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The map label for this gene is typA [H]

Identifier: 157825478

GI number: 157825478

Start: 355762

End: 357591

Strand: Reverse

Name: typA [H]

Synonym: A1C_01895

Alternate gene names: 157825478

Gene position: 357591-355762 (Counterclockwise)

Preceding gene: 157825493

Following gene: 157825470

Centisome position: 29.05

GC content: 41.48

Gene sequence:

>1830_bases
ATGACACCTATTCGTAATATAGCAATTATTGCCCACGTTGATCATGGGAAAACTACCCTTGTTGATAATATGCTTAAACA
AAGCGGGACATTTAGGGCTAACCAAGCAGTAGCCGAGCGTGCTATGGACTCTAATGATCTTGAGCGTGAGCGTGGAATAA
CAATACTAGCCAAATGCACTGCTCTTATGTGGAACGATATCCGTATTAATATCGTTGATACACCTGGGCATGCTGATTTT
GGCGGTGAAGTAGAACGCATATTAAGTATGGTTGACGGTGTCGTGCTACTTGTCGACGCTTCTGAAGGACCAATGCCGCA
AACAAAATTCGTGCTTTCTAAAGCTTTAAAGCTCAACTTAAAACCTATCGTTGTTATTAATAAAATCGATAGAGACGACC
AAAGAATTAAAGAAGTTATCGAAGAAGTATTCGAGCTATTTGTTGCACTCGAGGCAAATAACGACCAGCTTGATTTCCCT
ATAGTCTATGCATCAGGTAGAGCAGGCAGAGCATCTTTAAACTTTGATGATAAAATAAATCCTTTAGATAATTTAGCAGA
TGATTTAGCTCCGCTTTTCGACCTAATAGTAACACATGTACCTACGCCTGCAGCCGATGATAAAGCACCGTTTTCTATGC
TTATTACTACTAGAGAATATAATTCTTTCTTTGGGAGAGTTCTAACAGGGCGTGTACAAAACGGCACTGTCAAAATCAAC
CAAAACATAAAAGTATTAAATCGTGAGAATAAAGTACTTGAAACCGGACGTATCACTAAAATATTAGCCTTTAGAGGCTT
AGAGAGAATCGCTATAGATGAGGCTATAGCTGGTGATATTATTGCCGTAGCAGGGGTGGAAAACGCCAATGTTGCCGATA
CTATCTGCTCACCTGAAGTAACCGAAGCTGTACCATCTCTACCTATTGACCCCCCAACTTTATCCATGACTTTTAGCGTT
AATGACTCACCGCTTGCAGGAAGTGAAGGGACAAAAGTTACATCAAGCTTGATTGGAGCGAGGTTAATGCGTGAGATTGA
GAGTAACGTGGCACTAAAAGTTACCGAAGCAGCTGAAAAAAATGCTTTCCAAGTTGCGGGACGAGGAGAATTACAGCTTG
GTATCTTAATCGAAACTATGCGTCGCGAAGGGTTTGAGTTATCTATAAGTAGACCCGAAGTATTATTCCAAACCGATGGG
AAAGGTAACAAGCAAGAACCTATGGAAGAAATCCAGGTTGACGTTGATGACGATTATGTTGGAGTGGTCGTAAAATCTTT
AGCACTTAGAAAAGCTGACATGACTGATATGAGACCATCAGGCGGCGGTAAAAGCCGTGTTACGTTTATCGGACCGTCTA
GAGGGTTAATCGGTTATCACAGCCAATTTTTAACCGAAACACGAGGCACGGGAATTATGAACCGTATTTTCCACGGATAC
GCTAATTATAAAGGAGCTATCGCGGGAAGACGTAACGGCGTGCTAATCTCTAACGGTGACGGGGCGGCGGTAGCATATGC
TCTATGGAATCTAGAAGAAAGGGGGAAAATGTTTATAAACCCTAGCGATAAAGTATATAGAGGTATGATTATCGGAGAAC
ATAACCGTGAGAATGATTTAGAGGTAAACCCACTAAAAGCAAGACAACTAAGCAACGTTAGAGCTTCCGGAAAAGACGAA
GCCATAAGACTAACGCCGCCAATGCTTTTAACTCTAGAGCAGGCAATTAGCTATATACAAGATGATGAAAGGGTTGAAGT
AACACCAAAATCTATTCGTTTACGTAAAGCTCTACTTGACCCTAACGACCGTAAAAGAGCTGCGAAGTAG

Upstream 100 bases:

>100_bases
TGCAGTTAAACCAATTTATTTTTCAAGAACTTGATTCTATTTTTTGGTATTTTAGTGTATAATACGGAATACTATTGTAC
ACTTGTGAGAGTTTTTAAAG

Downstream 100 bases:

>100_bases
CAAGACATTACTAGTGAAAAATGTAACCTTGTTGCAGCGATCCCACTGTCATTCCTGCGAAAGCGTGGAACTATATATTT
GATAAAATAAACCTAAAAAC

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: Tyrosine phosphorylated protein A [H]

Number of amino acids: Translated: 609; Mature: 608

Protein sequence:

>609_residues
MTPIRNIAIIAHVDHGKTTLVDNMLKQSGTFRANQAVAERAMDSNDLERERGITILAKCTALMWNDIRINIVDTPGHADF
GGEVERILSMVDGVVLLVDASEGPMPQTKFVLSKALKLNLKPIVVINKIDRDDQRIKEVIEEVFELFVALEANNDQLDFP
IVYASGRAGRASLNFDDKINPLDNLADDLAPLFDLIVTHVPTPAADDKAPFSMLITTREYNSFFGRVLTGRVQNGTVKIN
QNIKVLNRENKVLETGRITKILAFRGLERIAIDEAIAGDIIAVAGVENANVADTICSPEVTEAVPSLPIDPPTLSMTFSV
NDSPLAGSEGTKVTSSLIGARLMREIESNVALKVTEAAEKNAFQVAGRGELQLGILIETMRREGFELSISRPEVLFQTDG
KGNKQEPMEEIQVDVDDDYVGVVVKSLALRKADMTDMRPSGGGKSRVTFIGPSRGLIGYHSQFLTETRGTGIMNRIFHGY
ANYKGAIAGRRNGVLISNGDGAAVAYALWNLEERGKMFINPSDKVYRGMIIGEHNRENDLEVNPLKARQLSNVRASGKDE
AIRLTPPMLLTLEQAISYIQDDERVEVTPKSIRLRKALLDPNDRKRAAK

Sequences:

>Translated_609_residues
MTPIRNIAIIAHVDHGKTTLVDNMLKQSGTFRANQAVAERAMDSNDLERERGITILAKCTALMWNDIRINIVDTPGHADF
GGEVERILSMVDGVVLLVDASEGPMPQTKFVLSKALKLNLKPIVVINKIDRDDQRIKEVIEEVFELFVALEANNDQLDFP
IVYASGRAGRASLNFDDKINPLDNLADDLAPLFDLIVTHVPTPAADDKAPFSMLITTREYNSFFGRVLTGRVQNGTVKIN
QNIKVLNRENKVLETGRITKILAFRGLERIAIDEAIAGDIIAVAGVENANVADTICSPEVTEAVPSLPIDPPTLSMTFSV
NDSPLAGSEGTKVTSSLIGARLMREIESNVALKVTEAAEKNAFQVAGRGELQLGILIETMRREGFELSISRPEVLFQTDG
KGNKQEPMEEIQVDVDDDYVGVVVKSLALRKADMTDMRPSGGGKSRVTFIGPSRGLIGYHSQFLTETRGTGIMNRIFHGY
ANYKGAIAGRRNGVLISNGDGAAVAYALWNLEERGKMFINPSDKVYRGMIIGEHNRENDLEVNPLKARQLSNVRASGKDE
AIRLTPPMLLTLEQAISYIQDDERVEVTPKSIRLRKALLDPNDRKRAAK
>Mature_608_residues
TPIRNIAIIAHVDHGKTTLVDNMLKQSGTFRANQAVAERAMDSNDLERERGITILAKCTALMWNDIRINIVDTPGHADFG
GEVERILSMVDGVVLLVDASEGPMPQTKFVLSKALKLNLKPIVVINKIDRDDQRIKEVIEEVFELFVALEANNDQLDFPI
VYASGRAGRASLNFDDKINPLDNLADDLAPLFDLIVTHVPTPAADDKAPFSMLITTREYNSFFGRVLTGRVQNGTVKINQ
NIKVLNRENKVLETGRITKILAFRGLERIAIDEAIAGDIIAVAGVENANVADTICSPEVTEAVPSLPIDPPTLSMTFSVN
DSPLAGSEGTKVTSSLIGARLMREIESNVALKVTEAAEKNAFQVAGRGELQLGILIETMRREGFELSISRPEVLFQTDGK
GNKQEPMEEIQVDVDDDYVGVVVKSLALRKADMTDMRPSGGGKSRVTFIGPSRGLIGYHSQFLTETRGTGIMNRIFHGYA
NYKGAIAGRRNGVLISNGDGAAVAYALWNLEERGKMFINPSDKVYRGMIIGEHNRENDLEVNPLKARQLSNVRASGKDEA
IRLTPPMLLTLEQAISYIQDDERVEVTPKSIRLRKALLDPNDRKRAAK

Specific function: Probably interacts with the ribosomes in a GTP dependent manner. GTPase that mediates interactions between enteropathogenic E.coli (EPEC) and epithelial cells [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=343, Percent_Identity=30.0291545189504, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI94966754, Length=182, Percent_Identity=36.2637362637363, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI18390331, Length=133, Percent_Identity=45.8646616541353, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI19923640, Length=178, Percent_Identity=38.2022471910112, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI25306287, Length=178, Percent_Identity=38.2022471910112, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI25306283, Length=178, Percent_Identity=38.2022471910112, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI4503483, Length=144, Percent_Identity=37.5, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI34147630, Length=284, Percent_Identity=29.5774647887324, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI310132016, Length=110, Percent_Identity=40, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI310110807, Length=110, Percent_Identity=40, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI310123363, Length=110, Percent_Identity=40, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI217272892, Length=136, Percent_Identity=37.5, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI217272894, Length=136, Percent_Identity=37.5, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI94966752, Length=178, Percent_Identity=27.5280898876405, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI48994988, Length=607, Percent_Identity=54.0362438220758, Blast_Score=660, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=512, Percent_Identity=25, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1789738, Length=154, Percent_Identity=38.961038961039, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1790835, Length=146, Percent_Identity=32.8767123287671, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789737, Length=285, Percent_Identity=29.1228070175439, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1790412, Length=285, Percent_Identity=29.1228070175439, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17557151, Length=252, Percent_Identity=35.3174603174603, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17556745, Length=132, Percent_Identity=42.4242424242424, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71988811, Length=142, Percent_Identity=37.3239436619718, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71988819, Length=142, Percent_Identity=37.3239436619718, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17533571, Length=134, Percent_Identity=42.5373134328358, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17506493, Length=172, Percent_Identity=33.1395348837209, Blast_Score=103, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17552882, Length=135, Percent_Identity=37.7777777777778, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17556456, Length=293, Percent_Identity=27.3037542662116, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25141371, Length=242, Percent_Identity=27.6859504132231, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=410, Percent_Identity=29.0243902439024, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324707, Length=163, Percent_Identity=38.0368098159509, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320593, Length=163, Percent_Identity=38.0368098159509, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6324761, Length=280, Percent_Identity=31.7857142857143, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6323098, Length=166, Percent_Identity=38.5542168674699, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324166, Length=180, Percent_Identity=37.2222222222222, Blast_Score=93, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6322359, Length=152, Percent_Identity=36.1842105263158, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI78706572, Length=251, Percent_Identity=33.0677290836653, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24582462, Length=133, Percent_Identity=45.1127819548872, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28574573, Length=137, Percent_Identity=40.1459854014599, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI281363316, Length=313, Percent_Identity=29.3929712460064, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17864358, Length=313, Percent_Identity=29.3929712460064, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585711, Length=166, Percent_Identity=35.5421686746988, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585713, Length=166, Percent_Identity=35.5421686746988, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585709, Length=166, Percent_Identity=35.5421686746988, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI221458488, Length=162, Percent_Identity=41.358024691358, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21357743, Length=171, Percent_Identity=36.8421052631579, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI19921738, Length=279, Percent_Identity=29.0322580645161, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28572034, Length=148, Percent_Identity=33.1081081081081, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19922690, Length=266, Percent_Identity=29.6992481203008, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 66952; Mature: 66820

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPIRNIAIIAHVDHGKTTLVDNMLKQSGTFRANQAVAERAMDSNDLERERGITILAKCT
CCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHCCCEEEEEHH
ALMWNDIRINIVDTPGHADFGGEVERILSMVDGVVLLVDASEGPMPQTKFVLSKALKLNL
HHEECCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCC
KPIVVINKIDRDDQRIKEVIEEVFELFVALEANNDQLDFPIVYASGRAGRASLNFDDKIN
CEEEEEECCCCCHHHHHHHHHHHHHHEEEEECCCCCEEEEEEEECCCCCCEECCCCCCCC
PLDNLADDLAPLFDLIVTHVPTPAADDKAPFSMLITTREYNSFFGRVLTGRVQNGTVKIN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEHHHHHHHHHHCCEECCCEEEEC
QNIKVLNRENKVLETGRITKILAFRGLERIAIDEAIAGDIIAVAGVENANVADTICSPEV
CCEEEEECCCCEECCCCHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCCCCHHHCCCCHH
TEAVPSLPIDPPTLSMTFSVNDSPLAGSEGTKVTSSLIGARLMREIESNVALKVTEAAEK
HHHCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCC
NAFQVAGRGELQLGILIETMRREGFELSISRPEVLFQTDGKGNKQEPMEEIQVDVDDDYV
CCEEECCCCCEEEHHHHHHHHCCCCEEEECCCEEEEEECCCCCCCCCHHHHEECCCCCHH
GVVVKSLALRKADMTDMRPSGGGKSRVTFIGPSRGLIGYHSQFLTETRGTGIMNRIFHGY
HHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
ANYKGAIAGRRNGVLISNGDGAAVAYALWNLEERGKMFINPSDKVYRGMIIGEHNRENDL
CCCCCCCCCCCCCEEEECCCCCEEEEEEECHHHCCCEEECCCCCEEEEEEEECCCCCCCC
EVNPLKARQLSNVRASGKDEAIRLTPPMLLTLEQAISYIQDDERVEVTPKSIRLRKALLD
EECCHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHCC
PNDRKRAAK
CCCHHCCCC
>Mature Secondary Structure 
TPIRNIAIIAHVDHGKTTLVDNMLKQSGTFRANQAVAERAMDSNDLERERGITILAKCT
CCCCEEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHCCCEEEEEHH
ALMWNDIRINIVDTPGHADFGGEVERILSMVDGVVLLVDASEGPMPQTKFVLSKALKLNL
HHEECCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCC
KPIVVINKIDRDDQRIKEVIEEVFELFVALEANNDQLDFPIVYASGRAGRASLNFDDKIN
CEEEEEECCCCCHHHHHHHHHHHHHHEEEEECCCCCEEEEEEEECCCCCCEECCCCCCCC
PLDNLADDLAPLFDLIVTHVPTPAADDKAPFSMLITTREYNSFFGRVLTGRVQNGTVKIN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEHHHHHHHHHHCCEECCCEEEEC
QNIKVLNRENKVLETGRITKILAFRGLERIAIDEAIAGDIIAVAGVENANVADTICSPEV
CCEEEEECCCCEECCCCHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCCCCHHHCCCCHH
TEAVPSLPIDPPTLSMTFSVNDSPLAGSEGTKVTSSLIGARLMREIESNVALKVTEAAEK
HHHCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCC
NAFQVAGRGELQLGILIETMRREGFELSISRPEVLFQTDGKGNKQEPMEEIQVDVDDDYV
CCEEECCCCCEEEHHHHHHHHCCCCEEEECCCEEEEEECCCCCCCCCHHHHEECCCCCHH
GVVVKSLALRKADMTDMRPSGGGKSRVTFIGPSRGLIGYHSQFLTETRGTGIMNRIFHGY
HHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
ANYKGAIAGRRNGVLISNGDGAAVAYALWNLEERGKMFINPSDKVYRGMIIGEHNRENDL
CCCCCCCCCCCCCEEEECCCCCEEEEEEECHHHCCCEEECCCCCEEEEEEEECCCCCCCC
EVNPLKARQLSNVRASGKDEAIRLTPPMLLTLEQAISYIQDDERVEVTPKSIRLRKALLD
EECCHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHCC
PNDRKRAAK
CCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9622352 [H]