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The map label for this gene is napA [H]

Identifier: 157960435

GI number: 157960435

Start: 748187

End: 749431

Strand: Reverse

Name: napA [H]

Synonym: Spea_0606

Alternate gene names: 157960435

Gene position: 749431-748187 (Counterclockwise)

Preceding gene: 157960436

Following gene: 157960433

Centisome position: 14.48

GC content: 47.63

Gene sequence:

>1245_bases
ATGCGCTTTCTATATTTAGTTCTTGTATTACTTACAGTTACCAGAATATTTGCAATTCTAGCCAAACGCTTAAACTTACC
GCCGATAGTGGGGGAATTAGTGTCGGGGATCGCGCTAGGGCTATTTCTGCACCGCTTTCAAGACTCATTTCCCCTGCTAT
GGCAGGTAACCCAAGGTGAAGCGTTTGAGGCGCTGGCCGATCTGGGGATGTTTTTCCTTATGCTACTCGCAGGTGTGCGC
ATGAGTCCCTTGGATTTTAAAAAGACCTCAGGTTCAGCACCCGCTGTGGCTATCGGTGGCATGTTAGTGCCAATTATTGC
AGGCACTATAATTGGACTGATGCTGTTTCCTGAATCCCCCTTCAAGACAATTCAGAGCTGGTTCTTAGGTACCGCCTTAG
CCGTTACTGCCGTACCGGTAACCATTCGTATGCTGATGGAGTTTAATCGCTTAGATACAGAAGAAGGGAGGACTATTATC
GCCGCAGCACTTTGGGACGACTTGTTAAGTCTATTTATCCTCGCACTGTTATTAGCTGCAATAAGCAATGGTGGAACGCT
CTCTTTTTCCTTTGACTTATGGGGGACCCTGTTGGCTAAGGTGCTACTGTTTTTCGCTATTACCATCCCAGCCGGTTATT
ACTTGTTTCCCCTTGTAGGTCGTTACCTCAAACTCACAAATATTCCTGATATCGATTTTAGTATGTTGTTAATCGCCTCT
CTAGCATACGCTGTACTCGCAGAAGTATTGGGGCTGCATTTCATTATTGGTGCCTTTGTCGCAGGTATGTTCTTTCACCC
CGCCGTAGTGGAGCAAGAGATCTATGACCGAGTAGAGGGGCAAACATCAGGTATTACATCGGGTTTCCTTGCGCCGATTT
TTTTCGTATCGATAGGCTTTCACCTCAACTTAACCGCTCTTATCTCTATTCCAGGCTTTGTCGCGCTACTCGTTACCGTT
GCCTTACTCAGTAAGCTTATTGGCGCCGGATTCTGTGCCCGCGCTACAGGGCATAGTACTCAAGAGTCTCTGCGGATCGG
AGTCGCGATGAGTGGCCGAGGGGCTGTAGAGATAGTATTGGCAGGCGTTGCATTGCAGGCAGGACTCTTCAACCACCCTG
ATCCTACGCCGCCTATTATAGCCGGGCTATTTTCCGCCATAGTGATCATGGCAATAGCGACCAGTATTATTACCCCGCTG
CTATTAGCCTTTTTAATTCGCCTTCACGGGGTCGATAAACAATAA

Upstream 100 bases:

>100_bases
CTGGCCCATCACATTCAAACTTTGATACCTGTCAAATATTAGACTTTATACAAGCTCACAACTATTCTCATACTAGTCAA
CCAGAGGGTTGGGAATACAG

Downstream 100 bases:

>100_bases
ATTCCAGACAAAAAAATACCCACACGAGGTGGGTATTTTAAGCCGGTTAATTCCTATCGCCTTAGTTTAGGCTAATAGTG
AAGTGTCTAAGCAACTGGCG

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MRFLYLVLVLLTVTRIFAILAKRLNLPPIVGELVSGIALGLFLHRFQDSFPLLWQVTQGEAFEALADLGMFFLMLLAGVR
MSPLDFKKTSGSAPAVAIGGMLVPIIAGTIIGLMLFPESPFKTIQSWFLGTALAVTAVPVTIRMLMEFNRLDTEEGRTII
AAALWDDLLSLFILALLLAAISNGGTLSFSFDLWGTLLAKVLLFFAITIPAGYYLFPLVGRYLKLTNIPDIDFSMLLIAS
LAYAVLAEVLGLHFIIGAFVAGMFFHPAVVEQEIYDRVEGQTSGITSGFLAPIFFVSIGFHLNLTALISIPGFVALLVTV
ALLSKLIGAGFCARATGHSTQESLRIGVAMSGRGAVEIVLAGVALQAGLFNHPDPTPPIIAGLFSAIVIMAIATSIITPL
LLAFLIRLHGVDKQ

Sequences:

>Translated_414_residues
MRFLYLVLVLLTVTRIFAILAKRLNLPPIVGELVSGIALGLFLHRFQDSFPLLWQVTQGEAFEALADLGMFFLMLLAGVR
MSPLDFKKTSGSAPAVAIGGMLVPIIAGTIIGLMLFPESPFKTIQSWFLGTALAVTAVPVTIRMLMEFNRLDTEEGRTII
AAALWDDLLSLFILALLLAAISNGGTLSFSFDLWGTLLAKVLLFFAITIPAGYYLFPLVGRYLKLTNIPDIDFSMLLIAS
LAYAVLAEVLGLHFIIGAFVAGMFFHPAVVEQEIYDRVEGQTSGITSGFLAPIFFVSIGFHLNLTALISIPGFVALLVTV
ALLSKLIGAGFCARATGHSTQESLRIGVAMSGRGAVEIVLAGVALQAGLFNHPDPTPPIIAGLFSAIVIMAIATSIITPL
LLAFLIRLHGVDKQ
>Mature_414_residues
MRFLYLVLVLLTVTRIFAILAKRLNLPPIVGELVSGIALGLFLHRFQDSFPLLWQVTQGEAFEALADLGMFFLMLLAGVR
MSPLDFKKTSGSAPAVAIGGMLVPIIAGTIIGLMLFPESPFKTIQSWFLGTALAVTAVPVTIRMLMEFNRLDTEEGRTII
AAALWDDLLSLFILALLLAAISNGGTLSFSFDLWGTLLAKVLLFFAITIPAGYYLFPLVGRYLKLTNIPDIDFSMLLIAS
LAYAVLAEVLGLHFIIGAFVAGMFFHPAVVEQEIYDRVEGQTSGITSGFLAPIFFVSIGFHLNLTALISIPGFVALLVTV
ALLSKLIGAGFCARATGHSTQESLRIGVAMSGRGAVEIVLAGVALQAGLFNHPDPTPPIIAGLFSAIVIMAIATSIITPL
LLAFLIRLHGVDKQ

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=399, Percent_Identity=27.0676691729323, Blast_Score=78, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6322367, Length=416, Percent_Identity=25.2403846153846, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 44421; Mature: 44421

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFLYLVLVLLTVTRIFAILAKRLNLPPIVGELVSGIALGLFLHRFQDSFPLLWQVTQGE
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCH
AFEALADLGMFFLMLLAGVRMSPLDFKKTSGSAPAVAIGGMLVPIIAGTIIGLMLFPESP
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
FKTIQSWFLGTALAVTAVPVTIRMLMEFNRLDTEEGRTIIAAALWDDLLSLFILALLLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
ISNGGTLSFSFDLWGTLLAKVLLFFAITIPAGYYLFPLVGRYLKLTNIPDIDFSMLLIAS
HCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LAYAVLAEVLGLHFIIGAFVAGMFFHPAVVEQEIYDRVEGQTSGITSGFLAPIFFVSIGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
HLNLTALISIPGFVALLVTVALLSKLIGAGFCARATGHSTQESLRIGVAMSGRGAVEIVL
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHEEEEEECCCCHHHHHH
AGVALQAGLFNHPDPTPPIIAGLFSAIVIMAIATSIITPLLLAFLIRLHGVDKQ
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRFLYLVLVLLTVTRIFAILAKRLNLPPIVGELVSGIALGLFLHRFQDSFPLLWQVTQGE
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCH
AFEALADLGMFFLMLLAGVRMSPLDFKKTSGSAPAVAIGGMLVPIIAGTIIGLMLFPESP
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
FKTIQSWFLGTALAVTAVPVTIRMLMEFNRLDTEEGRTIIAAALWDDLLSLFILALLLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
ISNGGTLSFSFDLWGTLLAKVLLFFAITIPAGYYLFPLVGRYLKLTNIPDIDFSMLLIAS
HCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LAYAVLAEVLGLHFIIGAFVAGMFFHPAVVEQEIYDRVEGQTSGITSGFLAPIFFVSIGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
HLNLTALISIPGFVALLVTVALLSKLIGAGFCARATGHSTQESLRIGVAMSGRGAVEIVL
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHEEEEEECCCCHHHHHH
AGVALQAGLFNHPDPTPPIIAGLFSAIVIMAIATSIITPLLLAFLIRLHGVDKQ
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]