Click here to switch to the map view.

The map label for this gene is hemC

Identifier: 157825828

GI number: 157825828

Start: 684699

End: 685604

Strand: Direct

Name: hemC

Synonym: A1C_03825

Alternate gene names: 157825828

Gene position: 684699-685604 (Clockwise)

Preceding gene: 157825827

Following gene: 157825833

Centisome position: 55.62

GC content: 34.77

Gene sequence:

>906_bases
ATGATAAATTCTATCAGAATAGGTACAAGAAACAGTCCACTTGCTTTAATACAAACTAATTTAGTGATTCAGCAAATCAA
ACAATTTTTTCCTGATATTAATTGTGCAATAGTACCTATTATTACTAGCGGTGATTTAATCCAAAATAAACCATTATACG
ATATAGGAGGTAAAGCTTTATTTTTAAAGGAAATAGAGCAAGCCTTGCTTGATAAAAAAATTGACTTAGCCGTTCATTCT
TTGAAAGACGTACCGGGTAGAATACCTGAAGAGCTAGTAATTTCCGCTGTTTTAGAGCGTGAAGACCCAAGAGATGTTTT
TGTATGTTTAAATTATAAATCCATAAAAGAACTGCCGCAACATTCCGTAATAGGTAGCTCGGCAGTCCGAAGAAAAGCAT
TTATCCAAAAAATAAGACCAGATTTAAAGGTAACAATTTTTAGAGGGAATGTTGATTCAAGAATAAAAAAGCTAATGACC
GGCGAAGTTGATGCAACAATTTTAGCATATGCGGGTCTGAAAAGGCTTGGAGCGTTTAATCCAGAATATTGTCATTTGAT
AGAATATTCGCATATGTTGCCGTGTGTAGGGCAGGGAGTCATTGCAGTTGAGATACGACAAAATGATAATTCTATGCTTG
AGATATGTAACCAAATTAATCATCTGCCTACCTGTGAACTAATAAAACCCGAAAGAGCGTTTTTAGAATATCTAGATGCT
AATTGCCGTACACCGATTGGTACTTACTCACAATATCTAGATGCGGATAATATACAAACCGATTTTATGCTTGGTAACCC
CGATTGCAGTAAAATAACCTTCCACACTGAAATTACCAATATCAAAACTTCAAAAGAAGGTGGCATCAAAGCCGCTAAAA
TGATGTTGAATCAACTGAAAAAATGA

Upstream 100 bases:

>100_bases
CTGATAGAACATGGCATGGAGGAAGTAATTATAAACATGAAGTAATTATAAACAGTAATATTTTAAGTTTTACTAGCCCT
TTTGAAATAGTAGAAAACAA

Downstream 100 bases:

>100_bases
TTTAAATAATTGTTCTATAATCTATATTATGGAAAATCAATGATAATAATGAAATGGTGCATTCGATTGGATTTGAACCA
ACGACCTTTGCCTTCGGAGG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MINSIRIGTRNSPLALIQTNLVIQQIKQFFPDINCAIVPIITSGDLIQNKPLYDIGGKALFLKEIEQALLDKKIDLAVHS
LKDVPGRIPEELVISAVLEREDPRDVFVCLNYKSIKELPQHSVIGSSAVRRKAFIQKIRPDLKVTIFRGNVDSRIKKLMT
GEVDATILAYAGLKRLGAFNPEYCHLIEYSHMLPCVGQGVIAVEIRQNDNSMLEICNQINHLPTCELIKPERAFLEYLDA
NCRTPIGTYSQYLDADNIQTDFMLGNPDCSKITFHTEITNIKTSKEGGIKAAKMMLNQLKK

Sequences:

>Translated_301_residues
MINSIRIGTRNSPLALIQTNLVIQQIKQFFPDINCAIVPIITSGDLIQNKPLYDIGGKALFLKEIEQALLDKKIDLAVHS
LKDVPGRIPEELVISAVLEREDPRDVFVCLNYKSIKELPQHSVIGSSAVRRKAFIQKIRPDLKVTIFRGNVDSRIKKLMT
GEVDATILAYAGLKRLGAFNPEYCHLIEYSHMLPCVGQGVIAVEIRQNDNSMLEICNQINHLPTCELIKPERAFLEYLDA
NCRTPIGTYSQYLDADNIQTDFMLGNPDCSKITFHTEITNIKTSKEGGIKAAKMMLNQLKK
>Mature_301_residues
MINSIRIGTRNSPLALIQTNLVIQQIKQFFPDINCAIVPIITSGDLIQNKPLYDIGGKALFLKEIEQALLDKKIDLAVHS
LKDVPGRIPEELVISAVLEREDPRDVFVCLNYKSIKELPQHSVIGSSAVRRKAFIQKIRPDLKVTIFRGNVDSRIKKLMT
GEVDATILAYAGLKRLGAFNPEYCHLIEYSHMLPCVGQGVIAVEIRQNDNSMLEICNQINHLPTCELIKPERAFLEYLDA
NCRTPIGTYSQYLDADNIQTDFMLGNPDCSKITFHTEITNIKTSKEGGIKAAKMMLNQLKK

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=262, Percent_Identity=37.7862595419847, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI66933009, Length=262, Percent_Identity=37.7862595419847, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI48994974, Length=302, Percent_Identity=41.0596026490066, Blast_Score=231, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6319996, Length=259, Percent_Identity=39.3822393822394, Blast_Score=179, Evalue=5e-46,
Organism=Drosophila melanogaster, GI20130425, Length=251, Percent_Identity=41.0358565737052, Blast_Score=176, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_RICAH (A8GNR5)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001493548.1
- ProteinModelPortal:   A8GNR5
- SMR:   A8GNR5
- STRING:   A8GNR5
- GeneID:   5644947
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_03825
- NMPDR:   fig|293614.3.peg.714
- eggNOG:   COG0181
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- ProtClustDB:   PRK00072
- BioCyc:   RAKA293614:A1C_03825-MONOMER
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 33807; Mature: 33807

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINSIRIGTRNSPLALIQTNLVIQQIKQFFPDINCAIVPIITSGDLIQNKPLYDIGGKAL
CCCCEECCCCCCCEEEHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCH
FLKEIEQALLDKKIDLAVHSLKDVPGRIPEELVISAVLEREDPRDVFVCLNYKSIKELPQ
HHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECHHHHHHCCH
HSVIGSSAVRRKAFIQKIRPDLKVTIFRGNVDSRIKKLMTGEVDATILAYAGLKRLGAFN
HHHHCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
PEYCHLIEYSHMLPCVGQGVIAVEIRQNDNSMLEICNQINHLPTCELIKPERAFLEYLDA
CCHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCCCCEECHHHHHHHHHCC
NCRTPIGTYSQYLDADNIQTDFMLGNPDCSKITFHTEITNIKTSKEGGIKAAKMMLNQLK
CCCCCCCHHHHHCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHC
K
C
>Mature Secondary Structure
MINSIRIGTRNSPLALIQTNLVIQQIKQFFPDINCAIVPIITSGDLIQNKPLYDIGGKAL
CCCCEECCCCCCCEEEHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCH
FLKEIEQALLDKKIDLAVHSLKDVPGRIPEELVISAVLEREDPRDVFVCLNYKSIKELPQ
HHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECHHHHHHCCH
HSVIGSSAVRRKAFIQKIRPDLKVTIFRGNVDSRIKKLMTGEVDATILAYAGLKRLGAFN
HHHHCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
PEYCHLIEYSHMLPCVGQGVIAVEIRQNDNSMLEICNQINHLPTCELIKPERAFLEYLDA
CCHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCCCCEECHHHHHHHHHCC
NCRTPIGTYSQYLDADNIQTDFMLGNPDCSKITFHTEITNIKTSKEGGIKAAKMMLNQLK
CCCCCCCHHHHHCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA