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The map label for this gene is hemN [H]

Identifier: 157373115

GI number: 157373115

Start: 5413029

End: 5414402

Strand: Reverse

Name: hemN [H]

Synonym: Spro_4884

Alternate gene names: 157373115

Gene position: 5414402-5413029 (Counterclockwise)

Preceding gene: 157373116

Following gene: 157373111

Centisome position: 99.37

GC content: 54.8

Gene sequence:

>1374_bases
ATGTCAGAGCAGGCAATTGTCTGGGATCTGGCCCTGATCCAGAAATATAACTATTCAGGGCCGCGTTATACCTCATACCC
CACAGCGCTGGAGTTCAACCAGGGCTATGACGAAGCGGCGTTTCAACGCGCTGCTGCGCGCTATCCAGAACGTCCGCTGT
CGCTGTATGTGCATATCCCTTTCTGCCACAAACTCTGCTATTTCTGTGGCTGCAATAAACTGGTGACGCGTCAGACGCAC
AAGGCCGATGAATATCTGGCGGTGCTGGCACAGGAAATCGCCCAGCGCGCGCCTCTGTTTGCCGGGCGTAAAGTTGGTCA
GTTGCATTGGGGTGGCGGCACACCGACCTATCTGAGCAAGTCGCAAATCAGCAAGCTGGTGGCAATGCTGCGCCAACACT
TTGATTTTCTCCCCGATTTGGAAATGTCGATCGAAGTCGATCCGCGCGAGATTGAGCTGGATGTGCTCGATCATTTACGC
AGCGAAGGCTTTAATCGCCTGAGCATGGGGGTGCAGGATTTCAATAAAGAAGTGCAGCGGCTGGTGAACCGTGAGCAGGA
TGAAACCTTTATCTTCGCTCTGATCGCTCGCGCCAAGGCTTTGGGCTTTAACTCCACCAATATTGATTTGATCTACGGGC
TGCCAAAGCAGACGCCGGAGAGCTTTGCTTACACCCTGCAGCGGGTGGCGGAACTCAACCCGGATCGCCTCAGCGTATTT
AACTACGCCCACATGCCGAACCTGTTTGCAGCCCAACGCAAAATCAAAGATGCGGATTTGCCCAGCGCGCAGCAGAAACT
GGATATCCTGCAGCAGACCATCGCCTCGCTGACCGAGTCCGGCTATCAGTTTATCGGCATGGACCACTTTGCCCGCCCGG
ATGATGAACTGGCCGTGGCACAGCGCGAAGGGAAACTGCACCGCAACTTCCAGGGGTACACCACTCAGGGTGACAGCGAT
TTGCTGGGGCTGGGCGTATCCGCCATCAGCATGCTGGGGGACAGCTATGCCCAGAACCAGAAAGAGCTGAAGACCTATTA
CAGTAGCGTAGAAGAGCAGGGGCATGCCTTGTGGCGCGGCTTGGCGATGACGGAAGACGACTGTCTGCGGCGTGAGGTAA
TCAAAACGCTGATCTGCAATTTCAAACTGGACTATCTGGCAATAGAGCAACAGTTCGCTATCGACTTCGCCGGCTATTTT
GCCGAAGACCTGCAACTGCTGGCACCGTTTGAACGTGATGGGCTGGTGGAGCGTGACGAGCAGGGTATTCGCGTTACACC
GCGCGGTCGGTTGCTGATCCGCAATATTTGCATGTGTTTTGATATCTACCTGCGACAACAGGCGCGCACTCAGCAATTCT
CTCGGGTTATTTGA

Upstream 100 bases:

>100_bases
CTAAACGCAAAACGCGTTTTCGCAGCGCTTCCGCGGCCAGACAGCGTAGACAACTGCCCATTTCCCGGCCCGGTAGAAAA
AAATATCGGAAGGAGTGAGC

Downstream 100 bases:

>100_bases
TCGATAAAGAAACGGCCGCATTAGCGGCCATTTTTTTAATTAGAAATTTAACTGAAGAAATTAATCAGTGCGGCGCACAA
CACCGCAGCAACGGCTGCCT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MSEQAIVWDLALIQKYNYSGPRYTSYPTALEFNQGYDEAAFQRAAARYPERPLSLYVHIPFCHKLCYFCGCNKLVTRQTH
KADEYLAVLAQEIAQRAPLFAGRKVGQLHWGGGTPTYLSKSQISKLVAMLRQHFDFLPDLEMSIEVDPREIELDVLDHLR
SEGFNRLSMGVQDFNKEVQRLVNREQDETFIFALIARAKALGFNSTNIDLIYGLPKQTPESFAYTLQRVAELNPDRLSVF
NYAHMPNLFAAQRKIKDADLPSAQQKLDILQQTIASLTESGYQFIGMDHFARPDDELAVAQREGKLHRNFQGYTTQGDSD
LLGLGVSAISMLGDSYAQNQKELKTYYSSVEEQGHALWRGLAMTEDDCLRREVIKTLICNFKLDYLAIEQQFAIDFAGYF
AEDLQLLAPFERDGLVERDEQGIRVTPRGRLLIRNICMCFDIYLRQQARTQQFSRVI

Sequences:

>Translated_457_residues
MSEQAIVWDLALIQKYNYSGPRYTSYPTALEFNQGYDEAAFQRAAARYPERPLSLYVHIPFCHKLCYFCGCNKLVTRQTH
KADEYLAVLAQEIAQRAPLFAGRKVGQLHWGGGTPTYLSKSQISKLVAMLRQHFDFLPDLEMSIEVDPREIELDVLDHLR
SEGFNRLSMGVQDFNKEVQRLVNREQDETFIFALIARAKALGFNSTNIDLIYGLPKQTPESFAYTLQRVAELNPDRLSVF
NYAHMPNLFAAQRKIKDADLPSAQQKLDILQQTIASLTESGYQFIGMDHFARPDDELAVAQREGKLHRNFQGYTTQGDSD
LLGLGVSAISMLGDSYAQNQKELKTYYSSVEEQGHALWRGLAMTEDDCLRREVIKTLICNFKLDYLAIEQQFAIDFAGYF
AEDLQLLAPFERDGLVERDEQGIRVTPRGRLLIRNICMCFDIYLRQQARTQQFSRVI
>Mature_456_residues
SEQAIVWDLALIQKYNYSGPRYTSYPTALEFNQGYDEAAFQRAAARYPERPLSLYVHIPFCHKLCYFCGCNKLVTRQTHK
ADEYLAVLAQEIAQRAPLFAGRKVGQLHWGGGTPTYLSKSQISKLVAMLRQHFDFLPDLEMSIEVDPREIELDVLDHLRS
EGFNRLSMGVQDFNKEVQRLVNREQDETFIFALIARAKALGFNSTNIDLIYGLPKQTPESFAYTLQRVAELNPDRLSVFN
YAHMPNLFAAQRKIKDADLPSAQQKLDILQQTIASLTESGYQFIGMDHFARPDDELAVAQREGKLHRNFQGYTTQGDSDL
LGLGVSAISMLGDSYAQNQKELKTYYSSVEEQGHALWRGLAMTEDDCLRREVIKTLICNFKLDYLAIEQQFAIDFAGYFA
EDLQLLAPFERDGLVERDEQGIRVTPRGRLLIRNICMCFDIYLRQQARTQQFSRVI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=248, Percent_Identity=28.2258064516129, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI87082341, Length=457, Percent_Identity=80.0875273522976, Blast_Score=780, Evalue=0.0,
Organism=Escherichia coli, GI1789325, Length=243, Percent_Identity=32.0987654320988, Blast_Score=127, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52354; Mature: 52223

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQAIVWDLALIQKYNYSGPRYTSYPTALEFNQGYDEAAFQRAAARYPERPLSLYVHIP
CCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCEEEEEECH
FCHKLCYFCGCNKLVTRQTHKADEYLAVLAQEIAQRAPLFAGRKVGQLHWGGGTPTYLSK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCH
SQISKLVAMLRQHFDFLPDLEMSIEVDPREIELDVLDHLRSEGFNRLSMGVQDFNKEVQR
HHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LVNREQDETFIFALIARAKALGFNSTNIDLIYGLPKQTPESFAYTLQRVAELNPDRLSVF
HHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEHH
NYAHMPNLFAAQRKIKDADLPSAQQKLDILQQTIASLTESGYQFIGMDHFARPDDELAVA
HHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCHHCCCCCHHHHHH
QREGKLHRNFQGYTTQGDSDLLGLGVSAISMLGDSYAQNQKELKTYYSSVEEQGHALWRG
HHCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
LAMTEDDCLRREVIKTLICNFKLDYLAIEQQFAIDFAGYFAEDLQLLAPFERDGLVERDE
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
QGIRVTPRGRLLIRNICMCFDIYLRQQARTQQFSRVI
CCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEQAIVWDLALIQKYNYSGPRYTSYPTALEFNQGYDEAAFQRAAARYPERPLSLYVHIP
CCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCEEEEEECH
FCHKLCYFCGCNKLVTRQTHKADEYLAVLAQEIAQRAPLFAGRKVGQLHWGGGTPTYLSK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCH
SQISKLVAMLRQHFDFLPDLEMSIEVDPREIELDVLDHLRSEGFNRLSMGVQDFNKEVQR
HHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LVNREQDETFIFALIARAKALGFNSTNIDLIYGLPKQTPESFAYTLQRVAELNPDRLSVF
HHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEHH
NYAHMPNLFAAQRKIKDADLPSAQQKLDILQQTIASLTESGYQFIGMDHFARPDDELAVA
HHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCHHCCCCCHHHHHH
QREGKLHRNFQGYTTQGDSDLLGLGVSAISMLGDSYAQNQKELKTYYSSVEEQGHALWRG
HHCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
LAMTEDDCLRREVIKTLICNFKLDYLAIEQQFAIDFAGYFAEDLQLLAPFERDGLVERDE
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
QGIRVTPRGRLLIRNICMCFDIYLRQQARTQQFSRVI
CCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7768836; 8346018; 9278503 [H]