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The map label for this gene is aaeR [H]

Identifier: 157372626

GI number: 157372626

Start: 4857368

End: 4858279

Strand: Direct

Name: aaeR [H]

Synonym: Spro_4393

Alternate gene names: 157372626

Gene position: 4857368-4858279 (Clockwise)

Preceding gene: 157372620

Following gene: 157372629

Centisome position: 89.14

GC content: 57.02

Gene sequence:

>912_bases
ATGGAAAGACTAAAACGGATGTCGGTATTCGCCAAAGTGGTTGAATGCGGGTCATTTACTGCGGCAGCGCGCCAGTTGGA
TATGAGCGTTTCATCTATCAGCCAGACCGTCTCCAAACTGGAGAATGAGCTGCAGGTCAAGCTGCTCAACCGCAGCACGC
GCAGCATTGGCCTGACGGAGGCCGGAAAAATCTATTATCAGGGCTGTCGCCGCATGCTGCTGGAAGTCAGCGAAGTGCAT
GAGCAGCTGTACGCGTTTAACAATACGCCGACCGGCACGCTGCGCATTGGTAGCTCATCCACCATGGCACAAAACGTGCT
GGCAACCATGACCGCAGATATGCTCAAAGAGTACCCCGGCCTGACGGTGAACCTGGTGACCGGCATCCCGGCACCGGATC
TGATCGCCGACGGGCTGGACGTAGTGATCCGCACCGGCGCGCTGCAGGATTCCAGCCTGTTCTCCAAACGCCTGGGTTCA
ATGCCGATGGTAGTGTGCGCCGCCAAAAGCTATCTCAGCCAACACGGCACGCCGCTAAAACCAAGCGATATGGTCAATTT
TTCCTGGCTGGAATACAGCGTGCGGCCAGACAGCGAGTTCGAGCTGATCGCGCCAGAAGGCATCAGCACGCGCATCTCGC
CGCAGGGACGCTTCGTCACCAACGATTCACAGACCATGATCCGCTGGCTGAAAGCCGGGGCCGGTATCGCCTATGCACCG
CTGATGTGGGTGATCGAGGAGATCAAACGCGGAGAGATCGAGATCCTGTTCAAAAACTACCATTCGGATCCTCGCCCGGT
GTACGCAGTGTACACCGAGAAAGACAAGCTGCCGCTCAAGGTACAGGTGTGCATCAACTACCTGACCGAGTACTTTAAGC
GCGTGGGGGAAGTCTATCAGGGCTACCGCTGA

Upstream 100 bases:

>100_bases
CGTTAGTAAGGTCTTTTCACCCGACCTGTTTATATTAGCGTGCTTACTATCAAGTCATCAACAATCTGTGATCTAAATCA
CTTTTAAGCCAGAGTGAATA

Downstream 100 bases:

>100_bases
GCAATACACGACGCGCCAAAGCGCCAAGCACCAGTATTGCCAGCATACCCAGCCCCCAGATTAACCAGACGGCGTACTTC
GCCCAGGTGAGCAACAGTGG

Product: putative DNA-binding transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MERLKRMSVFAKVVECGSFTAAARQLDMSVSSISQTVSKLENELQVKLLNRSTRSIGLTEAGKIYYQGCRRMLLEVSEVH
EQLYAFNNTPTGTLRIGSSSTMAQNVLATMTADMLKEYPGLTVNLVTGIPAPDLIADGLDVVIRTGALQDSSLFSKRLGS
MPMVVCAAKSYLSQHGTPLKPSDMVNFSWLEYSVRPDSEFELIAPEGISTRISPQGRFVTNDSQTMIRWLKAGAGIAYAP
LMWVIEEIKRGEIEILFKNYHSDPRPVYAVYTEKDKLPLKVQVCINYLTEYFKRVGEVYQGYR

Sequences:

