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The map label for this gene is fabR [H]

Identifier: 157373005

GI number: 157373005

Start: 5287143

End: 5287781

Strand: Reverse

Name: fabR [H]

Synonym: Spro_4773

Alternate gene names: 157373005

Gene position: 5287781-5287143 (Counterclockwise)

Preceding gene: 157373007

Following gene: 157373004

Centisome position: 97.04

GC content: 56.18

Gene sequence:

>639_bases
ATGCATATGGGCGTCAGAGCACAACAAAAAGAACGGACGCGTCGTTCCCTCATCGAGGCGGCCTTCAGCCAGCTAAGCGC
CGAACGCAGCTTCGCCAGCCTGAGCCTGCGTGAAGTCTCGCGTGAAGCGGGCATCGCACCGACGTCATTCTACCGTCACT
TTCGTGACGTGGATGAGTTGGGGCTGACCATGGTTGATGAGAGCGGCCTGATGCTGCGGCAACTGATGCGTCAGGCACGC
CAGCGTATTGCCAAGGGCGGCAGCGTGATCCGCACCTCGGTCTCCACCTTTATGGAGTTTATCGGCAATAATCCCAACGC
CTTCCGTTTGCTGTTGCGTGAGCGTTCCGGTACCTCGGCGGCTTTCCGTGCGGCAGTAGCGCGTGAGATCCAACATTTTA
TCGCCGAACTGGCAGATTACCTCGAGCTGGAAAACCATATGCCGCGCAGTTTTACCGAAGCGCAGGCGGAAGCCATGGTG
ACCATCGTGTTTAGCGCCGGTGCTGAAGCGCTGGACATCGATATCGAACAACGGCGTCGGCTTGAGGAACGTTTAGTGCT
GCAACTGCGGATGATTTCCAAAGGTGCTTATTATTGGTATCGCCGCCAACAAGAAAAAGCTTCTGTATCCCACGTATAA

Upstream 100 bases:

>100_bases
AAACTGTGACAGGGCGCGTTTGTATAAATGCTGTTGCAATAAAATTTGCTATATTGCCGGGTCTACGGCGTTAGACTGAC
AAAATGGATCTTATCTGGAT

Downstream 100 bases:

>100_bases
AAGGTAGAAAGCGATGGAAAAACCAAGCCGTGAGAATGGCACCTTACTGCTGGCGTTGATTGCCGGCCTCTCGATCAACG
GTTCGTTCGCCGCGTTGTTC

Product: DNA-binding transcriptional repressor FabR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MHMGVRAQQKERTRRSLIEAAFSQLSAERSFASLSLREVSREAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQAR
QRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGTSAAFRAAVAREIQHFIAELADYLELENHMPRSFTEAQAEAMV
TIVFSAGAEALDIDIEQRRRLEERLVLQLRMISKGAYYWYRRQQEKASVSHV

Sequences:

>Translated_212_residues
MHMGVRAQQKERTRRSLIEAAFSQLSAERSFASLSLREVSREAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQAR
QRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGTSAAFRAAVAREIQHFIAELADYLELENHMPRSFTEAQAEAMV
TIVFSAGAEALDIDIEQRRRLEERLVLQLRMISKGAYYWYRRQQEKASVSHV
>Mature_212_residues
MHMGVRAQQKERTRRSLIEAAFSQLSAERSFASLSLREVSREAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQAR
QRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGTSAAFRAAVAREIQHFIAELADYLELENHMPRSFTEAQAEAMV
TIVFSAGAEALDIDIEQRRRLEERLVLQLRMISKGAYYWYRRQQEKASVSHV

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=207, Percent_Identity=94.2028985507246, Blast_Score=400, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24302; Mature: 24302

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHMGVRAQQKERTRRSLIEAAFSQLSAERSFASLSLREVSREAGIAPTSFYRHFRDVDEL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GLTMVDESGLMLRQLMRQARQRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGTSA
CCEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHH
AFRAAVAREIQHFIAELADYLELENHMPRSFTEAQAEAMVTIVFSAGAEALDIDIEQRRR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEECCHHHHHH
LEERLVLQLRMISKGAYYWYRRQQEKASVSHV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHMGVRAQQKERTRRSLIEAAFSQLSAERSFASLSLREVSREAGIAPTSFYRHFRDVDEL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GLTMVDESGLMLRQLMRQARQRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGTSA
CCEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHH
AFRAAVAREIQHFIAELADYLELENHMPRSFTEAQAEAMVTIVFSAGAEALDIDIEQRRR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEECCHHHHHH
LEERLVLQLRMISKGAYYWYRRQQEKASVSHV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA