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The map label for this gene is lysC [H]

Identifier: 157372712

GI number: 157372712

Start: 4956021

End: 4957388

Strand: Direct

Name: lysC [H]

Synonym: Spro_4479

Alternate gene names: 157372712

Gene position: 4956021-4957388 (Clockwise)

Preceding gene: 157372711

Following gene: 157372713

Centisome position: 90.96

GC content: 59.87

Gene sequence:

>1368_bases
ATGAACCAAGCAGCACCCCAGAATTCCACCGTTGTCGCCAAATTCGGCGGCACCAGCGTTGCTGACTATGAAGCCATGAA
CCGCAGCGCCGACGTCGTACTCGCCAATCCGGACGTACGCCTGGTGGTCTTGTCCGCTTCTGCGGGCGTCACCAACCTGT
TGGTGGCTCTGGCCGAAGGCAGCGATGCCGACAAACGCCATTTCCAGCTCGATGAAATCCGTCGCATCCAATACGCTATC
CTTGATCGTCTCGACAATCCGGCGGTTGTCCGCGAAGAAATCGACCGCATGCTGGAAAACATCGCCATGCTGTCCGAAGC
GGCGTCGCTGGCAAACTCGGCGGCATTGACCGACGAACTGGTCAGCCATGGCGAACTGATGTCTACCCTGCTGTTTGTGG
AGATCCTGCGCGCTCGCCAGGTGCAGGCGGAATGGTTTGACGTGCGTAAAGTGATGCACACCGATGACCACTTCGGGCGT
GCCACACCGGACACCGCAGCGCTGAGCCAATTAGCCCAATCGCTGCTCAAACCGCGCCTGCAAGAAGCGCTGGTGGTGAC
CCAGGGCTTTATCGGCAGCGAGCCGAAAGGCCGCACCACCACGCTGGGCCGCGGCGGCAGCGATTACACCGCCGCACTGC
TGGGCGAAGCGCTGAGCGTCAGCCGGGTGGATATCTGGACCGACGTGCCGGGCATCTACACCACCGATCCGCGCGTGGTT
CCGGCGGCGAAACGCATTGATAAAATTACCTTCGAAGAAGCGGCAGAAATGGCGACCTTCGGTGCGAAAGTATTGCACCC
GGCGACCCTGCTGCCGGCGGTGCGCTGCGATATTCCGGTGTTTGTCGGTTCAAGCAAGGATCCGGCCGCCGGGGGGACCC
TGGTGTGTAATACCACCGAGAATCCGCCGCTGTTCCGCGCACTGGCACTGCGCCGCAAGCAAACCCTGCTGACACTGCAC
AGCCTCAACATGCTGCACGCACGCGGTTTCCTGGCCGAAGTGTTCAACACTCTGGCGCGCCATAATGTCTCGGTGGATCT
GATCACCACTTCTGAAGTCAGTATCGCGCTGACCATGGACACTACCGGCTCTACCAACACCGGTGGCAGCCCGCTGACCA
CCTCGTTGCTGACCGATCTTTCATCACTGTGTCGGGTGGAAGTGGAGGAAAACCTGGCGCTGGTGGCGTTGATTGGCAAC
AAACTTTCCCAGGCCTGCGGCGTGGGCAAAGAAGTGTTTGGCGTGCTCGATCCGTTCAATATCCGCATGATTTGCTACGG
TGCCAGCAGCTATAACCTGTGCTTCCTGGTGCCCGGTAACGACGCCGAGCAAGTGGTACGCACCCTGCATCACAATCTGT
TCGAATAA

Upstream 100 bases:

>100_bases
TTAACCTCTACGTCTGCCCCCTGCTTATCGCTCCTCCCTTGTGCCAAGGCTATGAAAAAAGCGCTCTCTGAATAGAGCCA
CCCTGACACGAGGTTTTTAC

Downstream 100 bases:

>100_bases
ACTATTATCATCCCTTGCGGGCGCAGCATGCTGCGCCCCTACATCTAAAAAATCAGTTCATAACCGTAGGGGTTCAGTCC
GCTGAACTCGCAAAAAAACA

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MNQAAPQNSTVVAKFGGTSVADYEAMNRSADVVLANPDVRLVVLSASAGVTNLLVALAEGSDADKRHFQLDEIRRIQYAI
LDRLDNPAVVREEIDRMLENIAMLSEAASLANSAALTDELVSHGELMSTLLFVEILRARQVQAEWFDVRKVMHTDDHFGR
ATPDTAALSQLAQSLLKPRLQEALVVTQGFIGSEPKGRTTTLGRGGSDYTAALLGEALSVSRVDIWTDVPGIYTTDPRVV
PAAKRIDKITFEEAAEMATFGAKVLHPATLLPAVRCDIPVFVGSSKDPAAGGTLVCNTTENPPLFRALALRRKQTLLTLH
SLNMLHARGFLAEVFNTLARHNVSVDLITTSEVSIALTMDTTGSTNTGGSPLTTSLLTDLSSLCRVEVEENLALVALIGN
KLSQACGVGKEVFGVLDPFNIRMICYGASSYNLCFLVPGNDAEQVVRTLHHNLFE

Sequences:

>Translated_455_residues
MNQAAPQNSTVVAKFGGTSVADYEAMNRSADVVLANPDVRLVVLSASAGVTNLLVALAEGSDADKRHFQLDEIRRIQYAI
LDRLDNPAVVREEIDRMLENIAMLSEAASLANSAALTDELVSHGELMSTLLFVEILRARQVQAEWFDVRKVMHTDDHFGR
ATPDTAALSQLAQSLLKPRLQEALVVTQGFIGSEPKGRTTTLGRGGSDYTAALLGEALSVSRVDIWTDVPGIYTTDPRVV
PAAKRIDKITFEEAAEMATFGAKVLHPATLLPAVRCDIPVFVGSSKDPAAGGTLVCNTTENPPLFRALALRRKQTLLTLH
SLNMLHARGFLAEVFNTLARHNVSVDLITTSEVSIALTMDTTGSTNTGGSPLTTSLLTDLSSLCRVEVEENLALVALIGN
KLSQACGVGKEVFGVLDPFNIRMICYGASSYNLCFLVPGNDAEQVVRTLHHNLFE
>Mature_455_residues
MNQAAPQNSTVVAKFGGTSVADYEAMNRSADVVLANPDVRLVVLSASAGVTNLLVALAEGSDADKRHFQLDEIRRIQYAI
LDRLDNPAVVREEIDRMLENIAMLSEAASLANSAALTDELVSHGELMSTLLFVEILRARQVQAEWFDVRKVMHTDDHFGR
ATPDTAALSQLAQSLLKPRLQEALVVTQGFIGSEPKGRTTTLGRGGSDYTAALLGEALSVSRVDIWTDVPGIYTTDPRVV
PAAKRIDKITFEEAAEMATFGAKVLHPATLLPAVRCDIPVFVGSSKDPAAGGTLVCNTTENPPLFRALALRRKQTLLTLH
SLNMLHARGFLAEVFNTLARHNVSVDLITTSEVSIALTMDTTGSTNTGGSPLTTSLLTDLSSLCRVEVEENLALVALIGN
KLSQACGVGKEVFGVLDPFNIRMICYGASSYNLCFLVPGNDAEQVVRTLHHNLFE

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=445, Percent_Identity=80.8988764044944, Blast_Score=686, Evalue=0.0,
Organism=Escherichia coli, GI1786183, Length=466, Percent_Identity=30.4721030042918, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1790376, Length=297, Percent_Identity=34.006734006734, Blast_Score=129, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6320893, Length=495, Percent_Identity=28.0808080808081, Blast_Score=168, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 49040; Mature: 49040

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQAAPQNSTVVAKFGGTSVADYEAMNRSADVVLANPDVRLVVLSASAGVTNLLVALAEG
CCCCCCCCCEEEEECCCCCCHHHHHHCCCCCEEEECCCEEEEEEECCCCHHHHHHHHCCC
SDADKRHFQLDEIRRIQYAILDRLDNPAVVREEIDRMLENIAMLSEAASLANSAALTDEL
CCCCHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSHGELMSTLLFVEILRARQVQAEWFDVRKVMHTDDHFGRATPDTAALSQLAQSLLKPRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
QEALVVTQGFIGSEPKGRTTTLGRGGSDYTAALLGEALSVSRVDIWTDVPGIYTTDPRVV
HHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCEECCCCEE
PAAKRIDKITFEEAAEMATFGAKVLHPATLLPAVRCDIPVFVGSSKDPAAGGTLVCNTTE
CHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCEEEECCCCCCCCCCEEEEECCC
NPPLFRALALRRKQTLLTLHSLNMLHARGFLAEVFNTLARHNVSVDLITTSEVSIALTMD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEEEEEE
TTGSTNTGGSPLTTSLLTDLSSLCRVEVEENLALVALIGNKLSQACGVGKEVFGVLDPFN
CCCCCCCCCCCHHHHHHHHHHHHHHEEHHCCEEEEEEHHHHHHHHHCCCHHHHHCCCCCC
IRMICYGASSYNLCFLVPGNDAEQVVRTLHHNLFE
EEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNQAAPQNSTVVAKFGGTSVADYEAMNRSADVVLANPDVRLVVLSASAGVTNLLVALAEG
CCCCCCCCCEEEEECCCCCCHHHHHHCCCCCEEEECCCEEEEEEECCCCHHHHHHHHCCC
SDADKRHFQLDEIRRIQYAILDRLDNPAVVREEIDRMLENIAMLSEAASLANSAALTDEL
CCCCHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSHGELMSTLLFVEILRARQVQAEWFDVRKVMHTDDHFGRATPDTAALSQLAQSLLKPRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
QEALVVTQGFIGSEPKGRTTTLGRGGSDYTAALLGEALSVSRVDIWTDVPGIYTTDPRVV
HHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCEECCCCEE
PAAKRIDKITFEEAAEMATFGAKVLHPATLLPAVRCDIPVFVGSSKDPAAGGTLVCNTTE
CHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCEEEECCCCCCCCCCEEEEECCC
NPPLFRALALRRKQTLLTLHSLNMLHARGFLAEVFNTLARHNVSVDLITTSEVSIALTMD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEEEEEE
TTGSTNTGGSPLTTSLLTDLSSLCRVEVEENLALVALIGNKLSQACGVGKEVFGVLDPFN
CCCCCCCCCCCHHHHHHHHHHHHHHEEHHCCEEEEEEHHHHHHHHHCCCHHHHHCCCCCC
IRMICYGASSYNLCFLVPGNDAEQVVRTLHHNLFE
EEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]