>Translated_303_residues
MERLKRMSVFAKVVECGSFTAAARQLDMSVSSISQTVSKLENELQVKLLNRSTRSIGLTEAGKIYYQGCRRMLLEVSEVH
EQLYAFNNTPTGTLRIGSSSTMAQNVLATMTADMLKEYPGLTVNLVTGIPAPDLIADGLDVVIRTGALQDSSLFSKRLGS
MPMVVCAAKSYLSQHGTPLKPSDMVNFSWLEYSVRPDSEFELIAPEGISTRISPQGRFVTNDSQTMIRWLKAGAGIAYAP
LMWVIEEIKRGEIEILFKNYHSDPRPVYAVYTEKDKLPLKVQVCINYLTEYFKRVGEVYQGYR
>Mature_303_residues
MERLKRMSVFAKVVECGSFTAAARQLDMSVSSISQTVSKLENELQVKLLNRSTRSIGLTEAGKIYYQGCRRMLLEVSEVH
EQLYAFNNTPTGTLRIGSSSTMAQNVLATMTADMLKEYPGLTVNLVTGIPAPDLIADGLDVVIRTGALQDSSLFSKRLGS
MPMVVCAAKSYLSQHGTPLKPSDMVNFSWLEYSVRPDSEFELIAPEGISTRISPQGRFVTNDSQTMIRWLKAGAGIAYAP
LMWVIEEIKRGEIEILFKNYHSDPRPVYAVYTEKDKLPLKVQVCINYLTEYFKRVGEVYQGYR

Specific function: Activates transcription of the aaeXAB operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=300, Percent_Identity=83.3333333333333, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI145693193, Length=297, Percent_Identity=29.2929292929293, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1786401, Length=300, Percent_Identity=29.6666666666667, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1787128, Length=267, Percent_Identity=27.7153558052434, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI87081978, Length=291, Percent_Identity=29.2096219931272, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789440, Length=303, Percent_Identity=25.7425742574257, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787589, Length=275, Percent_Identity=27.6363636363636, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI157672245, Length=190, Percent_Identity=30, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790262, Length=256, Percent_Identity=26.171875, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788706, Length=141, Percent_Identity=31.2056737588652, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788481, Length=146, Percent_Identity=30.8219178082192, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788297, Length=123, Percent_Identity=30.0813008130081, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789173, Length=262, Percent_Identity=25.1908396946565, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787601, Length=126, Percent_Identity=23.8095238095238, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33908; Mature: 33908

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERLKRMSVFAKVVECGSFTAAARQLDMSVSSISQTVSKLENELQVKLLNRSTRSIGLTE
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
AGKIYYQGCRRMLLEVSEVHEQLYAFNNTPTGTLRIGSSSTMAQNVLATMTADMLKEYPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCC
LTVNLVTGIPAPDLIADGLDVVIRTGALQDSSLFSKRLGSMPMVVCAAKSYLSQHGTPLK
CEEEEEECCCCHHHHHCCHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCC
PSDMVNFSWLEYSVRPDSEFELIAPEGISTRISPQGRFVTNDSQTMIRWLKAGAGIAYAP
CCCCCEEEEEEEEECCCCCEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHHCCCHHHHH
LMWVIEEIKRGEIEILFKNYHSDPRPVYAVYTEKDKLPLKVQVCINYLTEYFKRVGEVYQ
HHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
GYR
CCC
>Mature Secondary Structure
MERLKRMSVFAKVVECGSFTAAARQLDMSVSSISQTVSKLENELQVKLLNRSTRSIGLTE
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
AGKIYYQGCRRMLLEVSEVHEQLYAFNNTPTGTLRIGSSSTMAQNVLATMTADMLKEYPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCC
LTVNLVTGIPAPDLIADGLDVVIRTGALQDSSLFSKRLGSMPMVVCAAKSYLSQHGTPLK
CEEEEEECCCCHHHHHCCHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCC
PSDMVNFSWLEYSVRPDSEFELIAPEGISTRISPQGRFVTNDSQTMIRWLKAGAGIAYAP
CCCCCEEEEEEEEECCCCCEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHHCCCHHHHH
LMWVIEEIKRGEIEILFKNYHSDPRPVYAVYTEKDKLPLKVQVCINYLTEYFKRVGEVYQ
HHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
GYR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]