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The map label for this gene is aaeB [H]

Identifier: 157372623

GI number: 157372623

Start: 4853946

End: 4855913

Strand: Reverse

Name: aaeB [H]

Synonym: Spro_4390

Alternate gene names: 157372623

Gene position: 4855913-4853946 (Counterclockwise)

Preceding gene: 157372624

Following gene: 157372622

Centisome position: 89.12

GC content: 56.81

Gene sequence:

>1968_bases
ATGAATAACCCAACCTTTATTCGGCTGAGATTTGCCTTCAAGCTCAGCTTTGCGGTGGTGTTTGCGCTGTTCGTCGGCTT
CCATCTCAATCTGGAAACCCCACGCTGGTCGGCGATGACCGCCGCCATCGTGGCCGCCGGTACGGCCTTTGCCGCGGGCG
GCGAGCCTTTTTCCGGTGCTATTCGTCATCGCGGTTGGCTGCGTATTATCGGCACATTCATCGGCTGCTTTGTCGGCATA
GCGATTATCGTCACTACGGCGCGTGCGCCGGTGGTGATGTTGCTGCTGTGCTGCATTTGGGCCGGCTTCTGCACCTGGAT
TTCCTCTCTGGTTAAAGTTGAAAACTCCTATGCCTGGGGCCTGGCGGGTTATACCGCGCTAATCATTATTGTCACCGTTG
CCAGCAGCGAAGCGCATCTGCTGGAAGCGCCGCAGTTTGCTATTGAGCGCTGCAGCGAGATCGTGCTGGGGATCGTCAGC
GCCGTGCTGGCAGACTTGTTGTTCTCGCCGCGTTCAATCAAACAGGATATCGACCGGGCGGTGGATAAACTGCTGGTGGA
TCAGTACCTGTTGATGCAGATGTGCATCAGCAATGCCGAGAAAGAAGATATCGACCGCGCCTGGAGCAATTTGGTGAAGA
GCACCACAGCGCTGAACGGCATGCGCAGCAACCTGATGATGGAGTCATCACGCTGGCAAAAGGCGAATCGCCGCATTCTG
GCGCTGCATACGCTTTCGCTGACGTTGATTACCCAGGCCTGCGAGACCTATTTAATCCTGTTGAACCACCCGGATGCGCT
GAAAGAAAACGTTCGCGAGTTGCTGATGGTACCGGCCCAAACGCCGCAGGAAATCCATAAACGCATGAAGTTGTTGCGGC
AGGTGCTGACCACCAACCGTACCGACGAGACGTTAGTGACTATCACCAGTTGGGTGGGGGCGGCCACTCGCTACCTGCTG
CTGGCCAAAGGCGTACACACCAACAGCAGTATCAGTTCGGTAGAAGAAGGGGTGTTGAGCAGTGAGGTGGTGGTTAAACC
GACCTCGGCGGAAAGACACCACGCAATGATTAATGGTCTGCGCACCTTTGTGGCGACGGCCTTTGGCAGCCTGCTGTGGC
TGTGGACCGGCTGGACCTCCGGCAGCGGCTTTATGGTGATCATTGCGGTGATCACCTCCCTGGCGATGCGCACCCCGGCA
CCGCGCATGGTGGCGATGGACTTTATACTGGGCATGCTGGCGGCGATCCCGGTCGGCTCACTGTACTTTATGGTGATCCT
GCCGGCGACTCAGCAAAGTATTTTACTGCTGTGCCTCAGTCTGGGCCTGCTGGCGTTTTTCATCGGTATCGAAGTGCAGA
AACGACGGTTGGGCTCGCTTGGCCTGCTGGCGGGGACCATCAATATTCTGGTATTGAGCAACCCAATGGAGTTCAACGTC
ACGCAGTTCCTCGATGGTGCACTCGGCCAGTTCCTCGGCAGCTGTGTGGGCCTGATGGTGCTGCTGCTGATCCGCGATAA
CTCGCGTGAACGTACCGGTCGCACCTTGCTGAACCAGTTTGTCGGCAGCGCGGTATCGGCGCTGACTACCAAGGCCGCAC
GCCGTCAGCAAAACCACCTGCCGGCGCTGTATCAGCAGTTGAATCAGCTGCTGATGATGTTCCCGAACGATATTGCCAAG
TACCGATTGGCGCTGAACCTGATCATCGCTCACCAGCGTATGCAGCGGGCTGAGATCCCGGTCAGCGAGGAGCTTTCGGC
TTTCCATAAGCAGATCCGCAATACCGCCGACCACATGGTCTCGGCGAAGAACGAGGTAAAACGTGCTTATTATTACGATC
GGCTGTTGAGTGAAATGAACGATTATCAGCAGAAGCTGGTGGATTATCAGGCCCCGCTCAGCGTTACCGGGCCGGTAAAA
CGTCTGGCCGACATGCTGTATCGCTATCGCCACGCCCTGATTGACTGA

