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The map label for this gene is ilvY [H]

Identifier: 157372984

GI number: 157372984

Start: 5257262

End: 5258176

Strand: Direct

Name: ilvY [H]

Synonym: Spro_4752

Alternate gene names: 157372984

Gene position: 5257262-5258176 (Clockwise)

Preceding gene: 157372982

Following gene: 157372994

Centisome position: 96.48

GC content: 60.11

Gene sequence:

>915_bases
ATGCAACACTCTTGCTGCGAGCGTACTGATATGGATTTGCGTGATTTAAAGCTATTCCTCCATCTGGCTGAAAGCCATCA
CTTTGGCCGCACCGCCAAGGCGATGCACGTCAGTCCTTCGACGCTGTCCCGCCAGATCCAACGGCTGGAAGAGATCCTCG
GGCAACCGCTGTTTTTGCGCGATAACCGCACCGTGCAGCTCACCGACGCCGGTGAACAGTTAAAAGATTTTGCCCAGCAG
ACGCTGCTGCAGTACCAGCAACTGAAACATTCGCTGGGCCAACATGGCCCTTCGCTAAGCGGCGAATTACGGCTGTTTTG
CTCGGTTACCGCCGCCTACAGCCACCTGCCGCCGATCCTCGATCGCTTCCGCGCGCAGCATCCACTGGTAGAAATAAAAC
TGACCACCGGTGACGCCGCCGATGCGGTCGACAAAGTGCAGTCCAACGAAGCCGATCTCGGCATTGCCGGGCGGCCCGAA
ACCCTGCCCACCAGCGTGGCGTTCACTAAAATCGGTGAGATCCCGCTGGTGCTGATTGCCCCGGCGCTGCCCTGCGCGGT
ACGCAGCCAGGCGTTTGCCGAGCAGCCCGACTGGGCCAATATTCCGTTTATCCTGCCGGAGCACGGCCCGTCGCGAAAAC
GCATCGAGCTGTGGTTCCGTCGCCAGCGCATTACCAACCCGCTGATTTACGCCACCGTTGGCGGCCACGAGGCCATCGTT
TCGATGGTGGCGCTGGGCTGCGGCATCGCGCTGATCCCCGGCGTGGTGGTGGACAACAGCCCGGAGCCGGTGCGTAATCG
CATCTCGCAACTGGAGAATATTTCCATGGTCGAGCCGTTCGAGCTGGGGGTCTGCGTGCAGAAAAAACGCCTCAGCGATC
CGCTGATCGACGCTTTCTGGCGCTTACTTTCATAG

Upstream 100 bases:

>100_bases
TTCATTCCCCGCCCTGTCTGTGCGGAGATTCGTTAAACTCAATGTATAACAGGAAACGCGTTGCTTAAATTGATATATTA
CGAATGTGACATTGCAATTT

Downstream 100 bases:

>100_bases
GTCAGAGGGATCAACTTGCTTCATCGCCTCTACCTGCATCAGCCAGTGATAGAGCGGTTCCAGTTGCAGAAAGCCTTGCG
CCAGAGTCTGCACCAACCCG

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MQHSCCERTDMDLRDLKLFLHLAESHHFGRTAKAMHVSPSTLSRQIQRLEEILGQPLFLRDNRTVQLTDAGEQLKDFAQQ
TLLQYQQLKHSLGQHGPSLSGELRLFCSVTAAYSHLPPILDRFRAQHPLVEIKLTTGDAADAVDKVQSNEADLGIAGRPE
TLPTSVAFTKIGEIPLVLIAPALPCAVRSQAFAEQPDWANIPFILPEHGPSRKRIELWFRRQRITNPLIYATVGGHEAIV
SMVALGCGIALIPGVVVDNSPEPVRNRISQLENISMVEPFELGVCVQKKRLSDPLIDAFWRLLS

Sequences:

>Translated_304_residues
MQHSCCERTDMDLRDLKLFLHLAESHHFGRTAKAMHVSPSTLSRQIQRLEEILGQPLFLRDNRTVQLTDAGEQLKDFAQQ
TLLQYQQLKHSLGQHGPSLSGELRLFCSVTAAYSHLPPILDRFRAQHPLVEIKLTTGDAADAVDKVQSNEADLGIAGRPE
TLPTSVAFTKIGEIPLVLIAPALPCAVRSQAFAEQPDWANIPFILPEHGPSRKRIELWFRRQRITNPLIYATVGGHEAIV
SMVALGCGIALIPGVVVDNSPEPVRNRISQLENISMVEPFELGVCVQKKRLSDPLIDAFWRLLS
>Mature_304_residues
MQHSCCERTDMDLRDLKLFLHLAESHHFGRTAKAMHVSPSTLSRQIQRLEEILGQPLFLRDNRTVQLTDAGEQLKDFAQQ
TLLQYQQLKHSLGQHGPSLSGELRLFCSVTAAYSHLPPILDRFRAQHPLVEIKLTTGDAADAVDKVQSNEADLGIAGRPE
TLPTSVAFTKIGEIPLVLIAPALPCAVRSQAFAEQPDWANIPFILPEHGPSRKRIELWFRRQRITNPLIYATVGGHEAIV
SMVALGCGIALIPGVVVDNSPEPVRNRISQLENISMVEPFELGVCVQKKRLSDPLIDAFWRLLS

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=293, Percent_Identity=73.7201365187713, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1788887, Length=248, Percent_Identity=29.4354838709677, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI157672245, Length=177, Percent_Identity=33.8983050847458, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI2367136, Length=284, Percent_Identity=27.112676056338, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI145693105, Length=300, Percent_Identity=25.3333333333333, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1790399, Length=270, Percent_Identity=29.6296296296296, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787879, Length=253, Percent_Identity=28.0632411067194, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787806, Length=256, Percent_Identity=25.78125, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788297, Length=249, Percent_Identity=28.5140562248996, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=26.2068965517241, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787530, Length=262, Percent_Identity=24.4274809160305, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788296, Length=246, Percent_Identity=27.6422764227642, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI145693193, Length=123, Percent_Identity=34.9593495934959, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789440, Length=142, Percent_Identity=28.8732394366197, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788748, Length=305, Percent_Identity=23.2786885245902, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790262, Length=254, Percent_Identity=27.1653543307087, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788481, Length=249, Percent_Identity=24.4979919678715, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787589, Length=248, Percent_Identity=28.2258064516129, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33852; Mature: 33852

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHSCCERTDMDLRDLKLFLHLAESHHFGRTAKAMHVSPSTLSRQIQRLEEILGQPLFLR
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCEEEE
DNRTVQLTDAGEQLKDFAQQTLLQYQQLKHSLGQHGPSLSGELRLFCSVTAAYSHLPPIL
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHCHHHH
DRFRAQHPLVEIKLTTGDAADAVDKVQSNEADLGIAGRPETLPTSVAFTKIGEIPLVLIA
HHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEC
PALPCAVRSQAFAEQPDWANIPFILPEHGPSRKRIELWFRRQRITNPLIYATVGGHEAIV
CCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHH
SMVALGCGIALIPGVVVDNSPEPVRNRISQLENISMVEPFELGVCVQKKRLSDPLIDAFW
HHHHHHCCHHHHCCEEECCCCHHHHHHHHHHHCCCCCCCHHHCHHHHHHHCCCHHHHHHH
RLLS
HHHC
>Mature Secondary Structure
MQHSCCERTDMDLRDLKLFLHLAESHHFGRTAKAMHVSPSTLSRQIQRLEEILGQPLFLR
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCEEEE
DNRTVQLTDAGEQLKDFAQQTLLQYQQLKHSLGQHGPSLSGELRLFCSVTAAYSHLPPIL
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHCHHHH
DRFRAQHPLVEIKLTTGDAADAVDKVQSNEADLGIAGRPETLPTSVAFTKIGEIPLVLIA
HHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEC
PALPCAVRSQAFAEQPDWANIPFILPEHGPSRKRIELWFRRQRITNPLIYATVGGHEAIV
CCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHH
SMVALGCGIALIPGVVVDNSPEPVRNRISQLENISMVEPFELGVCVQKKRLSDPLIDAFW
HHHHHHCCHHHHCCEEECCCCHHHHHHHHHHHCCCCCCCHHHCHHHHHHHCCCHHHHHHH
RLLS
HHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3003115; 1379743; 9278503; 3550695 [H]