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The map label for this gene is ilvC [H]

Identifier: 157372983

GI number: 157372983

Start: 5255637

End: 5257112

Strand: Reverse

Name: ilvC [H]

Synonym: Spro_4751

Alternate gene names: 157372983

Gene position: 5257112-5255637 (Counterclockwise)

Preceding gene: 157372985

Following gene: 157372980

Centisome position: 96.48

GC content: 56.03

Gene sequence:

>1476_bases
ATGGCTAACTATTTCAACACCTTGAACCTGCGTCAGCAGTTGGCGCAATTGGGCAAGTGTCGCTTTATGGCACGTGAAGA
ATTTGCTGATGAAGCCGGCTACCTGAAAGGCAAAAAAGTGGTGATTGTCGGCTGTGGCGCGCAGGGGCTGAACCAGGGCC
TGAACATGCGTGACTCCGGCCTGGACGTGGCCTATGCCCTGCGTAAGGAAGCCATCGACGAAAAACGTCCTTCATGGCGT
AAAGCGACCGAAAACGGCTTCAAGGTAGGGACCTACGAAGATTTGATCCCACAGGCAGACCTGGTGGTTAACCTGACGCC
GGACAAGCAGCATACCTCGGTCGTTCGTGCCGTACAGCCGCTGATGAAAGACGGTGCGGCGCTGGGCTACTCCCACGGTT
TCAACATCGTAGAAGTGGGCGAGCAGGTACGTAAAGACATCACCGTAGTGATGGTAGCGCCAAAATGTCCGGGCACCGAA
GTGCGTGAAGAATACAAACGTGGTTTCGGCGTGCCGACTCTGATTGCGGTTCACCCGGAAAACGATCCGAAAGGCGAAGG
CATGGCGATTGCCAAGGCCTGGGCAGCGGCGACCGGCGGCCACCGTGCGGGCGTACTGGAATCTTCCTTCGTTGCCGAAG
TGAAATCGGACCTGATGGGCGAGCAGACCATTCTGTGCGGCATGCTGCAGGCGGGTTCGCTGCTGTGCTTCGACAAACTG
GTTGCTGAAGGCACTGACCCGGCTTATGCAGAAAAACTGATCCAGTTCGGCTGGGAAACCATCACCGAAGCGCTGAAGCA
GGGTGGCATCACCCTGATGATGGATCGTCTGTCCAACCCGGCCAAACTGCGTGCCTATGCGCTGTCTGAGCAACTGAAAG
GGATCATGGCACCGCTGTTCCAGAAACACATGGACGACATCATCTCCGGCGCTTTCTCCGGTGGCATGATGGCTGACTGG
GCAGAAGACGACGTGAAACTGCTGAACTGGCGTGAAGAGACCGGCAAATCGGCGTTCGAAAATGCGCCACAGTTCGAAGG
TAAAATCAGCGAGCAGGAATACTTTGACCATGGCGTGTTGATGGTAGCCATGGTGAAAGCCGGTGTTGAGCTGGCATTCG
AAACCATGGTTGACGCGGGTATCATCGAAGAATCCGCTTACTACGAATCACTGCATGAGCTGCCGCTGATCGCCAACACC
ATTGCGCGTAAGCGTCTGTACGAAATGAACGTGGTTATCTCTGATACCGCAGAATACGGCAACTACCTGTTCGCCAACGC
GGCAGTGCCGCTGCTGAAAGAGTTCATGACCACCCTGCAGGCGGGTGACCTGGGCAAATCCGTGGCCGGTACTTCGGTAG
ACAACGCGCAACTGCGTGACGTGAACGAAGCGGTACGTAATCACCCGATCGAATCCGTTGGCCGCAAGCTGCGCGGGTAT
ATGACCGATATGAAACGCATCGCGGTAGCAGGCTAA

Upstream 100 bases:

>100_bases
TGTTATACATTGAGTTTAACGAATCTCCGCACAGACAGGGCGGGGAATGAAAATAACATCGATACCCATAGTCGACACAA
CATCTAACTGGAGTACCACC

Downstream 100 bases:

>100_bases
ATACCCGGAGTCTTTCAAGCTGTAGCGTTGTTACCTGCACTATCACACCCCAGTCACTTACTAAAGTAAGCTCCTGGGGA
TGAGATAGCTTGGCGCCTAG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MANYFNTLNLRQQLAQLGKCRFMAREEFADEAGYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVAYALRKEAIDEKRPSWR
KATENGFKVGTYEDLIPQADLVVNLTPDKQHTSVVRAVQPLMKDGAALGYSHGFNIVEVGEQVRKDITVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKL
VAEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKGIMAPLFQKHMDDIISGAFSGGMMADW
AEDDVKLLNWREETGKSAFENAPQFEGKISEQEYFDHGVLMVAMVKAGVELAFETMVDAGIIEESAYYESLHELPLIANT
IARKRLYEMNVVISDTAEYGNYLFANAAVPLLKEFMTTLQAGDLGKSVAGTSVDNAQLRDVNEAVRNHPIESVGRKLRGY
MTDMKRIAVAG

Sequences:

>Translated_491_residues
MANYFNTLNLRQQLAQLGKCRFMAREEFADEAGYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVAYALRKEAIDEKRPSWR
KATENGFKVGTYEDLIPQADLVVNLTPDKQHTSVVRAVQPLMKDGAALGYSHGFNIVEVGEQVRKDITVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKL
VAEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKGIMAPLFQKHMDDIISGAFSGGMMADW
AEDDVKLLNWREETGKSAFENAPQFEGKISEQEYFDHGVLMVAMVKAGVELAFETMVDAGIIEESAYYESLHELPLIANT
IARKRLYEMNVVISDTAEYGNYLFANAAVPLLKEFMTTLQAGDLGKSVAGTSVDNAQLRDVNEAVRNHPIESVGRKLRGY
MTDMKRIAVAG
>Mature_490_residues
ANYFNTLNLRQQLAQLGKCRFMAREEFADEAGYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVAYALRKEAIDEKRPSWRK
ATENGFKVGTYEDLIPQADLVVNLTPDKQHTSVVRAVQPLMKDGAALGYSHGFNIVEVGEQVRKDITVVMVAPKCPGTEV
REEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLV
AEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKGIMAPLFQKHMDDIISGAFSGGMMADWA
EDDVKLLNWREETGKSAFENAPQFEGKISEQEYFDHGVLMVAMVKAGVELAFETMVDAGIIEESAYYESLHELPLIANTI
ARKRLYEMNVVISDTAEYGNYLFANAAVPLLKEFMTTLQAGDLGKSVAGTSVDNAQLRDVNEAVRNHPIESVGRKLRGYM
TDMKRIAVAG

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=491, Percent_Identity=90.224032586558, Blast_Score=905, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=295, Percent_Identity=32.2033898305085, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 53781; Mature: 53650

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNTLNLRQQLAQLGKCRFMAREEFADEAGYLKGKKVVIVGCGAQGLNQGLNMRDSG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCCCCCCC
LDVAYALRKEAIDEKRPSWRKATENGFKVGTYEDLIPQADLVVNLTPDKQHTSVVRAVQP
CHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHH
LMKDGAALGYSHGFNIVEVGEQVRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCHHCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKL
CCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHH
VAEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKGIMAPLF
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHH
QKHMDDIISGAFSGGMMADWAEDDVKLLNWREETGKSAFENAPQFEGKISEQEYFDHGVL
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHCHHHHCCHHHHCCCCCCCCCCHHHHHHHHHH
MVAMVKAGVELAFETMVDAGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEEEECCHHHC
NYLFANAAVPLLKEFMTTLQAGDLGKSVAGTSVDNAQLRDVNEAVRNHPIESVGRKLRGY
CEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
MTDMKRIAVAG
HHHHHHHHCCC
>Mature Secondary Structure 
ANYFNTLNLRQQLAQLGKCRFMAREEFADEAGYLKGKKVVIVGCGAQGLNQGLNMRDSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCCCCCCC
LDVAYALRKEAIDEKRPSWRKATENGFKVGTYEDLIPQADLVVNLTPDKQHTSVVRAVQP
CHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHH
LMKDGAALGYSHGFNIVEVGEQVRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCHHCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKL
CCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHH
VAEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKGIMAPLF
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHH
QKHMDDIISGAFSGGMMADWAEDDVKLLNWREETGKSAFENAPQFEGKISEQEYFDHGVL
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHCHHHHCCHHHHCCCCCCCCCCHHHHHHHHHH
MVAMVKAGVELAFETMVDAGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEEEECCHHHC
NYLFANAAVPLLKEFMTTLQAGDLGKSVAGTSVDNAQLRDVNEAVRNHPIESVGRKLRGY
CEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
MTDMKRIAVAG
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA