Click here to switch to the map view.

The map label for this gene is thyX [H]

Identifier: 157825541

GI number: 157825541

Start: 411948

End: 412832

Strand: Direct

Name: thyX [H]

Synonym: A1C_02260

Alternate gene names: 157825541

Gene position: 411948-412832 (Clockwise)

Preceding gene: 157825540

Following gene: 157825542

Centisome position: 33.46

GC content: 36.72

Gene sequence:

>885_bases
ATGCACAACACCACGAAAAGAGTAACAGTTCCGGCACTTGAAGAAATCTTATACGAGCCTATAAAAGTGTTAGATCATGG
CTTTATTAGAGTGATCGACTATATGGGGGATGATAGTGCTATAGTACAAGCGGCTCGTGTTTCTTACGGTAAGGGTACGA
AGCAGTTGAACCAAGATAAAGGGCTGATAAACTATTTGCTTCGTCATTATCATACCACTCCTTTTGAGATGTGTGATATC
AAGTTCCATATTAAACTACCAATATTTATTGCAAGACAATGGGTTAGGCATAGAACAGCTAGTGTTAACGAATATTCGGC
AAGGTACTCTATTTTAGGCAACGAATTTTATTTACCAGAACCGGCAAATATTGCTTCCCAATCTGTCGTAAATAAACAAT
GTAGAGAATGTGATAGCTTACCGAAAGAAGTGGCCGAAAAGGTCCTTGCAATCTTAGAGGAAGATGCTAGACAGTGCTAC
GTGCATTATAAGGAGCTGATGAATGCTGATGAAGATGGTAATATGATAGATGAGAATACCACCGGAATAGCAAGAGAGCT
TGCTCGTATGAATTTAACTTTAAATTATTATACGGAATGGTATTGGAAAATTAATTTACATAATTTGCTTCATTTCTTAA
GATTGCGTGCTGACACTCACGCACAATATGAAATTAGAGTTTATGCCGAAAAAATGCTTGAGATAGTCAAAGCTTGGGTT
CCTTTTACTTACGAAGCTTTTGAAGAATATCGTTTGCGAGGAGCAAATATTTCACGTAAAGGTTTATGCGTAATTAAAAG
AATGATAAACGGTGAACAAGTGACTCATAAGAGTAGTGGTATGACTAAAAGAGAGTGGGAAGAATTAATGAAGATATTTT
GTTAG

Upstream 100 bases:

>100_bases
ACATAGATTATTTTAGGAAGTTGATGAAAAAAAATAAAAGAATAAAAGTATTAAAAATGTGAAATCATTATTATGATAAT
TAAAGAATACAGAGGATAGA

Downstream 100 bases:

>100_bases
TTCTATGTCACTCCCGCGTAGGCGGGAATCCACTGCTTTCCTTTGTGTCATCCAATGATTTATTCACGGGGTGACAACAA
AAAATTTGGATTTCTGCTCC

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MHNTTKRVTVPALEEILYEPIKVLDHGFIRVIDYMGDDSAIVQAARVSYGKGTKQLNQDKGLINYLLRHYHTTPFEMCDI
KFHIKLPIFIARQWVRHRTASVNEYSARYSILGNEFYLPEPANIASQSVVNKQCRECDSLPKEVAEKVLAILEEDARQCY
VHYKELMNADEDGNMIDENTTGIARELARMNLTLNYYTEWYWKINLHNLLHFLRLRADTHAQYEIRVYAEKMLEIVKAWV
PFTYEAFEEYRLRGANISRKGLCVIKRMINGEQVTHKSSGMTKREWEELMKIFC

Sequences:

>Translated_294_residues
MHNTTKRVTVPALEEILYEPIKVLDHGFIRVIDYMGDDSAIVQAARVSYGKGTKQLNQDKGLINYLLRHYHTTPFEMCDI
KFHIKLPIFIARQWVRHRTASVNEYSARYSILGNEFYLPEPANIASQSVVNKQCRECDSLPKEVAEKVLAILEEDARQCY
VHYKELMNADEDGNMIDENTTGIARELARMNLTLNYYTEWYWKINLHNLLHFLRLRADTHAQYEIRVYAEKMLEIVKAWV
PFTYEAFEEYRLRGANISRKGLCVIKRMINGEQVTHKSSGMTKREWEELMKIFC
>Mature_294_residues
MHNTTKRVTVPALEEILYEPIKVLDHGFIRVIDYMGDDSAIVQAARVSYGKGTKQLNQDKGLINYLLRHYHTTPFEMCDI
KFHIKLPIFIARQWVRHRTASVNEYSARYSILGNEFYLPEPANIASQSVVNKQCRECDSLPKEVAEKVLAILEEDARQCY
VHYKELMNADEDGNMIDENTTGIARELARMNLTLNYYTEWYWKINLHNLLHFLRLRADTHAQYEIRVYAEKMLEIVKAWV
PFTYEAFEEYRLRGANISRKGLCVIKRMINGEQVTHKSSGMTKREWEELMKIFC

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 34537; Mature: 34537

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNTTKRVTVPALEEILYEPIKVLDHGFIRVIDYMGDDSAIVQAARVSYGKGTKQLNQDK
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCC
GLINYLLRHYHTTPFEMCDIKFHIKLPIFIARQWVRHRTASVNEYSARYSILGNEFYLPE
HHHHHHHHHHCCCCHHEEEEEEEEECHHHHHHHHHHHHHCCCHHHHHHHEEECCEEECCC
PANIASQSVVNKQCRECDSLPKEVAEKVLAILEEDARQCYVHYKELMNADEDGNMIDENT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
TGIARELARMNLTLNYYTEWYWKINLHNLLHFLRLRADTHAQYEIRVYAEKMLEIVKAWV
HHHHHHHHHHCCEEEEEEEEEEEEEHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHC
PFTYEAFEEYRLRGANISRKGLCVIKRMINGEQVTHKSSGMTKREWEELMKIFC
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MHNTTKRVTVPALEEILYEPIKVLDHGFIRVIDYMGDDSAIVQAARVSYGKGTKQLNQDK
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCC
GLINYLLRHYHTTPFEMCDIKFHIKLPIFIARQWVRHRTASVNEYSARYSILGNEFYLPE
HHHHHHHHHHCCCCHHEEEEEEEEECHHHHHHHHHHHHHCCCHHHHHHHEEECCEEECCC
PANIASQSVVNKQCRECDSLPKEVAEKVLAILEEDARQCYVHYKELMNADEDGNMIDENT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
TGIARELARMNLTLNYYTEWYWKINLHNLLHFLRLRADTHAQYEIRVYAEKMLEIVKAWV
HHHHHHHHHHCCEEEEEEEEEEEEEHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHC
PFTYEAFEEYRLRGANISRKGLCVIKRMINGEQVTHKSSGMTKREWEELMKIFC
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]