Click here to switch to the map view.

The map label for this gene is folE

Identifier: 157825652

GI number: 157825652

Start: 520423

End: 520995

Strand: Direct

Name: folE

Synonym: A1C_02870

Alternate gene names: 157825652

Gene position: 520423-520995 (Clockwise)

Preceding gene: 157825651

Following gene: 157825653

Centisome position: 42.27

GC content: 36.47

Gene sequence:

>573_bases
ATGAGTAAACCAACTAGAGAAGAAGCTACAGAGGCAGTAAGAACGTTACTAAAATTCATTGGTGAAGATCCAACTAGGGA
AGGGCTACTTAAAACACCTGATAGAGTAATTAACAGCTATACGGAAATATTTTCCGGTTATGGAAAGGATGTAGAGGAAA
TATTAAATACAAAATTTTACGATACTTGTAATTTTCAGGACTTTATCTCACTAGAAGGCATAAAATTTACCTCTTTTTGC
GAACATCATATGTTACCTTTTAACGGTACGGTACACATAGCTTATATTCCTGATAACTGTATTGTCGGCATAAGCAAGTT
AGCACGAATAGTAAATATTTTTGCTAAAAGGCTGCAAATTCAAGAAAAAATGACGGTACAAATAGCAGAAAGCGTACAGG
AGAATTTAAAGCCGCTTGGCGTTGCCGTTAAGATTGCTGCCTTGCATAGTTGTATGTCTATGCGTGGAGTGATGCAGGAT
CATAGCATAATGAATACCATGCATTATACGGGTATATTTGCCGAGCAGCAGAAATATCGCCATGAGTTTTTGAATCTTAC
CACGAAAAGATAA

Upstream 100 bases:

>100_bases
GGAATGATGGGCGGAGGAGGGCTTATTGCTATAGTAGGCGGCTTGATGTTTGTGTATATCTGTGTTAGAGTAATGTTTTT
TAAAAGTATAAAACTAGAAC

Downstream 100 bases:

>100_bases
GTGTATTTCTATGTTATTATCACAATATTTTTTACCTGTTTTAAAAGAAGAACCAAGTGAAGCTCAAGTAACTTCGCATA
AATTAATGCTTAGAAGCGGA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MSKPTREEATEAVRTLLKFIGEDPTREGLLKTPDRVINSYTEIFSGYGKDVEEILNTKFYDTCNFQDFISLEGIKFTSFC
EHHMLPFNGTVHIAYIPDNCIVGISKLARIVNIFAKRLQIQEKMTVQIAESVQENLKPLGVAVKIAALHSCMSMRGVMQD
HSIMNTMHYTGIFAEQQKYRHEFLNLTTKR

Sequences:

>Translated_190_residues
MSKPTREEATEAVRTLLKFIGEDPTREGLLKTPDRVINSYTEIFSGYGKDVEEILNTKFYDTCNFQDFISLEGIKFTSFC
EHHMLPFNGTVHIAYIPDNCIVGISKLARIVNIFAKRLQIQEKMTVQIAESVQENLKPLGVAVKIAALHSCMSMRGVMQD
HSIMNTMHYTGIFAEQQKYRHEFLNLTTKR
>Mature_189_residues
SKPTREEATEAVRTLLKFIGEDPTREGLLKTPDRVINSYTEIFSGYGKDVEEILNTKFYDTCNFQDFISLEGIKFTSFCE
HHMLPFNGTVHIAYIPDNCIVGISKLARIVNIFAKRLQIQEKMTVQIAESVQENLKPLGVAVKIAALHSCMSMRGVMQDH
SIMNTMHYTGIFAEQQKYRHEFLNLTTKR

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family

Homologues:

Organism=Homo sapiens, GI66932968, Length=192, Percent_Identity=41.1458333333333, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI4503949, Length=192, Percent_Identity=41.1458333333333, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI66932970, Length=163, Percent_Identity=38.6503067484663, Blast_Score=126, Evalue=9e-30,
Organism=Homo sapiens, GI66932972, Length=136, Percent_Identity=41.9117647058824, Blast_Score=125, Evalue=3e-29,
Organism=Escherichia coli, GI1788476, Length=171, Percent_Identity=35.672514619883, Blast_Score=108, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17560486, Length=179, Percent_Identity=43.0167597765363, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6321706, Length=180, Percent_Identity=40, Blast_Score=139, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24656782, Length=191, Percent_Identity=42.4083769633508, Blast_Score=152, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24656796, Length=191, Percent_Identity=42.4083769633508, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24656791, Length=191, Percent_Identity=42.4083769633508, Blast_Score=152, Evalue=1e-37,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): GCH1_RICAH (A8GN89)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001493372.1
- ProteinModelPortal:   A8GN89
- SMR:   A8GN89
- STRING:   A8GN89
- GeneID:   5645827
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_02870
- NMPDR:   fig|293614.3.peg.533
- eggNOG:   COG0302
- HOGENOM:   HBG370191
- OMA:   CEHHMIP
- ProtClustDB:   PRK09347
- BioCyc:   RAKA293614:A1C_02870-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00223
- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234
- TIGRFAMs:   TIGR00063

Pfam domain/function: PF01227 GTP_cyclohydroI

EC number: =3.5.4.16

Molecular weight: Translated: 21754; Mature: 21623

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPTREEATEAVRTLLKFIGEDPTREGLLKTPDRVINSYTEIFSGYGKDVEEILNTKFY
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCC
DTCNFQDFISLEGIKFTSFCEHHMLPFNGTVHIAYIPDNCIVGISKLARIVNIFAKRLQI
CCCCCHHHHHCCCCCHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
QEKMTVQIAESVQENLKPLGVAVKIAALHSCMSMRGVMQDHSIMNTMHYTGIFAEQQKYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HEFLNLTTKR
HHHHHHCCCC
>Mature Secondary Structure 
SKPTREEATEAVRTLLKFIGEDPTREGLLKTPDRVINSYTEIFSGYGKDVEEILNTKFY
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCC
DTCNFQDFISLEGIKFTSFCEHHMLPFNGTVHIAYIPDNCIVGISKLARIVNIFAKRLQI
CCCCCHHHHHCCCCCHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
QEKMTVQIAESVQENLKPLGVAVKIAALHSCMSMRGVMQDHSIMNTMHYTGIFAEQQKYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HEFLNLTTKR
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA