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The map label for this gene is fkpA [H]

Identifier: 157372788

GI number: 157372788

Start: 5031264

End: 5032097

Strand: Reverse

Name: fkpA [H]

Synonym: Spro_4556

Alternate gene names: 157372788

Gene position: 5032097-5031264 (Counterclockwise)

Preceding gene: 157372790

Following gene: 157372787

Centisome position: 92.35

GC content: 54.2

Gene sequence:

>834_bases
ATGAAATCTTTGTTTAAAGTCACGCTTCTGGCAACCACCATGGCTTTTGCTTTGAATGCGACCCAGGTTATGGCTGCTGA
TGCAGCTAAACCAGCAGAAGCGGCTAAAGCTGCCGACGCGGCACCAAGCACTGGCAAGTTCAAGAACGATGACGAGCAAG
CGGCTTACGCACTGGGTGCATCCCTGGGCCGTTACATGGACAACTCGCTGAAAGAGCAAGAAAAACTGGGCATCAAACTG
GATAAAGACCAGTTGATCTCAGGCGTTCAGGACGCTTTTGCCAACAAGAGCAAGCTGAACGATGCAGATATCGAAAAAAC
CCTGCAAAGCTTTGAAGCACGCGTGAAGGCTTCCGCTCAGGCGAAGATGGAGCAGGATGCGAAAGATAACGAAGCGAAAG
GCACCAAGTACCGTGATACCTTCGCTAAAGAAAAAGGCGTGAAGAAAACCGAGTCTGGCCTGCTGTATCAGGTAGAGAAG
CCAGGTACCGGCGCGGCGCCTAAAGACAGCGATACCGTTGTGGTGAACTACAAGGGCACCCTGACCGACGGTACCGAGTT
TGACAACTCCTACACCCGTGGTGAGCCACTGTCATTCCGTCTGGACGGTGTGATCCCAGGCTGGACCGAAGGCCTGAAAC
ACATCAAGAAAGGCGGCAAAATCAAGCTGGTTATCCCACCGGCGCTGGCCTACGGTAAAACTGGCGTCCCGGGTATTCCG
GCTAACTCCACTCTGGTGTTCGACGTTGAGCTGCTGGATGTGAAAGCCGCGCCGAAAGCGGACGCCAAGGCTGAGAAACC
GGCTGACGCAGCGGCCGATGCCAAAGCGCAGTAA

Upstream 100 bases:

>100_bases
TACCTGTGTGACTGTTTTGTTTTGTTTCGGACAGCTATAGTAGCCCGGTTATCTTACTTAATGATTGTTTGGGGCATCGC
TTCAGACACTGGAGAAATGG

Downstream 100 bases:

>100_bases
GTCTGCCTGAGCCCCACACCGCCGCGAACATTCTTCGCGGCGGTGTTCATTTCAGCCTGCCAAATCAGGCGTAACTTTCA
CCTCCTCCCCCACTGATCGC

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MKSLFKVTLLATTMAFALNATQVMAADAAKPAEAAKAADAAPSTGKFKNDDEQAAYALGASLGRYMDNSLKEQEKLGIKL
DKDQLISGVQDAFANKSKLNDADIEKTLQSFEARVKASAQAKMEQDAKDNEAKGTKYRDTFAKEKGVKKTESGLLYQVEK
PGTGAAPKDSDTVVVNYKGTLTDGTEFDNSYTRGEPLSFRLDGVIPGWTEGLKHIKKGGKIKLVIPPALAYGKTGVPGIP
ANSTLVFDVELLDVKAAPKADAKAEKPADAAADAKAQ

Sequences:

>Translated_277_residues
MKSLFKVTLLATTMAFALNATQVMAADAAKPAEAAKAADAAPSTGKFKNDDEQAAYALGASLGRYMDNSLKEQEKLGIKL
DKDQLISGVQDAFANKSKLNDADIEKTLQSFEARVKASAQAKMEQDAKDNEAKGTKYRDTFAKEKGVKKTESGLLYQVEK
PGTGAAPKDSDTVVVNYKGTLTDGTEFDNSYTRGEPLSFRLDGVIPGWTEGLKHIKKGGKIKLVIPPALAYGKTGVPGIP
ANSTLVFDVELLDVKAAPKADAKAEKPADAAADAKAQ
>Mature_277_residues
MKSLFKVTLLATTMAFALNATQVMAADAAKPAEAAKAADAAPSTGKFKNDDEQAAYALGASLGRYMDNSLKEQEKLGIKL
DKDQLISGVQDAFANKSKLNDADIEKTLQSFEARVKASAQAKMEQDAKDNEAKGTKYRDTFAKEKGVKKTESGLLYQVEK
PGTGAAPKDSDTVVVNYKGTLTDGTEFDNSYTRGEPLSFRLDGVIPGWTEGLKHIKKGGKIKLVIPPALAYGKTGVPGIP
ANSTLVFDVELLDVKAAPKADAKAEKPADAAADAKAQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI224809329, Length=112, Percent_Identity=42.8571428571429, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI224809327, Length=112, Percent_Identity=42.8571428571429, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4758384, Length=112, Percent_Identity=42.8571428571429, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI17149836, Length=105, Percent_Identity=49.5238095238095, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4503725, Length=105, Percent_Identity=49.5238095238095, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI224809331, Length=112, Percent_Identity=42.8571428571429, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=43.9252336448598, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI206725530, Length=91, Percent_Identity=46.1538461538462, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI17149844, Length=91, Percent_Identity=46.1538461538462, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI17149842, Length=91, Percent_Identity=46.1538461538462, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI8923659, Length=99, Percent_Identity=41.4141414141414, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI4503729, Length=111, Percent_Identity=40.5405405405405, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4503727, Length=185, Percent_Identity=33.5135135135135, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI33469985, Length=112, Percent_Identity=35.7142857142857, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1789745, Length=265, Percent_Identity=79.622641509434, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI87082390, Length=214, Percent_Identity=39.2523364485981, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17540882, Length=90, Percent_Identity=47.7777777777778, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71993519, Length=91, Percent_Identity=47.2527472527472, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17561782, Length=112, Percent_Identity=40.1785714285714, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561778, Length=263, Percent_Identity=25.4752851711027, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=91, Percent_Identity=53.8461538461538, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324194, Length=99, Percent_Identity=49.4949494949495, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323482, Length=110, Percent_Identity=40.9090909090909, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323566, Length=110, Percent_Identity=40, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24655568, Length=99, Percent_Identity=49.4949494949495, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281363946, Length=95, Percent_Identity=45.2631578947368, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17352457, Length=95, Percent_Identity=45.2631578947368, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583150, Length=130, Percent_Identity=37.6923076923077, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21356629, Length=100, Percent_Identity=49, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24647110, Length=93, Percent_Identity=43.010752688172, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 29389; Mature: 29389

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLFKVTLLATTMAFALNATQVMAADAAKPAEAAKAADAAPSTGKFKNDDEQAAYALGA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
SLGRYMDNSLKEQEKLGIKLDKDQLISGVQDAFANKSKLNDADIEKTLQSFEARVKASAQ
HHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHH
AKMEQDAKDNEAKGTKYRDTFAKEKGVKKTESGLLYQVEKPGTGAAPKDSDTVVVNYKGT
HHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEECCC
LTDGTEFDNSYTRGEPLSFRLDGVIPGWTEGLKHIKKGGKIKLVIPPALAYGKTGVPGIP
CCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHCCCCCCCCCC
ANSTLVFDVELLDVKAAPKADAKAEKPADAAADAKAQ
CCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKSLFKVTLLATTMAFALNATQVMAADAAKPAEAAKAADAAPSTGKFKNDDEQAAYALGA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
SLGRYMDNSLKEQEKLGIKLDKDQLISGVQDAFANKSKLNDADIEKTLQSFEARVKASAQ
HHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHH
AKMEQDAKDNEAKGTKYRDTFAKEKGVKKTESGLLYQVEKPGTGAAPKDSDTVVVNYKGT
HHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEECCC
LTDGTEFDNSYTRGEPLSFRLDGVIPGWTEGLKHIKKGGKIKLVIPPALAYGKTGVPGIP
CCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHCCCCCCCCCC
ANSTLVFDVELLDVKAAPKADAKAEKPADAAADAKAQ
CCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]