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The map label for this gene is arcA [H]

Identifier: 157960561

GI number: 157960561

Start: 910471

End: 911187

Strand: Reverse

Name: arcA [H]

Synonym: Spea_0733

Alternate gene names: 157960561

Gene position: 911187-910471 (Counterclockwise)

Preceding gene: 157960565

Following gene: 157960559

Centisome position: 17.61

GC content: 44.07

Gene sequence:

>717_bases
ATGCAAAACCCGCACATTCTGATTGTTGAAGATGAAGCAGTAACAAGAAACACACTTAGAAGTATTTTTGAAGCAGAAGG
ATATGTGGTAACTGAAGCCAATGACGGCGCTGAAATGCATAAGGCTATGCAAGACAACAAAGTTAACTTGGTGGTTATGG
ATATTAACTTACCAGGTAAGAACGGTCTTTTACTAGCTCGTGAGCTTCGTGAAATTAATAATATCGGTCTAATCTTCCTA
ACGGGCCGTGATAACGAAGTTGATAAGATCTTGGGTCTTGAAATTGGTGCTGATGATTATATCACTAAGCCATTCAACCC
ACGTGAATTGACAATCCGTGCTCGTAACCTATTAACTCGCGTTAATAGCACAGGTACAGATTCAGAAGAGAAAAGTGCAG
TTGAGTTCTACCGTTTCAACGGTTGGAGCCTTGAAATCAACAGCCGCTCTCTAGTTAGCCCACAAGGTGAGTCATACAAG
CTACCACGCAGCGAATTCCGCGCTATGCTTCACTTTGTTGAAAACCCAGGTAAGATCCTAAGCCGCGCAGACCTTCTAAT
GAAGATGACTGGCCGTGAGCTTAAGCCACACGACCGTACTGTTGACGTGACTATCCGTCGTATCCGTAAGCACTTCGAGA
GCTTGCCTGATACGCCAGAAATCATCGCAACAATCCACGGTGAAGGTTACCGTTTCTGCGGTAGCTTAGAAGATTAA

Upstream 100 bases:

>100_bases
TTGAAAGCACCTACGTGTATCAGTGAATTATCAGCATAACTAGATGGAGTATAAACTTTTTATACTCATGGTTAGAATTG
ACAGAAATTAGGTAATTAAT

Downstream 100 bases:

>100_bases
TTCTAAGCTCCGTTATATGTACTGTAAGCAGTACATATAAATAAAAAGCCAGTCGATTGACTGGCTTTTTTTATGCCCAG
ATTTAGATACCTTTGTGCCA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MQNPHILIVEDEAVTRNTLRSIFEAEGYVVTEANDGAEMHKAMQDNKVNLVVMDINLPGKNGLLLARELREINNIGLIFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTRVNSTGTDSEEKSAVEFYRFNGWSLEINSRSLVSPQGESYK
LPRSEFRAMLHFVENPGKILSRADLLMKMTGRELKPHDRTVDVTIRRIRKHFESLPDTPEIIATIHGEGYRFCGSLED

Sequences:

>Translated_238_residues
MQNPHILIVEDEAVTRNTLRSIFEAEGYVVTEANDGAEMHKAMQDNKVNLVVMDINLPGKNGLLLARELREINNIGLIFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTRVNSTGTDSEEKSAVEFYRFNGWSLEINSRSLVSPQGESYK
LPRSEFRAMLHFVENPGKILSRADLLMKMTGRELKPHDRTVDVTIRRIRKHFESLPDTPEIIATIHGEGYRFCGSLED
>Mature_238_residues
MQNPHILIVEDEAVTRNTLRSIFEAEGYVVTEANDGAEMHKAMQDNKVNLVVMDINLPGKNGLLLARELREINNIGLIFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTRVNSTGTDSEEKSAVEFYRFNGWSLEINSRSLVSPQGESYK
LPRSEFRAMLHFVENPGKILSRADLLMKMTGRELKPHDRTVDVTIRRIRKHFESLPDTPEIIATIHGEGYRFCGSLED

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=238, Percent_Identity=81.9327731092437, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=44.9339207048458, Blast_Score=196, Evalue=9e-52,
Organism=Escherichia coli, GI1789809, Length=235, Percent_Identity=36.1702127659575, Blast_Score=143, Evalue=8e-36,
Organism=Escherichia coli, GI1788394, Length=234, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1790860, Length=236, Percent_Identity=32.2033898305085, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=31.304347826087, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=31.140350877193, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI87082012, Length=230, Percent_Identity=31.7391304347826, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=31.0043668122271, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=29.2035398230088, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=28.448275862069, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=26.9911504424779, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1790552, Length=234, Percent_Identity=29.9145299145299, Blast_Score=84, Evalue=7e-18,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27052; Mature: 27052

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNPHILIVEDEAVTRNTLRSIFEAEGYVVTEANDGAEMHKAMQDNKVNLVVMDINLPGK
CCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCEEEEEEEEECCCC
NGLLLARELREINNIGLIFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTR
CCEEHHHHHHHHCCCEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEEHHHHHHHH
VNSTGTDSEEKSAVEFYRFNGWSLEINSRSLVSPQGESYKLPRSEFRAMLHFVENPGKIL
HCCCCCCCCHHCEEEEEEECCEEEEECCCEECCCCCCCCCCCHHHHHHHHHHHCCCHHHH
SRADLLMKMTGRELKPHDRTVDVTIRRIRKHFESLPDTPEIIATIHGEGYRFCGSLED
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEECCCCCC
>Mature Secondary Structure
MQNPHILIVEDEAVTRNTLRSIFEAEGYVVTEANDGAEMHKAMQDNKVNLVVMDINLPGK
CCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCEEEEEEEEECCCC
NGLLLARELREINNIGLIFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTR
CCEEHHHHHHHHCCCEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEEHHHHHHHH
VNSTGTDSEEKSAVEFYRFNGWSLEINSRSLVSPQGESYKLPRSEFRAMLHFVENPGKIL
HCCCCCCCCHHCEEEEEEECCEEEEECCCEECCCCCCCCCCCHHHHHHHHHHHCCCHHHH
SRADLLMKMTGRELKPHDRTVDVTIRRIRKHFESLPDTPEIIATIHGEGYRFCGSLED
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]