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The map label for this gene is iclR [H]

Identifier: 157372724

GI number: 157372724

Start: 4976624

End: 4977454

Strand: Direct

Name: iclR [H]

Synonym: Spro_4491

Alternate gene names: 157372724

Gene position: 4976624-4977454 (Clockwise)

Preceding gene: 157372722

Following gene: 157372725

Centisome position: 91.33

GC content: 59.57

Gene sequence:

>831_bases
ATGGTCACCCCTGCTCCTGCCAAACGTGGCAAAAAGCCCCGTGCTGCATCCCCGACCGCCAGTGCGGCGACCGGCCAGGT
ACAGTCGCTGACCCGTGGTCTGAAATTATTGGAATACATTGCCGAAGCTCAGGGCAATGTCGCACTAACCGATCTGGCCC
AACAGGCCGGCTTGCCGAACTCCACCACCCACCGCCTGCTCACCACCATGCAACAACAAGGGTTCGTGCGGCAGGTGGGC
GATCTGGGCCTGTGGACCATCGGCTCACACGCCTTTGTGGTCGGCAGCAGCTTTTTGCAGAGCCGTAATCTGTTGGCGAT
GGTGCACCCAACGCTGCGTCGCCTGATGGAGGAGTCCGGCGAGACGGTTAATCTGGCGGTGCTGGATACCAGCGAGTATC
AGGCCATTATTATCGATCAGGTACAGTGCACCGCGTTGATGCGCATGTCGGCACCGATCGGCGGTAAACTGCCGATGCAC
GCTTCCGGCGCGGGGAAAGCCTTTCTTTCCACCCTGCCGGATGAGCAGGTCACCAAACTGCTGCATAAAAAGGGCATGCA
AACCTATACCCAACATACTCTGACGCCGCACAACCTGAAGGAAGGGCTGGCGCAGATTCGCAAGCAGGGCTTTTCCTTTG
ACGATGAAGAACATGCGCTAGGTCTGCGCTGCGTAGCAGCCTGCATCTTCGACGAGCACCGTGAAGCCTTCGCCGCCATC
TCCATCTCCGGCCCGGTGTCTCGCATCACCGACAACCGCGTGACTGAGCTGGGCGCGTTGGTGATCCACGCGGCGAAAGA
GATCAGCCTGGAATATGGCGGCGTGCGTTAA

Upstream 100 bases:

>100_bases
AGGTTGCCGGGCAACAGATCCGATGAGCTGATTGACGGCTTGCAATTCACACGTAAAAAACGAAAATGAATTCCATCATA
CGGAAAAAGGAACGTGAATT

Downstream 100 bases:

>100_bases
AATACCCGTGATACTGCTGGCCTGATTCAAATTTATAAAATCCGGGCCAGCGGCATGAAAATACAATCAGGGAAATATCG
CACCACTGCTGGCACGGCAG

Product: transcriptional repressor IclR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MVTPAPAKRGKKPRAASPTASAATGQVQSLTRGLKLLEYIAEAQGNVALTDLAQQAGLPNSTTHRLLTTMQQQGFVRQVG
DLGLWTIGSHAFVVGSSFLQSRNLLAMVHPTLRRLMEESGETVNLAVLDTSEYQAIIIDQVQCTALMRMSAPIGGKLPMH
ASGAGKAFLSTLPDEQVTKLLHKKGMQTYTQHTLTPHNLKEGLAQIRKQGFSFDDEEHALGLRCVAACIFDEHREAFAAI
SISGPVSRITDNRVTELGALVIHAAKEISLEYGGVR

Sequences:

>Translated_276_residues
MVTPAPAKRGKKPRAASPTASAATGQVQSLTRGLKLLEYIAEAQGNVALTDLAQQAGLPNSTTHRLLTTMQQQGFVRQVG
DLGLWTIGSHAFVVGSSFLQSRNLLAMVHPTLRRLMEESGETVNLAVLDTSEYQAIIIDQVQCTALMRMSAPIGGKLPMH
ASGAGKAFLSTLPDEQVTKLLHKKGMQTYTQHTLTPHNLKEGLAQIRKQGFSFDDEEHALGLRCVAACIFDEHREAFAAI
SISGPVSRITDNRVTELGALVIHAAKEISLEYGGVR
>Mature_276_residues
MVTPAPAKRGKKPRAASPTASAATGQVQSLTRGLKLLEYIAEAQGNVALTDLAQQAGLPNSTTHRLLTTMQQQGFVRQVG
DLGLWTIGSHAFVVGSSFLQSRNLLAMVHPTLRRLMEESGETVNLAVLDTSEYQAIIIDQVQCTALMRMSAPIGGKLPMH
ASGAGKAFLSTLPDEQVTKLLHKKGMQTYTQHTLTPHNLKEGLAQIRKQGFSFDDEEHALGLRCVAACIFDEHREAFAAI
SISGPVSRITDNRVTELGALVIHAAKEISLEYGGVR

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=277, Percent_Identity=78.7003610108303, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI1786715, Length=268, Percent_Identity=41.4179104477612, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1788131, Length=248, Percent_Identity=29.8387096774194, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1786468, Length=226, Percent_Identity=30.5309734513274, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1789999, Length=251, Percent_Identity=32.6693227091633, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1788581, Length=253, Percent_Identity=29.6442687747036, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790752, Length=249, Percent_Identity=26.5060240963855, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29763; Mature: 29763

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTPAPAKRGKKPRAASPTASAATGQVQSLTRGLKLLEYIAEAQGNVALTDLAQQAGLPN
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
STTHRLLTTMQQQGFVRQVGDLGLWTIGSHAFVVGSSFLQSRNLLAMVHPTLRRLMEESG
CHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
ETVNLAVLDTSEYQAIIIDQVQCTALMRMSAPIGGKLPMHASGAGKAFLSTLPDEQVTKL
CEEEEEEEECCCCCEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHH
LHKKGMQTYTQHTLTPHNLKEGLAQIRKQGFSFDDEEHALGLRCVAACIFDEHREAFAAI
HHHCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEE
SISGPVSRITDNRVTELGALVIHAAKEISLEYGGVR
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVTPAPAKRGKKPRAASPTASAATGQVQSLTRGLKLLEYIAEAQGNVALTDLAQQAGLPN
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
STTHRLLTTMQQQGFVRQVGDLGLWTIGSHAFVVGSSFLQSRNLLAMVHPTLRRLMEESG
CHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
ETVNLAVLDTSEYQAIIIDQVQCTALMRMSAPIGGKLPMHASGAGKAFLSTLPDEQVTKL
CEEEEEEEECCCCCEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHH
LHKKGMQTYTQHTLTPHNLKEGLAQIRKQGFSFDDEEHALGLRCVAACIFDEHREAFAAI
HHHCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEE
SISGPVSRITDNRVTELGALVIHAAKEISLEYGGVR
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]