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The map label for this gene is uppS [H]

Identifier: 157825710

GI number: 157825710

Start: 578998

End: 579678

Strand: Reverse

Name: uppS [H]

Synonym: A1C_03180

Alternate gene names: 157825710

Gene position: 579678-578998 (Counterclockwise)

Preceding gene: 157825711

Following gene: 157825709

Centisome position: 47.09

GC content: 30.54

Gene sequence:

>681_bases
ATGACTAACATAAAACATTTAGCAATAATAATGGACGGCAATGCTCGTTGGGCAGATTGGCATAACTTAACAAAATCTGA
AGGACATAAAGCAGGTGCCGATAAAATTCGTGAATTACTGCCTGAGGTTATTAACCTTAATATACCTTATATAACTTTAT
ATACTTTCTCTTCCGAAAATTGGCAACGCTCAAACACGGAGGTAGATTTCTTAATAAAATTATTAAGTATTTATTTAAAA
AATGAATTAAACAGTTTACATAAAAACGGCGTTAAAATAAAAGTAATAGGTAGACTGAATTTATTAAGTAGCTCATTGCA
AAAACAAATAAATAATGCTATAGAATTAACAGAAAATAATAATAAAATAACACTTTGTATAGCTTTTAGTTATGGAAGTC
GCCAAGAAATAGTTGATGCATGCACAAAAATTATTGCAAGCGGTAAAAAAGAAGTAAGTGAAAGTGATATACAACATGCT
TTATATGATCCAGAAATGCCGGATGTAGATTTATTAATAAGAGCGGGCGGGGTTTATCGCATCAGTAATTTCTTGCTTTG
GCAGGCAGCTTATGCTGAATTATATTTCTCACCCAAATATTGGCCTGATTTTAATAAAGATGATATACTAGAAGCTATAA
ATGATTACTCAAAAAGGAAAAGAACATTTGGCAAAAGATAA

Upstream 100 bases:

>100_bases
GCTTCGCTCCTCGGAATGATGGTTTTAGTGTCCACGTAGCAGTACCCGCTCGCAATGACGGAAAAATTGATCCATACAGC
AACATCTAAAATATAAAATA

Downstream 100 bases:

>100_bases
ACAAAATATATACTTAAGAATCCTGTCCGGTGTAGTTTTAGTGCCGTTATTTGTTGTAGCTATATTATGGTTTAAGCCTT
TATTTTATATTCTAATGATA

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MTNIKHLAIIMDGNARWADWHNLTKSEGHKAGADKIRELLPEVINLNIPYITLYTFSSENWQRSNTEVDFLIKLLSIYLK
NELNSLHKNGVKIKVIGRLNLLSSSLQKQINNAIELTENNNKITLCIAFSYGSRQEIVDACTKIIASGKKEVSESDIQHA
LYDPEMPDVDLLIRAGGVYRISNFLLWQAAYAELYFSPKYWPDFNKDDILEAINDYSKRKRTFGKR

Sequences:

>Translated_226_residues
MTNIKHLAIIMDGNARWADWHNLTKSEGHKAGADKIRELLPEVINLNIPYITLYTFSSENWQRSNTEVDFLIKLLSIYLK
NELNSLHKNGVKIKVIGRLNLLSSSLQKQINNAIELTENNNKITLCIAFSYGSRQEIVDACTKIIASGKKEVSESDIQHA
LYDPEMPDVDLLIRAGGVYRISNFLLWQAAYAELYFSPKYWPDFNKDDILEAINDYSKRKRTFGKR
>Mature_225_residues
TNIKHLAIIMDGNARWADWHNLTKSEGHKAGADKIRELLPEVINLNIPYITLYTFSSENWQRSNTEVDFLIKLLSIYLKN
ELNSLHKNGVKIKVIGRLNLLSSSLQKQINNAIELTENNNKITLCIAFSYGSRQEIVDACTKIIASGKKEVSESDIQHAL
YDPEMPDVDLLIRAGGVYRISNFLLWQAAYAELYFSPKYWPDFNKDDILEAINDYSKRKRTFGKR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=222, Percent_Identity=39.6396396396396, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI45580738, Length=222, Percent_Identity=39.6396396396396, Blast_Score=154, Evalue=8e-38,
Organism=Escherichia coli, GI1786371, Length=232, Percent_Identity=41.8103448275862, Blast_Score=184, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71993029, Length=234, Percent_Identity=32.4786324786325, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319474, Length=210, Percent_Identity=37.6190476190476, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=213, Percent_Identity=30.9859154929577, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18857969, Length=221, Percent_Identity=35.7466063348416, Blast_Score=142, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 25969; Mature: 25838

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIKHLAIIMDGNARWADWHNLTKSEGHKAGADKIRELLPEVINLNIPYITLYTFSSEN
CCCCEEEEEEECCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCC
WQRSNTEVDFLIKLLSIYLKNELNSLHKNGVKIKVIGRLNLLSSSLQKQINNAIELTENN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHEEEEECC
NKITLCIAFSYGSRQEIVDACTKIIASGKKEVSESDIQHALYDPEMPDVDLLIRAGGVYR
CEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHH
ISNFLLWQAAYAELYFSPKYWPDFNKDDILEAINDYSKRKRTFGKR
HHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TNIKHLAIIMDGNARWADWHNLTKSEGHKAGADKIRELLPEVINLNIPYITLYTFSSEN
CCCEEEEEEECCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCC
WQRSNTEVDFLIKLLSIYLKNELNSLHKNGVKIKVIGRLNLLSSSLQKQINNAIELTENN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHEEEEECC
NKITLCIAFSYGSRQEIVDACTKIIASGKKEVSESDIQHALYDPEMPDVDLLIRAGGVYR
CEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHH
ISNFLLWQAAYAELYFSPKYWPDFNKDDILEAINDYSKRKRTFGKR
HHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]