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The map label for this gene is atoC [H]

Identifier: 157960548

GI number: 157960548

Start: 889568

End: 890950

Strand: Reverse

Name: atoC [H]

Synonym: Spea_0720

Alternate gene names: 157960548

Gene position: 890950-889568 (Counterclockwise)

Preceding gene: 157960549

Following gene: 157960541

Centisome position: 17.22

GC content: 49.89

Gene sequence:

>1383_bases
ATGAAACTCGCCAGAAATATTCTTCTTGTTGACGATGAAGCCTCTTGGCTTAGAACACTCTCCATCACGCTTAATCGTCT
CGTGCCAGAAGCGACTATCGATACCTGTGTCGATAGTCGCCAAGTGATGAGCCGATTGCAGACTGGCGACTATGCGCTGG
TACTGCTAGATCTGACCATGCCGTTTCATTCCGGCGAAGACTTGCTTGAGATGATCCGCAAAGAGTTTCCTAAGACCCGG
GTCATCATAGTCACGGGGGTTAACGAGGTCGACACTGCGGTGCGCTGCATTAAAAACGGTGCCTATGACTACTTTATCAA
AACAGACAAGGTCGACGATCTCGCCCGCACCGTTCGCCGAGCATTAGAAGTAGTAGGTCTTGAGCGTAACTATCTACGAA
TTAAAGAAAGCTTCTTAAGTCGCACATTAAGCCGCCCAGAAGTGTTCAATAATATCCTCACCTGTGAACCCGCGCTGCTG
GATCAGTTCCGCTATTTAGAGGCCGTAGCCTTAAGCCCCGAGCCCATTCTTATTCAAGGGGAAAGCGGCACAGGTAAGGA
TGAGTTTGCCAAGTCCTGTCATCAGCTTATTTGCGCCGATGCGCCCTTCATTAACGTCAACTTGGCGGGTATTAGCACTT
CGGCGTTCGAGCTACAGTTATTTGGCCAACTGCATACCGATGATGACGGCAAAGTTAGCGCTCAAGCAGGCGTGCTGCAC
CAAGTAAAAAACGGCCTACTCTACCTCAATGAGATTGGTGATCTCCCCATTGAGGCTCAGGCAAAGCTTGTGGATGTGAT
TGAGCATAAGCAGTATTACCCTATCGGCAGCGACAGAGCGTACCCGATATTGTGTAAAATTATCACCTCCACCCAGCACG
ACCTGTTAGCGCTGAATCAAGCGGGCAAGTTCAGGAGTGACTTGTTATATCGCCTACGCTCACACACCATCAAGCTGCCA
CCGCTGAGGCAACGTAAGCTAGATCTGTCGATGCTGATCAACCACTTTATTTGTTTAGCGGCCAAAGAGATGGGCTTATC
AGAGCCCCAGCAACCGAGCTCGCTAGCGCAGCAGTTATCAGAATATGCTTTCCCTGGTAATTTACATGAGCTTAAAGGCA
TGGTGTTTGATGCAGTGAGCCGTAGCGACGGTATTGCGCTGAATATCACGCCCTTTATGGAGGCGATAAACCTAAGCAAG
TCGAACGTTACCACTGACAGCGACCAGCTTATCTTCCCTAAGATTTTGCCCACATTAGCGCAGATGAGTGACGCCCTCAT
TCAAGAGGCGCTGAACCGCACCGCCAATAATCAAACTGCAGCGGCGCAGATGCTCGGCATCAGCCAGAGTGCGCTAAGCC
GTCGCATAACTAAAGAAAAATAG

Upstream 100 bases:

>100_bases
TGTGTAGCCGCATCATTAAAGAGCACAAGGCCGACATGCAGATCACCTCGCGCCTAGGCAAAGGCACTGTGATAAAAATA
CGCTTTCCTTTGGAGTACTA

Downstream 100 bases:

>100_bases
TAAAGAAAAGTAGTAAAGAAAAGTAGTAAAGAAAAATAACAGCTTCGGCGGTTTAATCTAAAAACAAAAATGCCAGCAAA
TTGCTGGCATTTTCCTTTTT

Product: Fis family two component sigma54 specific transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MKLARNILLVDDEASWLRTLSITLNRLVPEATIDTCVDSRQVMSRLQTGDYALVLLDLTMPFHSGEDLLEMIRKEFPKTR
VIIVTGVNEVDTAVRCIKNGAYDYFIKTDKVDDLARTVRRALEVVGLERNYLRIKESFLSRTLSRPEVFNNILTCEPALL
DQFRYLEAVALSPEPILIQGESGTGKDEFAKSCHQLICADAPFINVNLAGISTSAFELQLFGQLHTDDDGKVSAQAGVLH
QVKNGLLYLNEIGDLPIEAQAKLVDVIEHKQYYPIGSDRAYPILCKIITSTQHDLLALNQAGKFRSDLLYRLRSHTIKLP
PLRQRKLDLSMLINHFICLAAKEMGLSEPQQPSSLAQQLSEYAFPGNLHELKGMVFDAVSRSDGIALNITPFMEAINLSK
SNVTTDSDQLIFPKILPTLAQMSDALIQEALNRTANNQTAAAQMLGISQSALSRRITKEK

Sequences:

>Translated_460_residues
MKLARNILLVDDEASWLRTLSITLNRLVPEATIDTCVDSRQVMSRLQTGDYALVLLDLTMPFHSGEDLLEMIRKEFPKTR
VIIVTGVNEVDTAVRCIKNGAYDYFIKTDKVDDLARTVRRALEVVGLERNYLRIKESFLSRTLSRPEVFNNILTCEPALL
DQFRYLEAVALSPEPILIQGESGTGKDEFAKSCHQLICADAPFINVNLAGISTSAFELQLFGQLHTDDDGKVSAQAGVLH
QVKNGLLYLNEIGDLPIEAQAKLVDVIEHKQYYPIGSDRAYPILCKIITSTQHDLLALNQAGKFRSDLLYRLRSHTIKLP
PLRQRKLDLSMLINHFICLAAKEMGLSEPQQPSSLAQQLSEYAFPGNLHELKGMVFDAVSRSDGIALNITPFMEAINLSK
SNVTTDSDQLIFPKILPTLAQMSDALIQEALNRTANNQTAAAQMLGISQSALSRRITKEK
>Mature_460_residues
MKLARNILLVDDEASWLRTLSITLNRLVPEATIDTCVDSRQVMSRLQTGDYALVLLDLTMPFHSGEDLLEMIRKEFPKTR
VIIVTGVNEVDTAVRCIKNGAYDYFIKTDKVDDLARTVRRALEVVGLERNYLRIKESFLSRTLSRPEVFNNILTCEPALL
DQFRYLEAVALSPEPILIQGESGTGKDEFAKSCHQLICADAPFINVNLAGISTSAFELQLFGQLHTDDDGKVSAQAGVLH
QVKNGLLYLNEIGDLPIEAQAKLVDVIEHKQYYPIGSDRAYPILCKIITSTQHDLLALNQAGKFRSDLLYRLRSHTIKLP
PLRQRKLDLSMLINHFICLAAKEMGLSEPQQPSSLAQQLSEYAFPGNLHELKGMVFDAVSRSDGIALNITPFMEAINLSK
SNVTTDSDQLIFPKILPTLAQMSDALIQEALNRTANNQTAAAQMLGISQSALSRRITKEK

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=455, Percent_Identity=31.8681318681319, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI1790299, Length=475, Percent_Identity=29.0526315789474, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI1790437, Length=455, Percent_Identity=29.010989010989, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1789233, Length=312, Percent_Identity=33.3333333333333, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI87082117, Length=242, Percent_Identity=34.7107438016529, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1788905, Length=430, Percent_Identity=26.9767441860465, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1787583, Length=240, Percent_Identity=34.5833333333333, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87082152, Length=311, Percent_Identity=29.903536977492, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786524, Length=362, Percent_Identity=30.939226519337, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1789087, Length=266, Percent_Identity=30.4511278195489, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI87081872, Length=312, Percent_Identity=28.8461538461538, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1789828, Length=239, Percent_Identity=32.6359832635983, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI87081858, Length=292, Percent_Identity=27.0547945205479, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51298; Mature: 51298

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLARNILLVDDEASWLRTLSITLNRLVPEATIDTCVDSRQVMSRLQTGDYALVLLDLTM
CCCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
PFHSGEDLLEMIRKEFPKTRVIIVTGVNEVDTAVRCIKNGAYDYFIKTDKVDDLARTVRR
CCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHH
ALEVVGLERNYLRIKESFLSRTLSRPEVFNNILTCEPALLDQFRYLEAVALSPEPILIQG
HHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEC
ESGTGKDEFAKSCHQLICADAPFINVNLAGISTSAFELQLFGQLHTDDDGKVSAQAGVLH
CCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEEEEEECCCCCCEEHHHHHHH
QVKNGLLYLNEIGDLPIEAQAKLVDVIEHKQYYPIGSDRAYPILCKIITSTQHDLLALNQ
HHHCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHEEHHCCCHHHEECCC
AGKFRSDLLYRLRSHTIKLPPLRQRKLDLSMLINHFICLAAKEMGLSEPQQPSSLAQQLS
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
EYAFPGNLHELKGMVFDAVSRSDGIALNITPFMEAINLSKSNVTTDSDQLIFPKILPTLA
HHCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHH
QMSDALIQEALNRTANNQTAAAQMLGISQSALSRRITKEK
HHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCC
>Mature Secondary Structure
MKLARNILLVDDEASWLRTLSITLNRLVPEATIDTCVDSRQVMSRLQTGDYALVLLDLTM
CCCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
PFHSGEDLLEMIRKEFPKTRVIIVTGVNEVDTAVRCIKNGAYDYFIKTDKVDDLARTVRR
CCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHH
ALEVVGLERNYLRIKESFLSRTLSRPEVFNNILTCEPALLDQFRYLEAVALSPEPILIQG
HHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEC
ESGTGKDEFAKSCHQLICADAPFINVNLAGISTSAFELQLFGQLHTDDDGKVSAQAGVLH
CCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEEEEEECCCCCCEEHHHHHHH
QVKNGLLYLNEIGDLPIEAQAKLVDVIEHKQYYPIGSDRAYPILCKIITSTQHDLLALNQ
HHHCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHEEHHCCCHHHEECCC
AGKFRSDLLYRLRSHTIKLPPLRQRKLDLSMLINHFICLAAKEMGLSEPQQPSSLAQQLS
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
EYAFPGNLHELKGMVFDAVSRSDGIALNITPFMEAINLSKSNVTTDSDQLIFPKILPTLA
HHCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHH
QMSDALIQEALNRTANNQTAAAQMLGISQSALSRRITKEK
HHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]