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The map label for this gene is aaeA

Identifier: 157372624

GI number: 157372624

Start: 4855913

End: 4856848

Strand: Reverse

Name: aaeA

Synonym: Spro_4391

Alternate gene names: 157372624

Gene position: 4856848-4855913 (Counterclockwise)

Preceding gene: 157372625

Following gene: 157372623

Centisome position: 89.14

GC content: 58.12

Gene sequence:

>936_bases
GTGAAAAATTTTTCAATAAAAATAACCCGAATCGCGATCACTCTGATTCTGGTCCTGCTGGGGATCATAGCCATATTCAA
GGCCTGGGTGTTCTACACCGAATCCCCGTGGACGCGTGACGCCAAGTTCACCGCCGACGTGGTGGCGATCGCCCCGGACG
TCACCGGTCTATTGACCGATGTCCCTCTGGTGGATAACCAACTGGTGAAGAAAGGGCAGGTGCTGCTGGTGATTGACCAG
CCGCGCTACCAACAGGCCCTGGCGGAAGCCAATGCCGATGTCGCCTACTACCAGACGCTGGCGGCAGAAAAAAGACGTGA
AGCCGGCCGCCGTGTGCGCCTCGGCGTGCAGGCGATGTCGCAGGAAGAGATCGACCAGGCGAATAACGTATTGCAAACCG
TAGAGCATCAGCTGGCTAAGGCTGTAGCGACCCGTGAACTGGCTAAATTGGATCTGGAACGCACTACGGTACGCGCACCG
GCCGATGGCTGGATCACCAACCTGAACGTGCACGCCGGCGAATACATCACCCGGGGTTCAGTCGCCGTGGCGCTGGTGAA
GAAAAACAGCTTCTACATTCTGGCCTATCTGGAAGAAACCAAGCTCAATGGTCTGAACAAGGGCGACCGTGCGGAAATCA
CTCCGCTGGGCAGTAACCGCATCATGCACGGCACCGTCGATAGCGTGGCCGCCGCCGTCAACAACAGCAGCAGCACCGTG
AACAGCAAAGGACTGGCGTCGATCGACAGCAACCTGGAGTGGGTGCGTCTGGCGCAGCGCGTGCCGGTAAAAATCCTGCT
GGACGACAAAGACCAATTGCACCCGTACCCGGCTGGCACCACCGCTACCGTGGTGATCACCGGTAAGAATGACCGCGCTA
CCGACAGCGGCTCGCCTTTTGTGCGTTTGATGCATCGGCTGCGTGAGTTCGGTTAA

Upstream 100 bases:

>100_bases
ACCGGGATTTACGATTTTGTCTGGCATCCAGCGCTGTTTAATACTGCGCTGTACTGCTGTTTGTTCTATCTGATTACCTG
TCTTTTCGTTTGAGGTCGCT

Downstream 100 bases:

>100_bases
TGAATAACCCAACCTTTATTCGGCTGAGATTTGCCTTCAAGCTCAGCTTTGCGGTGGTGTTTGCGCTGTTCGTCGGCTTC
CATCTCAATCTGGAAACCCC

Product: p-hydroxybenzoic acid efflux subunit AaeA

Products: NA

Alternate protein names: pHBA efflux pump protein A

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKNFSIKITRIAITLILVLLGIIAIFKAWVFYTESPWTRDAKFTADVVAIAPDVTGLLTDVPLVDNQLVKKGQVLLVIDQ
PRYQQALAEANADVAYYQTLAAEKRREAGRRVRLGVQAMSQEEIDQANNVLQTVEHQLAKAVATRELAKLDLERTTVRAP
ADGWITNLNVHAGEYITRGSVAVALVKKNSFYILAYLEETKLNGLNKGDRAEITPLGSNRIMHGTVDSVAAAVNNSSSTV
NSKGLASIDSNLEWVRLAQRVPVKILLDDKDQLHPYPAGTTATVVITGKNDRATDSGSPFVRLMHRLREFG

Sequences:

>Translated_311_residues
MKNFSIKITRIAITLILVLLGIIAIFKAWVFYTESPWTRDAKFTADVVAIAPDVTGLLTDVPLVDNQLVKKGQVLLVIDQ
PRYQQALAEANADVAYYQTLAAEKRREAGRRVRLGVQAMSQEEIDQANNVLQTVEHQLAKAVATRELAKLDLERTTVRAP
ADGWITNLNVHAGEYITRGSVAVALVKKNSFYILAYLEETKLNGLNKGDRAEITPLGSNRIMHGTVDSVAAAVNNSSSTV
NSKGLASIDSNLEWVRLAQRVPVKILLDDKDQLHPYPAGTTATVVITGKNDRATDSGSPFVRLMHRLREFG
>Mature_311_residues
MKNFSIKITRIAITLILVLLGIIAIFKAWVFYTESPWTRDAKFTADVVAIAPDVTGLLTDVPLVDNQLVKKGQVLLVIDQ
PRYQQALAEANADVAYYQTLAAEKRREAGRRVRLGVQAMSQEEIDQANNVLQTVEHQLAKAVATRELAKLDLERTTVRAP
ADGWITNLNVHAGEYITRGSVAVALVKKNSFYILAYLEETKLNGLNKGDRAEITPLGSNRIMHGTVDSVAAAVNNSSSTV
NSKGLASIDSNLEWVRLAQRVPVKILLDDKDQLHPYPAGTTATVVITGKNDRATDSGSPFVRLMHRLREFG

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family

Homologues:

Organism=Escherichia coli, GI1789637, Length=311, Percent_Identity=72.9903536977492, Blast_Score=467, Evalue=1e-133,
Organism=Escherichia coli, GI87081951, Length=283, Percent_Identity=37.1024734982332, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI1790519, Length=291, Percent_Identity=28.5223367697594, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1788711, Length=337, Percent_Identity=24.9258160237389, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AAEA_SERP5 (A8GK45)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480613.1
- ProteinModelPortal:   A8GK45
- STRING:   A8GK45
- GeneID:   5606766
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_4391
- eggNOG:   COG1566
- HOGENOM:   HBG624965
- OMA:   YLLAYME
- ProtClustDB:   PRK10559
- BioCyc:   SPRO399741:SPRO_4391-MONOMER
- HAMAP:   MF_01544
- InterPro:   IPR022871
- InterPro:   IPR006143
- TIGRFAMs:   TIGR01730

Pfam domain/function: PF00529 HlyD

EC number: NA

Molecular weight: Translated: 34201; Mature: 34201

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1190a4a8)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNFSIKITRIAITLILVLLGIIAIFKAWVFYTESPWTRDAKFTADVVAIAPDVTGLLTD
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEEEEECCCHHHHHHC
VPLVDNQLVKKGQVLLVIDQPRYQQALAEANADVAYYQTLAAEKRREAGRRVRLGVQAMS
CCCCCHHHHCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHC
QEEIDQANNVLQTVEHQLAKAVATRELAKLDLERTTVRAPADGWITNLNVHAGEYITRGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEEECCCEEECCC
VAVALVKKNSFYILAYLEETKLNGLNKGDRAEITPLGSNRIMHGTVDSVAAAVNNSSSTV
EEEEEEECCCEEEEEEEEECCCCCCCCCCCCEEEECCCCCEEECCHHHHHHHHCCCCCCC
NSKGLASIDSNLEWVRLAQRVPVKILLDDKDQLHPYPAGTTATVVITGKNDRATDSGSPF
CCCCCHHHCCCHHHHHHHHHCCEEEEECCCHHCCCCCCCCEEEEEEECCCCCCCCCCCHH
VRLMHRLREFG
HHHHHHHHHCH
>Mature Secondary Structure
MKNFSIKITRIAITLILVLLGIIAIFKAWVFYTESPWTRDAKFTADVVAIAPDVTGLLTD
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEEEEECCCHHHHHHC
VPLVDNQLVKKGQVLLVIDQPRYQQALAEANADVAYYQTLAAEKRREAGRRVRLGVQAMS
CCCCCHHHHCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHC
QEEIDQANNVLQTVEHQLAKAVATRELAKLDLERTTVRAPADGWITNLNVHAGEYITRGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEEECCCEEECCC
VAVALVKKNSFYILAYLEETKLNGLNKGDRAEITPLGSNRIMHGTVDSVAAAVNNSSSTV
EEEEEEECCCEEEEEEEEECCCCCCCCCCCCEEEECCCCCEEECCHHHHHHHHCCCCCCC
NSKGLASIDSNLEWVRLAQRVPVKILLDDKDQLHPYPAGTTATVVITGKNDRATDSGSPF
CCCCCHHHCCCHHHHHHHHHCCEEEEECCCHHCCCCCCCCEEEEEEECCCCCCCCCCCHH
VRLMHRLREFG
HHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA