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The map label for this gene is envZ [H]

Identifier: 157825711

GI number: 157825711

Start: 579911

End: 581173

Strand: Reverse

Name: envZ [H]

Synonym: A1C_03185

Alternate gene names: 157825711

Gene position: 581173-579911 (Counterclockwise)

Preceding gene: 157825712

Following gene: 157825710

Centisome position: 47.21

GC content: 26.68

Gene sequence:

>1263_bases
ATGTTTATTATAATCATTCCGATTTTAATAGGACAAATCGTTGCTATATTCTTGTTTTACGATCGTCATTGGTATAATGT
TTCATATTATACTAGTACTATTATTATCAATGAAATAGAATCACTGATTAAAGAACATAGAAATAATTCAAGAAAGATAA
CCCATTTATCTGAAAATTATCTTAATTTATCTTATCAATTTCAGCTTAATAAAAAGTTATCTATAAAACAACCTAAATTA
AGTGAGCCTCTAACTATATTTAAAAATATTTTGGCTACAAAAATCCATGAAAAAAATATAGTTAAGCTGAATAAGGAAAA
TAAAATTGAAGTATTTTTAGAATTAAAGGATGGAATAATATTATACATTACTTTTCCTGCAAAATTACTACTTAATCCTA
CGGTATATATATTTGTTTTATGGATTATATCTTTAACTGTTATATTACTTTCTGTTTCTATTATTTTTTCCAAAAATCAA
ATTAAATCAATACTCAATCTTGCGGATAGCATGGATAAATTTGGTCGAGGTGTTTTAAAAGGCAAAATTTTTAAACCTTC
AGGAGCTTTAGAAATAAGAAAAGCAGGACTTGCTTTTTTAAAAATGAAAGCTCGTATTGAAAAACAAATTACTAAAAGAA
CCACTATGCTTGCTATGATTTCTCATGATCTTAGAACTCCTTTAACAAGAATGAAACTACAACTTGAATTAATGGAAGAA
AGCGAAGAAATTGAAGGGTTAAAACAAGATATATTAACTATGCAGCAAATGATAAATTCTTATTTAGATTTTGCTAAAGG
TGAAAGTACAGAAGAATTTGAAGAAATTTTGTTATTACCTTGGATAGAACATTTTTTAGACAAAAAATGGTCACATGTAG
ATATTGAATTTATAAAACTTAATAATATAGATAATTCAAAAGTACGAATTAAACCGAATTCTTTTGAAAGAGCCTTGTCT
AATTTAATCGGTAACGCTATAAAATATGGAACTAAAATTAAAATATCTTTGGCAGATAATCCATCTACCGTAGCTATAAT
TATTGAGGATAACGGTATCGGTATAGATGATACAGAAAAACATCTTGTATTTAAACCGTTTTATAGATCAGATAAAGCAA
GGCAGCTTGATAATGCAAGTAATGTAGGACTTGGGCTTGCTATTACTCAAGAAATAATAAACGATTATAAAGGCTCTATT
TATTTAGAAGATAGCAAAGATTTAGGCGGGCTATCGGTAAGAATTGAAATACCTAGAATATGA

Upstream 100 bases:

>100_bases
AGCAGGCTTATTGAGCCATACAGACAATGCAAATTACGTATACACATTACATATGAGCTTTATATCTAAATTATTACCGA
GAACATTATTTGTACGGTTT

Downstream 100 bases:

>100_bases
CTGCCGATGTCATTCCCGCATAGATACCAAATCGTCATTACGAAAAGAATTACGTAGTAATTCGACGAAGCAATCCAGTA
AAAAATTCTGATTTACAGAA

Product: osmolarity sensor protein EnvZ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MFIIIIPILIGQIVAIFLFYDRHWYNVSYYTSTIIINEIESLIKEHRNNSRKITHLSENYLNLSYQFQLNKKLSIKQPKL
SEPLTIFKNILATKIHEKNIVKLNKENKIEVFLELKDGIILYITFPAKLLLNPTVYIFVLWIISLTVILLSVSIIFSKNQ
IKSILNLADSMDKFGRGVLKGKIFKPSGALEIRKAGLAFLKMKARIEKQITKRTTMLAMISHDLRTPLTRMKLQLELMEE
SEEIEGLKQDILTMQQMINSYLDFAKGESTEEFEEILLLPWIEHFLDKKWSHVDIEFIKLNNIDNSKVRIKPNSFERALS
NLIGNAIKYGTKIKISLADNPSTVAIIIEDNGIGIDDTEKHLVFKPFYRSDKARQLDNASNVGLGLAITQEIINDYKGSI
YLEDSKDLGGLSVRIEIPRI

Sequences:

>Translated_420_residues
MFIIIIPILIGQIVAIFLFYDRHWYNVSYYTSTIIINEIESLIKEHRNNSRKITHLSENYLNLSYQFQLNKKLSIKQPKL
SEPLTIFKNILATKIHEKNIVKLNKENKIEVFLELKDGIILYITFPAKLLLNPTVYIFVLWIISLTVILLSVSIIFSKNQ
IKSILNLADSMDKFGRGVLKGKIFKPSGALEIRKAGLAFLKMKARIEKQITKRTTMLAMISHDLRTPLTRMKLQLELMEE
SEEIEGLKQDILTMQQMINSYLDFAKGESTEEFEEILLLPWIEHFLDKKWSHVDIEFIKLNNIDNSKVRIKPNSFERALS
NLIGNAIKYGTKIKISLADNPSTVAIIIEDNGIGIDDTEKHLVFKPFYRSDKARQLDNASNVGLGLAITQEIINDYKGSI
YLEDSKDLGGLSVRIEIPRI
>Mature_420_residues
MFIIIIPILIGQIVAIFLFYDRHWYNVSYYTSTIIINEIESLIKEHRNNSRKITHLSENYLNLSYQFQLNKKLSIKQPKL
SEPLTIFKNILATKIHEKNIVKLNKENKIEVFLELKDGIILYITFPAKLLLNPTVYIFVLWIISLTVILLSVSIIFSKNQ
IKSILNLADSMDKFGRGVLKGKIFKPSGALEIRKAGLAFLKMKARIEKQITKRTTMLAMISHDLRTPLTRMKLQLELMEE
SEEIEGLKQDILTMQQMINSYLDFAKGESTEEFEEILLLPWIEHFLDKKWSHVDIEFIKLNNIDNSKVRIKPNSFERALS
NLIGNAIKYGTKIKISLADNPSTVAIIIEDNGIGIDDTEKHLVFKPFYRSDKARQLDNASNVGLGLAITQEIINDYKGSI
YLEDSKDLGGLSVRIEIPRI

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=308, Percent_Identity=29.5454545454545, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1790346, Length=273, Percent_Identity=30.4029304029304, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787894, Length=312, Percent_Identity=25.9615384615385, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082128, Length=303, Percent_Identity=26.4026402640264, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786783, Length=250, Percent_Identity=26.4, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=23.0769230769231, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=243, Percent_Identity=30.4526748971193, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786600, Length=213, Percent_Identity=28.169014084507, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789149, Length=244, Percent_Identity=27.0491803278689, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790551, Length=240, Percent_Identity=23.75, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788549, Length=211, Percent_Identity=25.5924170616114, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48330; Mature: 48330

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIIIIPILIGQIVAIFLFYDRHWYNVSYYTSTIIINEIESLIKEHRNNSRKITHLSENY
CEEEEEHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEECCC
LNLSYQFQLNKKLSIKQPKLSEPLTIFKNILATKIHEKNIVKLNKENKIEVFLELKDGII
EEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEECCCEE
LYITFPAKLLLNPTVYIFVLWIISLTVILLSVSIIFSKNQIKSILNLADSMDKFGRGVLK
EEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHC
GKIFKPSGALEIRKAGLAFLKMKARIEKQITKRTTMLAMISHDLRTPLTRMKLQLELMEE
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
SEEIEGLKQDILTMQQMINSYLDFAKGESTEEFEEILLLPWIEHFLDKKWSHVDIEFIKL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
NNIDNSKVRIKPNSFERALSNLIGNAIKYGTKIKISLADNPSTVAIIIEDNGIGIDDTEK
CCCCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCCCCCC
HLVFKPFYRSDKARQLDNASNVGLGLAITQEIINDYKGSIYLEDSKDLGGLSVRIEIPRI
CEEECCHHCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCC
>Mature Secondary Structure
MFIIIIPILIGQIVAIFLFYDRHWYNVSYYTSTIIINEIESLIKEHRNNSRKITHLSENY
CEEEEEHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEECCC
LNLSYQFQLNKKLSIKQPKLSEPLTIFKNILATKIHEKNIVKLNKENKIEVFLELKDGII
EEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEECCCEE
LYITFPAKLLLNPTVYIFVLWIISLTVILLSVSIIFSKNQIKSILNLADSMDKFGRGVLK
EEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHC
GKIFKPSGALEIRKAGLAFLKMKARIEKQITKRTTMLAMISHDLRTPLTRMKLQLELMEE
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
SEEIEGLKQDILTMQQMINSYLDFAKGESTEEFEEILLLPWIEHFLDKKWSHVDIEFIKL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
NNIDNSKVRIKPNSFERALSNLIGNAIKYGTKIKISLADNPSTVAIIIEDNGIGIDDTEK
CCCCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCCCCCC
HLVFKPFYRSDKARQLDNASNVGLGLAITQEIINDYKGSIYLEDSKDLGGLSVRIEIPRI
CEEECCHHCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]