Upstream 100 bases:

>100_bases
GCACCACCGCTACCGTGGTGATCACCGGTAAGAATGACCGCGCTACCGACAGCGGCTCGCCTTTTGTGCGTTTGATGCAT
CGGCTGCGTGAGTTCGGTTA

Downstream 100 bases:

>100_bases
TACCTCAAATTTTCTTGCCGGGGCTATACTTGCCTGAGATAGCCCCGTTTCAGAGTTGCACTGAGTGCCTGACCGGCTGC
AAAATGGCATGATTAGCTTG

Product: p-hydroxybenzoic acid efflux subunit AaeB

Products: NA

Alternate protein names: pHBA efflux pump protein B [H]

Number of amino acids: Translated: 655; Mature: 655

Protein sequence:

>655_residues
MNNPTFIRLRFAFKLSFAVVFALFVGFHLNLETPRWSAMTAAIVAAGTAFAAGGEPFSGAIRHRGWLRIIGTFIGCFVGI
AIIVTTARAPVVMLLLCCIWAGFCTWISSLVKVENSYAWGLAGYTALIIIVTVASSEAHLLEAPQFAIERCSEIVLGIVS
AVLADLLFSPRSIKQDIDRAVDKLLVDQYLLMQMCISNAEKEDIDRAWSNLVKSTTALNGMRSNLMMESSRWQKANRRIL
ALHTLSLTLITQACETYLILLNHPDALKENVRELLMVPAQTPQEIHKRMKLLRQVLTTNRTDETLVTITSWVGAATRYLL
LAKGVHTNSSISSVEEGVLSSEVVVKPTSAERHHAMINGLRTFVATAFGSLLWLWTGWTSGSGFMVIIAVITSLAMRTPA
PRMVAMDFILGMLAAIPVGSLYFMVILPATQQSILLLCLSLGLLAFFIGIEVQKRRLGSLGLLAGTINILVLSNPMEFNV
TQFLDGALGQFLGSCVGLMVLLLIRDNSRERTGRTLLNQFVGSAVSALTTKAARRQQNHLPALYQQLNQLLMMFPNDIAK
YRLALNLIIAHQRMQRAEIPVSEELSAFHKQIRNTADHMVSAKNEVKRAYYYDRLLSEMNDYQQKLVDYQAPLSVTGPVK
RLADMLYRYRHALID

Sequences:

>Translated_655_residues
MNNPTFIRLRFAFKLSFAVVFALFVGFHLNLETPRWSAMTAAIVAAGTAFAAGGEPFSGAIRHRGWLRIIGTFIGCFVGI
AIIVTTARAPVVMLLLCCIWAGFCTWISSLVKVENSYAWGLAGYTALIIIVTVASSEAHLLEAPQFAIERCSEIVLGIVS
AVLADLLFSPRSIKQDIDRAVDKLLVDQYLLMQMCISNAEKEDIDRAWSNLVKSTTALNGMRSNLMMESSRWQKANRRIL
ALHTLSLTLITQACETYLILLNHPDALKENVRELLMVPAQTPQEIHKRMKLLRQVLTTNRTDETLVTITSWVGAATRYLL
LAKGVHTNSSISSVEEGVLSSEVVVKPTSAERHHAMINGLRTFVATAFGSLLWLWTGWTSGSGFMVIIAVITSLAMRTPA
PRMVAMDFILGMLAAIPVGSLYFMVILPATQQSILLLCLSLGLLAFFIGIEVQKRRLGSLGLLAGTINILVLSNPMEFNV
TQFLDGALGQFLGSCVGLMVLLLIRDNSRERTGRTLLNQFVGSAVSALTTKAARRQQNHLPALYQQLNQLLMMFPNDIAK
YRLALNLIIAHQRMQRAEIPVSEELSAFHKQIRNTADHMVSAKNEVKRAYYYDRLLSEMNDYQQKLVDYQAPLSVTGPVK
RLADMLYRYRHALID
>Mature_655_residues
MNNPTFIRLRFAFKLSFAVVFALFVGFHLNLETPRWSAMTAAIVAAGTAFAAGGEPFSGAIRHRGWLRIIGTFIGCFVGI
AIIVTTARAPVVMLLLCCIWAGFCTWISSLVKVENSYAWGLAGYTALIIIVTVASSEAHLLEAPQFAIERCSEIVLGIVS
AVLADLLFSPRSIKQDIDRAVDKLLVDQYLLMQMCISNAEKEDIDRAWSNLVKSTTALNGMRSNLMMESSRWQKANRRIL
ALHTLSLTLITQACETYLILLNHPDALKENVRELLMVPAQTPQEIHKRMKLLRQVLTTNRTDETLVTITSWVGAATRYLL
LAKGVHTNSSISSVEEGVLSSEVVVKPTSAERHHAMINGLRTFVATAFGSLLWLWTGWTSGSGFMVIIAVITSLAMRTPA
PRMVAMDFILGMLAAIPVGSLYFMVILPATQQSILLLCLSLGLLAFFIGIEVQKRRLGSLGLLAGTINILVLSNPMEFNV
TQFLDGALGQFLGSCVGLMVLLLIRDNSRERTGRTLLNQFVGSAVSALTTKAARRQQNHLPALYQQLNQLLMMFPNDIAK
YRLALNLIIAHQRMQRAEIPVSEELSAFHKQIRNTADHMVSAKNEVKRAYYYDRLLSEMNDYQQKLVDYQAPLSVTGPVK
RLADMLYRYRHALID

Specific function: Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell [H]

COG id: COG1289

COG function: function code S; Predicted membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family [H]

Homologues:

Organism=Escherichia coli, GI1789636, Length=647, Percent_Identity=63.5239567233385, Blast_Score=844, Evalue=0.0,
Organism=Escherichia coli, GI1787933, Length=565, Percent_Identity=22.3008849557522, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006726 [H]

Pfam domain/function: PF04632 FUSC [H]

EC number: NA

Molecular weight: Translated: 72752; Mature: 72752

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNPTFIRLRFAFKLSFAVVFALFVGFHLNLETPRWSAMTAAIVAAGTAFAAGGEPFSGA
CCCCCEEEEEHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCHHHCCCCCCCCHH
IRHRGWLRIIGTFIGCFVGIAIIVTTARAPVVMLLLCCIWAGFCTWISSLVKVENSYAWG
HHHCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
LAGYTALIIIVTVASSEAHLLEAPQFAIERCSEIVLGIVSAVLADLLFSPRSIKQDIDRA
HHHHHHHHHHHEECCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VDKLLVDQYLLMQMCISNAEKEDIDRAWSNLVKSTTALNGMRSNLMMESSRWQKANRRIL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
ALHTLSLTLITQACETYLILLNHPDALKENVRELLMVPAQTPQEIHKRMKLLRQVLTTNR
EEHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
TDETLVTITSWVGAATRYLLLAKGVHTNSSISSVEEGVLSSEVVVKPTSAERHHAMINGL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEECCCCCHHHHHHHHHH
RTFVATAFGSLLWLWTGWTSGSGFMVIIAVITSLAMRTPAPRMVAMDFILGMLAAIPVGS
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHH
LYFMVILPATQQSILLLCLSLGLLAFFIGIEVQKRRLGSLGLLAGTINILVLSNPMEFNV
HHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEEECCCCCCCH
TQFLDGALGQFLGSCVGLMVLLLIRDNSRERTGRTLLNQFVGSAVSALTTKAARRQQNHL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PALYQQLNQLLMMFPNDIAKYRLALNLIIAHQRMQRAEIPVSEELSAFHKQIRNTADHMV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SAKNEVKRAYYYDRLLSEMNDYQQKLVDYQAPLSVTGPVKRLADMLYRYRHALID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNNPTFIRLRFAFKLSFAVVFALFVGFHLNLETPRWSAMTAAIVAAGTAFAAGGEPFSGA
CCCCCEEEEEHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCHHHCCCCCCCCHH
IRHRGWLRIIGTFIGCFVGIAIIVTTARAPVVMLLLCCIWAGFCTWISSLVKVENSYAWG
HHHCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
LAGYTALIIIVTVASSEAHLLEAPQFAIERCSEIVLGIVSAVLADLLFSPRSIKQDIDRA
HHHHHHHHHHHEECCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VDKLLVDQYLLMQMCISNAEKEDIDRAWSNLVKSTTALNGMRSNLMMESSRWQKANRRIL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
ALHTLSLTLITQACETYLILLNHPDALKENVRELLMVPAQTPQEIHKRMKLLRQVLTTNR
EEHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
TDETLVTITSWVGAATRYLLLAKGVHTNSSISSVEEGVLSSEVVVKPTSAERHHAMINGL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEECCCCCHHHHHHHHHH
RTFVATAFGSLLWLWTGWTSGSGFMVIIAVITSLAMRTPAPRMVAMDFILGMLAAIPVGS
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHH
LYFMVILPATQQSILLLCLSLGLLAFFIGIEVQKRRLGSLGLLAGTINILVLSNPMEFNV
HHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEEECCCCCCCH
TQFLDGALGQFLGSCVGLMVLLLIRDNSRERTGRTLLNQFVGSAVSALTTKAARRQQNHL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PALYQQLNQLLMMFPNDIAKYRLALNLIIAHQRMQRAEIPVSEELSAFHKQIRNTADHMV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SAKNEVKRAYYYDRLLSEMNDYQQKLVDYQAPLSVTGPVKRLADMLYRYRHALID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA