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The map label for this gene is plsB

Identifier: 157372695

GI number: 157372695

Start: 4933206

End: 4935671

Strand: Direct

Name: plsB

Synonym: Spro_4462

Alternate gene names: 157372695

Gene position: 4933206-4935671 (Clockwise)

Preceding gene: 157372690

Following gene: 157372698

Centisome position: 90.54

GC content: 56.41

Gene sequence:

>2466_bases
ATGTCAGGTTGGCGTAAAATTTATTATAAACTATTGAATTTACCACTCAAACTGTTGGTAAGAAGTAAGGTTATCCCTTC
AGATCCGGTCACGGAGTTAGGGTTGGATCCCTCACGGCCGATTTTGTATGTTTTACCTTATAATTCCAAGGCGGATTTGC
TGACGCTGCGCACCCAGTGCCTGGCGCAAGATCTGCCCGACCCCCTCAATCCGCTGGAGATAGACGGCACCGTGCTGCCA
AGCCACGTGTTTATTCACGACGGCCCGCGCGTATTCCGCTACTACACGCCGAAAGAAGAGTCGGTAAAACTGTTCCACGA
CTATCTGGACCTGCACCGCAGTAATCCGGATCTCGACATTCAGATGCTGCCGGTTTCGGTGATGTTTGGCCGCTCTCCGG
GGCGCGAAGGTCACGGCACACCGCATCTGCGTCTGCTGAATGGCGTGCAGAAATTCTTCGCCGTGCTGTGGCTCGGCCGC
GACAGCTTTGTCCGTTTTTCCAATACCGTTTCGCTGCGCCGCATGGCCACCGAGCACGGTACGGACAAAATCATTGCGCA
GAAACTGGCTCGCGTAGCGCGCATGCACTTCTCGCGTCAGCGTCTGGCCGCCGTCGGCCCAAGCCTGCCGGCCCGTCAGG
ACCTGTTCAACAAACTGTTGGCGTCCAAGGCGATCGAAAAAGCGGTCGAGGACGAAGCTCGCAGCAAGAAGATTTCCCAC
GAAAAAGCCCAGCAGAATGCCATTGCGCTGATGGAAGAGATCGCTGCCGACTTCTCTTACGAGACGGTGCGCCTTTCCGA
TCGCGTGCTGAGCTGGACCTGGAACAGACTGTATCAAGGTATCAACGTCACGAACGCAGAACGCGTGCGTCAGTTGGCGC
AGGACGGCCACGAGATTGTTTATGTGCCCTGCCACCGCAGCCACATGGACTACCTTCTGCTGTCCTACGTGCTGTATCAC
CAGGGTCTGGTACCGCCGCACATTGCTGCCGGTATCAATCTCAACTTCTGGCCGGCCGGGCCGATCTTCCGTCGCCTGGG
CGCTTTCTTTATCCGCCGCACTTTCAAAGGCAACAAGCTGTACTCGACGGTATTCCGTGAATACCTCGGCGAGCTGTTTA
CCCGCGGTTACTCGGTGGAATACTTTGTTGAAGGTGGCCGTTCCCGTACCGGACGTTTACTGGAACCGAAGACCGGCACC
CTGTCGATGACCATTCAGGCGATGCTGCGCGGCGGTAGCCGTCCTATCACACTGGTGCCGATTTACATCGGTTACGAACA
CGTGATGGAAGTGGGTACCTACGCCAAAGAGTTGCGTGGCGCGACCAAGGAAAAAGAGAGCCTGTTGCAGATGCTGCGCG
GCCTGCGCAAGCTGCGTAATCTCGGCCAGGGTTACGTCAACTTTGGTGATCCACTGCCGTTGACCGCTTACCTGAACCAG
AATGTGCCACAGTGGCGCGAATCCATTGACCCGATCGAAGCCCAGCGCCCAAGCTGGTTAACGCCGACGGTCAACGATTT
GGCGGCCAAGATCATGGTGCGCATCAACAATGCCGCCGCCGCCAACGCCATGAACCTGTGTTCCACGGCGCTGCTGGCCT
CACGCCAACGCTCGCTGACCCGCGAGCAGTTGCTTGAGCAGTTGGAATGCTACCTGCAACTGATGCGCAATGTGCCTTAT
GCCGGTGACGTTACCGTACCAACCCAAACGCCGGATGAGCTGCTGGATCATGCGCTGAACATGAACAAGTTCGAGGTGGA
GAAGGATAACATCGGCGATATCATCATCCTGCCGCGCGAGCAGGCGGTGTTGATGACCTATTACCGTAACAATATCCATC
ATCTGTTGGTTCTGCCATCGCTGATCGCCACTATCGTGATGCATCACCGCCGGGTATCGCGCGCTGAACTGCTAAGGCAG
ATTGGCCTGATTTACCCAATGCTGAAGGCTGAACTGTTCCTGCATAACGACAAGGAACAACTGCCGGAAGTGCTACGGCC
ACTGATCGACGAAATGATCCGTCAGCAACTGATCTGCGATAAGGGTGACGATCTGGTGTTGAATCCGGCACGCATCCGTC
CATTGCAGTTGTTGGCCGCCGGTGTCCGCGAAACGCTGCAGCGCTATGCCATCACCATGTCGATCCTCAGTGCCAATCCA
AGCATCAACCGCGGTGCGCTGGAGAAAGAGAGCCGTATTATGGCCCAGCGTCTGTCGGTGCTGCATGGCATCAACGCGCC
GGAGTTCTTCGACAAGGCGGTGTTCTCCACCCTGGTGGCGACGCTGCGTGCAGAAGGCTACATCAATGACATCGGCGATG
CGGTCCGTGAGCACACCATGGAGGTCTACAACATGCTGAGCGATTTGATTACCCCGGAAATCAAGCTGACCATTGAGAGC
GTCAGTATGCCGGCGGAAACCAACGCGTTGCCGGAAACGGTCGCAGCGGAAGAGAAAGAAGACTAA

Upstream 100 bases:

>100_bases
CAGGAAACTCTCCCGGCTCTCGGTTTTCCAACACCACAGATCTGCTACCCGGTTTCTGGTATGCTTGCGGCGCATTGCTA
ACAAGAGGCTTCACGTTGTT

Downstream 100 bases:

>100_bases
TCCATTGATACAAAACAAAAAGGCACCCTAGGGTGCCTTTTTTATTGCGGTAACGCCTTAACCCTGCCAGTAACTCAGAG
CAATACCGATAAACAACACC

Product: glycerol-3-phosphate acyltransferase

Products: NA

Alternate protein names: GPAT

Number of amino acids: Translated: 821; Mature: 820

Protein sequence:

>821_residues
MSGWRKIYYKLLNLPLKLLVRSKVIPSDPVTELGLDPSRPILYVLPYNSKADLLTLRTQCLAQDLPDPLNPLEIDGTVLP
SHVFIHDGPRVFRYYTPKEESVKLFHDYLDLHRSNPDLDIQMLPVSVMFGRSPGREGHGTPHLRLLNGVQKFFAVLWLGR
DSFVRFSNTVSLRRMATEHGTDKIIAQKLARVARMHFSRQRLAAVGPSLPARQDLFNKLLASKAIEKAVEDEARSKKISH
EKAQQNAIALMEEIAADFSYETVRLSDRVLSWTWNRLYQGINVTNAERVRQLAQDGHEIVYVPCHRSHMDYLLLSYVLYH
QGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKLYSTVFREYLGELFTRGYSVEYFVEGGRSRTGRLLEPKTGT
LSMTIQAMLRGGSRPITLVPIYIGYEHVMEVGTYAKELRGATKEKESLLQMLRGLRKLRNLGQGYVNFGDPLPLTAYLNQ
NVPQWRESIDPIEAQRPSWLTPTVNDLAAKIMVRINNAAAANAMNLCSTALLASRQRSLTREQLLEQLECYLQLMRNVPY
AGDVTVPTQTPDELLDHALNMNKFEVEKDNIGDIIILPREQAVLMTYYRNNIHHLLVLPSLIATIVMHHRRVSRAELLRQ
IGLIYPMLKAELFLHNDKEQLPEVLRPLIDEMIRQQLICDKGDDLVLNPARIRPLQLLAAGVRETLQRYAITMSILSANP
SINRGALEKESRIMAQRLSVLHGINAPEFFDKAVFSTLVATLRAEGYINDIGDAVREHTMEVYNMLSDLITPEIKLTIES
VSMPAETNALPETVAAEEKED

Sequences:

