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The map label for this gene is cvrA [H]

Identifier: 157372711

GI number: 157372711

Start: 4953857

End: 4955665

Strand: Direct

Name: cvrA [H]

Synonym: Spro_4478

Alternate gene names: 157372711

Gene position: 4953857-4955665 (Clockwise)

Preceding gene: 157372709

Following gene: 157372712

Centisome position: 90.92

GC content: 59.48

Gene sequence:

>1809_bases
ATGGAATTATCTGCCCCGTTGATGTTGGTGGTTATTGGATTGAGTTCGCTGCTGGCGCAGTGGCTGGCCTGGCTGTTACG
CCTGCCGGCCATTCTGCCGCTGCTGGTGTTTGGCGTGGTACTGGGCCCGGTGGTGCATTGGGTCCAGCCGGACGCGCTGT
TTGGCGATTTGCTGTTCCCGCTGGTGTCGCTGTCGGTCGCCATTATTCTGTTCGAAGGCGCGCTGACGCTGCGGGTCGAG
GAAATTCGTGGCCTGGGTGGCGTAGTGCGCAACCTGGTAACCATCGGCATGCTGATGACCTTTCTGGTGATTGGCGTGGC
CTGCTGGTGGCTGCTGGACTTTCCGCCCGAACTGGCGGCGCTGATCGGTGCGGTAACGGTGGTCACCGGCCCGACGGTGA
TCGCCCCGCTGATGCGGGTGGTGCGACCCAACGCCAATATCAACCAGGTGCTGCGCTGGGAAGGGATAGTGATCGACCCG
GTCGGCGCTATCTTCACCCTGCTGGTGTTTGAATTTATCGTACTGAAACAGCATTCGGAATCTTACACCCACCTGTTCTA
CACCCTGGGTATTACCGCCGCCGTCGGTCTGGTGGCCGGCGCACTGTTCGGTTACCTGCTGGGCGTGGCGCTACGCCGTG
TCTGGCTGCCGGGCTACCTGCAAAACCTGGCGGTGCTGGCAATTATGCTCACCGCTTTTGGCCTGTCCAACGCCATTGCC
GACGAGTCCGGCCTGCTGACCGTCACGGTGATGGGCATTTGGCTGGCCAATATGCGCGATGTCGATACCAGCGACATCCT
GGCATTTAAAGAAGAGCTGTCGGCGATCCTGATTTCGGCGCTGTTTATCATTTTGGCGGCACGGCTTGATATCCAGGCGT
TGTGGAATATGGGCTGGCCGCTGCTGGGCCTGCTGCTGGTGGTGCAGTTTATTGCAAGGCCGCTGTGTATTGCGGTGTCG
ACCTGGCGCTCCTCCCTGCACTGGCGCGATCGGCTGCTGCTGTGCTGGATTTCGCCACGCGGTATCGTTGCTGCGGCGGT
CAGTTCACTGTTCGCCCTGACCTTGCAACGCAGCGGTTATCCAGGAGCCGATCGCCTGGTGACCGTGGTGTTCGCCGTGA
TCATCGGTACCGTGGTGCTGCAAAGCCTGACCAGCAGCATGATGGCACGCTGGTTGCGGGTACAGCAGCAAAAACCACGC
GGCGTGCTGATCGTCGGCGCCAACAGCGTGGCGCGCATGCTGGCGCAGGCGTTGATAAAAATGAATATCCCGGTGATCGT
CACCGACAGCAGTTGGGAGTATTACCGCCAGGCGCGTATGGACGGCATCCCCGCCTATTATGGCCATGCTTACTCCGAAC
ATGCCGAGAACTACCTCGATCTCAGCGATACCGCGCAGGTGCTGGCCCTGTCGCCCAACCGCCATCAGAATGCGCTGGCG
GTCTATCACTTTGGCCATATTTTTGGCGACGGGCAGGTGTTCGCCATCCGCTCCGGCGCCCCGCTGAAAGGTCGCGGCAA
CAGTGGTGAAAGCTCGCGCTTTCGTCGGCATGAAGTTTTATTTAATCAAGAAGCCACTTATGGCCGCTTAAGCAGTCTGA
TCGCCCAGGGGGCGACCATCAAGGCCACCAAGCTGAACGAGAACTTTGGCTGGCTGGAATATCTTGAGAAACATCAGGGC
GTTATTCCGCTATTCAGTCAGCGCGAGGACGGCACTTTGCAGCCGATCGGTACCGGTTTCGTCCCGGCGATGCCCTGTAC
GCTGATTGCACTGGTACAAGATGAAAATCCCTCAACGTCCGGACGTTGA

Upstream 100 bases:

>100_bases
TGTCACTAAACTGTGTCAGGTTATCACCACGTCATTGACGTAATTAGGCTAAGGATGCGCGGCCAATCAGGCTGCGGTTT
GAAACACGAAGGACATGACT

Downstream 100 bases:

>100_bases
CAGCAGCGCGATTACCGGCTATTCCTAACAGCCTACTTGCGCACCCGGTGCGCAAGCCAGAAGAGGTGCGTCGCCCAGGT
AGAGTGTCAGAGGAGCCGTT

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MELSAPLMLVVIGLSSLLAQWLAWLLRLPAILPLLVFGVVLGPVVHWVQPDALFGDLLFPLVSLSVAIILFEGALTLRVE
EIRGLGGVVRNLVTIGMLMTFLVIGVACWWLLDFPPELAALIGAVTVVTGPTVIAPLMRVVRPNANINQVLRWEGIVIDP
VGAIFTLLVFEFIVLKQHSESYTHLFYTLGITAAVGLVAGALFGYLLGVALRRVWLPGYLQNLAVLAIMLTAFGLSNAIA
DESGLLTVTVMGIWLANMRDVDTSDILAFKEELSAILISALFIILAARLDIQALWNMGWPLLGLLLVVQFIARPLCIAVS
TWRSSLHWRDRLLLCWISPRGIVAAAVSSLFALTLQRSGYPGADRLVTVVFAVIIGTVVLQSLTSSMMARWLRVQQQKPR
GVLIVGANSVARMLAQALIKMNIPVIVTDSSWEYYRQARMDGIPAYYGHAYSEHAENYLDLSDTAQVLALSPNRHQNALA
VYHFGHIFGDGQVFAIRSGAPLKGRGNSGESSRFRRHEVLFNQEATYGRLSSLIAQGATIKATKLNENFGWLEYLEKHQG
VIPLFSQREDGTLQPIGTGFVPAMPCTLIALVQDENPSTSGR

Sequences:

>Translated_602_residues
MELSAPLMLVVIGLSSLLAQWLAWLLRLPAILPLLVFGVVLGPVVHWVQPDALFGDLLFPLVSLSVAIILFEGALTLRVE
EIRGLGGVVRNLVTIGMLMTFLVIGVACWWLLDFPPELAALIGAVTVVTGPTVIAPLMRVVRPNANINQVLRWEGIVIDP
VGAIFTLLVFEFIVLKQHSESYTHLFYTLGITAAVGLVAGALFGYLLGVALRRVWLPGYLQNLAVLAIMLTAFGLSNAIA
DESGLLTVTVMGIWLANMRDVDTSDILAFKEELSAILISALFIILAARLDIQALWNMGWPLLGLLLVVQFIARPLCIAVS
TWRSSLHWRDRLLLCWISPRGIVAAAVSSLFALTLQRSGYPGADRLVTVVFAVIIGTVVLQSLTSSMMARWLRVQQQKPR
GVLIVGANSVARMLAQALIKMNIPVIVTDSSWEYYRQARMDGIPAYYGHAYSEHAENYLDLSDTAQVLALSPNRHQNALA
VYHFGHIFGDGQVFAIRSGAPLKGRGNSGESSRFRRHEVLFNQEATYGRLSSLIAQGATIKATKLNENFGWLEYLEKHQG
VIPLFSQREDGTLQPIGTGFVPAMPCTLIALVQDENPSTSGR
>Mature_602_residues
MELSAPLMLVVIGLSSLLAQWLAWLLRLPAILPLLVFGVVLGPVVHWVQPDALFGDLLFPLVSLSVAIILFEGALTLRVE
EIRGLGGVVRNLVTIGMLMTFLVIGVACWWLLDFPPELAALIGAVTVVTGPTVIAPLMRVVRPNANINQVLRWEGIVIDP
VGAIFTLLVFEFIVLKQHSESYTHLFYTLGITAAVGLVAGALFGYLLGVALRRVWLPGYLQNLAVLAIMLTAFGLSNAIA
DESGLLTVTVMGIWLANMRDVDTSDILAFKEELSAILISALFIILAARLDIQALWNMGWPLLGLLLVVQFIARPLCIAVS
TWRSSLHWRDRLLLCWISPRGIVAAAVSSLFALTLQRSGYPGADRLVTVVFAVIIGTVVLQSLTSSMMARWLRVQQQKPR
GVLIVGANSVARMLAQALIKMNIPVIVTDSSWEYYRQARMDGIPAYYGHAYSEHAENYLDLSDTAQVLALSPNRHQNALA
VYHFGHIFGDGQVFAIRSGAPLKGRGNSGESSRFRRHEVLFNQEATYGRLSSLIAQGATIKATKLNENFGWLEYLEKHQG
VIPLFSQREDGTLQPIGTGFVPAMPCTLIALVQDENPSTSGR

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=332, Percent_Identity=25.9036144578313, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018421
- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 65861; Mature: 65861

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELSAPLMLVVIGLSSLLAQWLAWLLRLPAILPLLVFGVVLGPVVHWVQPDALFGDLLFP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LVSLSVAIILFEGALTLRVEEIRGLGGVVRNLVTIGMLMTFLVIGVACWWLLDFPPELAA
HHHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LIGAVTVVTGPTVIAPLMRVVRPNANINQVLRWEGIVIDPVGAIFTLLVFEFIVLKQHSE
HHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHEECCEEECCHHHHHHHHHHHHHHHHHCCC
SYTHLFYTLGITAAVGLVAGALFGYLLGVALRRVWLPGYLQNLAVLAIMLTAFGLSNAIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHC
DESGLLTVTVMGIWLANMRDVDTSDILAFKEELSAILISALFIILAARLDIQALWNMGWP
CCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
LLGLLLVVQFIARPLCIAVSTWRSSLHWRDRLLLCWISPRGIVAAAVSSLFALTLQRSGY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCC
PGADRLVTVVFAVIIGTVVLQSLTSSMMARWLRVQQQKPRGVLIVGANSVARMLAQALIK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHH
MNIPVIVTDSSWEYYRQARMDGIPAYYGHAYSEHAENYLDLSDTAQVLALSPNRHQNALA
CCCCEEEECCCHHHHHHHHHCCCCHHHCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCEE
VYHFGHIFGDGQVFAIRSGAPLKGRGNSGESSRFRRHEVLFNQEATYGRLSSLIAQGATI
EEEEHEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCEE
KATKLNENFGWLEYLEKHQGVIPLFSQREDGTLQPIGTGFVPAMPCTLIALVQDENPSTS
EEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEECCCCCCC
GR
CC
>Mature Secondary Structure
MELSAPLMLVVIGLSSLLAQWLAWLLRLPAILPLLVFGVVLGPVVHWVQPDALFGDLLFP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LVSLSVAIILFEGALTLRVEEIRGLGGVVRNLVTIGMLMTFLVIGVACWWLLDFPPELAA
HHHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LIGAVTVVTGPTVIAPLMRVVRPNANINQVLRWEGIVIDPVGAIFTLLVFEFIVLKQHSE
HHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHEECCEEECCHHHHHHHHHHHHHHHHHCCC
SYTHLFYTLGITAAVGLVAGALFGYLLGVALRRVWLPGYLQNLAVLAIMLTAFGLSNAIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHC
DESGLLTVTVMGIWLANMRDVDTSDILAFKEELSAILISALFIILAARLDIQALWNMGWP
CCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
LLGLLLVVQFIARPLCIAVSTWRSSLHWRDRLLLCWISPRGIVAAAVSSLFALTLQRSGY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCC
PGADRLVTVVFAVIIGTVVLQSLTSSMMARWLRVQQQKPRGVLIVGANSVARMLAQALIK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHH
MNIPVIVTDSSWEYYRQARMDGIPAYYGHAYSEHAENYLDLSDTAQVLALSPNRHQNALA
CCCCEEEECCCHHHHHHHHHCCCCHHHCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCEE
VYHFGHIFGDGQVFAIRSGAPLKGRGNSGESSRFRRHEVLFNQEATYGRLSSLIAQGATI
EEEEHEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCEE
KATKLNENFGWLEYLEKHQGVIPLFSQREDGTLQPIGTGFVPAMPCTLIALVQDENPSTS
EEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEECCCCCCC
GR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA