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The map label for this gene is yahK [H]

Identifier: 157372674

GI number: 157372674

Start: 4915574

End: 4916626

Strand: Direct

Name: yahK [H]

Synonym: Spro_4441

Alternate gene names: 157372674

Gene position: 4915574-4916626 (Clockwise)

Preceding gene: 157372673

Following gene: 157372680

Centisome position: 90.21

GC content: 58.02

Gene sequence:

>1053_bases
ATGAACATTACGCACGCCTATGCCGCGCACGATGCCAAGTCAGCGCTTGTTCCTTTTGATTACACGCCGCGCACCCTGCG
CGACCACGATGTGCAAATCAACGTTCTGTTCTGCGGCGTCTGCCATTCTGATCTGCACCAGGCCCGCAACGAATGGAGCA
ACACGATTTTCCCGGTAGTGCCCGGCCACGAGATTGTTGGCCGCGTAAGTGCCGTCGGCAGCCATGTTTCACGCTATCAG
GTCGGCGATTTGGTCGGCGTGGGTTGTATGGTGGACTCTTGCCGTAGCTGTCCGAGCTGTGAAGAAGGGCTGGAGCAATA
CTGTGAAAACGGCTTTACCGGCACCTATAACGGACAGGATCGGCAAACCGGTGCCATCACCTACGGCGGCTACTCAACCG
CGATGACCGTGGACCAGGACTTTGTGCTGCGGGTGCCGGAGAACCTCGATCCGGCCGGTGTAGCGCCACTGCTGTGCGCC
GGTATCACCACCTATTCCCCGTTGCGCCAATGGGGTGCCGGCCCCGGTAAAAAGGTTGGCATTGTTGGTCTGGGCGGATT
AGGACATATGGGGGTCAAATTGGCCCGGGCGATGGGCGCGCATGTGGTGCTGTTCACTACCTCAGAATCCAAAGTCGAGG
ATGCCAAACGCCTCGGTGCCCACGAAGTGGTCATTTCCCGTGCCCCGGAACAGATGGCGCAGCACACCAACAGCTTCGAC
TTTATTCTTAACACCGTCGCAGCCCAGCACGATCTGAACCCGTTCCTTAACCTGCTGCGCCGCGACGGCACCCTGACGCT
GGTCGGTGCCCCGGAACACGATCACCCGTCACCGCAGGTGTTTAATCTGATCATGAAACGCCGCCGCCTCGCCGGTTCGC
TGATCGGCGGTATTGCAGAAACCCAGGAGATGCTGGATTTCTGTGGTCAGCACGGTATTACCTCAGACATCGAACTGATC
CCGATGCAGCAAATCAACCAGGCCTATGAGCGGATGCTGAAAAGCGACGTGAAATACCGTTTCGTGGTGGATATCAACTC
GCTGCGAGCTTAA

Upstream 100 bases:

>100_bases
ATCAATGTTCCCTCTGTGGCCACCTGCTGTATCCAGGCCGCGTCTCACCGGCATCCTGCTGCCGGAAGTAGTTCCCCACC
CTTTGATGACTGGAGTGACC

Downstream 100 bases:

>100_bases
CTCTAAGGGCGCCATTCATTGTGGCGCCCGATTTTTGCTTACAGTTGTTTAATCACCCGTGCCGGGTTGCCGCCGACCAC
GCAGTTGGCCGGTACGTCTT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MNITHAYAAHDAKSALVPFDYTPRTLRDHDVQINVLFCGVCHSDLHQARNEWSNTIFPVVPGHEIVGRVSAVGSHVSRYQ
VGDLVGVGCMVDSCRSCPSCEEGLEQYCENGFTGTYNGQDRQTGAITYGGYSTAMTVDQDFVLRVPENLDPAGVAPLLCA
GITTYSPLRQWGAGPGKKVGIVGLGGLGHMGVKLARAMGAHVVLFTTSESKVEDAKRLGAHEVVISRAPEQMAQHTNSFD
FILNTVAAQHDLNPFLNLLRRDGTLTLVGAPEHDHPSPQVFNLIMKRRRLAGSLIGGIAETQEMLDFCGQHGITSDIELI
PMQQINQAYERMLKSDVKYRFVVDINSLRA

Sequences:

>Translated_350_residues
MNITHAYAAHDAKSALVPFDYTPRTLRDHDVQINVLFCGVCHSDLHQARNEWSNTIFPVVPGHEIVGRVSAVGSHVSRYQ
VGDLVGVGCMVDSCRSCPSCEEGLEQYCENGFTGTYNGQDRQTGAITYGGYSTAMTVDQDFVLRVPENLDPAGVAPLLCA
GITTYSPLRQWGAGPGKKVGIVGLGGLGHMGVKLARAMGAHVVLFTTSESKVEDAKRLGAHEVVISRAPEQMAQHTNSFD
FILNTVAAQHDLNPFLNLLRRDGTLTLVGAPEHDHPSPQVFNLIMKRRRLAGSLIGGIAETQEMLDFCGQHGITSDIELI
PMQQINQAYERMLKSDVKYRFVVDINSLRA
>Mature_350_residues
MNITHAYAAHDAKSALVPFDYTPRTLRDHDVQINVLFCGVCHSDLHQARNEWSNTIFPVVPGHEIVGRVSAVGSHVSRYQ
VGDLVGVGCMVDSCRSCPSCEEGLEQYCENGFTGTYNGQDRQTGAITYGGYSTAMTVDQDFVLRVPENLDPAGVAPLLCA
GITTYSPLRQWGAGPGKKVGIVGLGGLGHMGVKLARAMGAHVVLFTTSESKVEDAKRLGAHEVVISRAPEQMAQHTNSFD
FILNTVAAQHDLNPFLNLLRRDGTLTLVGAPEHDHPSPQVFNLIMKRRRLAGSLIGGIAETQEMLDFCGQHGITSDIELI
PMQQINQAYERMLKSDVKYRFVVDINSLRA

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=352, Percent_Identity=25.5681818181818, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI34577061, Length=356, Percent_Identity=24.7191011235955, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI71743840, Length=359, Percent_Identity=23.3983286908078, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI262073058, Length=359, Percent_Identity=23.3983286908078, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786518, Length=346, Percent_Identity=64.1618497109827, Blast_Score=420, Evalue=1e-119,
Organism=Escherichia coli, GI87082401, Length=345, Percent_Identity=35.3623188405797, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI87081918, Length=343, Percent_Identity=26.530612244898, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI226510992, Length=315, Percent_Identity=25.7142857142857, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788073, Length=257, Percent_Identity=28.4046692607004, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790045, Length=279, Percent_Identity=25.089605734767, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788407, Length=278, Percent_Identity=25.8992805755396, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788075, Length=257, Percent_Identity=25.2918287937743, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=324, Percent_Identity=26.8518518518519, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17562584, Length=327, Percent_Identity=27.217125382263, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17562582, Length=330, Percent_Identity=28.4848484848485, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI25146526, Length=310, Percent_Identity=26.7741935483871, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=333, Percent_Identity=26.4264264264264, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=261, Percent_Identity=25.6704980842912, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=330, Percent_Identity=37.8787878787879, Blast_Score=194, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319949, Length=339, Percent_Identity=35.3982300884956, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319621, Length=335, Percent_Identity=32.5373134328358, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6323729, Length=327, Percent_Identity=30.5810397553517, Blast_Score=159, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6323961, Length=328, Percent_Identity=32.3170731707317, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6324486, Length=330, Percent_Identity=32.1212121212121, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6319258, Length=319, Percent_Identity=26.6457680250784, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=369, Percent_Identity=25.2032520325203, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17737895, Length=375, Percent_Identity=24.8, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737897, Length=221, Percent_Identity=28.9592760180996, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 38174; Mature: 38174

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITHAYAAHDAKSALVPFDYTPRTLRDHDVQINVLFCGVCHSDLHQARNEWSNTIFPVV
CCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHCCCEEEEC
PGHEIVGRVSAVGSHVSRYQVGDLVGVGCMVDSCRSCPSCEEGLEQYCENGFTGTYNGQD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCC
RQTGAITYGGYSTAMTVDQDFVLRVPENLDPAGVAPLLCAGITTYSPLRQWGAGPGKKVG
CCCCEEEECCCEEEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
IVGLGGLGHMGVKLARAMGAHVVLFTTSESKVEDAKRLGAHEVVISRAPEQMAQHTNSFD
EEEECCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCHHHHHHHCCHHHHHHHCCCHH
FILNTVAAQHDLNPFLNLLRRDGTLTLVGAPEHDHPSPQVFNLIMKRRRLAGSLIGGIAE
HHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TQEMLDFCGQHGITSDIELIPMQQINQAYERMLKSDVKYRFVVDINSLRA
HHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHCCCCEEEEEECHHHCC
>Mature Secondary Structure
MNITHAYAAHDAKSALVPFDYTPRTLRDHDVQINVLFCGVCHSDLHQARNEWSNTIFPVV
CCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHCCCEEEEC
PGHEIVGRVSAVGSHVSRYQVGDLVGVGCMVDSCRSCPSCEEGLEQYCENGFTGTYNGQD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCC
RQTGAITYGGYSTAMTVDQDFVLRVPENLDPAGVAPLLCAGITTYSPLRQWGAGPGKKVG
CCCCEEEECCCEEEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
IVGLGGLGHMGVKLARAMGAHVVLFTTSESKVEDAKRLGAHEVVISRAPEQMAQHTNSFD
EEEECCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCHHHHHHHCCHHHHHHHCCCHH
FILNTVAAQHDLNPFLNLLRRDGTLTLVGAPEHDHPSPQVFNLIMKRRRLAGSLIGGIAE
HHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TQEMLDFCGQHGITSDIELIPMQQINQAYERMLKSDVKYRFVVDINSLRA
HHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHCCCCEEEEEECHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]