>Translated_821_residues
MSGWRKIYYKLLNLPLKLLVRSKVIPSDPVTELGLDPSRPILYVLPYNSKADLLTLRTQCLAQDLPDPLNPLEIDGTVLP
SHVFIHDGPRVFRYYTPKEESVKLFHDYLDLHRSNPDLDIQMLPVSVMFGRSPGREGHGTPHLRLLNGVQKFFAVLWLGR
DSFVRFSNTVSLRRMATEHGTDKIIAQKLARVARMHFSRQRLAAVGPSLPARQDLFNKLLASKAIEKAVEDEARSKKISH
EKAQQNAIALMEEIAADFSYETVRLSDRVLSWTWNRLYQGINVTNAERVRQLAQDGHEIVYVPCHRSHMDYLLLSYVLYH
QGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKLYSTVFREYLGELFTRGYSVEYFVEGGRSRTGRLLEPKTGT
LSMTIQAMLRGGSRPITLVPIYIGYEHVMEVGTYAKELRGATKEKESLLQMLRGLRKLRNLGQGYVNFGDPLPLTAYLNQ
NVPQWRESIDPIEAQRPSWLTPTVNDLAAKIMVRINNAAAANAMNLCSTALLASRQRSLTREQLLEQLECYLQLMRNVPY
AGDVTVPTQTPDELLDHALNMNKFEVEKDNIGDIIILPREQAVLMTYYRNNIHHLLVLPSLIATIVMHHRRVSRAELLRQ
IGLIYPMLKAELFLHNDKEQLPEVLRPLIDEMIRQQLICDKGDDLVLNPARIRPLQLLAAGVRETLQRYAITMSILSANP
SINRGALEKESRIMAQRLSVLHGINAPEFFDKAVFSTLVATLRAEGYINDIGDAVREHTMEVYNMLSDLITPEIKLTIES
VSMPAETNALPETVAAEEKED
>Mature_820_residues
SGWRKIYYKLLNLPLKLLVRSKVIPSDPVTELGLDPSRPILYVLPYNSKADLLTLRTQCLAQDLPDPLNPLEIDGTVLPS
HVFIHDGPRVFRYYTPKEESVKLFHDYLDLHRSNPDLDIQMLPVSVMFGRSPGREGHGTPHLRLLNGVQKFFAVLWLGRD
SFVRFSNTVSLRRMATEHGTDKIIAQKLARVARMHFSRQRLAAVGPSLPARQDLFNKLLASKAIEKAVEDEARSKKISHE
KAQQNAIALMEEIAADFSYETVRLSDRVLSWTWNRLYQGINVTNAERVRQLAQDGHEIVYVPCHRSHMDYLLLSYVLYHQ
GLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKLYSTVFREYLGELFTRGYSVEYFVEGGRSRTGRLLEPKTGTL
SMTIQAMLRGGSRPITLVPIYIGYEHVMEVGTYAKELRGATKEKESLLQMLRGLRKLRNLGQGYVNFGDPLPLTAYLNQN
VPQWRESIDPIEAQRPSWLTPTVNDLAAKIMVRINNAAAANAMNLCSTALLASRQRSLTREQLLEQLECYLQLMRNVPYA
GDVTVPTQTPDELLDHALNMNKFEVEKDNIGDIIILPREQAVLMTYYRNNIHHLLVLPSLIATIVMHHRRVSRAELLRQI
GLIYPMLKAELFLHNDKEQLPEVLRPLIDEMIRQQLICDKGDDLVLNPARIRPLQLLAAGVRETLQRYAITMSILSANPS
INRGALEKESRIMAQRLSVLHGINAPEFFDKAVFSTLVATLRAEGYINDIGDAVREHTMEVYNMLSDLITPEIKLTIESV
SMPAETNALPETVAAEEKED

Specific function: De novo phospholipid biosynthesis; first step. [C]

COG id: COG2937

COG function: function code I; Glycerol-3-phosphate O-acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPAT/DAPAT family

Homologues:

Organism=Homo sapiens, GI7657134, Length=443, Percent_Identity=28.8939051918736, Blast_Score=158, Evalue=3e-38,
Organism=Homo sapiens, GI190358539, Length=239, Percent_Identity=33.4728033472803, Blast_Score=123, Evalue=7e-28,
Organism=Escherichia coli, GI87082362, Length=803, Percent_Identity=81.4445828144458, Blast_Score=1337, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988723, Length=272, Percent_Identity=33.8235294117647, Blast_Score=148, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI25147672, Length=278, Percent_Identity=30.5755395683453, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71988728, Length=190, Percent_Identity=38.4210526315789, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI17864692, Length=276, Percent_Identity=30.4347826086957, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24650752, Length=486, Percent_Identity=25.3086419753086, Blast_Score=138, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21357731, Length=486, Percent_Identity=25.3086419753086, Blast_Score=138, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24650754, Length=486, Percent_Identity=25.3086419753086, Blast_Score=138, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PLSB_SERP5 (A8GKB6)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480684.1
- STRING:   A8GKB6
- GeneID:   5602699
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_4462
- eggNOG:   COG2937
- HOGENOM:   HBG296590
- OMA:   VIYVPCH
- ProtClustDB:   PRK04974
- BioCyc:   SPRO399741:SPRO_4462-MONOMER
- HAMAP:   MF_00393
- InterPro:   IPR002123
- InterPro:   IPR022284
- SMART:   SM00563
- TIGRFAMs:   TIGR03703

Pfam domain/function: PF01553 Acyltransferase

EC number: =2.3.1.15

Molecular weight: Translated: 93298; Mature: 93167

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGWRKIYYKLLNLPLKLLVRSKVIPSDPVTELGLDPSRPILYVLPYNSKADLLTLRTQC
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCEEEEECCCCCCHHHHHHHHH
LAQDLPDPLNPLEIDGTVLPSHVFIHDGPRVFRYYTPKEESVKLFHDYLDLHRSNPDLDI
HHHHCCCCCCCEECCCEECCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCEE
QMLPVSVMFGRSPGREGHGTPHLRLLNGVQKFFAVLWLGRDSFVRFSNTVSLRRMATEHG
EEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
TDKIIAQKLARVARMHFSRQRLAAVGPSLPARQDLFNKLLASKAIEKAVEDEARSKKISH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKAQQNAIALMEEIAADFSYETVRLSDRVLSWTWNRLYQGINVTNAERVRQLAQDGHEIV
HHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEE
YVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKL
EECCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHH
YSTVFREYLGELFTRGYSVEYFVEGGRSRTGRLLEPKTGTLSMTIQAMLRGGSRPITLVP
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCCCCHHHHHHHHHCCCCCCEEEEE
IYIGYEHVMEVGTYAKELRGATKEKESLLQMLRGLRKLRNLGQGYVNFGDPLPLTAYLNQ
EECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCC
NVPQWRESIDPIEAQRPSWLTPTVNDLAAKIMVRINNAAAANAMNLCSTALLASRQRSLT
CCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHH
REQLLEQLECYLQLMRNVPYAGDVTVPTQTPDELLDHALNMNKFEVEKDNIGDIIILPRE
HHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHCCCCCEEECCCCCCCEEEECCC
QAVLMTYYRNNIHHLLVLPSLIATIVMHHRRVSRAELLRQIGLIYPMLKAELFLHNDKEQ
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LPEVLRPLIDEMIRQQLICDKGDDLVLNPARIRPLQLLAAGVRETLQRYAITMSILSANP
HHHHHHHHHHHHHHHHHHCCCCCCEEECCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
SINRGALEKESRIMAQRLSVLHGINAPEFFDKAVFSTLVATLRAEGYINDIGDAVREHTM
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EVYNMLSDLITPEIKLTIESVSMPAETNALPETVAAEEKED
HHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure 
SGWRKIYYKLLNLPLKLLVRSKVIPSDPVTELGLDPSRPILYVLPYNSKADLLTLRTQC
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCEEEEECCCCCCHHHHHHHHH
LAQDLPDPLNPLEIDGTVLPSHVFIHDGPRVFRYYTPKEESVKLFHDYLDLHRSNPDLDI
HHHHCCCCCCCEECCCEECCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCEE
QMLPVSVMFGRSPGREGHGTPHLRLLNGVQKFFAVLWLGRDSFVRFSNTVSLRRMATEHG
EEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
TDKIIAQKLARVARMHFSRQRLAAVGPSLPARQDLFNKLLASKAIEKAVEDEARSKKISH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKAQQNAIALMEEIAADFSYETVRLSDRVLSWTWNRLYQGINVTNAERVRQLAQDGHEIV
HHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEE
YVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKL
EECCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHH
YSTVFREYLGELFTRGYSVEYFVEGGRSRTGRLLEPKTGTLSMTIQAMLRGGSRPITLVP
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCCCCHHHHHHHHHCCCCCCEEEEE
IYIGYEHVMEVGTYAKELRGATKEKESLLQMLRGLRKLRNLGQGYVNFGDPLPLTAYLNQ
EECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCC
NVPQWRESIDPIEAQRPSWLTPTVNDLAAKIMVRINNAAAANAMNLCSTALLASRQRSLT
CCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHH
REQLLEQLECYLQLMRNVPYAGDVTVPTQTPDELLDHALNMNKFEVEKDNIGDIIILPRE
HHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHCCCCCEEECCCCCCCEEEECCC
QAVLMTYYRNNIHHLLVLPSLIATIVMHHRRVSRAELLRQIGLIYPMLKAELFLHNDKEQ
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LPEVLRPLIDEMIRQQLICDKGDDLVLNPARIRPLQLLAAGVRETLQRYAITMSILSANP
HHHHHHHHHHHHHHHHHHCCCCCCEEECCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
SINRGALEKESRIMAQRLSVLHGINAPEFFDKAVFSTLVATLRAEGYINDIGDAVREHTM
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EVYNMLSDLITPEIKLTIESVSMPAETNALPETVAAEEKED
HHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA