCACTCTAGGTGATGCAAATGCGACAACGATTCCAGCTGTCGGGGCTAGGCTTGAAGATAG
AGCCGCTATCGTCGCTGCAAGCAATGCTGATATCTCAATCGGTACATCTGATTACGGTTTTATGAGCGGTACTTCTATGG
CAACTCCAGCGGTATCGGGTATTGCAGCACGTGTTTGGTCTAACCATAACCAATGTACCGGTGAGGAGATCCGCGCGGCA
TTAAATGCCAGTGCAAGAGACTCTGGTGCAAGTGGTCACGATGTTTACTTCGGACACGGTATTGTTGATGCGGCAGCTGC
GGATGCATACCTAACGGCCAATGGTTGCTCTGGTGGTGACGGTGGAGGAGAGACTGGCGCGGGTGATGGCCTGACGGTAA
CTGCGGACAGCTATAAGCAGCGTGGAGTTAAGAAAGTGGATCTTAACTTTAGTGGCGCAGCGGGTAGCAGTGTTGATGTT
TACCGCAACGGTTCTGAAATCGGGACCGTCTCTAGTTCAGCAACGTATACCGACAGCATTAGCACTAATGGTGGCGGAAC
CTATACCTATAAGGCGTGTGATGCTGGAACATCTACTTGTAGCGAAGAGATCAGCGTAACGTTTTAA

Upstream 100 bases:

>100_bases
GGTTTTTTTGACCAATAAACCACTAAAAAAAAGTTTAAAAAGCTAATAATAACTAGGCTTAGATTTACGGCCTAATACCA
TGATTTTGGAGCGAATAAAT

Downstream 100 bases:

>100_bases
TTTTTAAGCTCAGTTAAACTAGAGCAAAAAGGCCTGCATCAGCAGGCCTTTTTATGTTTGATTGACACTTAAATCCTGTT
CTGCTTAGAGTGCTTGCAGT

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MRLTKVATALVALSLGVSAGATASERYVIQVDNDKKGIIKALAKKVGGELNLDGNGFIAATFSGKDLSQVKGLLNNPHVK
LVEVDQPRFLMSFSDDAGNPMTQQVTPYAVYQSKVNDIGFNASAGMKVCVIDSGLDRSNQDFVWNNISGDNDSGTGDWDQ
NGGPHGTHVAGTIGAADNNVGVVGMAPGVDMHIIKVFNADGWGYSSDLAHAADLCSNAGANIISMSLGGGGSNSTESNAF
QSFSDAGGLVLAAAGNDGNSVRSYPAGYPSVMMIGANDATDAIADFSQFPSCTTGRGKKQRTDLSICVEIAAGGVDTLST
YPAGMATASNMSVDGNPLASSSMENAGSVSGSTYFMGTAEATDFGANGKVCVIDRGAISFHDKVLNCENSGGVGAVIINN
ESGMLYGTLGDANATTIPAVGARLEDRAAIVAASNADISIGTSDYGFMSGTSMATPAVSGIAARVWSNHNQCTGEEIRAA
LNASARDSGASGHDVYFGHGIVDAAAADAYLTANGCSGGDGGGETGAGDGLTVTADSYKQRGVKKVDLNFSGAAGSSVDV
YRNGSEIGTVSSSATYTDSISTNGGGTYTYKACDAGTSTCSEEISVTF

Sequences:

>Translated_608_residues
MRLTKVATALVALSLGVSAGATASERYVIQVDNDKKGIIKALAKKVGGELNLDGNGFIAATFSGKDLSQVKGLLNNPHVK
LVEVDQPRFLMSFSDDAGNPMTQQVTPYAVYQSKVNDIGFNASAGMKVCVIDSGLDRSNQDFVWNNISGDNDSGTGDWDQ
NGGPHGTHVAGTIGAADNNVGVVGMAPGVDMHIIKVFNADGWGYSSDLAHAADLCSNAGANIISMSLGGGGSNSTESNAF
QSFSDAGGLVLAAAGNDGNSVRSYPAGYPSVMMIGANDATDAIADFSQFPSCTTGRGKKQRTDLSICVEIAAGGVDTLST
YPAGMATASNMSVDGNPLASSSMENAGSVSGSTYFMGTAEATDFGANGKVCVIDRGAISFHDKVLNCENSGGVGAVIINN
ESGMLYGTLGDANATTIPAVGARLEDRAAIVAASNADISIGTSDYGFMSGTSMATPAVSGIAARVWSNHNQCTGEEIRAA
LNASARDSGASGHDVYFGHGIVDAAAADAYLTANGCSGGDGGGETGAGDGLTVTADSYKQRGVKKVDLNFSGAAGSSVDV
YRNGSEIGTVSSSATYTDSISTNGGGTYTYKACDAGTSTCSEEISVTF
>Mature_608_residues
MRLTKVATALVALSLGVSAGATASERYVIQVDNDKKGIIKALAKKVGGELNLDGNGFIAATFSGKDLSQVKGLLNNPHVK
LVEVDQPRFLMSFSDDAGNPMTQQVTPYAVYQSKVNDIGFNASAGMKVCVIDSGLDRSNQDFVWNNISGDNDSGTGDWDQ
NGGPHGTHVAGTIGAADNNVGVVGMAPGVDMHIIKVFNADGWGYSSDLAHAADLCSNAGANIISMSLGGGGSNSTESNAF
QSFSDAGGLVLAAAGNDGNSVRSYPAGYPSVMMIGANDATDAIADFSQFPSCTTGRGKKQRTDLSICVEIAAGGVDTLST
YPAGMATASNMSVDGNPLASSSMENAGSVSGSTYFMGTAEATDFGANGKVCVIDRGAISFHDKVLNCENSGGVGAVIINN
ESGMLYGTLGDANATTIPAVGARLEDRAAIVAASNADISIGTSDYGFMSGTSMATPAVSGIAARVWSNHNQCTGEEIRAA
LNASARDSGASGHDVYFGHGIVDAAAADAYLTANGCSGGDGGGETGAGDGLTVTADSYKQRGVKKVDLNFSGAAGSSVDV
YRNGSEIGTVSSSATYTDSISTNGGGTYTYKACDAGTSTCSEEISVTF

Specific function: Has a broad substrate specificity with a slight preference to large hydrophobic amino acid residues at the P1 position [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 61558; Mature: 61558

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTKVATALVALSLGVSAGATASERYVIQVDNDKKGIIKALAKKVGGELNLDGNGFIAA
CCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEECCCEEEEE
TFSGKDLSQVKGLLNNPHVKLVEVDQPRFLMSFSDDAGNPMTQQVTPYAVYQSKVNDIGF
EECCCCHHHHHHHHCCCCEEEEEECCCEEEEEECCCCCCCCHHCCCCHHHHHHHHHHCCC
NASAGMKVCVIDSGLDRSNQDFVWNNISGDNDSGTGDWDQNGGPHGTHVAGTIGAADNNV
CCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCE
GVVGMAPGVDMHIIKVFNADGWGYSSDLAHAADLCSNAGANIISMSLGGGGSNSTESNAF
EEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHH
QSFSDAGGLVLAAAGNDGNSVRSYPAGYPSVMMIGANDATDAIADFSQFPSCTTGRGKKQ
HHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCC
RTDLSICVEIAAGGVDTLSTYPAGMATASNMSVDGNPLASSSMENAGSVSGSTYFMGTAE
CCCEEEEEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
ATDFGANGKVCVIDRGAISFHDKVLNCENSGGVGAVIINNESGMLYGTLGDANATTIPAV
CCCCCCCCCEEEEECCCCEECCEEEECCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCC
GARLEDRAAIVAASNADISIGTSDYGFMSGTSMATPAVSGIAARVWSNHNQCTGEEIRAA
CCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHH
LNASARDSGASGHDVYFGHGIVDAAAADAYLTANGCSGGDGGGETGAGDGLTVTADSYKQ
HCCCCCCCCCCCCEEEEECCCHHHHCCCEEEEECCCCCCCCCCCCCCCCCEEEEECHHHH
RGVKKVDLNFSGAAGSSVDVYRNGSEIGTVSSSATYTDSISTNGGGTYTYKACDAGTSTC
CCCEEEEEEECCCCCCEEEEEECCCCEECCCCCCEEECCCCCCCCCEEEEEECCCCCCCC
SEEISVTF
CCCEEEEC
>Mature Secondary Structure
MRLTKVATALVALSLGVSAGATASERYVIQVDNDKKGIIKALAKKVGGELNLDGNGFIAA
CCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEECCCEEEEE
TFSGKDLSQVKGLLNNPHVKLVEVDQPRFLMSFSDDAGNPMTQQVTPYAVYQSKVNDIGF
EECCCCHHHHHHHHCCCCEEEEEECCCEEEEEECCCCCCCCHHCCCCHHHHHHHHHHCCC
NASAGMKVCVIDSGLDRSNQDFVWNNISGDNDSGTGDWDQNGGPHGTHVAGTIGAADNNV
CCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCE
GVVGMAPGVDMHIIKVFNADGWGYSSDLAHAADLCSNAGANIISMSLGGGGSNSTESNAF
EEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHH
QSFSDAGGLVLAAAGNDGNSVRSYPAGYPSVMMIGANDATDAIADFSQFPSCTTGRGKKQ
HHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCC
RTDLSICVEIAAGGVDTLSTYPAGMATASNMSVDGNPLASSSMENAGSVSGSTYFMGTAE
CCCEEEEEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
ATDFGANGKVCVIDRGAISFHDKVLNCENSGGVGAVIINNESGMLYGTLGDANATTIPAV
CCCCCCCCCEEEEECCCCEECCEEEECCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCC
GARLEDRAAIVAASNADISIGTSDYGFMSGTSMATPAVSGIAARVWSNHNQCTGEEIRAA
CCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHH
LNASARDSGASGHDVYFGHGIVDAAAADAYLTANGCSGGDGGGETGAGDGLTVTADSYKQ
HCCCCCCCCCCCCEEEEECCCHHHHCCCEEEEECCCCCCCCCCCCCCCCCEEEEECHHHH
RGVKKVDLNFSGAAGSSVDVYRNGSEIGTVSSSATYTDSISTNGGGTYTYKACDAGTSTC
CCCEEEEEEECCCCCCEEEEEECCCCEECCCCCCEEECCCCCCCCCEEEEEECCCCCCCC
SEEISVTF
CCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11375149 [H]